ATE111918T1 - Spezifische spaltung von peptidbindungen durch organische tertiäre phosphine mit nukleophilen seitenketten. - Google Patents
Spezifische spaltung von peptidbindungen durch organische tertiäre phosphine mit nukleophilen seitenketten.Info
- Publication number
- ATE111918T1 ATE111918T1 AT89103906T AT89103906T ATE111918T1 AT E111918 T1 ATE111918 T1 AT E111918T1 AT 89103906 T AT89103906 T AT 89103906T AT 89103906 T AT89103906 T AT 89103906T AT E111918 T1 ATE111918 T1 AT E111918T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide bonds
- specific cleavage
- side chains
- tertiary phosphines
- organic tertiary
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6818—Sequencing of polypeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5004—Acyclic saturated phosphines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- C07K1/128—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general sequencing
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17657188A | 1988-04-01 | 1988-04-01 | |
| US17657388A | 1988-04-01 | 1988-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE111918T1 true ATE111918T1 (de) | 1994-10-15 |
Family
ID=26872381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89103906T ATE111918T1 (de) | 1988-04-01 | 1989-03-06 | Spezifische spaltung von peptidbindungen durch organische tertiäre phosphine mit nukleophilen seitenketten. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0339217B1 (de) |
| JP (1) | JPH0215092A (de) |
| AT (1) | ATE111918T1 (de) |
| CA (1) | CA1330800C (de) |
| DE (1) | DE68918323T2 (de) |
| ES (1) | ES2064374T3 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL213309B1 (pl) | 2006-02-09 | 2013-02-28 | Polska Akademia Nauk Inst Biochemii I Biofizyki | Sposób hydrolizy wiazania peptydowego |
| AU2010230563A1 (en) | 2009-04-02 | 2011-09-22 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain Fab fragments |
| NZ701769A (en) | 2009-09-16 | 2016-06-24 | Genentech Inc | Coiled coil and/or tether containing protein complexes and uses thereof |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| CN103068846B9 (zh) | 2010-08-24 | 2016-09-28 | 弗·哈夫曼-拉罗切有限公司 | 包含二硫键稳定性Fv片段的双特异性抗体 |
| EP2655413B1 (de) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung |
| MX2014009565A (es) | 2012-02-10 | 2014-11-10 | Genentech Inc | Anticuerpos monocatenarios y otros heteromultimeros. |
| RU2015100656A (ru) | 2012-06-27 | 2016-08-20 | Ф. Хоффманн-Ля Рош Аг | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения |
| KR20150023889A (ko) | 2012-06-27 | 2015-03-05 | 에프. 호프만-라 로슈 아게 | 2 개 이상의 상이한 결합 단위를 함유하는 맞춤-제작된 고도로 선별적이고 다중-특이적인 표적화 단위의 선별 및 제조 방법 및 이의 용도 |
| WO2016087416A1 (en) | 2014-12-03 | 2016-06-09 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3628910A (en) * | 1966-05-02 | 1971-12-21 | American Cyanamid Co | Compositions for the deformation of keratin |
| FR1574239A (de) * | 1967-07-12 | 1969-07-11 | ||
| US3754035A (en) * | 1970-01-29 | 1973-08-21 | American Cyanamid Co | Tertiary organophosphines |
| US3970532A (en) * | 1975-01-16 | 1976-07-20 | Borg-Warner Corporation | 2-Hydroxyethylphosphines |
-
1989
- 1989-03-06 EP EP89103906A patent/EP0339217B1/de not_active Expired - Lifetime
- 1989-03-06 DE DE68918323T patent/DE68918323T2/de not_active Expired - Fee Related
- 1989-03-06 ES ES89103906T patent/ES2064374T3/es not_active Expired - Lifetime
- 1989-03-06 AT AT89103906T patent/ATE111918T1/de not_active IP Right Cessation
- 1989-03-30 CA CA000595161A patent/CA1330800C/en not_active Expired - Fee Related
- 1989-04-01 JP JP1083848A patent/JPH0215092A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE68918323T2 (de) | 1995-05-18 |
| CA1330800C (en) | 1994-07-19 |
| ES2064374T3 (es) | 1995-02-01 |
| DE68918323D1 (de) | 1994-10-27 |
| EP0339217B1 (de) | 1994-09-21 |
| JPH0215092A (ja) | 1990-01-18 |
| EP0339217A2 (de) | 1989-11-02 |
| EP0339217A3 (en) | 1990-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |