JP6068464B2 - γ−セクレターゼ調節剤としての新規な置換インドール誘導体 - Google Patents

γ−セクレターゼ調節剤としての新規な置換インドール誘導体 Download PDF

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JP6068464B2
JP6068464B2 JP2014519557A JP2014519557A JP6068464B2 JP 6068464 B2 JP6068464 B2 JP 6068464B2 JP 2014519557 A JP2014519557 A JP 2014519557A JP 2014519557 A JP2014519557 A JP 2014519557A JP 6068464 B2 JP6068464 B2 JP 6068464B2
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fluoro
alkyloxy
alkyl
formula
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JP2014518286A (ja
JP2014518286A5 (enExample
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マイン,ガレット,バーロンド
ポール ビショッフ,フランソワ
ポール ビショッフ,フランソワ
ジイセン,ヘンリクス,ヤコブス,マリア
ベルター,アドリアーナ,イングリッド
ピーテルス,サージ,マリア,アロイシウス
ベルテロ,ディディエ,ジャン−クロード
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ヤンセン ファーマシューティカルズ,インコーポレーテッド
ヤンセン ファーマシューティカルズ,インコーポレーテッド
セルゾーム リミテッド
セルゾーム リミテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
JP2014519557A 2011-07-15 2012-07-12 γ−セクレターゼ調節剤としての新規な置換インドール誘導体 Expired - Fee Related JP6068464B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11174120 2011-07-15
EP11174120.3 2011-07-15
PCT/EP2012/063667 WO2013010904A1 (en) 2011-07-15 2012-07-12 Novel substituted indole derivatives as gamma secretase modulators

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JP2014518286A JP2014518286A (ja) 2014-07-28
JP2014518286A5 JP2014518286A5 (enExample) 2015-08-20
JP6068464B2 true JP6068464B2 (ja) 2017-01-25

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JP2014519557A Expired - Fee Related JP6068464B2 (ja) 2011-07-15 2012-07-12 γ−セクレターゼ調節剤としての新規な置換インドール誘導体

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US (1) US9115143B2 (enExample)
EP (1) EP2731948B1 (enExample)
JP (1) JP6068464B2 (enExample)
KR (1) KR101913135B1 (enExample)
CN (1) CN103874702B (enExample)
AR (1) AR087182A1 (enExample)
AU (1) AU2012285931B2 (enExample)
BR (1) BR112014000713A2 (enExample)
CA (1) CA2841102C (enExample)
EA (1) EA023045B1 (enExample)
ES (1) ES2555167T3 (enExample)
IL (1) IL230422B (enExample)
IN (1) IN2014MN00258A (enExample)
MX (1) MX2014000626A (enExample)
TW (1) TWI567079B (enExample)
WO (1) WO2013010904A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010089292A1 (en) 2009-02-06 2010-08-12 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
EP2427453B1 (en) 2009-05-07 2013-07-17 Janssen Pharmaceuticals, Inc. Substituted indazole and aza-indazole derivatives as gamma secretase modulators
EA021047B1 (ru) 2009-07-15 2015-03-31 Янссен Фармасьютикалз, Инк. Замещенные производные триазола и имидазола в качестве модуляторов гамма-секретазы
PE20121511A1 (es) 2010-01-15 2012-12-06 Janssen Pharmaceuticals Inc Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa
CA2827969A1 (en) 2011-03-24 2012-09-27 Janssen Pharmaceuticals, Inc. Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
EA023045B1 (ru) 2011-07-15 2016-04-29 Янссен Фармасьютикалз, Инк. Новые замещенные производные индола в качестве модуляторов гамма-секретазы
JP6106745B2 (ja) 2012-05-16 2017-04-05 ヤンセン ファーマシューティカルズ,インコーポレーテッド (特に)アルツハイマー病の治療に有用な置換3,4−ジヒドロ−2H−ピリド[1,2−a]ピラジン−1,6−ジオン誘導体
EP2738172A1 (en) * 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
US10112943B2 (en) 2012-12-20 2018-10-30 Janssen Pharmaceutica Nv Substituted imidazoles as gamma secretase modulators
WO2014111457A1 (en) 2013-01-17 2014-07-24 Janssen Pharmaceutica Nv Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
CA3031675A1 (en) 2016-07-30 2018-02-08 Bristol-Myers Squibb Company Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors
US10660877B2 (en) 2016-09-09 2020-05-26 Bristol-Myers Squibb Company Pyridyl substituted indole compounds
JOP20190060A1 (ar) 2016-09-26 2019-03-26 Chugai Pharmaceutical Co Ltd مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1
US11130756B2 (en) 2017-08-04 2021-09-28 Bristol-Myers Squibb Company [1,2,4]Triazolo[4,3-A]pyridinyl substituted indole compounds
CN110997656B (zh) 2017-08-04 2023-04-14 百时美施贵宝公司 用作tlr7/8/9抑制剂的取代的吲哚化合物
CN111201229B (zh) 2017-10-11 2024-08-23 豪夫迈·罗氏有限公司 用作rip1激酶抑制剂的二环化合物
WO2019099336A1 (en) * 2017-11-14 2019-05-23 Bristol-Myers Squibb Company Substituted indole compounds
EA202091477A1 (ru) 2017-12-15 2020-10-28 Бристол-Маерс Сквибб Компани Замещенные соединения простых индольных эфиров
EA202091484A1 (ru) 2017-12-18 2021-03-25 Бристол-Маерс Сквибб Компани 4-азаиндольные соединения
CA3085761A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Triazole n-linked carbamoylcyclohexyl acids as lpa antagonists
JP7291145B2 (ja) 2017-12-19 2023-06-14 ブリストル-マイヤーズ スクイブ カンパニー Tlr阻害剤として有効な置換されたインドール化合物
WO2019126081A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Amide substituted indole compounds useful as tlr inhibitors
EA202091480A1 (ru) 2017-12-20 2020-11-06 Бристол-Маерс Сквибб Компани Аминоиндольные соединения, пригодные в качестве ингибиторов tlr
EP3728264B1 (en) 2017-12-20 2021-12-01 Bristol-Myers Squibb Company Diazaindole compounds
AU2018393003A1 (en) 2017-12-20 2020-08-06 Bristol-Myers Squibb Company Aryl and heteroaryl substituted indole compounds
WO2020048904A1 (en) 2018-09-03 2020-03-12 F. Hoffmann-La Roche Ag Bicyclic heteroaryl derivatives
EP3628669A1 (en) * 2018-09-28 2020-04-01 GenKyoTex Suisse SA Novel compounds as nadph oxidase inhibitors
ES2963696T3 (es) 2018-10-24 2024-04-01 Bristol Myers Squibb Co Compuestos diméricos de indol sustituidos
US12172995B2 (en) 2018-10-24 2024-12-24 Bristol-Myers Squibb Company Substituted indole and indazole compounds
SI3894411T1 (sl) 2018-12-13 2024-10-30 F. Hoffmann - La Roche Ag Derivati 7-fenoksi-N-(3-azabiciklo(3.2.1)oktan-8-il)-6,7-dihidro-5H- pirolo(1,2-b)(1,2,4)triazol-2-amina in sorodne spojine kot modulatorji gama-sekretaze za zdravljenje Alzheimerjeve bolezni
US12187723B2 (en) 2019-05-09 2025-01-07 Bristol-Myers Squibb Company Substituted benzimidazolone compounds
CN114761404B (zh) 2019-10-01 2025-02-21 百时美施贵宝公司 经取代的双环杂芳基化合物
JP7545467B2 (ja) 2019-10-04 2024-09-04 ブリストル-マイヤーズ スクイブ カンパニー 置換カルバゾール化合物

