JPH0421478B2 - - Google Patents

Info

Publication number
JPH0421478B2
JPH0421478B2 JP59175326A JP17532684A JPH0421478B2 JP H0421478 B2 JPH0421478 B2 JP H0421478B2 JP 59175326 A JP59175326 A JP 59175326A JP 17532684 A JP17532684 A JP 17532684A JP H0421478 B2 JPH0421478 B2 JP H0421478B2
Authority
JP
Japan
Prior art keywords
same
carried out
reverse osmosis
salt
eluate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59175326A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6070097A (ja
Inventor
Gennari Fuederiko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioresearch SRL
Original Assignee
Bioresearch SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch SRL filed Critical Bioresearch SRL
Publication of JPS6070097A publication Critical patent/JPS6070097A/ja
Publication of JPH0421478B2 publication Critical patent/JPH0421478B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP59175326A 1983-08-24 1984-08-24 安定なｓ−アデノシル−ｌ−メチオニン塩の製造方法 Granted JPS6070097A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22622-A/83 1983-08-24
IT22622/83A IT1169773B (it) 1983-08-24 1983-08-24 Processo per la produzione di sali stabili della solfo-adenosil-l-metionina

Publications (2)

Publication Number Publication Date
JPS6070097A JPS6070097A (ja) 1985-04-20
JPH0421478B2 true JPH0421478B2 (enExample) 1992-04-10

Family

ID=11198536

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59175326A Granted JPS6070097A (ja) 1983-08-24 1984-08-24 安定なｓ−アデノシル−ｌ−メチオニン塩の製造方法

Country Status (14)

Country Link
US (1) US4621056A (enExample)
EP (1) EP0141914B1 (enExample)
JP (1) JPS6070097A (enExample)
KR (1) KR900009054B1 (enExample)
AT (1) ATE31550T1 (enExample)
AU (1) AU569107B2 (enExample)
CA (1) CA1223535A (enExample)
DE (1) DE3468234D1 (enExample)
DK (1) DK162240C (enExample)
ES (1) ES8506044A1 (enExample)
FI (1) FI77043C (enExample)
IT (1) IT1169773B (enExample)
MX (1) MX7625E (enExample)
NO (1) NO159669C (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007132831A1 (ja) 2006-05-16 2007-11-22 Mitsubishi Gas Chemical Company, Inc. 保存安定性に優れたｓ－アデノシル－ｌ－メチオニン含有乾燥酵母の製造方法、その製造物及び経口摂取用組成物
WO2008090905A1 (ja) 2007-01-25 2008-07-31 Mitsubishi Gas Chemical Company, Inc. 保存安定性に優れたｓ－アデノシル－ｌ－メチオニン含有乾燥酵母の製造方法、その製造物及びその成型された組成物

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
US4794174A (en) * 1987-02-10 1988-12-27 Southern Research Institute 5'deoxy-5'-substituted adenosines
US5180714A (en) * 1990-10-31 1993-01-19 Health Research, Inc. Adenosine compounds for the treatment of diseases caused by parasitic protozoa
IT1315236B1 (it) * 1999-10-05 2003-02-03 Chementecno Srl Processo per la purificazione di s-adenosil-l-metionina e per lapreparazione dei suoi sali farmaceuticamente accettabili.
IT1318535B1 (it) 2000-05-25 2003-08-27 Chementecno Srl Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.
IT1317920B1 (it) * 2000-10-20 2003-07-15 Univ Roma S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer.
US6649753B2 (en) * 2001-06-07 2003-11-18 Orchid Chemicals & Pharmaceuticals Ltd. Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
US6881837B2 (en) 2001-06-07 2005-04-19 Orchid Chemicals & Pharmaceuticals Ltd. Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
EP1812454A2 (en) 2004-06-23 2007-08-01 Orchid Chemicals and Pharmaceuticals Ltd Chemical synthesis of s-adenosyl-l-methionine with enrichment of (s,s)-isomer
CN101374529B (zh) 2006-01-17 2012-08-08 三菱瓦斯化学株式会社 使s-腺苷-l-甲硫氨酸稳定化的方法以及稳定化后的组合物
CN102321136B (zh) * 2011-09-19 2014-10-22 北京化工大学 S-腺苷-l-甲硫氨酸对甲苯磺酸硫酸双盐的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE37913B1 (en) * 1972-08-02 1977-11-09 Bioresearch Sas Salt of s-adenosyl-l-methionine
JPS5631897B2 (enExample) * 1972-11-13 1981-07-24
US3962034A (en) * 1973-02-01 1976-06-08 Ajinomoto Co., Inc. Method for producing s-adenosylmethionine or methylthioadenosine by yeast
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
FR2275220A1 (fr) * 1974-06-21 1976-01-16 Merieux Inst Procede d'obtention de sels organiques de la s.adenosyl-l-methionine. nouveaux sels organiques obtenus des medicaments comprenant un ou plusieurs nouveaux sels obtenus
AR221676A1 (es) * 1974-07-12 1981-03-13 Bioresearch Sas Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
DE2646269A1 (de) * 1975-10-16 1977-04-28 Yamasa Shoyu Kk Stabilisierte s-adenosyl-l-methionin- zubereitung und verfahren zur herstellung derselben
JPS53107485A (en) * 1977-02-28 1978-09-19 Yamasa Shoyu Co Ltd Preparation of s-adenosyl-l-methionine salt
GB2001976B (en) * 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
JPS5699499A (en) * 1980-01-10 1981-08-10 Kanegafuchi Chem Ind Co Ltd Composition containing s-adenosyl-l-methionine, and its preparation
IT1137892B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137640B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
GB2116172B (en) * 1982-02-25 1986-07-09 Nippon Zeon Co Microbial cells containing s-adenosyl methionine in high concentrations and process for production of s adenosyl methionine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007132831A1 (ja) 2006-05-16 2007-11-22 Mitsubishi Gas Chemical Company, Inc. 保存安定性に優れたｓ－アデノシル－ｌ－メチオニン含有乾燥酵母の製造方法、その製造物及び経口摂取用組成物
WO2008090905A1 (ja) 2007-01-25 2008-07-31 Mitsubishi Gas Chemical Company, Inc. 保存安定性に優れたｓ－アデノシル－ｌ－メチオニン含有乾燥酵母の製造方法、その製造物及びその成型された組成物

Also Published As

Publication number Publication date
NO843366L (no) 1985-02-25
ATE31550T1 (de) 1988-01-15
ES535378A0 (es) 1985-06-16
FI843315A7 (fi) 1985-02-25
NO159669C (no) 1989-01-25
NO159669B (no) 1988-10-17
MX7625E (es) 1990-03-27
IT1169773B (it) 1987-06-03
US4621056A (en) 1986-11-04
FI843315A0 (fi) 1984-08-22
DK402884A (da) 1985-02-25
KR900009054B1 (ko) 1990-12-17
IT8322622A0 (it) 1983-08-24
JPS6070097A (ja) 1985-04-20
AU3232884A (en) 1985-02-28
KR850001750A (ko) 1985-04-01
DK402884D0 (da) 1984-08-23
ES8506044A1 (es) 1985-06-16
FI77043C (fi) 1989-01-10
DE3468234D1 (en) 1988-02-04
DK162240C (da) 1992-03-02
FI77043B (fi) 1988-09-30
DK162240B (da) 1991-09-30
IT8322622A1 (it) 1985-02-24
CA1223535A (en) 1987-06-30
EP0141914A1 (en) 1985-05-22
EP0141914B1 (en) 1987-12-23
AU569107B2 (en) 1988-01-21

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