JP6486686B2 - 単鎖抗体及び他のヘテロ多量体 - Google Patents

単鎖抗体及び他のヘテロ多量体 Download PDF

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Publication number
JP6486686B2
JP6486686B2 JP2014556732A JP2014556732A JP6486686B2 JP 6486686 B2 JP6486686 B2 JP 6486686B2 JP 2014556732 A JP2014556732 A JP 2014556732A JP 2014556732 A JP2014556732 A JP 2014556732A JP 6486686 B2 JP6486686 B2 JP 6486686B2
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tether
domain
antibody
clh
chain antibody
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Expired - Fee Related
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JP2014556732A
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JP2015508077A5 (enExample
JP2015508077A (ja
Inventor
ベルント ヴラニック，
ベルント ヴラニック，
ダン エル． イートン，
ダン エル． イートン，
エリン エイチ． クリステンセン，
エリン エイチ． クリステンセン，
チエンション ウー，
チエンション ウー，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014556732A 2012-02-10 2013-02-08 単鎖抗体及び他のヘテロ多量体 Expired - Fee Related JP6486686B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261597486P 2012-02-10 2012-02-10
US61/597,486 2012-02-10
PCT/US2013/025365 WO2013119966A2 (en) 2012-02-10 2013-02-08 Single-chain antibodies and other heteromultimers

Related Child Applications (1)

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JP2017233979A Division JP2018070634A (ja) 2012-02-10 2017-12-06 単鎖抗体及び他のヘテロ多量体

Publications (3)

Publication Number Publication Date
JP2015508077A JP2015508077A (ja) 2015-03-16
JP2015508077A5 JP2015508077A5 (enExample) 2016-04-07
JP6486686B2 true JP6486686B2 (ja) 2019-03-20

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JP2014556732A Expired - Fee Related JP6486686B2 (ja) 2012-02-10 2013-02-08 単鎖抗体及び他のヘテロ多量体
JP2017233979A Pending JP2018070634A (ja) 2012-02-10 2017-12-06 単鎖抗体及び他のヘテロ多量体

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JP2017233979A Pending JP2018070634A (ja) 2012-02-10 2017-12-06 単鎖抗体及び他のヘテロ多量体

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US (1) US9688758B2 (enExample)
EP (1) EP2812357B1 (enExample)
JP (2) JP6486686B2 (enExample)
KR (1) KR20140127854A (enExample)
CN (1) CN104105711B (enExample)
BR (1) BR112014019579A2 (enExample)
CA (1) CA2861124A1 (enExample)
MX (1) MX2014009565A (enExample)
RU (1) RU2644341C2 (enExample)
WO (1) WO2013119966A2 (enExample)

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RU2639287C2 (ru) 2012-06-27 2017-12-20 Ф. Хоффманн-Ля Рош Аг Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
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JP2015508077A (ja) 2015-03-16
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