JP5093998B2 - 色素沈着予防又は改善剤 - Google Patents

色素沈着予防又は改善剤 Download PDF

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Publication number
JP5093998B2
JP5093998B2 JP2005194428A JP2005194428A JP5093998B2 JP 5093998 B2 JP5093998 B2 JP 5093998B2 JP 2005194428 A JP2005194428 A JP 2005194428A JP 2005194428 A JP2005194428 A JP 2005194428A JP 5093998 B2 JP5093998 B2 JP 5093998B2
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Japan
Prior art keywords
pigmentation
weight
test example
component
visual comparison
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Expired - Lifetime
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JP2005194428A
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English (en)
Japanese (ja)
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JP2006206575A (ja
Inventor
史樹 原野
茂生 篠原
雅彦 田中
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2005194428A priority Critical patent/JP5093998B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to ES05785273T priority patent/ES2421606T3/es
Priority to HK07111091.8A priority patent/HK1105859B/xx
Priority to CA2580147A priority patent/CA2580147C/en
Priority to KR1020077007652A priority patent/KR101254615B1/ko
Priority to PCT/JP2005/017363 priority patent/WO2006033343A1/ja
Priority to EP05785273.3A priority patent/EP1806120B1/en
Priority to AU2005285903A priority patent/AU2005285903B2/en
Priority to US11/663,303 priority patent/US20080260878A1/en
Priority to BRPI0515585-1A priority patent/BRPI0515585A/pt
Priority to CN2005800318371A priority patent/CN101027032B/zh
Priority to TW094132627A priority patent/TWI359662B/zh
Publication of JP2006206575A publication Critical patent/JP2006206575A/ja
Application granted granted Critical
Publication of JP5093998B2 publication Critical patent/JP5093998B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2005194428A 2004-09-22 2005-07-01 色素沈着予防又は改善剤 Expired - Lifetime JP5093998B2 (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2005194428A JP5093998B2 (ja) 2004-09-22 2005-07-01 色素沈着予防又は改善剤
US11/663,303 US20080260878A1 (en) 2004-09-22 2005-09-21 Composition for Prevention or Alleviation of Pigmentation
CA2580147A CA2580147C (en) 2004-09-22 2005-09-21 Composition for prevention or alleviation of pigmentation
KR1020077007652A KR101254615B1 (ko) 2004-09-22 2005-09-21 색소 침착 예방 또는 개선용 조성물
PCT/JP2005/017363 WO2006033343A1 (ja) 2004-09-22 2005-09-21 色素沈着予防又は改善用組成物
EP05785273.3A EP1806120B1 (en) 2004-09-22 2005-09-21 Composition for prevention or alleviation of pigmentation
ES05785273T ES2421606T3 (es) 2004-09-22 2005-09-21 Composición para la prevención o el alivio de la pigmentación
HK07111091.8A HK1105859B (en) 2004-09-22 2005-09-21 Composition for prevention or alleviation of pigmentation
BRPI0515585-1A BRPI0515585A (pt) 2004-09-22 2005-09-21 composição para prevenção ou melhora de pigmentação
CN2005800318371A CN101027032B (zh) 2004-09-22 2005-09-21 预防或减轻色素沉着的组合物
TW094132627A TWI359662B (enExample) 2004-09-22 2005-09-21
AU2005285903A AU2005285903B2 (en) 2004-09-22 2005-09-21 Composition for prevention or alleviation of pigmentation

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2004274454 2004-09-22
JP2004274454 2004-09-22
JP2004376562 2004-12-27
JP2004376562 2004-12-27
JP2005194428A JP5093998B2 (ja) 2004-09-22 2005-07-01 色素沈着予防又は改善剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012144388A Division JP5514268B2 (ja) 2004-09-22 2012-06-27 色素沈着予防又は改善剤

Publications (2)

Publication Number Publication Date
JP2006206575A JP2006206575A (ja) 2006-08-10
JP5093998B2 true JP5093998B2 (ja) 2012-12-12

Family

ID=36090101

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005194428A Expired - Lifetime JP5093998B2 (ja) 2004-09-22 2005-07-01 色素沈着予防又は改善剤

Country Status (11)

Country Link
US (1) US20080260878A1 (enExample)
EP (1) EP1806120B1 (enExample)
JP (1) JP5093998B2 (enExample)
KR (1) KR101254615B1 (enExample)
CN (1) CN101027032B (enExample)
AU (1) AU2005285903B2 (enExample)
BR (1) BRPI0515585A (enExample)
CA (1) CA2580147C (enExample)
ES (1) ES2421606T3 (enExample)
TW (1) TWI359662B (enExample)
WO (1) WO2006033343A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012180379A (ja) * 2004-09-22 2012-09-20 Otsuka Pharmaceut Co Ltd 色素沈着予防又は改善剤