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0571253T3 (da) * 1992-05-19 1999-07-19 Adir Benzimidazolderivater med antidiabetisk og antiblodpladekoagulerende virkning
US5767144A (en) 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
EP0839144B1 (en) 1995-07-13 2001-09-19 Knoll GmbH Piperazine derivatives as therapeutic agents
CN1156445C (zh) 1999-06-10 2004-07-07 沃尼尔·朗伯公司 采用二氢异吲哚衍生物抑制淀粉样蛋白聚集和使淀粉样蛋白沉积成像的方法
WO2001078721A1 (en) 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research Aβ42 LOWERING AGENTS
WO2001087845A2 (en) 2000-05-15 2001-11-22 Fujisawa Pharmaceutical Co., Ltd. N-containing heterocyclic compounds and their use as 5-ht antagonists
DE10109867A1 (de) 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Verwendung von Triazolverbindungen zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
DE10238002A1 (de) 2002-08-20 2004-03-04 Merck Patent Gmbh Benzimidazolderivate
CN1753891A (zh) 2003-02-27 2006-03-29 霍夫曼-拉罗奇有限公司 Ccr-3受体拮抗剂
EP1628666B1 (en) 2003-05-14 2015-09-23 NeuroGenetic Pharmaceuticals, Inc. Compouds and uses thereof in modulating amyloid beta
MXPA06001660A (es) 2003-08-14 2006-04-28 Hoffmann La Roche Moduladores gabanergicos.
ATE483708T1 (de) 2004-03-08 2010-10-15 Prosidion Ltd Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase
CA2566094A1 (en) 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Cinnamide compound
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
CA2600570C (en) 2005-03-14 2011-12-06 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as .beta.-secretase inhibitors
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
CA2623317A1 (en) 2005-09-22 2007-03-29 Sanofi-Aventis Amino-alkyl-amide derivatives as ccr3 receptor liquids
WO2007043786A1 (en) 2005-10-10 2007-04-19 Seiyang Yang Dynamic-based verification apparatus for verification from electronic system level to gate level, and verification method using the same
WO2007044895A2 (en) 2005-10-11 2007-04-19 Chemtura Corporation Diaromatic amines
WO2007058942A2 (en) 2005-11-10 2007-05-24 Schering Corporation Imidazopyrazines as protein kinase inhibitors
JP2009539762A (ja) 2006-03-13 2009-11-19 ファイザー・プロダクツ・インク H3受容体のテトラリン拮抗薬
GB0606774D0 (en) 2006-04-03 2006-05-10 Novartis Ag Organic compounds
US7893058B2 (en) 2006-05-15 2011-02-22 Janssen Pharmaceutica Nv Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
US7951818B2 (en) 2006-12-01 2011-05-31 Galapagos Nv Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases
CN101631779A (zh) 2006-12-12 2010-01-20 先灵公司 含有三环系统的天冬氨酰蛋白酶抑制剂
CA2672960A1 (en) 2006-12-20 2008-07-10 Schering Corporation Novel jnk inhibitors
CA2677296A1 (en) 2007-02-08 2008-08-14 Merck & Co., Inc. Therapeutic agents
AU2008215948A1 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperazine derivatives for treatment of AD and related conditions
EP2120573A4 (en) 2007-02-12 2011-05-25 Merck Sharp & Dohme piperidine
WO2008137139A1 (en) 2007-05-07 2008-11-13 Schering Corporation Gamma secretase modulators
DE602008004769D1 (en) 2007-05-11 2011-03-10 Hoffmann La Roche Hetarylaniline als modulatoren für amyloid beta
US8242150B2 (en) 2007-06-13 2012-08-14 Merck Sharp & Dohme Corp. Triazole derivatives for treating alzheimer'S disease and related conditions
WO2009005729A1 (en) 2007-06-29 2009-01-08 Schering Corporation Gamma secretase modulators
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
CN101848897A (zh) 2007-09-06 2010-09-29 先灵公司 γ分泌酶调节剂
GB0720444D0 (en) 2007-10-18 2007-11-28 Glaxo Group Ltd Novel compounds
MX2010006243A (es) * 2007-12-06 2010-08-31 Schering Corp Moduladores de gamma secretasa.
CA2708300A1 (en) 2007-12-11 2009-06-18 Schering Corporation Gamma secretase modulators
KR101247840B1 (ko) 2008-02-22 2013-03-26 에프. 호프만-라 로슈 아게 아밀로이드 베타 조절제
US20100137320A1 (en) 2008-02-29 2010-06-03 Schering Corporation Gamma secretase modulators
WO2010010188A1 (en) 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases.
JP5529876B2 (ja) 2008-10-17 2014-06-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Mmp−13阻害剤として有用なヘテロアリール置換インドール化合物
WO2010054067A1 (en) 2008-11-06 2010-05-14 Schering Corporation Gamma secretase modulators
WO2010052199A1 (en) 2008-11-10 2010-05-14 F. Hoffmann-La Roche Ag Heterocyclic gamma secretase modulators
EP2367817A4 (en) 2008-12-03 2012-05-09 Via Pharmaceuticals Inc INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
WO2010089292A1 (en) 2009-02-06 2010-08-12 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
JP2012051806A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
AU2010218714A1 (en) * 2009-02-26 2011-09-08 Eisai R&D Management Co., Ltd. Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
CA2751534A1 (en) 2009-03-03 2010-09-10 Pfizer Inc. Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators
WO2010106745A1 (ja) 2009-03-16 2010-09-23 パナソニック株式会社 アプリケーション実行装置
WO2010114971A1 (en) * 2009-04-03 2010-10-07 Sepracor Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
AU2010241929A1 (en) 2009-04-27 2011-10-06 High Point Pharmaceuticals, Llc Substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors
EP2427453B1 (en) 2009-05-07 2013-07-17 Janssen Pharmaceuticals, Inc. Substituted indazole and aza-indazole derivatives as gamma secretase modulators
JP2010274429A (ja) 2009-05-26 2010-12-09 Ihi Corp アライメントステージ
EA021047B1 (ru) 2009-07-15 2015-03-31 Янссен Фармасьютикалз, Инк. Замещенные производные триазола и имидазола в качестве модуляторов гамма-секретазы
PE20121511A1 (es) 2010-01-15 2012-12-06 Janssen Pharmaceuticals Inc Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa
TW201307347A (zh) * 2010-11-01 2013-02-16 Arqule Inc 經取代苯並-咪唑並-吡啶並-二氮呯化合物
CA2827969A1 (en) 2011-03-24 2012-09-27 Janssen Pharmaceuticals, Inc. Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
JP5767393B2 (ja) 2011-03-31 2015-08-19 ファイザー・インク 新規二環式ピリジノン
EA023045B1 (ru) 2011-07-15 2016-04-29 Янссен Фармасьютикалз, Инк. Новые замещенные производные индола в качестве модуляторов гамма-секретазы

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Publication number Publication date
EA201490287A1 (ru) 2014-05-30
TWI567079B (zh) 2017-01-21
EP2731948B1 (en) 2015-09-09
JP2014518286A (ja) 2014-07-28
KR101913135B1 (ko) 2018-10-30
EA023045B1 (ru) 2016-04-29
CA2841102C (en) 2019-08-13
EP2731948A1 (en) 2014-05-21
CN103874702A (zh) 2014-06-18
AR087182A1 (es) 2014-02-26
KR20140063595A (ko) 2014-05-27
CA2841102A1 (en) 2013-01-24
ES2555167T3 (es) 2015-12-29
MX2014000626A (es) 2014-04-30
NZ619683A (en) 2015-01-30
US20140148450A1 (en) 2014-05-29
TW201315736A (zh) 2013-04-16
IL230422B (en) 2018-03-29
US9115143B2 (en) 2015-08-25
AU2012285931B2 (en) 2017-01-12
IN2014MN00258A (enExample) 2015-09-25
BR112014000713A2 (pt) 2017-01-10
CN103874702B (zh) 2015-12-09
WO2013010904A1 (en) 2013-01-24

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