ATE31550T1 - Verfahren zur herstellung von stabilen s-adenosyl-l-methioninsalzen. - Google Patents

Verfahren zur herstellung von stabilen s-adenosyl-l-methioninsalzen.

Info

Publication number
ATE31550T1
ATE31550T1 AT84109109T AT84109109T ATE31550T1 AT E31550 T1 ATE31550 T1 AT E31550T1 AT 84109109 T AT84109109 T AT 84109109T AT 84109109 T AT84109109 T AT 84109109T AT E31550 T1 ATE31550 T1 AT E31550T1
Authority
AT
Austria
Prior art keywords
same
stable
adenosyl
preparation
passage
Prior art date
Application number
AT84109109T
Other languages
English (en)
Inventor
Federico Gennari
Original Assignee
Bioresearch Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Spa filed Critical Bioresearch Spa
Application granted granted Critical
Publication of ATE31550T1 publication Critical patent/ATE31550T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT84109109T 1983-08-24 1984-08-01 Verfahren zur herstellung von stabilen s-adenosyl-l-methioninsalzen. ATE31550T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22622/83A IT1169773B (it) 1983-08-24 1983-08-24 Processo per la produzione di sali stabili della solfo-adenosil-l-metionina

Publications (1)

Publication Number Publication Date
ATE31550T1 true ATE31550T1 (de) 1988-01-15

Family

ID=11198536

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84109109T ATE31550T1 (de) 1983-08-24 1984-08-01 Verfahren zur herstellung von stabilen s-adenosyl-l-methioninsalzen.

Country Status (14)

Country Link
US (1) US4621056A (de)
EP (1) EP0141914B1 (de)
JP (1) JPS6070097A (de)
KR (1) KR900009054B1 (de)
AT (1) ATE31550T1 (de)
AU (1) AU569107B2 (de)
CA (1) CA1223535A (de)
DE (1) DE3468234D1 (de)
DK (1) DK162240C (de)
ES (1) ES535378A0 (de)
FI (1) FI77043C (de)
IT (1) IT1169773B (de)
MX (1) MX7625E (de)
NO (1) NO159669C (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
US4794174A (en) * 1987-02-10 1988-12-27 Southern Research Institute 5'deoxy-5'-substituted adenosines
US5180714A (en) * 1990-10-31 1993-01-19 Health Research, Inc. Adenosine compounds for the treatment of diseases caused by parasitic protozoa
IT1315236B1 (it) * 1999-10-05 2003-02-03 Chementecno Srl Processo per la purificazione di s-adenosil-l-metionina e per lapreparazione dei suoi sali farmaceuticamente accettabili.
IT1318535B1 (it) * 2000-05-25 2003-08-27 Chementecno Srl Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.
IT1317920B1 (it) * 2000-10-20 2003-07-15 Univ Roma S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer.
US6649753B2 (en) * 2001-06-07 2003-11-18 Orchid Chemicals & Pharmaceuticals Ltd. Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
US6881837B2 (en) 2001-06-07 2005-04-19 Orchid Chemicals & Pharmaceuticals Ltd. Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
US7667034B2 (en) 2004-06-23 2010-02-23 Orchid Chemicals & Pharmaceuticals Limited Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
JP5071112B2 (ja) 2006-01-17 2012-11-14 三菱瓦斯化学株式会社 Ｓ−アデノシル−ｌ−メチオニンの安定化法及び安定化された組成物
EP2017331B1 (de) 2006-05-16 2015-04-01 Mitsubishi Gas Chemical Company, Inc. Verfahren zur herstellung von s-adenosyl-l-methionin enthaltender trockenhefe mit ausgezeichneter lagerstabilität
WO2008090905A1 (ja) 2007-01-25 2008-07-31 Mitsubishi Gas Chemical Company, Inc. 保存安定性に優れたｓ－アデノシル－ｌ－メチオニン含有乾燥酵母の製造方法、その製造物及びその成型された組成物
CN102321136B (zh) * 2011-09-19 2014-10-22 北京化工大学 S-腺苷-l-甲硫氨酸对甲苯磺酸硫酸双盐的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE37913B1 (en) * 1972-08-02 1977-11-09 Bioresearch Sas Salt of s-adenosyl-l-methionine
JPS5631897B2 (de) * 1972-11-13 1981-07-24
US3962034A (en) * 1973-02-01 1976-06-08 Ajinomoto Co., Inc. Method for producing s-adenosylmethionine or methylthioadenosine by yeast
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
FR2275220A1 (fr) * 1974-06-21 1976-01-16 Merieux Inst Procede d'obtention de sels organiques de la s.adenosyl-l-methionine. nouveaux sels organiques obtenus des medicaments comprenant un ou plusieurs nouveaux sels obtenus
AR221676A1 (es) * 1974-07-12 1981-03-13 Bioresearch Sas Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
DE2646269A1 (de) * 1975-10-16 1977-04-28 Yamasa Shoyu Kk Stabilisierte s-adenosyl-l-methionin- zubereitung und verfahren zur herstellung derselben
JPS53107485A (en) * 1977-02-28 1978-09-19 Yamasa Shoyu Co Ltd Preparation of s-adenosyl-l-methionine salt
GB2001976B (en) * 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
JPS5699499A (en) * 1980-01-10 1981-08-10 Kanegafuchi Chem Ind Co Ltd Composition containing s-adenosyl-l-methionine, and its preparation
IT1137640B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137892B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
GB2116172B (en) * 1982-02-25 1986-07-09 Nippon Zeon Co Microbial cells containing s-adenosyl methionine in high concentrations and process for production of s adenosyl methionine

Also Published As

Publication number Publication date
IT8322622A0 (it) 1983-08-24
KR850001750A (ko) 1985-04-01
DK402884A (da) 1985-02-25
NO159669C (no) 1989-01-25
FI77043B (fi) 1988-09-30
US4621056A (en) 1986-11-04
FI77043C (fi) 1989-01-10
JPH0421478B2 (de) 1992-04-10
NO843366L (no) 1985-02-25
NO159669B (no) 1988-10-17
DK162240B (da) 1991-09-30
FI843315A (fi) 1985-02-25
AU569107B2 (en) 1988-01-21
IT1169773B (it) 1987-06-03
IT8322622A1 (it) 1985-02-24
CA1223535A (en) 1987-06-30
KR900009054B1 (ko) 1990-12-17
JPS6070097A (ja) 1985-04-20
ES8506044A1 (es) 1985-06-16
ES535378A0 (es) 1985-06-16
AU3232884A (en) 1985-02-28
MX7625E (es) 1990-03-27
FI843315A0 (fi) 1984-08-22
EP0141914A1 (de) 1985-05-22
EP0141914B1 (de) 1987-12-23
DK402884D0 (da) 1984-08-23
DE3468234D1 (en) 1988-02-04
DK162240C (da) 1992-03-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee