JP6542212B2 - ブロモドメイン阻害剤としての新規キナゾリノン - Google Patents

ブロモドメイン阻害剤としての新規キナゾリノン Download PDF

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JP6542212B2
JP6542212B2 JP2016530632A JP2016530632A JP6542212B2 JP 6542212 B2 JP6542212 B2 JP 6542212B2 JP 2016530632 A JP2016530632 A JP 2016530632A JP 2016530632 A JP2016530632 A JP 2016530632A JP 6542212 B2 JP6542212 B2 JP 6542212B2
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amino
dimethoxy
cancer
pyridin
mmol
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JP2016527263A (ja
JP2016527263A5 (enExample
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ジョン・フレデリック・クイン
ウラジミール・フレブニコフ
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Zenith Epigenetics Ltd
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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JP2016530632A 2013-07-31 2014-07-30 ブロモドメイン阻害剤としての新規キナゾリノン Active JP6542212B2 (ja)

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US201361860403P 2013-07-31 2013-07-31
US61/860,403 2013-07-31
PCT/IB2014/002510 WO2015015318A2 (en) 2013-07-31 2014-07-30 Novel quinazolinones as bromodomain inhibitors

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JP2016527263A JP2016527263A (ja) 2016-09-08
JP2016527263A5 JP2016527263A5 (enExample) 2017-09-07
JP6542212B2 true JP6542212B2 (ja) 2019-07-10

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US (2) US9855271B2 (enExample)
EP (1) EP3027604B1 (enExample)
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