JP4845743B2 - サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 - Google Patents
サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 Download PDFInfo
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- JP4845743B2 JP4845743B2 JP2006553181A JP2006553181A JP4845743B2 JP 4845743 B2 JP4845743 B2 JP 4845743B2 JP 2006553181 A JP2006553181 A JP 2006553181A JP 2006553181 A JP2006553181 A JP 2006553181A JP 4845743 B2 JP4845743 B2 JP 4845743B2
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/776,988 US7119200B2 (en) | 2002-09-04 | 2004-02-11 | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US10/776,988 | 2004-02-11 | ||
| PCT/US2005/003859 WO2005077954A2 (en) | 2004-02-11 | 2005-02-08 | Pyrazolopyrimidine-derivatives as cyclin dependent kinase inhibitors |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2010157338A Division JP2010215675A (ja) | 2004-02-11 | 2010-07-09 | サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 |
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| JP2007522220A JP2007522220A (ja) | 2007-08-09 |
| JP2007522220A5 JP2007522220A5 (US07846941-20101207-C00217.png) | 2010-08-26 |
| JP4845743B2 true JP4845743B2 (ja) | 2011-12-28 |
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| JP2010157338A Withdrawn JP2010215675A (ja) | 2004-02-11 | 2010-07-09 | サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 |
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| JP2010157338A Withdrawn JP2010215675A (ja) | 2004-02-11 | 2010-07-09 | サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 |
Country Status (27)
Cited By (1)
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| JP2010215675A (ja) * | 2004-02-11 | 2010-09-30 | Schering Corp | サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 |
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| US7196078B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7196092B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| KR20050115252A (ko) | 2003-02-28 | 2005-12-07 | 데이진 화-마 가부시키가이샤 | 피라졸로[1,5-ａ]피리미딘 유도체 |
| EP1608652A1 (en) * | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| GB0321475D0 (en) * | 2003-09-12 | 2003-10-15 | Glaxo Group Ltd | Novel compounds |
| JPWO2005035516A1 (ja) * | 2003-10-10 | 2006-12-21 | 小野薬品工業株式会社 | 新規縮合複素環化合物およびその用途 |
| BRPI0510623A (pt) * | 2004-05-06 | 2007-10-30 | Pfizer | compostos de derivados de prolina e morfolina |
| US20080287405A1 (en) * | 2004-05-14 | 2008-11-20 | Thannickal Victor J | Compositions and Methods Relating to Protein Kinase Inhibitors |
| EP1753429A1 (en) * | 2004-05-28 | 2007-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| JP5208510B2 (ja) * | 2004-11-23 | 2013-06-12 | アストラゼネカ・アクチエボラーグ | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
| US7850960B2 (en) | 2004-12-30 | 2010-12-14 | University Of Washington | Methods for regulation of stem cells |
| JP2008543761A (ja) * | 2005-06-09 | 2008-12-04 | シェーリング コーポレイション | ３−アミノ−４−置換ピラゾール誘導体の合成 |
| US7932257B2 (en) * | 2005-07-22 | 2011-04-26 | Sunesis Pharmaceuticals, Inc. | Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors |
| EP1922321A1 (en) * | 2005-08-09 | 2008-05-21 | Eirx Therapeutics Ltd | Pyrazoloý1,5-a¨pyrimidine compounds and pharmaceutical compositions containing them |
| JP5152922B2 (ja) * | 2005-10-06 | 2013-02-27 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼを阻害するためのピラゾロ［１，５−ａ］ピリミジン誘導体の使用およびプロテインキナーゼを阻害する方法 |
| CA2856037C (en) * | 2005-12-28 | 2017-03-07 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| US20090069315A1 (en) * | 2006-03-08 | 2009-03-12 | Rajeev Sivasankaran | Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders |
| WO2007139732A1 (en) * | 2006-05-22 | 2007-12-06 | Schering Corporation | Pyrazolo [1, 5-a] pyrimidines as cdk inhibitors |
| EP2032989B2 (en) | 2006-06-30 | 2015-10-28 | Merck Sharp & Dohme Corp. | Igfbp2 biomarker |
| US7786306B2 (en) * | 2006-08-18 | 2010-08-31 | Schering Corporation | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same |
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2010
- 2010-07-09 JP JP2010157338A patent/JP2010215675A/ja not_active Withdrawn
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2011
- 2011-04-04 HR HR20110245T patent/HRP20110245T1/hr unknown
- 2011-04-05 CY CY20111100349T patent/CY1112400T1/el unknown
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| JPS4864097A (US07846941-20101207-C00217.png) * | 1971-12-09 | 1973-09-05 | ||
| JPS6157587A (ja) * | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
| US5602137A (en) * | 1993-06-10 | 1997-02-11 | Beiersdorf-Lilly Gmbh | Pyrimidine compounds and their use as pharmaceuticals |
| JP2006502163A (ja) * | 2002-09-04 | 2006-01-19 | シェーリング コーポレイション | サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン |
| JP2006519226A (ja) * | 2003-02-28 | 2006-08-24 | 帝人ファーマ株式会社 | ピラゾロ［１，５−ａ］ピリミジン誘導体 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010215675A (ja) * | 2004-02-11 | 2010-09-30 | Schering Corp | サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 |
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