CN101027032B - 预防或减轻色素沉着的组合物 - Google Patents

预防或减轻色素沉着的组合物 Download PDF

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Publication number
CN101027032B
CN101027032B CN2005800318371A CN200580031837A CN101027032B CN 101027032 B CN101027032 B CN 101027032B CN 2005800318371 A CN2005800318371 A CN 2005800318371A CN 200580031837 A CN200580031837 A CN 200580031837A CN 101027032 B CN101027032 B CN 101027032B
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weight
composition
pigmentation
component
salts
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Chinese (zh)
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CN101027032A (zh
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原野史树
篠原茂生
田中雅彦
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2005800318371A 2004-09-22 2005-09-21 预防或减轻色素沉着的组合物 Expired - Fee Related CN101027032B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP274454/2004 2004-09-22
JP2004274454 2004-09-22
JP376562/2004 2004-12-27
JP2004376562 2004-12-27
JP2005194428A JP5093998B2 (ja) 2004-09-22 2005-07-01 色素沈着予防又は改善剤
JP194428/2005 2005-07-01
PCT/JP2005/017363 WO2006033343A1 (ja) 2004-09-22 2005-09-21 色素沈着予防又は改善用組成物

Publications (2)

Publication Number Publication Date
CN101027032A CN101027032A (zh) 2007-08-29
CN101027032B true CN101027032B (zh) 2010-11-24

Family

ID=36090101

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800318371A Expired - Fee Related CN101027032B (zh) 2004-09-22 2005-09-21 预防或减轻色素沉着的组合物

Country Status (11)

Country Link
US (1) US20080260878A1 (enExample)
EP (1) EP1806120B1 (enExample)
JP (1) JP5093998B2 (enExample)
KR (1) KR101254615B1 (enExample)
CN (1) CN101027032B (enExample)
AU (1) AU2005285903B2 (enExample)
BR (1) BRPI0515585A (enExample)
CA (1) CA2580147C (enExample)
ES (1) ES2421606T3 (enExample)
TW (1) TWI359662B (enExample)
WO (1) WO2006033343A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3031283A1 (en) 2004-01-22 2005-08-04 University Of Miami Topical co-enzyme q10 formulations and methods of use
JP5514268B2 (ja) * 2004-09-22 2014-06-04 大塚製薬株式会社 色素沈着予防又は改善剤
JP5015620B2 (ja) * 2007-01-30 2012-08-29 株式会社クラレ 皮膚外用剤
AU2009233785B2 (en) 2008-04-11 2015-08-20 Berg Llc Methods and use of inducing apoptosis in cancer cells
JP5263940B2 (ja) * 2008-05-29 2013-08-14 株式会社 資生堂 皮膚外用剤
BRPI1010576A2 (pt) 2009-05-11 2016-03-15 Berg Biosystems Llc métodos para tratamento de distúrbios oncológicos usando transferidores epimetabólicos, moléculas intracelulares multidimensionais ou influenciadores ambientais.
JP5748961B2 (ja) * 2010-03-19 2015-07-15 ポーラ化成工業株式会社 組成物
AU2011270096B2 (en) 2010-06-25 2014-06-12 Otsuka Pharmaceutical Co., Ltd. Agent for suppressing the formation of abnormal skin cells caused by exposure to light
US20130129651A1 (en) * 2010-08-03 2013-05-23 Hayashibara Co., Ltd. Agent for enhancing the effect of skin-whitening ingredients and uses thereof
EP2694463B8 (en) 2011-04-04 2019-10-09 Berg LLC Treating central nervous system tumors with coenzyme q10
CN102813642A (zh) * 2012-09-13 2012-12-12 中南大学湘雅二医院 一种祛斑抗皮肤衰老的复方制剂
JP6166544B2 (ja) * 2013-02-13 2017-07-19 第一三共ヘルスケア株式会社 色素沈着症の予防又は治療剤
CN105263486A (zh) * 2013-04-04 2016-01-20 现代药品株式会社 改善了皮肤渗透的外用剂组合物
SG11201508272YA (en) 2013-04-08 2015-11-27 Berg Llc Treatment of cancer using coenzyme q10 combination therapies
JP6595478B2 (ja) 2013-09-04 2019-10-23 バーグ エルエルシー コエンザイムｑ１０の連続注入によるがんの治療方法
WO2017087576A1 (en) 2015-11-16 2017-05-26 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
AU2018248422B2 (en) * 2017-04-04 2024-02-15 Anti-Plasmin Technologies, Llc Methods to enhance a non-surgical medical treatment
KR102014602B1 (ko) * 2017-10-19 2019-08-29 주식회사 삼성인터네셔널 기미 개선용 화장료 조성물
TWI815855B (zh) 2018-01-31 2023-09-21 日商大塚製藥股份有限公司 含有磷酸腺苷及傳明酸的外用組成物之變色抑制方法
CN111840417A (zh) * 2019-04-30 2020-10-30 成都铜雀台医学美容医院有限公司 一种治疗黄褐斑的针剂、其制备方法及应用
US20230218557A1 (en) * 2020-05-14 2023-07-13 Palani Llc A fatty acid based composition for treatment and/or prevention of enveloped-virus related infections
US20240182511A1 (en) * 2021-04-09 2024-06-06 Merck Sharp & Dohme Llc Novel forms of cyclic dinucleotide compounds
KR102726678B1 (ko) * 2022-04-20 2024-11-07 주식회사 바른바름 4-알킬레졸시놀을 포함하는 고체지질 나노입자, 이를 포함하는 화장료 조성물 및 화장품

