DE68918323D1 - Spezifische Spaltung von Peptidbindungen durch organische tertiäre Phosphine mit nukleophilen Seitenketten. - Google Patents

Spezifische Spaltung von Peptidbindungen durch organische tertiäre Phosphine mit nukleophilen Seitenketten.

Info

Publication number
DE68918323D1
DE68918323D1 DE68918323T DE68918323T DE68918323D1 DE 68918323 D1 DE68918323 D1 DE 68918323D1 DE 68918323 T DE68918323 T DE 68918323T DE 68918323 T DE68918323 T DE 68918323T DE 68918323 D1 DE68918323 D1 DE 68918323D1
Authority
DE
Germany
Prior art keywords
peptide bonds
specific cleavage
side chains
tertiary phosphines
organic tertiary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918323T
Other languages
English (en)
Other versions
DE68918323T2 (de
Inventor
Lois M Hinman
Libby S Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meda Pharmaceuticals Inc
Original Assignee
Carter Wallace Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carter Wallace Inc filed Critical Carter Wallace Inc
Application granted granted Critical
Publication of DE68918323D1 publication Critical patent/DE68918323D1/de
Publication of DE68918323T2 publication Critical patent/DE68918323T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5004—Acyclic saturated phosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/128—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE68918323T 1988-04-01 1989-03-06 Spezifische Spaltung von Peptidbindungen durch organische tertiäre Phosphine mit nukleophilen Seitenketten. Expired - Fee Related DE68918323T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17657188A 1988-04-01 1988-04-01
US17657388A 1988-04-01 1988-04-01

Publications (2)

Publication Number Publication Date
DE68918323D1 true DE68918323D1 (de) 1994-10-27
DE68918323T2 DE68918323T2 (de) 1995-05-18

Family

ID=26872381

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918323T Expired - Fee Related DE68918323T2 (de) 1988-04-01 1989-03-06 Spezifische Spaltung von Peptidbindungen durch organische tertiäre Phosphine mit nukleophilen Seitenketten.

Country Status (6)

Country Link
EP (1) EP0339217B1 (de)
JP (1) JPH0215092A (de)
AT (1) ATE111918T1 (de)
CA (1) CA1330800C (de)
DE (1) DE68918323T2 (de)
ES (1) ES2064374T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego
JP5501439B2 (ja) 2009-04-02 2014-05-21 ロシュ グリクアート アクチェンゲゼルシャフト 完全長抗体と単鎖Ｆａｂフラグメントとを含む多重特異的抗体
WO2011034605A2 (en) 2009-09-16 2011-03-24 Genentech, Inc. Coiled coil and/or tether containing protein complexes and uses thereof
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
WO2012025530A1 (en) 2010-08-24 2012-03-01 F. Hoffmann-La Roche Ag Bispecific antibodies comprising a disulfide stabilized - fv fragment
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
MX2014009565A (es) 2012-02-10 2014-11-10 Genentech Inc Anticuerpos monocatenarios y otros heteromultimeros.
ES2597228T3 (es) 2012-06-27 2017-01-17 F. Hoffmann-La Roche Ag Procedimiento para la selección y la producción de entidades de objetivación, como dianas, altamente selectivas y multiespecíficas, personalizadas, las cuales contienen por lo menos dos entidades de unión diferentes, y utilización de éstas
WO2014001325A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3628910A (en) * 1966-05-02 1971-12-21 American Cyanamid Co Compositions for the deformation of keratin
FR1574239A (de) * 1967-07-12 1969-07-11
US3754035A (en) * 1970-01-29 1973-08-21 American Cyanamid Co Tertiary organophosphines
US3970532A (en) * 1975-01-16 1976-07-20 Borg-Warner Corporation 2-Hydroxyethylphosphines

Also Published As

Publication number Publication date
JPH0215092A (ja) 1990-01-18
DE68918323T2 (de) 1995-05-18
EP0339217A3 (en) 1990-01-03
EP0339217B1 (de) 1994-09-21
EP0339217A2 (de) 1989-11-02
ATE111918T1 (de) 1994-10-15
CA1330800C (en) 1994-07-19
ES2064374T3 (es) 1995-02-01

Similar Documents

Publication Publication Date Title
NL300118I2 (nl) Voor Factor VIIIC coderende DNA-sequenties en verwante DNA-constructen.
ATE105867T1 (de) Immunaffinitäts-reinigungssystem.
DE68918323T2 (de) Spezifische Spaltung von Peptidbindungen durch organische tertiäre Phosphine mit nukleophilen Seitenketten.
DK0700998T3 (da) Rekombinant mersacidin samt en fremgangsmåde til fremstilling deraf
DE3650676D1 (de) Verfahren und mittel zur sortierung und bestimmung biologischer informationen
DE68925043T2 (de) Synthetische Peptide und deren Mischungen für den Nachweis von HIV-Antikörpern
DE69318559D1 (de) Peptide brauchbar als microsequezierungsstandard und verfahren zu ihrer anwendung
DE3873273D1 (de) Verfahren zur selektiven spaltung von fusionsproteinen.
ATE97494T1 (de) Geraete und verfahren zur bestimmung der sequenz von aminosaeuren.
NO904129D0 (no) Antistoffer mot hoeykonserverte aminosyresekvenser fra immunogene forbindelser, fremgangsmaate for fremstilling av antistoffer samt anvendelse derav i immunoanalyser.
DE69613086D1 (de) Antigenen Peptide mit Glycinsubstitution
DE69831584T2 (de) Polypeptide mit wasserkanalaktivität und dna sequenzen
WO1990000179A3 (fr) Nouvelles proteins, adn les codant et leur usage
SE8803986D0 (sv) Method for sequencing peptides or proteins
ES2114004T3 (es) Procedimiento de preparacion de peptidos con un residuo prolina amidado en la posicion c-terminal.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee