JP2010523085A5 - - Google Patents
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- JP2010523085A5 JP2010523085A5 JP2010501162A JP2010501162A JP2010523085A5 JP 2010523085 A5 JP2010523085 A5 JP 2010523085A5 JP 2010501162 A JP2010501162 A JP 2010501162A JP 2010501162 A JP2010501162 A JP 2010501162A JP 2010523085 A5 JP2010523085 A5 JP 2010523085A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- composition according
- deamidation profile
- fragment
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 13
- 230000006240 deamidation Effects 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 210000000628 antibody-producing cell Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 230000001064 anti-interferon Effects 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 238000011072 cell harvest Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90923207P | 2007-03-30 | 2007-03-30 | |
| US90911707P | 2007-03-30 | 2007-03-30 | |
| US60/909,232 | 2007-03-30 | ||
| US60/909,117 | 2007-03-30 | ||
| PCT/US2008/058133 WO2008121616A2 (en) | 2007-03-30 | 2008-03-25 | Antibodies with decreased deamidation profiles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523085A JP2010523085A (ja) | 2010-07-15 |
| JP2010523085A5 true JP2010523085A5 (cg-RX-API-DMAC7.html) | 2011-05-12 |
| JP5466635B2 JP5466635B2 (ja) | 2014-04-09 |
Family
ID=39808854
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501162A Expired - Fee Related JP5466635B2 (ja) | 2007-03-30 | 2008-03-25 | 脱アミド化プロフィールが低減した抗体 |
| JP2010501161A Active JP5456658B2 (ja) | 2007-03-30 | 2008-03-25 | 抗体製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501161A Active JP5456658B2 (ja) | 2007-03-30 | 2008-03-25 | 抗体製剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20100209434A1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2068923A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5466635B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101540823B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101678103A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2008232902B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0809674A2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2682292A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009010389A (cg-RX-API-DMAC7.html) |
| RU (2) | RU2491094C2 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2008121616A2 (cg-RX-API-DMAC7.html) |
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2008
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- 2008-03-25 JP JP2010501162A patent/JP5466635B2/ja not_active Expired - Fee Related
- 2008-03-25 CA CA002682292A patent/CA2682292A1/en not_active Abandoned
- 2008-03-25 MX MX2009010389A patent/MX2009010389A/es active IP Right Grant
- 2008-03-25 EP EP08744323A patent/EP2077859A4/en not_active Ceased
- 2008-03-25 CA CA002682170A patent/CA2682170A1/en not_active Abandoned
- 2008-03-25 US US12/593,775 patent/US20100209434A1/en not_active Abandoned
- 2008-03-25 AU AU2008232902A patent/AU2008232902B2/en not_active Ceased
- 2008-03-25 JP JP2010501161A patent/JP5456658B2/ja active Active
- 2008-03-25 AU AU2008232903A patent/AU2008232903B9/en not_active Ceased
- 2008-03-25 BR BRPI0809674-0A2A patent/BRPI0809674A2/pt not_active IP Right Cessation
- 2008-03-25 EP EP12196199.9A patent/EP2703007A1/en not_active Withdrawn
- 2008-03-25 WO PCT/US2008/058133 patent/WO2008121616A2/en not_active Ceased
- 2008-03-25 WO PCT/US2008/058132 patent/WO2008121615A2/en not_active Ceased
- 2008-03-25 KR KR1020097022550A patent/KR101540823B1/ko active Active
- 2008-03-25 CN CN200880017255A patent/CN101678103A/zh active Pending
- 2008-03-25 US US12/593,767 patent/US20110130544A1/en not_active Abandoned
- 2008-03-25 RU RU2009139905/10A patent/RU2491094C2/ru active
-
2013
- 2013-05-08 RU RU2013121156/10A patent/RU2580012C2/ru not_active IP Right Cessation
-
2014
- 2014-09-08 US US14/480,145 patent/US20150071943A1/en not_active Abandoned
- 2014-11-10 US US14/537,890 patent/US20150152179A1/en not_active Abandoned
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