JP5596023B2 - レセプターチロシンキナーゼのインヒビターとしてのイミダゾピリジン誘導体 - Google Patents

レセプターチロシンキナーゼのインヒビターとしてのイミダゾピリジン誘導体 Download PDF

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JP5596023B2
JP5596023B2 JP2011512999A JP2011512999A JP5596023B2 JP 5596023 B2 JP5596023 B2 JP 5596023B2 JP 2011512999 A JP2011512999 A JP 2011512999A JP 2011512999 A JP2011512999 A JP 2011512999A JP 5596023 B2 JP5596023 B2 JP 5596023B2
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compound
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JP2011512999A
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JP2011522866A (ja
JP2011522866A5 (enExample
Inventor
ブライアン、ジョン、ウィリアムス
バレリオ、ベルディーニ
マリア、グラツィア、カー
マイルズ、スチュワート、コングリーブ
マーティン、フレデリクソン
シャルロット、メアリー、グリフィス‐ジョーンズ
クリストファー、チャールズ、フレデリック、ハムレット
アンドリュー、マディン
クリストファー、ウィリアム、マレー
ラジディープ、カー、ベニング
ゴードン、サクスティ
エマ、ビッカースタッフェ
アンドリュー、ジェームズ、ウッドヘッド
スティーブン、ジョン、ウッドヘッド
エディ、ジャン、エドガー、フレイヌ
トム、コルネリス、オルタンス、ホファールツ
パトリック、レネ、アンギボー
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2011512999A 2008-06-13 2009-06-12 レセプターチロシンキナーゼのインヒビターとしてのイミダゾピリジン誘導体 Expired - Fee Related JP5596023B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6118408P 2008-06-13 2008-06-13
US61/061,184 2008-06-13
GB0810902.7 2008-06-13
GBGB0810902.7A GB0810902D0 (en) 2008-06-13 2008-06-13 New compounds
PCT/EP2009/057318 WO2009150240A1 (en) 2008-06-13 2009-06-12 Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases

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JP2011522866A JP2011522866A (ja) 2011-08-04
JP2011522866A5 JP2011522866A5 (enExample) 2012-05-17
JP5596023B2 true JP5596023B2 (ja) 2014-09-24

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US (1) US8796244B2 (enExample)
EP (1) EP2300465B1 (enExample)
JP (1) JP5596023B2 (enExample)
KR (1) KR101745730B1 (enExample)
CN (1) CN102137859B (enExample)
AU (1) AU2009256584B2 (enExample)
BR (1) BRPI0915084B8 (enExample)
CA (1) CA2727062A1 (enExample)
DK (1) DK2300465T3 (enExample)
ES (1) ES2735979T3 (enExample)
GB (1) GB0810902D0 (enExample)
HR (1) HRP20191027T1 (enExample)
HU (1) HUE045300T2 (enExample)
IL (1) IL209864A (enExample)
LT (1) LT2300465T (enExample)
MX (1) MX2010013743A (enExample)
NZ (1) NZ589781A (enExample)
RU (1) RU2518089C2 (enExample)
SI (1) SI2300465T1 (enExample)
WO (1) WO2009150240A1 (enExample)
ZA (1) ZA201008961B (enExample)

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