JP7716166B1 - Ｌ－グルタミン酸生産菌およびｌ－グルタミン酸の製造方法 - Google Patents

Ｌ－グルタミン酸生産菌およびｌ－グルタミン酸の製造方法

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Publication number
JP7716166B1
JP7716166B1 JP2025534315A JP2025534315A JP7716166B1 JP 7716166 B1 JP7716166 B1 JP 7716166B1 JP 2025534315 A JP2025534315 A JP 2025534315A JP 2025534315 A JP2025534315 A JP 2025534315A JP 7716166 B1 JP7716166 B1 JP 7716166B1
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Prior art keywords
gene
amino acid
glutamic acid
glya
mutant
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JP2025534315A
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English (en)
Japanese (ja)
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JPWO2025141837A5 (https=
JPWO2025141837A1 (https=
Inventor
智恵 ▲浜▼野（小関）
公太 井上
史人 大西
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/02—Hydroxymethyl-, formyl- and related transferases (2.1.2)
    • C12Y201/02001—Glycine hydroxymethyltransferase (2.1.2.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2025534315A 2023-12-28 2023-12-28 Ｌ－グルタミン酸生産菌およびｌ－グルタミン酸の製造方法 Active JP7716166B1 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2023/047150 WO2025141837A1 (ja) 2023-12-28 2023-12-28 Ｌ－グルタミン酸生産菌およびｌ－グルタミン酸の製造方法

Publications (3)

Publication Number Publication Date
JPWO2025141837A1 JPWO2025141837A1 (https=) 2025-07-03
JP7716166B1 true JP7716166B1 (ja) 2025-07-31
JPWO2025141837A5 JPWO2025141837A5 (https=) 2025-11-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2025534315A Active JP7716166B1 (ja) 2023-12-28 2023-12-28 Ｌ－グルタミン酸生産菌およびｌ－グルタミン酸の製造方法

Country Status (3)

Country Link
EP (1) EP4692312A1 (https=)
JP (1) JP7716166B1 (https=)
WO (1) WO2025141837A1 (https=)

Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2009501512A (ja) * 2005-06-17 2009-01-22 アイアンウッド ファーマシューティカルズ インコーポレイテッド 改良されたアミノ酸及び代謝産物生合成
WO2014185430A1 (ja) * 2013-05-13 2014-11-20 味の素株式会社 Ｌ－アミノ酸の製造法

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Also Published As

Publication number Publication date
JPWO2025141837A1 (https=) 2025-07-03
WO2025141837A1 (ja) 2025-07-03
EP4692312A1 (en) 2026-02-11

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