EA201690862A1 - Соединения для позитронно-эмиссионной томографии - Google Patents

Соединения для позитронно-эмиссионной томографии

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Publication number
EA201690862A1
EA201690862A1 EA201690862A EA201690862A EA201690862A1 EA 201690862 A1 EA201690862 A1 EA 201690862A1 EA 201690862 A EA201690862 A EA 201690862A EA 201690862 A EA201690862 A EA 201690862A EA 201690862 A1 EA201690862 A1 EA 201690862A1
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Eurasian Patent Office
Prior art keywords
radionuclide
radical
group
emission tomography
positron
Prior art date
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EA201690862A
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English (en)
Other versions
EA035171B1 (ru
Inventor
Ионтчо Р. Влахов
Кристофер П. Лимон
Филип С. Лоу
Гарт Л. Пархам
Циньшоу Чэнь
Original Assignee
Эндосайт, Инк.
Пурдью Рисерч Фаундейшн
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Application filed by Эндосайт, Инк., Пурдью Рисерч Фаундейшн filed Critical Эндосайт, Инк.
Publication of EA201690862A1 publication Critical patent/EA201690862A1/ru
Publication of EA035171B1 publication Critical patent/EA035171B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nuclear Medicine (AREA)

Abstract

В настоящем документе описаны соединения, композиции и способы для диагностирования и/или наблюдения патогенного заболевания с использованием позитронно-эмиссионной томографии. Кроме того, описаны конъюгаты формулы B-L-Р, где В представляет собой радикал, представляющий собой средство нацеливания, выбранное из связывающихся с рецептором витамина лигандов, связывающихся с PSMA лигандов (таких как фолат) или ингибиторов PSMA, L представляет собой бивалентный линкер, содержащий аспарагиновую кислоту, лизин или агинин, и Р представляет собой радикал, представляющий собой средство визуализации или средство лучевой терапии, такой как радионуклид или содержащая радионуклид группа, или радикал, представляющий собой соединение, способное к связыванию с радионуклидом или содержащей радионуклид группой, например металлохелатирующей группой.
EA201690862A 2013-11-14 2014-11-13 Конъюгаты на основе связывающихся с psma лигандов или ингибиторов psma для позитронно-эмиссионной томографии EA035171B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361904400P 2013-11-14 2013-11-14
US201361904387P 2013-11-14 2013-11-14
US201361909822P 2013-11-27 2013-11-27
PCT/US2014/065467 WO2015073678A1 (en) 2013-11-14 2014-11-13 Compounds for positron emission tomography

Publications (2)

Publication Number Publication Date
EA201690862A1 true EA201690862A1 (ru) 2016-12-30
EA035171B1 EA035171B1 (ru) 2020-05-08

Family

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Family Applications (1)

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EA201690862A EA035171B1 (ru) 2013-11-14 2014-11-13 Конъюгаты на основе связывающихся с psma лигандов или ингибиторов psma для позитронно-эмиссионной томографии

Country Status (14)

Country Link
US (3) US20160287731A1 (ru)
EP (3) EP3069147A4 (ru)
JP (5) JP6464166B2 (ru)
KR (1) KR102457827B1 (ru)
CN (2) CN105849568B (ru)
AU (3) AU2014348601A1 (ru)
BR (1) BR112016010927A2 (ru)
CA (1) CA2930581A1 (ru)
EA (1) EA035171B1 (ru)
IL (2) IL245612A0 (ru)
MX (2) MX2016006219A (ru)
SG (1) SG10201803618RA (ru)
TW (1) TWI657827B (ru)
WO (1) WO2015073678A1 (ru)

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WO2015073678A1 (en) 2015-05-21
NZ719939A (en) 2022-03-25
US20190275181A1 (en) 2019-09-12
TW201609153A (zh) 2016-03-16
US20220125958A1 (en) 2022-04-28
TWI657827B (zh) 2019-05-01
AU2021200067A1 (en) 2021-03-18
IL261259B (en) 2020-07-30
MX2022014611A (es) 2023-01-11
EP3777898A2 (en) 2021-02-17
CN108514646B (zh) 2021-07-16
BR112016010927A2 (pt) 2017-08-08
AU2021200067B2 (en) 2023-02-02
CN105849568B (zh) 2018-05-04
EP3533473A2 (en) 2019-09-04
SG10201803618RA (en) 2018-06-28
AU2014348601A1 (en) 2016-05-26
CA2930581A1 (en) 2015-05-21
CN105849568A (zh) 2016-08-10
JP2020165975A (ja) 2020-10-08
JP6464166B2 (ja) 2019-02-06
EP3069147A1 (en) 2016-09-21
KR102457827B1 (ko) 2022-10-24
JP2016540747A (ja) 2016-12-28
MX2016006219A (es) 2016-10-28
JP7299285B2 (ja) 2023-06-27
EP3533473A3 (en) 2019-12-18
IL261259A (en) 2018-10-31
CN108514646A (zh) 2018-09-11
JP2023107988A (ja) 2023-08-03
EA035171B1 (ru) 2020-05-08
AU2023202704A1 (en) 2023-05-18
JP2019023232A (ja) 2019-02-14
IL245612A0 (en) 2016-06-30
EP3069147A4 (en) 2017-10-11
KR20160079887A (ko) 2016-07-06
US20160287731A1 (en) 2016-10-06
JP2022023172A (ja) 2022-02-07
EP3777898A3 (en) 2021-04-21

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