JP6861166B2 - サイクリン依存性キナーゼの阻害剤 - Google Patents

サイクリン依存性キナーゼの阻害剤 Download PDF

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JP6861166B2
JP6861166B2 JP2017550748A JP2017550748A JP6861166B2 JP 6861166 B2 JP6861166 B2 JP 6861166B2 JP 2017550748 A JP2017550748 A JP 2017550748A JP 2017550748 A JP2017550748 A JP 2017550748A JP 6861166 B2 JP6861166 B2 JP 6861166B2
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alkyl
optionally substituted
substituted
carbamate
ring
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JP2018515434A (ja
JP2018515434A5 (https=
Inventor
グレイ，ナサニエル，エス．
チャン，ティンフー
クウィアトコウスキ，ニコラス，ポール
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Priority to JP2021054539A priority Critical patent/JP7200282B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2017550748A 2015-03-27 2016-03-25 サイクリン依存性キナーゼの阻害剤 Active JP6861166B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021054539A JP7200282B2 (ja) 2015-03-27 2021-03-29 サイクリン依存性キナーゼの阻害剤
JP2022204259A JP2023052006A (ja) 2015-03-27 2022-12-21 サイクリン依存性キナーゼの阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562139352P 2015-03-27 2015-03-27
US62/139,352 2015-03-27
PCT/US2016/024345 WO2016160617A2 (en) 2015-03-27 2016-03-25 Inhibitors of cyclin-dependent kinases

Related Child Applications (1)

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JP2021054539A Division JP7200282B2 (ja) 2015-03-27 2021-03-29 サイクリン依存性キナーゼの阻害剤

Publications (3)

Publication Number Publication Date
JP2018515434A JP2018515434A (ja) 2018-06-14
JP2018515434A5 JP2018515434A5 (https=) 2019-05-09
JP6861166B2 true JP6861166B2 (ja) 2021-04-21

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JP2017550748A Active JP6861166B2 (ja) 2015-03-27 2016-03-25 サイクリン依存性キナーゼの阻害剤
JP2021054539A Active JP7200282B2 (ja) 2015-03-27 2021-03-29 サイクリン依存性キナーゼの阻害剤
JP2022204259A Pending JP2023052006A (ja) 2015-03-27 2022-12-21 サイクリン依存性キナーゼの阻害剤

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JP2021054539A Active JP7200282B2 (ja) 2015-03-27 2021-03-29 サイクリン依存性キナーゼの阻害剤
JP2022204259A Pending JP2023052006A (ja) 2015-03-27 2022-12-21 サイクリン依存性キナーゼの阻害剤

Country Status (8)

Country Link
US (4) US10550121B2 (https=)
EP (1) EP3273966B1 (https=)
JP (3) JP6861166B2 (https=)
CN (1) CN107427521B (https=)
AU (1) AU2016243529B2 (https=)
CA (1) CA2978518C (https=)
HK (1) HK1246645A1 (https=)
WO (1) WO2016160617A2 (https=)

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US9758522B2 (en) 2012-10-19 2017-09-12 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
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CN111217814B (zh) * 2018-11-26 2022-08-26 天津科技大学 一类联哌啶衍生物及其作为抗肿瘤药物的应用
JP7660063B2 (ja) 2018-12-28 2025-04-10 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用
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WO2024242416A1 (ko) * 2023-05-22 2024-11-28 주식회사 셀러스 신규한 cdk7 억제 화합물 및 이의 용도
WO2025040170A1 (zh) * 2023-08-24 2025-02-27 杭州德睿智药科技有限公司 作为CDKs抑制剂的新型并杂环类新化合物及其应用
CN117586234A (zh) * 2023-11-23 2024-02-23 盛韧 靶向cdkl3的小分子抑制剂hz1及其衍生物hz1-x
WO2025153034A1 (zh) * 2024-01-19 2025-07-24 上海海雁医药科技有限公司 一种吡唑并嘧啶衍生物的磷酸盐多晶型物及其应用
WO2026012479A1 (zh) * 2024-07-12 2026-01-15 上海先声再明医药生物科技有限公司 选择性cdk2抑制剂及其应用
CN119462661A (zh) * 2024-09-24 2025-02-18 烟台皓元生物医药科技有限公司 一种azd-8421及其中间体的制备方法
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CN121444888B (zh) * 2026-01-07 2026-03-06 吉林大学 一种动物肥胖模型的构建方法及应用

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