JP6239598B2 - 薬物複合体、複合体形成方法、およびその使用 - Google Patents

薬物複合体、複合体形成方法、およびその使用 Download PDF

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JP6239598B2
JP6239598B2 JP2015512770A JP2015512770A JP6239598B2 JP 6239598 B2 JP6239598 B2 JP 6239598B2 JP 2015512770 A JP2015512770 A JP 2015512770A JP 2015512770 A JP2015512770 A JP 2015512770A JP 6239598 B2 JP6239598 B2 JP 6239598B2
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JP2015518832A5 (https=
JP2015518832A (ja
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ジェンウェイ・ミャオ
ユーフォン・ホン
トン・ジュウ
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Sorrento Therapeutics Inc
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015512770A 2012-05-15 2013-05-14 薬物複合体、複合体形成方法、およびその使用 Active JP6239598B2 (ja)

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US201261647300P 2012-05-15 2012-05-15
US61/647,300 2012-05-15
US201261648406P 2012-05-17 2012-05-17
US201261648532P 2012-05-17 2012-05-17
US61/648,406 2012-05-17
US61/648,532 2012-05-17
US201261652512P 2012-05-29 2012-05-29
US61/652,512 2012-05-29
PCT/US2013/041027 WO2013173392A1 (en) 2012-05-15 2013-05-14 Drug-conjugates, conjugation methods, and uses thereof

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