JP5856980B2 - (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス - Google Patents
(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス Download PDFInfo
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- JP5856980B2 JP5856980B2 JP2012551175A JP2012551175A JP5856980B2 JP 5856980 B2 JP5856980 B2 JP 5856980B2 JP 2012551175 A JP2012551175 A JP 2012551175A JP 2012551175 A JP2012551175 A JP 2012551175A JP 5856980 B2 JP5856980 B2 JP 5856980B2
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- trifluoromethyl
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- 0 *CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[n]2 Chemical compound *CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[n]2 0.000 description 3
- VVQFLWDFZUIVDL-ZHACJKMWSA-N CCOC(/C=C1/C(N2CCOCC2)=CCC1)=O Chemical compound CCOC(/C=C1/C(N2CCOCC2)=CCC1)=O VVQFLWDFZUIVDL-ZHACJKMWSA-N 0.000 description 1
- MOIBBQFSBRXTDL-UHFFFAOYSA-N CCOC(CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[nH]2)=O Chemical compound CCOC(CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[nH]2)=O MOIBBQFSBRXTDL-UHFFFAOYSA-N 0.000 description 1
- MVGWUTBTXDYMND-QGZVFWFLSA-N OC(C[C@@H](CC1)c2c1c1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc1[nH]2)=O Chemical compound OC(C[C@@H](CC1)c2c1c1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc1[nH]2)=O MVGWUTBTXDYMND-QGZVFWFLSA-N 0.000 description 1
- JKEHZGXRXDVGJN-UHFFFAOYSA-N [NH-][NH+](c1ccccc1C1CCCC1)[IH]#CC(F)(F)F Chemical compound [NH-][NH+](c1ccccc1C1CCCC1)[IH]#CC(F)(F)F JKEHZGXRXDVGJN-UHFFFAOYSA-N 0.000 description 1
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- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/272—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions
- C07C17/278—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of only halogenated hydrocarbons
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- C07D209/82—Carbazoles; Hydrogenated carbazoles
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- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33683510P | 2010-01-27 | 2010-01-27 | |
| US61/336,835 | 2010-01-27 | ||
| PCT/US2011/000153 WO2011094008A1 (en) | 2010-01-27 | 2011-01-27 | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015103394A Division JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518106A JP2013518106A (ja) | 2013-05-20 |
| JP2013518106A5 JP2013518106A5 (OSRAM) | 2014-02-20 |
| JP5856980B2 true JP5856980B2 (ja) | 2016-02-10 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551175A Active JP5856980B2 (ja) | 2010-01-27 | 2011-01-27 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
| JP2015103394A Withdrawn JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2015103394A Withdrawn JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
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| Country | Link |
|---|---|
| US (5) | US8853419B2 (OSRAM) |
| EP (3) | EP2528894A1 (OSRAM) |
| JP (2) | JP5856980B2 (OSRAM) |
| CN (2) | CN103221391B (OSRAM) |
| CA (1) | CA2786994C (OSRAM) |
| ES (1) | ES2937386T3 (OSRAM) |
| SG (3) | SG10201500639TA (OSRAM) |
| WO (1) | WO2011094008A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015154782A (ja) * | 2010-01-27 | 2015-08-27 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
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| SI2326621T1 (sl) | 2008-07-23 | 2016-10-28 | Arena Pharmaceuticals, Inc. | Substituirani derivati 1,2,3,4-tetrahidrociklopenta(b)indol-3-il)ocetne kisline, uporabni pri zdravljenju avtoimunskih in vnetnih motenj |
| NZ591001A (en) | 2008-08-27 | 2012-11-30 | Arena Pharm Inc | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
| CN105503882B (zh) | 2010-03-03 | 2019-07-05 | 艾尼纳制药公司 | 制备s1p1受体调节剂及其晶体形式的方法 |
| CN102659664B (zh) * | 2012-03-28 | 2015-01-21 | 中国计量学院 | 合成分离拉洛皮兰及其类似物的方法 |
| CN116850181A (zh) * | 2015-01-06 | 2023-10-10 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
| AU2016284162A1 (en) * | 2015-06-22 | 2018-02-01 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(Compound1) for use in SIP1 receptor-associated disorders |
| CN106349006B (zh) * | 2016-08-26 | 2019-02-05 | 大连奇凯医药科技有限公司 | 3-三氟甲基苯乙腈的制备方法 |
| CA3053416A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
| AU2018220521A1 (en) * | 2017-02-16 | 2019-09-05 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| EP3653594A4 (en) * | 2017-07-13 | 2021-03-31 | Toray Fine Chemicals Co., Ltd. | CYCLOALKYL (TRIFLUOROMETHYL) BENZENE MANUFACTURING PROCESS |
| WO2019236757A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
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| CN109678715B (zh) * | 2018-11-28 | 2019-11-12 | 中国药科大学 | 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途 |
| CN113226307A (zh) * | 2018-11-30 | 2021-08-06 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病况的方法 |
| EP3908276B1 (en) | 2019-01-08 | 2025-06-11 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| CA3156182A1 (en) * | 2019-10-01 | 2021-04-08 | Arena Pharmaceuticals, Inc. | METHODS FOR PROCESSING S1P1 RECEIVER BOUND STATES |
| CA3156298A1 (en) | 2019-10-31 | 2021-05-06 | Laetitia POUZOL | Combination of a cxcr7 antagonist with an s1p1 receptor modulator |
| BR112022007348A2 (pt) | 2019-11-20 | 2022-07-12 | Arena Pharm Inc | Métodos para tratar condições relacionadas ao receptor s1p1 |
| CN111763148B (zh) * | 2020-06-19 | 2022-10-28 | 广州大学 | 一种含三氟甲基的炔基环戊烯衍生物及其制备方法和应用 |
| CN114105745B (zh) * | 2020-08-28 | 2024-07-23 | 广东东阳光药业股份有限公司 | 辛波莫德中间体及其制备方法 |
| CN116887826A (zh) * | 2020-11-09 | 2023-10-13 | 阿芮纳制药有限公司 | 治疗与s1p1受体相关的病症的方法 |
| WO2023278141A1 (en) * | 2021-07-02 | 2023-01-05 | Arena Pharmaceuticals, Inc. | Administration of a compound to individuals with hepatic impairment |
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| WO2023135506A1 (en) | 2022-01-13 | 2023-07-20 | Arena Pharmaceuticals, Inc. | Etrasimod for use in treating s1p1 receptor-associated disorders in combination with hormone treatment |
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| NL293572A (OSRAM) | 1962-06-07 | |||
| CH478819A (de) | 1965-10-22 | 1969-09-30 | Ciba Geigy | Verfahren zur Herstellung neuer N,N'-Di-(pyrimidyl-(4)-aminoalkyl)-diazacycloalkanen |
| CH480410A (de) | 1967-01-09 | 1969-10-31 | Geigy Ag J R | Verfahren zur Herstellung von wasserlöslichen Azopyrimidinfarbstoffen |
| CA961052A (en) | 1967-01-12 | 1975-01-14 | Max Schellenbaum | N-2-ethylhexyl-n'-aryl ureas and preparation containing them |
| US3608087A (en) | 1968-06-21 | 1971-09-21 | Merck & Co Inc | Feed compositions |
| US3887329A (en) | 1969-05-05 | 1975-06-03 | Ciba Geigy Ag | Hexamethyl phosphotriamide-dye compositions |
| US3686238A (en) | 1970-01-19 | 1972-08-22 | Syntex Corp | Glycerol esterified with 2-naphthyl-acetic acids and fatty acids |
| US3852434A (en) | 1970-09-11 | 1974-12-03 | Merck & Co Inc | Potentiation of ({31 ) cis-1,2-epoxypropyl)phosphonic acid and analogues thereof |
| US3966744A (en) | 1971-01-11 | 1976-06-29 | Syva Company | Spin labeled compounds |
| US3690834A (en) | 1971-01-11 | 1972-09-12 | Syva Co | Ligand determination with spin labeled compounds by receptor displacement |
| DE2106585A1 (de) | 1971-02-11 | 1972-08-24 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Aminothiodiazole und Thiodiazol-Azofarbstoffe |
| DE2226703A1 (de) | 1972-05-25 | 1973-12-13 | Schering Ag | Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung |
| US3966764A (en) | 1972-07-10 | 1976-06-29 | Syva Company | Ligand determination of spin labeled compounds by receptor displacement-amphetamine analogs |
| US3849420A (en) | 1972-10-20 | 1974-11-19 | Dow Chemical Co | Bis-(alkylthio-and alkylsulfonyl)-pentachloroquinolines |
| CH574206A5 (OSRAM) | 1972-11-16 | 1976-04-15 | Ciba Geigy Ag | |
| DE2340569C2 (de) | 1973-08-10 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | Azofarbstoffe |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015154782A (ja) * | 2010-01-27 | 2015-08-27 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
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| US8853419B2 (en) | 2014-10-07 |
| SG10201906876PA (en) | 2019-09-27 |
| US20170159088A1 (en) | 2017-06-08 |
| US20160016904A1 (en) | 2016-01-21 |
| JP2015154782A (ja) | 2015-08-27 |
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| EP2528894A1 (en) | 2012-12-05 |
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| US9175320B2 (en) | 2015-11-03 |
| US20220259627A1 (en) | 2022-08-18 |
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| EP3378854A1 (en) | 2018-09-26 |
| CA2786994C (en) | 2018-01-16 |
| US11674163B2 (en) | 2023-06-13 |
| US9447041B2 (en) | 2016-09-20 |
| CN103221391A (zh) | 2013-07-24 |
| US11149292B2 (en) | 2021-10-19 |
| ES2937386T3 (es) | 2023-03-28 |
| EP4148045A1 (en) | 2023-03-15 |
| SG182610A1 (en) | 2012-08-30 |
| WO2011094008A1 (en) | 2011-08-04 |
| CN108558740B (zh) | 2021-10-19 |
| CA2786994A1 (en) | 2011-08-04 |
| CN108558740A (zh) | 2018-09-21 |
| US20140357690A1 (en) | 2014-12-04 |
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