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0904774A1 (en) * 1997-09-23 1999-03-31 Pfizer Products Inc. Resorcinol derivatives
FR2787710A1 (fr) * 1998-12-29 2000-06-30 Clarins Composition cosmetique a effet eclaircissant pour la peau
US6300369B1 (en) * 1994-10-24 2001-10-09 Margaret Ancira Hydroxy-kojic acid skin peel

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52148615A (en) * 1976-06-07 1977-12-10 Shiyouji Yamashita Aqueous biologically active solution
JP2928414B2 (ja) * 1991-09-20 1999-08-03 ポーラ化成工業株式会社 皮膚外用剤
JP3818674B2 (ja) * 1992-06-02 2006-09-06 三省製薬株式会社 皮膚外用剤
JPH09295915A (ja) * 1996-04-26 1997-11-18 Kikkoman Corp 皮膚化粧料
JPH107541A (ja) * 1996-06-20 1998-01-13 Noevir Co Ltd 皮膚外用剤
JP3687277B2 (ja) * 1997-06-10 2005-08-24 サンスター株式会社 美白化粧料
EP1003473A1 (en) * 1998-04-27 2000-05-31 Color Access, Inc. Composition and method for treatment of aging skin
US6503523B2 (en) * 1998-05-07 2003-01-07 Gs Development A.B. Skin care agents containing combinations of active agents consisting of vitamin a derivatives and UBI- or plastoquinones
JP2001206833A (ja) * 2000-01-25 2001-07-31 Kao Corp 化粧料
WO2002011717A1 (en) * 2000-08-07 2002-02-14 Juvenon, Inc. Cosmetics to support skin metabolism
JP2002179516A (ja) * 2000-12-13 2002-06-26 Pola Chem Ind Inc 美白用組成物
JP2002284664A (ja) * 2001-03-29 2002-10-03 Shiseido Co Ltd 美白用皮膚外用剤
WO2003032941A2 (de) * 2001-10-13 2003-04-24 Beiersdorf Ag Kosmetische und/oder dermatologische wirkstoffkombination
JP2003160461A (ja) * 2001-11-21 2003-06-03 Shiseido Co Ltd 皮膚外用剤
CN100471502C (zh) * 2002-04-09 2009-03-25 大塚制药株式会社 细胞增殖用组合物
CA2487789C (en) * 2002-05-20 2012-04-03 Otsuka Pharmaceutical Co., Ltd. Composition for improving melasma and composition for reducing skin dullness
JP4129574B2 (ja) * 2002-08-06 2008-08-06 大塚製薬株式会社 老化防止剤
JP2004075645A (ja) * 2002-08-22 2004-03-11 Kanebo Ltd 化粧料
JP2004107262A (ja) * 2002-09-19 2004-04-08 Nikko Chemical Co Ltd 美白化粧料
JP2004238386A (ja) * 2002-12-11 2004-08-26 Mikimoto Pharmaceut Co Ltd 医薬品、医薬部外品および化粧品
JP2004262853A (ja) * 2003-03-03 2004-09-24 Kanebo Ltd 化粧料
JP2005120023A (ja) * 2003-10-16 2005-05-12 Shiseido Co Ltd 皮膚外用剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300369B1 (en) * 1994-10-24 2001-10-09 Margaret Ancira Hydroxy-kojic acid skin peel
EP0904774A1 (en) * 1997-09-23 1999-03-31 Pfizer Products Inc. Resorcinol derivatives
FR2787710A1 (fr) * 1998-12-29 2000-06-30 Clarins Composition cosmetique a effet eclaircissant pour la peau

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Publication number Publication date
AU2005285903B2 (en) 2011-03-03
CA2580147A1 (en) 2006-03-30
HK1105859A1 (en) 2008-02-29
JP2006206575A (ja) 2006-08-10
ES2421606T3 (es) 2013-09-04
EP1806120B1 (en) 2013-05-22
TWI359662B (enExample) 2012-03-11
JP5093998B2 (ja) 2012-12-12
EP1806120A4 (en) 2009-01-28
WO2006033343A1 (ja) 2006-03-30
EP1806120A1 (en) 2007-07-11
US20080260878A1 (en) 2008-10-23
BRPI0515585A (pt) 2008-07-29
CN101027032A (zh) 2007-08-29
KR101254615B1 (ko) 2013-04-15
CA2580147C (en) 2013-01-22
KR20070100226A (ko) 2007-10-10
AU2005285903A1 (en) 2006-03-30

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