CA2841102C - Novel substituted indole derivatives as gamma secretase modulators - Google Patents
Novel substituted indole derivatives as gamma secretase modulators Download PDFInfo
- Publication number
- CA2841102C CA2841102C CA2841102A CA2841102A CA2841102C CA 2841102 C CA2841102 C CA 2841102C CA 2841102 A CA2841102 A CA 2841102A CA 2841102 A CA2841102 A CA 2841102A CA 2841102 C CA2841102 C CA 2841102C
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- substituents
- fluoro
- 4alkyloxy
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
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| EP11174120.3 | 2011-07-15 | ||
| PCT/EP2012/063667 WO2013010904A1 (en) | 2011-07-15 | 2012-07-12 | Novel substituted indole derivatives as gamma secretase modulators |
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| CA2841102C true CA2841102C (en) | 2019-08-13 |
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| EP2427453B1 (en) | 2009-05-07 | 2013-07-17 | Janssen Pharmaceuticals, Inc. | Substituted indazole and aza-indazole derivatives as gamma secretase modulators |
| EA021047B1 (ru) | 2009-07-15 | 2015-03-31 | Янссен Фармасьютикалз, Инк. | Замещенные производные триазола и имидазола в качестве модуляторов гамма-секретазы |
| PE20121511A1 (es) | 2010-01-15 | 2012-12-06 | Janssen Pharmaceuticals Inc | Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa |
| CA2827969A1 (en) | 2011-03-24 | 2012-09-27 | Janssen Pharmaceuticals, Inc. | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
| EA023045B1 (ru) | 2011-07-15 | 2016-04-29 | Янссен Фармасьютикалз, Инк. | Новые замещенные производные индола в качестве модуляторов гамма-секретазы |
| JP6106745B2 (ja) | 2012-05-16 | 2017-04-05 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | （特に）アルツハイマー病の治療に有用な置換３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体 |
| EP2738172A1 (en) * | 2012-11-28 | 2014-06-04 | Almirall, S.A. | New bicyclic compounds as crac channel modulators |
| US10112943B2 (en) | 2012-12-20 | 2018-10-30 | Janssen Pharmaceutica Nv | Substituted imidazoles as gamma secretase modulators |
| WO2014111457A1 (en) | 2013-01-17 | 2014-07-24 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| CA3031675A1 (en) | 2016-07-30 | 2018-02-08 | Bristol-Myers Squibb Company | Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors |
| US10660877B2 (en) | 2016-09-09 | 2020-05-26 | Bristol-Myers Squibb Company | Pyridyl substituted indole compounds |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| US11130756B2 (en) | 2017-08-04 | 2021-09-28 | Bristol-Myers Squibb Company | [1,2,4]Triazolo[4,3-A]pyridinyl substituted indole compounds |
| CN110997656B (zh) | 2017-08-04 | 2023-04-14 | 百时美施贵宝公司 | 用作tlr7/8/9抑制剂的取代的吲哚化合物 |
| CN111201229B (zh) | 2017-10-11 | 2024-08-23 | 豪夫迈·罗氏有限公司 | 用作rip1激酶抑制剂的二环化合物 |
| WO2019099336A1 (en) * | 2017-11-14 | 2019-05-23 | Bristol-Myers Squibb Company | Substituted indole compounds |
| EA202091477A1 (ru) | 2017-12-15 | 2020-10-28 | Бристол-Маерс Сквибб Компани | Замещенные соединения простых индольных эфиров |
| EA202091484A1 (ru) | 2017-12-18 | 2021-03-25 | Бристол-Маерс Сквибб Компани | 4-азаиндольные соединения |
| CA3085761A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Triazole n-linked carbamoylcyclohexyl acids as lpa antagonists |
| JP7291145B2 (ja) | 2017-12-19 | 2023-06-14 | ブリストル－マイヤーズ スクイブ カンパニー | Ｔｌｒ阻害剤として有効な置換されたインドール化合物 |
| WO2019126081A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Amide substituted indole compounds useful as tlr inhibitors |
| EA202091480A1 (ru) | 2017-12-20 | 2020-11-06 | Бристол-Маерс Сквибб Компани | Аминоиндольные соединения, пригодные в качестве ингибиторов tlr |
| EP3728264B1 (en) | 2017-12-20 | 2021-12-01 | Bristol-Myers Squibb Company | Diazaindole compounds |
| AU2018393003A1 (en) | 2017-12-20 | 2020-08-06 | Bristol-Myers Squibb Company | Aryl and heteroaryl substituted indole compounds |
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| EP3628669A1 (en) * | 2018-09-28 | 2020-04-01 | GenKyoTex Suisse SA | Novel compounds as nadph oxidase inhibitors |
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| CN114761404B (zh) | 2019-10-01 | 2025-02-21 | 百时美施贵宝公司 | 经取代的双环杂芳基化合物 |
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2012
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- 2012-07-12 JP JP2014519557A patent/JP6068464B2/ja not_active Expired - Fee Related
- 2012-07-12 MX MX2014000626A patent/MX2014000626A/es unknown
- 2012-07-12 EP EP12733754.1A patent/EP2731948B1/en active Active
- 2012-07-12 CA CA2841102A patent/CA2841102C/en not_active Expired - Fee Related
- 2012-07-12 CN CN201280034912.XA patent/CN103874702B/zh not_active Expired - Fee Related
- 2012-07-12 IN IN258MUN2014 patent/IN2014MN00258A/en unknown
- 2012-07-12 AU AU2012285931A patent/AU2012285931B2/en not_active Ceased
- 2012-07-12 US US14/233,078 patent/US9115143B2/en not_active Expired - Fee Related
- 2012-07-12 TW TW101125035A patent/TWI567079B/zh not_active IP Right Cessation
- 2012-07-12 KR KR1020147003465A patent/KR101913135B1/ko not_active Expired - Fee Related
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- 2012-07-12 BR BR112014000713A patent/BR112014000713A2/pt active Search and Examination
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- 2012-07-13 AR ARP120102548A patent/AR087182A1/es not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| EA201490287A1 (ru) | 2014-05-30 |
| JP6068464B2 (ja) | 2017-01-25 |
| TWI567079B (zh) | 2017-01-21 |
| EP2731948B1 (en) | 2015-09-09 |
| JP2014518286A (ja) | 2014-07-28 |
| KR101913135B1 (ko) | 2018-10-30 |
| EA023045B1 (ru) | 2016-04-29 |
| EP2731948A1 (en) | 2014-05-21 |
| CN103874702A (zh) | 2014-06-18 |
| AR087182A1 (es) | 2014-02-26 |
| KR20140063595A (ko) | 2014-05-27 |
| CA2841102A1 (en) | 2013-01-24 |
| ES2555167T3 (es) | 2015-12-29 |
| MX2014000626A (es) | 2014-04-30 |
| NZ619683A (en) | 2015-01-30 |
| US20140148450A1 (en) | 2014-05-29 |
| TW201315736A (zh) | 2013-04-16 |
| IL230422B (en) | 2018-03-29 |
| US9115143B2 (en) | 2015-08-25 |
| AU2012285931B2 (en) | 2017-01-12 |
| IN2014MN00258A (enExample) | 2015-09-25 |
| BR112014000713A2 (pt) | 2017-01-10 |
| CN103874702B (zh) | 2015-12-09 |
| WO2013010904A1 (en) | 2013-01-24 |
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