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WO2005069916A2 (en) 2004-01-22 2005-08-04 University Of Miami Topical co-enzyme q10 formulations and methods of use
JP5015620B2 (ja) * 2007-01-30 2012-08-29 株式会社クラレ 皮膚外用剤
BRPI0911658A2 (pt) 2008-04-11 2015-10-13 Cytotech Labs Llc métodos e usos de indução de apoptose em células de câncer
JP5263940B2 (ja) * 2008-05-29 2013-08-14 株式会社 資生堂 皮膚外用剤
EA023913B1 (ru) 2009-05-11 2016-07-29 БЕРГ ФАРМА ЭлЭлСи Способы лечения метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
JP5748961B2 (ja) * 2010-03-19 2015-07-15 ポーラ化成工業株式会社 組成物
ES2508591T3 (es) 2010-06-25 2014-10-16 Otsuka Pharmaceutical Co., Ltd. Agente para suprimir la formación de células de la piel anormales causada por la exposición a la luz
JP5837497B2 (ja) * 2010-08-03 2015-12-24 株式会社林原 美白強化剤とその用途
WO2012138765A1 (en) 2011-04-04 2012-10-11 Berg Pharma Llc Methods of treating central nervous system tumors
CN102813642A (zh) * 2012-09-13 2012-12-12 中南大学湘雅二医院 一种祛斑抗皮肤衰老的复方制剂
JP6166544B2 (ja) * 2013-02-13 2017-07-19 第一三共ヘルスケア株式会社 色素沈着症の予防又は治療剤
CN105263486A (zh) 2013-04-04 2016-01-20 现代药品株式会社 改善了皮肤渗透的外用剂组合物
EA032775B1 (ru) 2013-04-08 2019-07-31 Берг Ллк Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10
SG10201907816RA (en) 2013-09-04 2019-09-27 Berg Llc Methods of treatment of cancer by continuous infusion of coenzyme q10
US20170189350A1 (en) 2015-11-16 2017-07-06 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
BR112019020766B1 (pt) * 2017-04-04 2022-11-29 Anti-Plasmin Technologies, Llc Composição para aperfeiçoar um tratamento médico não cirúrgico
KR102014602B1 (ko) * 2017-10-19 2019-08-29 주식회사 삼성인터네셔널 기미 개선용 화장료 조성물
SG11202007228WA (en) 2018-01-31 2020-08-28 Otsuka Pharma Co Ltd Method for suppressing discoloration of external composition containing adenosine phosphate and tranexamic acid
CN111840417A (zh) * 2019-04-30 2020-10-30 成都铜雀台医学美容医院有限公司 一种治疗黄褐斑的针剂、其制备方法及应用
AU2021271330A1 (en) * 2020-05-14 2022-12-15 Palani Llc A fatty acid based composition for treatment and/or prevention of enveloped-virus related infections
US20240182511A1 (en) * 2021-04-09 2024-06-06 Merck Sharp & Dohme Llc Novel forms of cyclic dinucleotide compounds
KR102726678B1 (ko) * 2022-04-20 2024-11-07 주식회사 바른바름 4-알킬레졸시놀을 포함하는 고체지질 나노입자, 이를 포함하는 화장료 조성물 및 화장품

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012180379A (ja) * 2004-09-22 2012-09-20 Otsuka Pharmaceut Co Ltd 色素沈着予防又は改善剤

Also Published As

Publication number Publication date
BRPI0515585A (pt) 2008-07-29
EP1806120A1 (en) 2007-07-11
TWI359662B (enExample) 2012-03-11
US20080260878A1 (en) 2008-10-23
ES2421606T3 (es) 2013-09-04
CA2580147C (en) 2013-01-22
KR20070100226A (ko) 2007-10-10
EP1806120B1 (en) 2013-05-22
JP2006206575A (ja) 2006-08-10
AU2005285903B2 (en) 2011-03-03
CA2580147A1 (en) 2006-03-30
KR101254615B1 (ko) 2013-04-15
EP1806120A4 (en) 2009-01-28
CN101027032B (zh) 2010-11-24
HK1105859A1 (en) 2008-02-29
AU2005285903A1 (en) 2006-03-30
CN101027032A (zh) 2007-08-29
WO2006033343A1 (ja) 2006-03-30

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