JP5165688B2 - 化合物 - Google Patents

化合物 Download PDF

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Publication number
JP5165688B2
JP5165688B2 JP2009535119A JP2009535119A JP5165688B2 JP 5165688 B2 JP5165688 B2 JP 5165688B2 JP 2009535119 A JP2009535119 A JP 2009535119A JP 2009535119 A JP2009535119 A JP 2009535119A JP 5165688 B2 JP5165688 B2 JP 5165688B2
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JP
Japan
Prior art keywords
pyridin
propylsulfanyl
acetic acid
piperidyl
cyclohexylcarbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2009535119A
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English (en)
Japanese (ja)
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JP2010508338A5 (en:Method
JP2010508338A (ja
Inventor
マッコウル，ウィリアム
パッカー，マーティン
スコット，ジェームズ・スチュアート
ホウィッタモア，ポール・ロバート・オーウェン
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AstraZeneca AB
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AstraZeneca AB
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Publication of JP2010508338A publication Critical patent/JP2010508338A/ja
Publication of JP2010508338A5 publication Critical patent/JP2010508338A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2009535119A 2006-11-03 2007-10-31 化合物 Active JP5165688B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86430306P 2006-11-03 2006-11-03
US86424706P 2006-11-03 2006-11-03
US60/864,303 2006-11-03
US60/864,247 2006-11-03
PCT/GB2007/004131 WO2008053194A2 (en) 2006-11-03 2007-10-31 Pyridine carboxamides as 11-beta-hsd1 inhibitors

Publications (3)

Publication Number Publication Date
JP2010508338A JP2010508338A (ja) 2010-03-18
JP2010508338A5 JP2010508338A5 (en:Method) 2012-08-16
JP5165688B2 true JP5165688B2 (ja) 2013-03-21

Family

ID=39304797

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009535119A Active JP5165688B2 (ja) 2006-11-03 2007-10-31 化合物

Country Status (30)

Country Link
US (3) US7964618B2 (en:Method)
EP (2) EP2086939B8 (en:Method)
JP (1) JP5165688B2 (en:Method)
KR (1) KR101465275B1 (en:Method)
CN (3) CN102603711A (en:Method)
AR (1) AR063458A1 (en:Method)
AT (1) ATE475649T1 (en:Method)
AU (1) AU2007315955B2 (en:Method)
BR (1) BRPI0717970C1 (en:Method)
CA (1) CA2668006C (en:Method)
CL (1) CL2007003176A1 (en:Method)
CO (1) CO6321130A2 (en:Method)
CY (1) CY1110813T1 (en:Method)
DE (1) DE602007008137D1 (en:Method)
DK (1) DK2086939T3 (en:Method)
ES (2) ES2347491T3 (en:Method)
HR (1) HRP20100522T1 (en:Method)
IL (1) IL198231A0 (en:Method)
MX (1) MX2009004707A (en:Method)
NO (1) NO20091603L (en:Method)
NZ (1) NZ576501A (en:Method)
PE (1) PE20081487A1 (en:Method)
PL (1) PL2086939T3 (en:Method)
PT (1) PT2086939E (en:Method)
RS (1) RS51451B (en:Method)
RU (1) RU2451674C2 (en:Method)
SI (1) SI2086939T1 (en:Method)
TW (1) TW200827346A (en:Method)
UY (1) UY30681A1 (en:Method)
WO (1) WO2008053194A2 (en:Method)

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CN101573336A (zh) 2009-11-04
US20090312372A1 (en) 2009-12-17
IL198231A0 (en) 2009-12-24
ES2423206T3 (es) 2013-09-18
BRPI0717970C1 (pt) 2021-05-25
US20090306075A1 (en) 2009-12-10
DE602007008137D1 (en) 2010-09-09
PE20081487A1 (es) 2009-01-11
US20080269288A1 (en) 2008-10-30
PL2086939T3 (pl) 2011-09-30
CA2668006A1 (en) 2008-05-08
AR063458A1 (es) 2009-01-28
RU2009115830A (ru) 2010-12-10
KR20090075865A (ko) 2009-07-09
CY1110813T1 (el) 2015-06-10
BRPI0717970A2 (pt) 2013-11-05
CN101573336B (zh) 2012-03-21
AU2007315955A1 (en) 2008-05-08
WO2008053194A3 (en) 2008-10-02
DK2086939T3 (da) 2010-10-11
KR101465275B1 (ko) 2014-11-27
NO20091603L (no) 2009-05-28
CA2668006C (en) 2016-05-24
EP2086939B1 (en) 2010-07-28
AU2007315955B2 (en) 2011-04-14
CO6321130A2 (es) 2011-09-20
EP2086939B8 (en) 2011-06-22
RS51451B (sr) 2011-04-30
ES2347491T3 (es) 2010-10-29
EP2233480B1 (en) 2013-05-29
CN101787016B (zh) 2013-08-28
RU2451674C2 (ru) 2012-05-27
CN101787016A (zh) 2010-07-28
PT2086939E (pt) 2010-09-17
ATE475649T1 (de) 2010-08-15
SI2086939T1 (sl) 2010-10-29
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NZ576501A (en) 2011-03-31
BRPI0717970B1 (pt) 2019-10-22
BRPI0717970B8 (pt) 2020-12-01
EP2233480A1 (en) 2010-09-29
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JP2010508338A (ja) 2010-03-18
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