TWI471134B - 肌醇磷脂3-激酶抑制劑化合物及化療劑之組合及使用方法 - Google Patents

肌醇磷脂3-激酶抑制劑化合物及化療劑之組合及使用方法 Download PDF

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TWI471134B
TWI471134B TW97134764A TW97134764A TWI471134B TW I471134 B TWI471134 B TW I471134B TW 97134764 A TW97134764 A TW 97134764A TW 97134764 A TW97134764 A TW 97134764A TW I471134 B TWI471134 B TW I471134B
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Taiwan
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formula
acid
cancer
compound
chemotherapeutic agent
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TW97134764A
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English (en)
Chinese (zh)
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TW200920377A (en
Inventor
Marcia Belvin
Lori Friedman
Klaus Hoeflich
Deepak Sampath
Ulka Vijapurkar
Jeffrey Wallin
Leisa Johnson
Mallika Singh
Sonal Patel
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Genentech Inc
Hoffmann La Roche
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Application filed by Genentech Inc, Hoffmann La Roche filed Critical Genentech Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW97134764A 2007-09-12 2008-09-10 肌醇磷脂3-激酶抑制劑化合物及化療劑之組合及使用方法 TWI471134B (zh)

Applications Claiming Priority (1)

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US97177307P 2007-09-12 2007-09-12

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TW200920377A TW200920377A (en) 2009-05-16
TWI471134B true TWI471134B (zh) 2015-02-01

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TW97134764A TWI471134B (zh) 2007-09-12 2008-09-10 肌醇磷脂3-激酶抑制劑化合物及化療劑之組合及使用方法

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US (3) US8247397B2 (OSRAM)
EP (1) EP2205242B1 (OSRAM)
JP (1) JP5658565B2 (OSRAM)
KR (1) KR101584823B1 (OSRAM)
CN (1) CN101939006B (OSRAM)
AR (1) AR068402A1 (OSRAM)
AU (1) AU2008298948B2 (OSRAM)
BR (1) BRPI0816769A2 (OSRAM)
CA (1) CA2699202C (OSRAM)
CL (1) CL2008002687A1 (OSRAM)
ES (1) ES2537352T3 (OSRAM)
IL (1) IL204333A (OSRAM)
MX (1) MX338504B (OSRAM)
PE (2) PE20090678A1 (OSRAM)
RU (1) RU2523890C2 (OSRAM)
TW (1) TWI471134B (OSRAM)
WO (1) WO2009036082A2 (OSRAM)
ZA (1) ZA201002475B (OSRAM)

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