FR3107648B1 - conjugués anticorps-médicament anti-CD56 et leur utilisation en thérapie - Google Patents
conjugués anticorps-médicament anti-CD56 et leur utilisation en thérapie Download PDFInfo
- Publication number
- FR3107648B1 FR3107648B1 FR2001974A FR2001974A FR3107648B1 FR 3107648 B1 FR3107648 B1 FR 3107648B1 FR 2001974 A FR2001974 A FR 2001974A FR 2001974 A FR2001974 A FR 2001974A FR 3107648 B1 FR3107648 B1 FR 3107648B1
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- France
- Prior art keywords
- antibody
- therapy
- drug conjugates
- conjugates
- drug
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- 239000000611 antibody drug conjugate Substances 0.000 title abstract 3
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title abstract 3
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Conjugués anticorps-médicament anti-CD56 et leur utilisation en thérapie L’invention concerne des conjugués anticorps-médicament, et leur utilisation en thérapie, notamment pour traiter les cancers CD56+.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2001974A FR3107648B1 (fr) | 2020-02-27 | 2020-02-27 | conjugués anticorps-médicament anti-CD56 et leur utilisation en thérapie |
PCT/FR2021/050332 WO2021170961A1 (fr) | 2020-02-27 | 2021-02-26 | Conjugués anticorps-médicament anti-cd56 et leur utilisation en thérapie |
CA3166699A CA3166699A1 (fr) | 2020-02-27 | 2021-02-26 | Conjugues anticorps-medicament anti-cd56 et leur utilisation en therapie |
JP2022552310A JP2023515845A (ja) | 2020-02-27 | 2021-02-26 | 抗-cd56抗体-薬物複合体およびその治療での使用 |
US17/802,274 US20230144142A1 (en) | 2020-02-27 | 2021-02-26 | Anti-cd56 antibody-drug conjugates and their use in therapy |
EP21714002.9A EP4110405A1 (fr) | 2020-02-27 | 2021-02-26 | Conjugués anticorps-médicament anti-cd56 et leur utilisation en thérapie |
CN202180017269.9A CN115515642A (zh) | 2020-02-27 | 2021-02-26 | 抗cd56抗体-药物偶联物及其在治疗中的用途 |
AU2021227413A AU2021227413A1 (en) | 2020-02-27 | 2021-02-26 | Anti-CD56 antibody-drug conjugates and their use in therapy |
US18/333,261 US20230405140A1 (en) | 2020-02-27 | 2023-06-12 | Anti-cd56 antibody-drug conjugates and their use in therapy |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2001974A FR3107648B1 (fr) | 2020-02-27 | 2020-02-27 | conjugués anticorps-médicament anti-CD56 et leur utilisation en thérapie |
FR2001974 | 2020-02-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3107648A1 FR3107648A1 (fr) | 2021-09-03 |
FR3107648B1 true FR3107648B1 (fr) | 2022-03-18 |
Family
ID=71894885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR2001974A Active FR3107648B1 (fr) | 2020-02-27 | 2020-02-27 | conjugués anticorps-médicament anti-CD56 et leur utilisation en thérapie |
Country Status (8)
Country | Link |
---|---|
US (2) | US20230144142A1 (fr) |
EP (1) | EP4110405A1 (fr) |
JP (1) | JP2023515845A (fr) |
CN (1) | CN115515642A (fr) |
AU (1) | AU2021227413A1 (fr) |
CA (1) | CA3166699A1 (fr) |
FR (1) | FR3107648B1 (fr) |
WO (1) | WO2021170961A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3131835A1 (fr) * | 2022-01-17 | 2023-07-21 | Mc Saf | Procédé de préparation de conjugués anticorps-médicament |
FR3131836A1 (fr) * | 2022-01-17 | 2023-07-21 | Mc Saf | Conjugués anticorps-médicament pour utilisation thérapeutique |
WO2024040194A1 (fr) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditionnement pour l'ingénierie de cellules immunitaires in vivo |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3008408B1 (fr) * | 2013-07-11 | 2018-03-09 | Mc Saf | Nouveaux conjugues anticorps-medicament et leur utilisation en therapie |
US10548987B2 (en) | 2015-07-31 | 2020-02-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody-drug conjugates for targeting CD56-positive tumors |
CN107744592B (zh) * | 2017-09-15 | 2020-04-28 | 四川大学 | 抗cd56抗体与海兔毒素偶联复合物及其制备方法和用途 |
CN107715119B (zh) * | 2017-09-15 | 2020-11-10 | 四川大学 | 抗cd56抗体与多卡霉素偶联复合物及其制备方法和用途 |
-
2020
- 2020-02-27 FR FR2001974A patent/FR3107648B1/fr active Active
-
2021
- 2021-02-26 CA CA3166699A patent/CA3166699A1/fr active Pending
- 2021-02-26 US US17/802,274 patent/US20230144142A1/en active Pending
- 2021-02-26 WO PCT/FR2021/050332 patent/WO2021170961A1/fr unknown
- 2021-02-26 CN CN202180017269.9A patent/CN115515642A/zh active Pending
- 2021-02-26 EP EP21714002.9A patent/EP4110405A1/fr active Pending
- 2021-02-26 AU AU2021227413A patent/AU2021227413A1/en active Pending
- 2021-02-26 JP JP2022552310A patent/JP2023515845A/ja active Pending
-
2023
- 2023-06-12 US US18/333,261 patent/US20230405140A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3166699A1 (fr) | 2021-09-02 |
WO2021170961A1 (fr) | 2021-09-02 |
AU2021227413A1 (en) | 2022-10-20 |
US20230405140A1 (en) | 2023-12-21 |
JP2023515845A (ja) | 2023-04-14 |
FR3107648A1 (fr) | 2021-09-03 |
EP4110405A1 (fr) | 2023-01-04 |
US20230144142A1 (en) | 2023-05-11 |
CN115515642A (zh) | 2022-12-23 |
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Legal Events
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PLFP | Fee payment |
Year of fee payment: 2 |
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PLSC | Publication of the preliminary search report |
Effective date: 20210903 |
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TP | Transmission of property |
Owner name: MC SAF, FR Effective date: 20211014 |
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TP | Transmission of property |
Owner name: MCSAF INSIDE ONCOLOGY, FR Effective date: 20220822 |
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