TWI359662B - - Google Patents

Download PDF

Info

Publication number
TWI359662B
TWI359662B TW094132627A TW94132627A TWI359662B TW I359662 B TWI359662 B TW I359662B TW 094132627 A TW094132627 A TW 094132627A TW 94132627 A TW94132627 A TW 94132627A TW I359662 B TWI359662 B TW I359662B
Authority
TW
Taiwan
Prior art keywords
pigmentation
composition
weight
test example
improving
Prior art date
Application number
TW094132627A
Other languages
English (en)
Chinese (zh)
Inventor
Fumiki Harano
Shigeo Shinohara
Masahiko Tanaka
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of TWI359662B publication Critical patent/TWI359662B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW094132627A 2004-09-22 2005-09-21 TWI359662B (enExample)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004274454 2004-09-22
JP2004376562 2004-12-27
JP2005194428A JP5093998B2 (ja) 2004-09-22 2005-07-01 色素沈着予防又は改善剤

Publications (1)

Publication Number Publication Date
TWI359662B true TWI359662B (enExample) 2012-03-11

Family

ID=36090101

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094132627A TWI359662B (enExample) 2004-09-22 2005-09-21

Country Status (11)

Country Link
US (1) US20080260878A1 (enExample)
EP (1) EP1806120B1 (enExample)
JP (1) JP5093998B2 (enExample)
KR (1) KR101254615B1 (enExample)
CN (1) CN101027032B (enExample)
AU (1) AU2005285903B2 (enExample)
BR (1) BRPI0515585A (enExample)
CA (1) CA2580147C (enExample)
ES (1) ES2421606T3 (enExample)
TW (1) TWI359662B (enExample)
WO (1) WO2006033343A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005069916A2 (en) 2004-01-22 2005-08-04 University Of Miami Topical co-enzyme q10 formulations and methods of use
JP5514268B2 (ja) * 2004-09-22 2014-06-04 大塚製薬株式会社 色素沈着予防又は改善剤
JP5015620B2 (ja) * 2007-01-30 2012-08-29 株式会社クラレ 皮膚外用剤
BRPI0911658A2 (pt) 2008-04-11 2015-10-13 Cytotech Labs Llc métodos e usos de indução de apoptose em células de câncer
JP5263940B2 (ja) * 2008-05-29 2013-08-14 株式会社 資生堂 皮膚外用剤
EA023913B1 (ru) 2009-05-11 2016-07-29 БЕРГ ФАРМА ЭлЭлСи Способы лечения метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
JP5748961B2 (ja) * 2010-03-19 2015-07-15 ポーラ化成工業株式会社 組成物
ES2508591T3 (es) 2010-06-25 2014-10-16 Otsuka Pharmaceutical Co., Ltd. Agente para suprimir la formación de células de la piel anormales causada por la exposición a la luz
JP5837497B2 (ja) * 2010-08-03 2015-12-24 株式会社林原 美白強化剤とその用途
WO2012138765A1 (en) 2011-04-04 2012-10-11 Berg Pharma Llc Methods of treating central nervous system tumors
CN102813642A (zh) * 2012-09-13 2012-12-12 中南大学湘雅二医院 一种祛斑抗皮肤衰老的复方制剂
JP6166544B2 (ja) * 2013-02-13 2017-07-19 第一三共ヘルスケア株式会社 色素沈着症の予防又は治療剤
CN105263486A (zh) 2013-04-04 2016-01-20 现代药品株式会社 改善了皮肤渗透的外用剂组合物
EA032775B1 (ru) 2013-04-08 2019-07-31 Берг Ллк Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10
SG10201907816RA (en) 2013-09-04 2019-09-27 Berg Llc Methods of treatment of cancer by continuous infusion of coenzyme q10
US20170189350A1 (en) 2015-11-16 2017-07-06 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
BR112019020766B1 (pt) * 2017-04-04 2022-11-29 Anti-Plasmin Technologies, Llc Composição para aperfeiçoar um tratamento médico não cirúrgico
KR102014602B1 (ko) * 2017-10-19 2019-08-29 주식회사 삼성인터네셔널 기미 개선용 화장료 조성물
SG11202007228WA (en) 2018-01-31 2020-08-28 Otsuka Pharma Co Ltd Method for suppressing discoloration of external composition containing adenosine phosphate and tranexamic acid
CN111840417A (zh) * 2019-04-30 2020-10-30 成都铜雀台医学美容医院有限公司 一种治疗黄褐斑的针剂、其制备方法及应用
AU2021271330A1 (en) * 2020-05-14 2022-12-15 Palani Llc A fatty acid based composition for treatment and/or prevention of enveloped-virus related infections
US20240182511A1 (en) * 2021-04-09 2024-06-06 Merck Sharp & Dohme Llc Novel forms of cyclic dinucleotide compounds
KR102726678B1 (ko) * 2022-04-20 2024-11-07 주식회사 바른바름 4-알킬레졸시놀을 포함하는 고체지질 나노입자, 이를 포함하는 화장료 조성물 및 화장품

