JP6464166B2 - 陽電子放出断層撮影用の化合物 - Google Patents

陽電子放出断層撮影用の化合物 Download PDF

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Publication number
JP6464166B2
JP6464166B2 JP2016529948A JP2016529948A JP6464166B2 JP 6464166 B2 JP6464166 B2 JP 6464166B2 JP 2016529948 A JP2016529948 A JP 2016529948A JP 2016529948 A JP2016529948 A JP 2016529948A JP 6464166 B2 JP6464166 B2 JP 6464166B2
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acid
linker
conjugate
methyl
preceding clauses
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JP2016540747A5 (https=
JP2016540747A (ja
Inventor
アール．ブラホフ イオンチョ
アール．ブラホフ イオンチョ
ピー．リーモン クリストファー
ピー．リーモン クリストファー
エス．ロー フィリップ
エス．ロー フィリップ
エル．パラム ガース
エル．パラム ガース
チェン チンショウ
チェン チンショウ
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Purdue Research Foundation
Endocyte Inc
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Purdue Research Foundation
Endocyte Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nuclear Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016529948A 2013-11-14 2014-11-13 陽電子放出断層撮影用の化合物 Active JP6464166B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361904387P 2013-11-14 2013-11-14
US201361904400P 2013-11-14 2013-11-14
US61/904,400 2013-11-14
US61/904,387 2013-11-14
US201361909822P 2013-11-27 2013-11-27
US61/909,822 2013-11-27
PCT/US2014/065467 WO2015073678A1 (en) 2013-11-14 2014-11-13 Compounds for positron emission tomography

Related Child Applications (1)

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JP2018208786A Division JP2019023232A (ja) 2013-11-14 2018-11-06 陽電子放出断層撮影用の化合物

Publications (3)

Publication Number Publication Date
JP2016540747A JP2016540747A (ja) 2016-12-28
JP2016540747A5 JP2016540747A5 (https=) 2017-11-30
JP6464166B2 true JP6464166B2 (ja) 2019-02-06

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JP2016529948A Active JP6464166B2 (ja) 2013-11-14 2014-11-13 陽電子放出断層撮影用の化合物
JP2018208786A Pending JP2019023232A (ja) 2013-11-14 2018-11-06 陽電子放出断層撮影用の化合物
JP2020060644A Pending JP2020165975A (ja) 2013-11-14 2020-03-30 陽電子放出断層撮影用の化合物
JP2021175168A Active JP7299285B2 (ja) 2013-11-14 2021-10-27 陽電子放出断層撮影用の化合物
JP2023098521A Active JP7693751B2 (ja) 2013-11-14 2023-06-15 陽電子放出断層撮影用の化合物
JP2025093836A Pending JP2025120291A (ja) 2013-11-14 2025-06-05 陽電子放出断層撮影用の化合物

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JP2018208786A Pending JP2019023232A (ja) 2013-11-14 2018-11-06 陽電子放出断層撮影用の化合物
JP2020060644A Pending JP2020165975A (ja) 2013-11-14 2020-03-30 陽電子放出断層撮影用の化合物
JP2021175168A Active JP7299285B2 (ja) 2013-11-14 2021-10-27 陽電子放出断層撮影用の化合物
JP2023098521A Active JP7693751B2 (ja) 2013-11-14 2023-06-15 陽電子放出断層撮影用の化合物
JP2025093836A Pending JP2025120291A (ja) 2013-11-14 2025-06-05 陽電子放出断層撮影用の化合物

Country Status (15)

Country Link
US (4) US20160287731A1 (https=)
EP (4) EP3069147A4 (https=)
JP (6) JP6464166B2 (https=)
KR (1) KR102457827B1 (https=)
CN (2) CN105849568B (https=)
AU (4) AU2014348601A1 (https=)
BR (1) BR112016010927A2 (https=)
CA (1) CA2930581A1 (https=)
EA (1) EA035171B1 (https=)
ES (1) ES3013992T3 (https=)
IL (2) IL245612A0 (https=)
MX (2) MX2016006219A (https=)
SG (1) SG10201803618RA (https=)
TW (1) TWI657827B (https=)
WO (1) WO2015073678A1 (https=)

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