JP6180663B2 - Ｔｉｇｉｔに対する抗体 - Google Patents

Ｔｉｇｉｔに対する抗体 Download PDF

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Publication number
JP6180663B2
JP6180663B2 JP2016564332A JP2016564332A JP6180663B2 JP 6180663 B2 JP6180663 B2 JP 6180663B2 JP 2016564332 A JP2016564332 A JP 2016564332A JP 2016564332 A JP2016564332 A JP 2016564332A JP 6180663 B2 JP6180663 B2 JP 6180663B2
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Prior art keywords
antibody
tigit
antigen
antibodies
binding
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Japanese (ja)
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JP2017520512A (ja
Inventor
マーク・エフ・モーラー
セン−ホイ・ティモシー・チェン
ブリジット・デボー
モハン・スリニバサン
スーザン・エイチ・ジュリアン
ポール・オー・シェパード
ダニエル・エフ・アードゥレル
インドラニ・チャクラボーティ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016564332A 2014-12-23 2015-12-22 Ｔｉｇｉｔに対する抗体 Active JP6180663B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462096267P 2014-12-23 2014-12-23
US62/096,267 2014-12-23
PCT/US2015/067332 WO2016106302A1 (en) 2014-12-23 2015-12-22 Antibodies to tigit

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017138861A Division JP6633032B2 (ja) 2014-12-23 2017-07-18 Ｔｉｇｉｔに対する抗体

Publications (2)

Publication Number Publication Date
JP2017520512A JP2017520512A (ja) 2017-07-27
JP6180663B2 true JP6180663B2 (ja) 2017-08-16

Family

ID=55168435

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2016564332A Active JP6180663B2 (ja) 2014-12-23 2015-12-22 Ｔｉｇｉｔに対する抗体
JP2017138861A Active JP6633032B2 (ja) 2014-12-23 2017-07-18 Ｔｉｇｉｔに対する抗体
JP2019223659A Pending JP2020062026A (ja) 2014-12-23 2019-12-11 Ｔｉｇｉｔに対する抗体
JP2021102155A Pending JP2021177759A (ja) 2014-12-23 2021-06-21 Ｔｉｇｉｔに対する抗体
JP2023111614A Pending JP2023139046A (ja) 2014-12-23 2023-07-06 Ｔｉｇｉｔに対する抗体
JP2025087824A Pending JP2025128184A (ja) 2014-12-23 2025-05-27 Ｔｉｇｉｔに対する抗体

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2017138861A Active JP6633032B2 (ja) 2014-12-23 2017-07-18 Ｔｉｇｉｔに対する抗体
JP2019223659A Pending JP2020062026A (ja) 2014-12-23 2019-12-11 Ｔｉｇｉｔに対する抗体
JP2021102155A Pending JP2021177759A (ja) 2014-12-23 2021-06-21 Ｔｉｇｉｔに対する抗体
JP2023111614A Pending JP2023139046A (ja) 2014-12-23 2023-07-06 Ｔｉｇｉｔに対する抗体
JP2025087824A Pending JP2025128184A (ja) 2014-12-23 2025-05-27 Ｔｉｇｉｔに対する抗体

Country Status (23)

Country Link
US (3) US10189902B2 (enExample)
EP (2) EP4249066A3 (enExample)
JP (6) JP6180663B2 (enExample)
KR (1) KR102644115B1 (enExample)
CN (3) CN107207594B (enExample)
AR (1) AR103268A1 (enExample)
AU (2) AU2015369683C1 (enExample)
BR (1) BR112017013385A2 (enExample)
CL (1) CL2017001660A1 (enExample)
CO (1) CO2017006989A2 (enExample)
EA (1) EA039219B1 (enExample)
IL (2) IL253013B (enExample)
MA (1) MA40662B1 (enExample)
MX (2) MX389267B (enExample)
MY (1) MY187045A (enExample)
PE (1) PE20171244A1 (enExample)
PH (2) PH12022550771A1 (enExample)
SG (2) SG10202006538TA (enExample)
TN (1) TN2017000267A1 (enExample)
TW (1) TWI708786B (enExample)
UY (1) UY36471A (enExample)
WO (1) WO2016106302A1 (enExample)
ZA (2) ZA201704981B (enExample)

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* Cited by examiner, † Cited by third party
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