JP5658565B2 - ホスホイノシチド３−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法 - Google Patents

ホスホイノシチド３−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法 Download PDF

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Publication number
JP5658565B2
JP5658565B2 JP2010524965A JP2010524965A JP5658565B2 JP 5658565 B2 JP5658565 B2 JP 5658565B2 JP 2010524965 A JP2010524965 A JP 2010524965A JP 2010524965 A JP2010524965 A JP 2010524965A JP 5658565 B2 JP5658565 B2 JP 5658565B2
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formula
compound
methyl
combination
cancer
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Japanese (ja)
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JP2010539177A (ja
JP2010539177A5 (OSRAM
Inventor
ベルヴィン，マルシア
フリエドマン，ロリ
ホエフリッチ，クラウス
サンパス，ディーパック
ビジャプルカ，ウルカ
ワリン，ジェフリー
ジョンソン，レイサ
シング，マリカ
パテル，ソナル
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F Hoffmann La Roche AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010524965A 2007-09-12 2008-09-10 ホスホイノシチド３−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法 Expired - Fee Related JP5658565B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97177307P 2007-09-12 2007-09-12
US60/971,773 2007-09-12
PCT/US2008/075883 WO2009036082A2 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use

Publications (3)

Publication Number Publication Date
JP2010539177A JP2010539177A (ja) 2010-12-16
JP2010539177A5 JP2010539177A5 (OSRAM) 2011-11-04
JP5658565B2 true JP5658565B2 (ja) 2015-01-28

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ID=39942941

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JP2010524965A Expired - Fee Related JP5658565B2 (ja) 2007-09-12 2008-09-10 ホスホイノシチド３−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法

Country Status (18)

Country Link
US (3) US8247397B2 (OSRAM)
EP (1) EP2205242B1 (OSRAM)
JP (1) JP5658565B2 (OSRAM)
KR (1) KR101584823B1 (OSRAM)
CN (1) CN101939006B (OSRAM)
AR (1) AR068402A1 (OSRAM)
AU (1) AU2008298948B2 (OSRAM)
BR (1) BRPI0816769A2 (OSRAM)
CA (1) CA2699202C (OSRAM)
CL (1) CL2008002687A1 (OSRAM)
ES (1) ES2537352T3 (OSRAM)
IL (1) IL204333A (OSRAM)
MX (1) MX338504B (OSRAM)
PE (2) PE20090678A1 (OSRAM)
RU (1) RU2523890C2 (OSRAM)
TW (1) TWI471134B (OSRAM)
WO (1) WO2009036082A2 (OSRAM)
ZA (1) ZA201002475B (OSRAM)

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AU2008298948A1 (en) 2009-03-19
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PE20140100A1 (es) 2014-02-12
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ZA201002475B (en) 2011-06-29
US20110223619A1 (en) 2011-09-15
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US20090098135A1 (en) 2009-04-16
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