JP5466635B2 - 脱アミド化プロフィールが低減した抗体 - Google Patents

脱アミド化プロフィールが低減した抗体 Download PDF

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JP5466635B2
JP5466635B2 JP2010501162A JP2010501162A JP5466635B2 JP 5466635 B2 JP5466635 B2 JP 5466635B2 JP 2010501162 A JP2010501162 A JP 2010501162A JP 2010501162 A JP2010501162 A JP 2010501162A JP 5466635 B2 JP5466635 B2 JP 5466635B2
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antibody
cells
antibodies
deamidation
another embodiment
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JP2010523085A5 (cg-RX-API-DMAC7.html
JP2010523085A (ja
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ラム，クリパ
ヴェンカト，ラガバン
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メディミューン，エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification

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  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
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  • Dermatology (AREA)
  • Biochemistry (AREA)
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  • Endocrinology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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JP2010501162A 2007-03-30 2008-03-25 脱アミド化プロフィールが低減した抗体 Expired - Fee Related JP5466635B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US90923207P 2007-03-30 2007-03-30
US90911707P 2007-03-30 2007-03-30
US60/909,232 2007-03-30
US60/909,117 2007-03-30
PCT/US2008/058133 WO2008121616A2 (en) 2007-03-30 2008-03-25 Antibodies with decreased deamidation profiles

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JP2010523085A JP2010523085A (ja) 2010-07-15
JP2010523085A5 JP2010523085A5 (cg-RX-API-DMAC7.html) 2011-05-12
JP5466635B2 true JP5466635B2 (ja) 2014-04-09

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JP2010501162A Expired - Fee Related JP5466635B2 (ja) 2007-03-30 2008-03-25 脱アミド化プロフィールが低減した抗体
JP2010501161A Active JP5456658B2 (ja) 2007-03-30 2008-03-25 抗体製剤

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US (4) US20100209434A1 (cg-RX-API-DMAC7.html)
EP (3) EP2068923A4 (cg-RX-API-DMAC7.html)
JP (2) JP5466635B2 (cg-RX-API-DMAC7.html)
KR (1) KR101540823B1 (cg-RX-API-DMAC7.html)
CN (1) CN101678103A (cg-RX-API-DMAC7.html)
AU (2) AU2008232902B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0809674A2 (cg-RX-API-DMAC7.html)
CA (2) CA2682292A1 (cg-RX-API-DMAC7.html)
MX (1) MX2009010389A (cg-RX-API-DMAC7.html)
RU (2) RU2491094C2 (cg-RX-API-DMAC7.html)
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WO2008121616A3 (en) 2009-01-08
EP2068923A4 (en) 2010-11-24
JP5456658B2 (ja) 2014-04-02
EP2077859A2 (en) 2009-07-15
BRPI0809674A2 (pt) 2014-10-07
RU2009139905A (ru) 2011-05-10
AU2008232903B2 (en) 2013-08-15
MX2009010389A (es) 2010-01-20
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EP2068923A2 (en) 2009-06-17
KR20100016001A (ko) 2010-02-12
US20150152179A1 (en) 2015-06-04
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WO2008121616A2 (en) 2008-10-09
EP2703007A1 (en) 2014-03-05
RU2013121156A (ru) 2014-11-20
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EP2077859A4 (en) 2010-11-24
JP2010523085A (ja) 2010-07-15
RU2491094C2 (ru) 2013-08-27
AU2008232903A1 (en) 2008-10-09
US20110130544A1 (en) 2011-06-02
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