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52148615A (en) * 1976-06-07 1977-12-10 Shiyouji Yamashita Aqueous biologically active solution
JP2928414B2 (ja) * 1991-09-20 1999-08-03 ポーラ化成工業株式会社 皮膚外用剤
JP3818674B2 (ja) * 1992-06-02 2006-09-06 三省製薬株式会社 皮膚外用剤
US5874463A (en) * 1994-10-24 1999-02-23 Ancira; Margaret Hydroxy-kojic acid skin peel
JPH09295915A (ja) * 1996-04-26 1997-11-18 Kikkoman Corp 皮膚化粧料
JPH107541A (ja) * 1996-06-20 1998-01-13 Noevir Co Ltd 皮膚外用剤
JP3687277B2 (ja) * 1997-06-10 2005-08-24 サンスター株式会社 美白化粧料
BR9803596A (pt) * 1997-09-23 2000-04-25 Pfizer Prod Inc Derivados do resorcinol.
KR100426753B1 (ko) * 1998-04-27 2004-04-13 칼라 액세스, 인크. 피부 노화 치료 조성물 및 방법
US6503523B2 (en) * 1998-05-07 2003-01-07 Gs Development A.B. Skin care agents containing combinations of active agents consisting of vitamin a derivatives and UBI- or plastoquinones
FR2787710B1 (fr) * 1998-12-29 2001-02-23 Clarins Composition cosmetique a effet eclaircissant pour la peau
JP2001206833A (ja) * 2000-01-25 2001-07-31 Kao Corp 化粧料
WO2002011717A1 (en) * 2000-08-07 2002-02-14 Juvenon, Inc. Cosmetics to support skin metabolism
JP2002179516A (ja) * 2000-12-13 2002-06-26 Pola Chem Ind Inc 美白用組成物
JP2002284664A (ja) * 2001-03-29 2002-10-03 Shiseido Co Ltd 美白用皮膚外用剤
EP1455744A2 (de) * 2001-10-13 2004-09-15 Beiersdorf AG Kosmetische und/oder dermatologische wirkstoffkombination
JP2003160461A (ja) * 2001-11-21 2003-06-03 Shiseido Co Ltd 皮膚外用剤
BR0309127A (pt) * 2002-04-09 2005-02-01 Otsuka Pharma Co Ltd Composição para proliferação de células
BR0311154A (pt) * 2002-05-20 2005-03-29 Otsuka Pharma Co Ltd Composição para melhorar o melasma e composição para reduzir a opacidade da pele
JP4129574B2 (ja) * 2002-08-06 2008-08-06 大塚製薬株式会社 老化防止剤
JP2004075645A (ja) * 2002-08-22 2004-03-11 Kanebo Ltd 化粧料
JP2004107262A (ja) * 2002-09-19 2004-04-08 Nikko Chemical Co Ltd 美白化粧料
JP2004238386A (ja) * 2002-12-11 2004-08-26 Mikimoto Pharmaceut Co Ltd 医薬品、医薬部外品および化粧品
JP2004262853A (ja) * 2003-03-03 2004-09-24 Kanebo Ltd 化粧料
JP2005120023A (ja) * 2003-10-16 2005-05-12 Shiseido Co Ltd 皮膚外用剤

Also Published As

Publication number Publication date
BRPI0515585A (pt) 2008-07-29
EP1806120A1 (en) 2007-07-11
US20080260878A1 (en) 2008-10-23
ES2421606T3 (es) 2013-09-04
CA2580147C (en) 2013-01-22
JP5093998B2 (ja) 2012-12-12
KR20070100226A (ko) 2007-10-10
EP1806120B1 (en) 2013-05-22
JP2006206575A (ja) 2006-08-10
AU2005285903B2 (en) 2011-03-03
CA2580147A1 (en) 2006-03-30
KR101254615B1 (ko) 2013-04-15
EP1806120A4 (en) 2009-01-28
CN101027032B (zh) 2010-11-24
HK1105859A1 (en) 2008-02-29
AU2005285903A1 (en) 2006-03-30
CN101027032A (zh) 2007-08-29
WO2006033343A1 (ja) 2006-03-30

Similar Documents

Publication Publication Date Title
TWI359662B (enExample)
CN105640870B (zh) 一种含酵母提取物的皮肤护理组合物及皮肤护理产品
JP5766258B2 (ja) 色素沈着予防又は改善剤
EP1550459B1 (en) Parakeratosis inhibitor, pore-shrinking agent and skin preparation for external use
JP2009079018A (ja) 頭皮用化粧料
CN106265365A (zh) 一种美白组合物与一种皮肤护理产品
JP2007022923A (ja) 毛包アポトーシス反応阻害剤および毛髪化粧料組成物
JPH1179951A (ja) チロシナーゼ活性促進剤
JP2003231626A (ja) Ａｔｐ産生促進剤
KR20000022127A (ko) 두부용 조성물
JP2008088075A (ja) プロフィラグリン／フィラグリン産生促進剤、表皮角化細胞増殖促進剤、表皮／角層正常化用皮膚外用剤、プロフィラグリン及び／又はフィラグリン産生促進方法、及び表皮角化細胞増殖促進方法
JP2004067626A (ja) 外用剤組成物
JPH03167113A (ja) 養毛剤
JP4285939B2 (ja) 皮膚外用剤
JP5856761B2 (ja) 皮膚外用剤およびその製造方法
JP2011084523A (ja) 線維芽細胞増殖因子−７産生促進剤、及びそれを含有する頭皮・頭髪用化粧料、並びに飲食物
JP4306950B2 (ja) 美白化粧料
JP3496896B2 (ja) 養毛剤及び毛髪用化粧料
JP5000964B2 (ja) テストステロン５α−リダクターゼ活性阻害剤、アンドロゲンレセプター拮抗剤、その用途、及びアンドロゲン活性発現の抑制方法
JPS617206A (ja) 細胞賦活剤
JP4976714B2 (ja) 皮膚色不均一性改善剤、皮膚外用剤、化粧料及び皮膚色不均一性改善方法
CN107951765B (zh) 紫笋茶提取物及其应用
JP2002114700A (ja) メラノサイト活性化剤
JP4327989B2 (ja) 頭髪化粧料
JP2015083571A (ja) 線維芽細胞増殖因子−７産生促進剤、及びそれを含有する頭皮・頭髪用化粧料、並びに飲食物

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees