CN1044479C - 抗凝血酶多肽的制备方法 - Google Patents

抗凝血酶多肽的制备方法 Download PDF

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Publication number
CN1044479C
CN1044479C CN92101143A CN92101143A CN1044479C CN 1044479 C CN1044479 C CN 1044479C CN 92101143 A CN92101143 A CN 92101143A CN 92101143 A CN92101143 A CN 92101143A CN 1044479 C CN1044479 C CN 1044479C
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gly
polypeptide
cys
glu
ser
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Expired - Fee Related
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CN92101143A
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Chinese (zh)
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CN1066272A (zh
Inventor
P·瑟米恩托斯
P·D·T·督伯特
G·尼狄
E·萨彻里
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Pfizer Italia SRL
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Farmitalia Carlo Erba SRL
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Priority claimed from GB919104260A external-priority patent/GB9104260D0/en
Priority claimed from GB919119954A external-priority patent/GB9119954D0/en
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of CN1066272A publication Critical patent/CN1066272A/zh
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86Viral vectors
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • C07K2319/00Fusion polypeptide
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2710/00011Details
    • C12N2710/14011Baculoviridae
    • C12N2710/14111Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/00011Details
    • C12N2710/14011Baculoviridae
    • C12N2710/14111Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141Use of virus, viral particle or viral elements as a vector
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    • C12N2760/20011Rhabdoviridae
    • C12N2760/20211Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN92101143A 1991-02-28 1992-02-27 抗凝血酶多肽的制备方法 Expired - Fee Related CN1044479C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919104260A GB9104260D0 (en) 1991-02-28 1991-02-28 Anti-thrombin polypeptides
GB9119954.7 1991-09-18
GB9104260.6 1991-09-18
GB919119954A GB9119954D0 (en) 1991-09-18 1991-09-18 Antithrombin polypeptides

Publications (2)

Publication Number Publication Date
CN1066272A CN1066272A (zh) 1992-11-18
CN1044479C true CN1044479C (zh) 1999-08-04

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CN92101143A Expired - Fee Related CN1044479C (zh) 1991-02-28 1992-02-27 抗凝血酶多肽的制备方法

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US (2) US5356875A (enExample)
EP (1) EP0501821B1 (enExample)
JP (1) JPH05247090A (enExample)
KR (1) KR100218818B1 (enExample)
CN (1) CN1044479C (enExample)
AT (1) ATE175236T1 (enExample)
AU (1) AU643876B2 (enExample)
CA (1) CA2061920A1 (enExample)
CZ (1) CZ283458B6 (enExample)
DE (1) DE69228015T2 (enExample)
DK (1) DK0501821T3 (enExample)
ES (1) ES2129426T3 (enExample)
FI (1) FI920861A7 (enExample)
GR (1) GR3029364T3 (enExample)
HU (1) HU215580B (enExample)
IE (1) IE920622A1 (enExample)
IL (1) IL101062A0 (enExample)
MX (1) MX9200795A (enExample)
MY (1) MY110327A (enExample)
NO (1) NO300138B1 (enExample)
NZ (1) NZ241715A (enExample)
TW (1) TW214556B (enExample)
YU (1) YU19792A (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1266561B1 (it) * 1993-07-22 1997-01-09 Mini Ricerca Scient Tecnolog Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
CN1064968C (zh) * 1996-07-10 2001-04-25 中国人民解放军第一军医大学 重组蛋白提取纯化方法
EP0998942A4 (en) 1997-01-20 2006-08-16 Japan Energy Corp METHOD FOR STABILIZING PEPTIDES AND FREEZERED MEDICINAL COMPOSITIONS THEREOF
US6077825A (en) 1997-03-13 2000-06-20 Auburn University Antithrombin protein and DNA sequences from black fly
JP2000080046A (ja) * 1998-09-03 2000-03-21 Dai Ichi Seiyaku Co Ltd 多臓器障害の予防・治療剤
CN102876654A (zh) * 2012-10-19 2013-01-16 广东海洋大学 一种桑蚕丝素固定化凝血酶的制备方法
CN104193809B (zh) * 2014-09-28 2016-08-17 顾玉奎 一种凝血酶抑制及其制备方法、应用
CN104193807B (zh) * 2014-09-28 2016-06-15 广州贝奥吉因生物科技有限公司 凝血酶抑制多肽及其制备方法、应用
CN105646702B (zh) * 2016-04-13 2019-03-01 中国科学院昆明动物研究所 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用
CN108059672B (zh) * 2016-11-08 2021-06-11 中国科学院昆明动物研究所 森林山蛭抗血栓肽Sylvestin及其基因和应用
CN110468174A (zh) * 2019-08-21 2019-11-19 北京中医药大学 一种水蛭活性寡肽的制备方法
CN111454352B (zh) * 2020-03-05 2021-07-23 中国科学院昆明动物研究所 一种活性蛋白hmei-a、活性蛋白hmei-a的编码基因及应用
CN112114069B (zh) * 2020-09-18 2023-05-16 江苏艾迪药业股份有限公司 凝血酶的亲和色谱柱、制备方法及应用
CN112480210B (zh) * 2020-11-25 2021-09-17 广东海洋大学 一种抗凝血活性肽及其用途
KR102354461B1 (ko) * 2021-02-19 2022-01-20 김건언 덕트 일체형 조명등기구
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
IT1250689B (it) * 1991-07-22 1995-04-21 Marco Gerna Analoghi dell'irudina e procedimento per la loro preparazione

Also Published As

Publication number Publication date
EP0501821A2 (en) 1992-09-02
NO920777D0 (no) 1992-02-27
TW214556B (enExample) 1993-10-11
HU9200620D0 (en) 1992-05-28
ATE175236T1 (de) 1999-01-15
NZ241715A (en) 1993-07-27
KR920016468A (ko) 1992-09-24
AU643876B2 (en) 1993-11-25
IL101062A0 (en) 1992-11-15
DE69228015T2 (de) 1999-06-02
NO920777L (no) 1992-08-31
YU19792A (sh) 1994-06-10
CZ283458B6 (cs) 1998-04-15
HUT64592A (en) 1994-01-28
CN1066272A (zh) 1992-11-18
FI920861L (fi) 1992-08-29
FI920861A7 (fi) 1992-08-29
EP0501821B1 (en) 1998-12-30
DK0501821T3 (da) 1999-08-30
IE920622A1 (en) 1992-09-09
CS58492A3 (en) 1992-09-16
GR3029364T3 (en) 1999-05-28
US5439820A (en) 1995-08-08
KR100218818B1 (ko) 1999-10-01
US5356875A (en) 1994-10-18
CA2061920A1 (en) 1992-08-29
MY110327A (en) 1998-04-30
JPH05247090A (ja) 1993-09-24
NO300138B1 (no) 1997-04-14
ES2129426T3 (es) 1999-06-16
AU1122192A (en) 1992-09-03
MX9200795A (es) 1992-08-01
DE69228015D1 (de) 1999-02-11
FI920861A0 (fi) 1992-02-26
HU215580B (hu) 1999-01-28
EP0501821A3 (en) 1993-03-03

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