DK283889A - Nye polypeptider med antikoagulerende virkning - Google Patents

Nye polypeptider med antikoagulerende virkning Download PDF

Info

Publication number
DK283889A
DK283889A DK283889A DK283889A DK283889A DK 283889 A DK283889 A DK 283889A DK 283889 A DK283889 A DK 283889A DK 283889 A DK283889 A DK 283889A DK 283889 A DK283889 A DK 283889A
Authority
DK
Denmark
Prior art keywords
new polypeptides
anticoagulative effect
anticoagulative
effect
polypeptides
Prior art date
Application number
DK283889A
Other languages
Danish (da)
English (en)
Other versions
DK283889D0 (da
Inventor
Reinhard Maschler
Verena Steiner
Markus Gerhard Gruetter
Fritz Raschdorf
Original Assignee
Ciba Geigy Ag
Ucp Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888813876A external-priority patent/GB8813876D0/en
Application filed by Ciba Geigy Ag, Ucp Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of DK283889D0 publication Critical patent/DK283889D0/da
Publication of DK283889A publication Critical patent/DK283889A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK283889A 1988-06-11 1989-06-09 Nye polypeptider med antikoagulerende virkning DK283889A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888813876A GB8813876D0 (en) 1988-06-11 1988-06-11 Novel polypeptides with anticoagulant activity
GB888818123A GB8818123D0 (en) 1988-06-11 1988-07-29 Novel polypeptides with anticoagulant activity

Publications (2)

Publication Number Publication Date
DK283889D0 DK283889D0 (da) 1989-06-09
DK283889A true DK283889A (da) 1989-12-12

Family

ID=26294006

Family Applications (1)

Application Number Title Priority Date Filing Date
DK283889A DK283889A (da) 1988-06-11 1989-06-09 Nye polypeptider med antikoagulerende virkning

Country Status (10)

Country Link
US (1) US5114922A (es)
EP (1) EP0347376B1 (es)
JP (1) JPH02117697A (es)
AU (1) AU625375B2 (es)
CA (1) CA1339106C (es)
DE (1) DE58907266T2 (es)
DK (1) DK283889A (es)
ES (1) ES2052062T3 (es)
IE (1) IE61809B1 (es)
PT (1) PT90798B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052712T3 (es) * 1987-04-09 1994-07-16 Delta Biotechnology Ltd Vector de levadura.
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
CA2026377A1 (en) * 1989-10-03 1991-04-04 John L. Krstenansky Radiolabeled anticoagulant peptides
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
CA2035917C (en) * 1990-02-13 2001-10-02 John L. Krstenansky Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
EP0540574B1 (en) * 1990-07-24 1996-09-11 Merrell Pharmaceuticals Inc. Anticoagulant peptides
GB9022040D0 (en) * 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
CA2255396A1 (en) * 1990-11-08 1992-05-09 Nippon Mining Company Limited Hirudin analog, method of manufacturing thereof and anti-coagulant composition, and secretion vector, transformed microorganisms containing said vector and manufacturing method ofproducts which is produced from said microorganism
IL101062A0 (en) * 1991-02-28 1992-11-15 Erba Carlo Spa Anti-thrombin polypeptides and their preparation
US6719975B1 (en) * 1991-06-27 2004-04-13 Farmitalia Carlo Erba S.R.L. Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
WO1994023735A1 (en) * 1993-04-09 1994-10-27 Bio-Technology General Corp. Novel polypeptide having factor xa inhibitory activity
US5824641A (en) * 1993-04-09 1998-10-20 Bio-Technology General Corp Method of treating of preventing influenza
JP3532920B2 (ja) * 1993-06-11 2004-05-31 メレル ファーマスーティカルズ インコーポレイテッド 三機能性の抗血栓及び抗血小板ペプチド類
HUT72926A (en) * 1993-08-04 1996-06-28 Ciba Geigy Ag High molecular weight desulphatohirudin
RU2112528C1 (ru) * 1994-12-23 1998-06-10 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН СПОСОБ ПОЛУЧЕНИЯ ФЕРМЕНТА ДЕСТАБИЛАЗЫ, ОБЛАДАЮЩЕГО ФИБРИНОЛИТИЧЕСКОЙ, ТРОМБОЛИТИЧЕСКОЙ, ЭНДО- И ЭКЗО- ε(γ GLY)-LYS-ИЗОПЕПТИДАЗНОЙ И АМИДОЛИТИЧЕСКОЙ АКТИВНОСТЬЮ
GB9509271D0 (en) * 1995-05-05 1995-06-28 Biopharm Res & Dev Ltd Blood clot stabilisation inhibitors
CN102914612B (zh) * 2011-08-06 2015-10-21 河北以岭医药研究院有限公司 一种菲牛蛭药材指纹图谱的测定方法
CN105646702B (zh) * 2016-04-13 2019-03-01 中国科学院昆明动物研究所 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
CN86101096A (zh) * 1985-04-26 1986-10-22 株式会社岛津制作所 印字绘图器
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
IL83912A (en) * 1986-09-18 1993-05-13 Pennsylvania Hospital Protein having anticoagulant and antimetastatic properties
FR2630638B1 (fr) * 1988-05-02 1997-08-08 Inst Nat Sante Rech Med Implant oculaire et son procede de preparation

Also Published As

Publication number Publication date
JPH02117697A (ja) 1990-05-02
IE891856L (en) 1989-12-11
AU625375B2 (en) 1992-07-09
EP0347376B1 (en) 1994-03-23
PT90798B (pt) 1994-10-31
AU3630189A (en) 1989-12-14
DE58907266T2 (de) 1994-09-29
ES2052062T3 (es) 1994-07-01
PT90798A (pt) 1989-12-29
DK283889D0 (da) 1989-06-09
IE61809B1 (en) 1994-11-30
CA1339106C (en) 1997-07-29
US5114922A (en) 1992-05-19
EP0347376A3 (en) 1990-07-04
EP0347376A2 (en) 1989-12-20
DE58907266D1 (de) 1994-04-28

Similar Documents

Publication Publication Date Title
DK283889D0 (da) Nye polypeptider med antikoagulerende virkning
DK61689A (da) Heterocyclisk forbindelse med femleddet ring
DK14890A (da) Peptider med t-hjaelpercelleaktivitet
DK441189D0 (da) Skrue med tilhoerende haette
FR2629544B1 (fr) Butee reglable
DK381889A (da) Benzamidderivater
FI893534A (fi) Rullrotations-offsetpress med tryckplaot foer flytande plaotombyte.
DE68928024D1 (de) Schalter
DK8591D0 (da) Interleukin-l inhibotor
IT1225195B (it) Profilatrice
DK355189D0 (da) Nye proteiner
DK616889A (da) Nye alfa-cyano-beta-oxopropionamider
FI91488B (fi) Seula
DK462189A (da) Skab med udleveringsmiddel
DK330889A (da) Annellerede indolketoner med en imidazolylalkylsubstituent
FI895989A0 (fi) Triazinoligomerestrar- och amider med en tetrametylpiperidylgrupp i aendstaellning.
DK150890D0 (da) Registerenhed med bevaegeligt registerark
DK124390A (da) Prostaglandinderivater med antitrombotisk virkning
DK171588D0 (da) Nye indolforbindelser
FI882188A (fi) Cylinderlaos med skivformigt skaer
SE8803166D0 (sv) Vikpall med dammsperr
SE8801231D0 (sv) New use
DK477789D0 (da) Nye polypeptider
SE8903482D0 (sv) Underbyggnad
KR860014291U (ko) 의자의 요동식 받침대

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment