JP4612304B2 - 微細針経皮的輸送装置 - Google Patents
微細針経皮的輸送装置 Download PDFInfo
- Publication number
- JP4612304B2 JP4612304B2 JP2003539743A JP2003539743A JP4612304B2 JP 4612304 B2 JP4612304 B2 JP 4612304B2 JP 2003539743 A JP2003539743 A JP 2003539743A JP 2003539743 A JP2003539743 A JP 2003539743A JP 4612304 B2 JP4612304 B2 JP 4612304B2
- Authority
- JP
- Japan
- Prior art keywords
- needle
- transport device
- actuator
- reservoir
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- BEWKWPGEQDECPX-UHFFFAOYSA-N CCC(C1)C(C)CCC1=C Chemical compound CCC(C1)C(C)CCC1=C BEWKWPGEQDECPX-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M2005/1401—Functional features
- A61M2005/1405—Patient controlled analgesia [PCA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14204—Pressure infusion, e.g. using pumps with gas-producing electrochemical cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
- A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1581—Right-angle needle-type devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0266—Shape memory materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/65—Impedance, e.g. conductivity, capacity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Diabetes (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- External Artificial Organs (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Surgical Instruments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Oscillators With Electromechanical Resonators (AREA)
Description
2H2O(l)→O2(g)+4H+(aq)+4e−
他方は以下に示す陰極で生じる還元反応である。
2H2O(l)+2e−→H2(g)+OH−
電子数の釣り合いを保つため、陰極での還元反応は陽極での酸化反応の2倍生じなければならない。したがって、陰極での還元反応を2倍して2つの酸化および還元反応を足し合わせると、全体としての反応は、
6H2O(l)+4e−
→2H2(g)+O2(g)+4H+(aq)+4OH−(aq)+4e−
となる。H+とOH−がH2Oを形成し、さらに等式の両辺に現れるイオン種を相殺すると、全体として正味の反応は、
6H2O(l)→2H2(g)+O2(g)
となる。
ngc=nge/(eNA)=7.784×10−6mol/C
ここで、ngeは、上記反応系に投入された電子1個当たりに生成される気体のモル数、すなわち4分の3(3/4)であり、eは1個の電子の電荷であり、NAはアボガドロ定数である。この変換は、例えば3桁を超える大きな体積変化を引き起こし、この体積変化が、リザーバ46から薬を吐出するために利用される。水の水素および酸素への変換が生じると、体積膨張によってフレキシブル膜48が押されて、リザーバ46から薬および任意の担体あるいはその他の化合物や溶媒が、微細針14を通して放出される。
11 接続具
12 投薬器
14 微細針
16 電池
18 プロセッサ
20 ハウジング
22 表示器
24 通信カード
26 電磁石
28 真空ポンプ
30 アクチュエータ
32 インピーダンス・センサ
34 スピーカ
37 圧力センサ
62 先端
Claims (27)
- 特定成分の物質を収容するリザーバと
各々がボアを有する複数の針と、
各針の前記ボアを通して生体の目標部位とリザーバとの間で物質をポンプ作用で輸送するアクチュエータと、
各針を動かすロータリ・アクチュエータと、
を備え、生体の表面を介して物質を輸送する経皮的輸送装置であって、
前記針が前記装置を前記生体の表面に対して取り外し可能に固定させ、
生体の目標部位に前記物質を輸送するための前記ボアが、針の第1端部から針の第2端部までの針の長さに沿って延びており、前記装置が前記生体の体表面に置かれたとき、前記第2端部が前記体表面とほぼ平行であり、前記ロータリ・アクチュエータにより前記第2端部が前記体表面に平行な方向に移動して前記体表面から体内に貫入するように設定されている経皮的輸送装置。 - 請求項1において、前記アクチュエータが前記物質を前記生体内に注入する経皮的輸送装置。
- 請求項1において、前記アクチュエータは可逆性アクチュエータであり、前記物質をヴァイアル内に吸引する経皮的輸送装置。
- 請求項1において、前記アクチュエータの電源が遮断されているとき、各針が格納状態にある経皮的輸送装置。
- 請求項1において、前記アクチュエータが蒸気発生器を備えている経皮的輸送装置。
- 請求項1において、前記アクチュエータが電気化学的反応によって動作する経皮的輸送装置。
- 請求項1において、前記アクチュエータが導電性ポリマーである経皮的輸送装置。
- 請求項1において、さらに、各針の前記第2端部を該端部の長手方向に振動させる振動子を備え、この振動作用により前記針を体内に貫入するのに必要な力を減少させる経皮的輸送装置。
- 請求項8において、前記振動子が前記針の振動を発生させる圧電結晶である経皮的輸送装置。
- 請求項1において、さらに、患者の状態を監視するセンサを備えた経皮的輸送装置。
- 請求項10において、前記患者の状態が患者のグルコース濃度の状態である経皮的輸送装置。
- 請求項11において、前記物質が患者に注入されるインシュリンであり、この注入されるインシュリンの量が前記グルコース濃度に基づく経皮的輸送装置。
- 請求項1において、さらに、ベース部および制御ユニットを備え、各針がこのベース部内に位置する経皮的輸送装置。
- 請求項13において、前記ベース部および制御ユニットが、接続可能な別個のユニットである経皮的輸送装置。
- 請求項1において、前記第2端部が傾斜面を有している経皮的輸送装置。
- 請求項15において、前記傾斜面が面取りされた経皮的輸送装置。
- 請求項1において、さらに、前記輸送装置に動作指令を与えるコントローラを備えた経皮的輸送装置。
- 請求項1において、前記針のうち少なくとも1本が、中実の先端と、前記ボアの周りに該先端に沿って位置する開口とを有する経皮的輸送装置。
- 請求項1において、前記アクチュエータが前記第1端部をリザーバ内に移動させることにより、前記ボアがリザーバと流体連通している経皮的輸送装置。
- 請求項1において、各針が曲げられて曲げ部を有している経皮的輸送装置。
- 特定成分の物質を収容するリザーバと、
前記リザーバと生体との間で前記物質の輸送を行う複数の針と、
を備えた生体の表面を介して物質を輸送する経皮的輸送装置であって、
前記針が前記装置を前記生体の表面に対して取り外し可能に固定させ、針の全長にわたって針の第1端部から針の第2端部まで延びるボアを有しており、前記装置が生体の体表面に置かれたとき、前記第2端部が前記体表面とほぼ平行であり、前記第2端部が前記体表面にほぼ平行な方向に移動して前記体表面から体内に貫入するように設定され、さらに前記第2端部が傾斜した先端を有しており、この先端に前記物質を放出する開口を設けて、前記生体内への前記物質の拡散方向を制御しており、
前記複数の針の少なくとも2本が、それぞれ異なる方向から前記体表面に貫入する経皮的輸送装置。 - 請求項21において、さらに、1本以上の追加の針を備えた経皮的輸送装置。
- 請求項21において、前記針が約30μm〜250μmの外径を有する経皮的輸送装置。
- 請求項21において、前記針が約10μm〜100μmの内径を有する経皮的輸送装置。
- 請求項21において、前記先端が約10°〜60°で傾斜している経皮的輸送装置。
- 請求項21において、前記針が304ステンレス鋼で製作されている経皮的輸送装置。
- 特定成分の物質を収容するリザーバと、
ボアおよび曲げ部を有する針と、
この針の前記ボアを通して生体の目標部位とリザーバとの間で物質をポンプ作用で輸送するアクチュエータと、
を備えた生体の表面を介して物質を輸送する経皮的輸送装置であって、
前記針が前記装置を前記生体の表面に対して取り外し可能に固定させ、
前記ボアが針の第1端部から、前記針の曲げ部によって形成された第2端部までの針の長さに沿って延びており、前記装置が前記生体の体表面に置かれたとき、前記第2端部が前記体表面とほぼ平行であり、前記第2端部が前記体表面にほぼ平行な方向に移動して前記体表面から体内に貫入するように設定されている経皮的輸送装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33842501P | 2001-10-26 | 2001-10-26 | |
US39948902P | 2002-07-29 | 2002-07-29 | |
PCT/US2002/033794 WO2003037404A1 (en) | 2001-10-26 | 2002-10-21 | Microneedle transdermal transport device |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009114990A Division JP2009240790A (ja) | 2001-10-26 | 2009-05-11 | 微細針経皮的輸送装置 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005507713A JP2005507713A (ja) | 2005-03-24 |
JP2005507713A5 JP2005507713A5 (ja) | 2006-01-05 |
JP4612304B2 true JP4612304B2 (ja) | 2011-01-12 |
Family
ID=26991185
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003539742A Pending JP2005525141A (ja) | 2001-10-26 | 2002-10-18 | 微細針輸送装置 |
JP2003539743A Expired - Fee Related JP4612304B2 (ja) | 2001-10-26 | 2002-10-21 | 微細針経皮的輸送装置 |
JP2003539746A Expired - Fee Related JP4610193B2 (ja) | 2001-10-26 | 2002-10-22 | 吸引機構を有する経皮的輸送装置 |
JP2003539744A Expired - Fee Related JP4610192B2 (ja) | 2001-10-26 | 2002-10-22 | インピーダンス・センサ |
JP2003539745A Pending JP2005507715A (ja) | 2001-10-26 | 2002-10-22 | 電気分解式アクチュエータを有する経皮的輸送装置 |
JP2005304325A Pending JP2006081918A (ja) | 2001-10-26 | 2005-10-19 | 蒸気発生式アクチュエータを有する経皮的輸送装置 |
JP2009114989A Pending JP2009219886A (ja) | 2001-10-26 | 2009-05-11 | 微細針輸送装置 |
JP2009114992A Pending JP2009219888A (ja) | 2001-10-26 | 2009-05-11 | 吸引機構を有する経皮的輸送装置 |
JP2009114990A Pending JP2009240790A (ja) | 2001-10-26 | 2009-05-11 | 微細針経皮的輸送装置 |
JP2009114991A Pending JP2009219887A (ja) | 2001-10-26 | 2009-05-11 | インピーダンス・センサ |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003539742A Pending JP2005525141A (ja) | 2001-10-26 | 2002-10-18 | 微細針輸送装置 |
Family Applications After (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003539746A Expired - Fee Related JP4610193B2 (ja) | 2001-10-26 | 2002-10-22 | 吸引機構を有する経皮的輸送装置 |
JP2003539744A Expired - Fee Related JP4610192B2 (ja) | 2001-10-26 | 2002-10-22 | インピーダンス・センサ |
JP2003539745A Pending JP2005507715A (ja) | 2001-10-26 | 2002-10-22 | 電気分解式アクチュエータを有する経皮的輸送装置 |
JP2005304325A Pending JP2006081918A (ja) | 2001-10-26 | 2005-10-19 | 蒸気発生式アクチュエータを有する経皮的輸送装置 |
JP2009114989A Pending JP2009219886A (ja) | 2001-10-26 | 2009-05-11 | 微細針輸送装置 |
JP2009114992A Pending JP2009219888A (ja) | 2001-10-26 | 2009-05-11 | 吸引機構を有する経皮的輸送装置 |
JP2009114990A Pending JP2009240790A (ja) | 2001-10-26 | 2009-05-11 | 微細針経皮的輸送装置 |
JP2009114991A Pending JP2009219887A (ja) | 2001-10-26 | 2009-05-11 | インピーダンス・センサ |
Country Status (8)
Country | Link |
---|---|
US (7) | US7429258B2 (ja) |
EP (5) | EP1439871B1 (ja) |
JP (10) | JP2005525141A (ja) |
AT (3) | ATE420680T1 (ja) |
AU (3) | AU2002353840B2 (ja) |
CA (5) | CA2464483C (ja) |
DE (3) | DE60230896D1 (ja) |
WO (5) | WO2003037403A1 (ja) |
Families Citing this family (402)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6461292B1 (en) | 1999-08-12 | 2002-10-08 | Obtech Medical Ag | Anal incontinence treatment with wireless energy supply |
US6482145B1 (en) | 2000-02-14 | 2002-11-19 | Obtech Medical Ag | Hydraulic anal incontinence treatment |
US6471635B1 (en) | 2000-02-10 | 2002-10-29 | Obtech Medical Ag | Anal incontinence disease treatment with controlled wireless energy supply |
US6464628B1 (en) | 1999-08-12 | 2002-10-15 | Obtech Medical Ag | Mechanical anal incontinence |
ES2241780T3 (es) | 2000-02-10 | 2005-11-01 | Potencia Medical Ag | Aparato mecanico para el tratamiento de la impotencia. |
ES2309622T3 (es) | 2000-02-10 | 2008-12-16 | Potencia Medical Ag | Tratamiento controlado de incontinencia urinaria. |
BR0108182B1 (pt) | 2000-02-10 | 2010-06-29 | aparelho para o tratamento de incontinência urinária com suprimento de energia sem fio. | |
WO2001050832A2 (en) | 2000-02-11 | 2001-07-19 | Potencia Medical Ag | Controlled impotence treatment |
ATE416743T1 (de) | 2000-02-11 | 2008-12-15 | Potentica Ag | Vorrichtung mit energieumwandlungsmitteln zur impotenzbehandlung |
US20030100929A1 (en) | 2000-02-14 | 2003-05-29 | Peter Forsell | Controlled penile prosthesis |
BR0108307B1 (pt) | 2000-02-14 | 2009-12-01 | aparelho de prótese para o tratamento de impotência sexual masculina com dispositivo de suprimento de energia sem fio. | |
US7442165B2 (en) | 2000-02-14 | 2008-10-28 | Obtech Medical Ag | Penile prosthesis |
US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
EP1227094B1 (en) * | 2001-01-30 | 2005-12-14 | Nissan Chemical Industries Ltd. | Isocyanurate compound and method for producing the same |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US6966880B2 (en) * | 2001-10-16 | 2005-11-22 | Agilent Technologies, Inc. | Universal diagnostic platform |
US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
US7858112B2 (en) * | 2002-02-28 | 2010-12-28 | Lintec Corporation | Percutaneous absorption system and percutaneous absorption method |
US7115108B2 (en) * | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
US6912417B1 (en) | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US8784335B2 (en) * | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9795334B2 (en) * | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US20040039289A1 (en) * | 2002-04-30 | 2004-02-26 | Christensen Lars Hofmann | Needle insertion sensor |
US7722595B2 (en) | 2002-05-06 | 2010-05-25 | Becton, Dickinson And Company | Method and device for controlling drug pharmacokinetics |
EP1389476A1 (fr) * | 2002-08-14 | 2004-02-18 | Precimedix S.A. | Dispositif de programmation d'une pompe pour l'injection de medicaments |
CA2497086A1 (en) * | 2002-08-30 | 2004-03-11 | Becton, Dickinson And Company | Method of controlling pharmacokinetics of immunomodulatory compounds |
US20120296233A9 (en) * | 2002-09-05 | 2012-11-22 | Freeman Dominique M | Methods and apparatus for an analyte detecting device |
US7530975B2 (en) | 2002-09-06 | 2009-05-12 | Massachusetts Institute Of Technology | Measuring properties of an anatomical body |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US20060178573A1 (en) * | 2003-03-06 | 2006-08-10 | Kermani Mahyar Z | System and method for piercing dermal tissue |
WO2006001797A1 (en) * | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US20070065463A1 (en) | 2003-06-20 | 2007-03-22 | Ronald Aung-Din | Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions |
MXPA06001409A (es) * | 2003-08-04 | 2006-08-25 | Johnson & Johnson | Metodo y dispositivo para mejorar flujo de agente trasdermico. |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
EP1527792A1 (en) | 2003-10-27 | 2005-05-04 | Novo Nordisk A/S | Medical injection device mountable to the skin |
US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
EP1680154B1 (en) | 2003-10-31 | 2012-01-04 | ALZA Corporation | Self-actuating applicator for microprojection array |
US7361182B2 (en) | 2003-12-19 | 2008-04-22 | Lightnix, Inc. | Medical lancet |
US8224410B2 (en) | 2003-12-22 | 2012-07-17 | Hadvary Paul | Dermally affixed sensor device |
US20070083151A1 (en) * | 2003-12-29 | 2007-04-12 | Carter Chad J | Medical devices and kits including same |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
SI1729848T1 (sl) | 2004-03-08 | 2015-08-31 | Ichor Medical Systems Inc. | Izboljšani aparat za električno posredovan dovod terapevtske snovi |
ES2574802T3 (es) * | 2004-04-12 | 2016-06-22 | Allergan, Inc. | Sistema de inyección multi-sitio |
US20050288566A1 (en) * | 2004-04-30 | 2005-12-29 | Levendusky Joseph A | Apparatus with partially insulated needle for measuring tissue impedance |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US9775553B2 (en) * | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
EP1765194A4 (en) * | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR MANUFACTURING A DEVICE FOR SAMPLING LIQUIDS |
US8247946B2 (en) | 2004-06-14 | 2012-08-21 | Massachusetts Institute Of Technology | Electrochemical actuator |
CA2570092A1 (en) | 2004-06-14 | 2005-12-29 | Massachusetts Institute Of Technology | Electrochemical methods, devices, and structures |
US7872396B2 (en) * | 2004-06-14 | 2011-01-18 | Massachusetts Institute Of Technology | Electrochemical actuator |
WO2006004887A2 (en) | 2004-06-29 | 2006-01-12 | Spine Wave, Inc. | Methods for treating defects and injuries of an intervertebral disc |
US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
US8696619B2 (en) * | 2004-08-10 | 2014-04-15 | Robert P. Schnall | Drug delivery devices |
WO2006018642A1 (en) | 2004-08-16 | 2006-02-23 | Functional Microstructures Limited | Method of producing a microneedle or microimplant |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
CN101060882B (zh) | 2004-11-18 | 2010-06-16 | 3M创新有限公司 | 微针阵列施放器和保持器 |
EP2388078B1 (en) | 2004-11-18 | 2013-03-20 | 3M Innovative Properties Co. | Method of contact coating a microneedle array |
AU2005306422A1 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
JP4927751B2 (ja) * | 2004-11-18 | 2012-05-09 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイのコーティング方法 |
US20080009800A1 (en) * | 2004-12-02 | 2008-01-10 | Nickel Janice H | Transdermal drug delivery device |
CN100367906C (zh) * | 2004-12-08 | 2008-02-13 | 圣美迪诺医疗科技(湖州)有限公司 | 皮下植入式生物传感器 |
US7833189B2 (en) | 2005-02-11 | 2010-11-16 | Massachusetts Institute Of Technology | Controlled needle-free transport |
US7850645B2 (en) | 2005-02-11 | 2010-12-14 | Boston Scientific Scimed, Inc. | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power |
EP1709989A1 (de) * | 2005-04-04 | 2006-10-11 | Christoph Burckhardt AG | Tätowierpistolenspitze |
EP1709906A1 (de) * | 2005-04-07 | 2006-10-11 | F. Hoffmann-La Roche Ag | Verfahren und Vorrichtung zur Entnahme von Körperflüssigkeit |
US10035008B2 (en) * | 2005-04-07 | 2018-07-31 | 3M Innovative Properties Company | System and method for tool feedback sensing |
WO2006108809A1 (en) | 2005-04-13 | 2006-10-19 | Novo Nordisk A/S | Medical skin mountable device and system |
US8372040B2 (en) | 2005-05-24 | 2013-02-12 | Chrono Therapeutics, Inc. | Portable drug delivery device including a detachable and replaceable administration or dosing element |
EP2921169A1 (en) * | 2005-05-24 | 2015-09-23 | Chrono Therapeutics, Inc. | Portable drug delivery device including a detachable and replaceable administration or dosing element |
US20080269666A1 (en) * | 2005-05-25 | 2008-10-30 | Georgia Tech Research Corporation | Microneedles and Methods for Microinfusion |
US8021357B2 (en) * | 2005-05-27 | 2011-09-20 | Olympus Corporation | Body-insertable apparatus |
US8505544B2 (en) * | 2005-05-31 | 2013-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Optically-implemented microsurgery system and approach |
EP1893256B1 (en) * | 2005-06-16 | 2012-09-26 | Novo Nordisk A/S | Method and apparatus for assisting patients in self administration of medication |
US20080195035A1 (en) | 2005-06-24 | 2008-08-14 | Frederickson Franklyn L | Collapsible Patch and Method of Application |
WO2007002521A2 (en) | 2005-06-27 | 2007-01-04 | 3M Innovative Properties Company | Microneedle array applicator device |
WO2007006055A2 (en) | 2005-07-06 | 2007-01-11 | Vascular Pathways Inc. | Intravenous catheter insertion device and method of use |
IL175460A (en) | 2006-05-07 | 2011-05-31 | Doron Aurbach | Drug delivery device |
US9687186B2 (en) | 2005-07-21 | 2017-06-27 | Steadymed Ltd. | Drug delivery device |
US8518069B2 (en) | 2005-09-07 | 2013-08-27 | Cabochon Aesthetics, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9011473B2 (en) | 2005-09-07 | 2015-04-21 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9358033B2 (en) | 2005-09-07 | 2016-06-07 | Ulthera, Inc. | Fluid-jet dissection system and method for reducing the appearance of cellulite |
US9486274B2 (en) | 2005-09-07 | 2016-11-08 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US10548659B2 (en) | 2006-01-17 | 2020-02-04 | Ulthera, Inc. | High pressure pre-burst for improved fluid delivery |
US20070185432A1 (en) * | 2005-09-19 | 2007-08-09 | Transport Pharmaceuticals, Inc. | Electrokinetic system and method for delivering methotrexate |
US20070066934A1 (en) * | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
JP4935286B2 (ja) * | 2005-10-12 | 2012-05-23 | パナソニック株式会社 | 血液センサ |
WO2007045644A1 (en) | 2005-10-17 | 2007-04-26 | Novo Nordisk A/S | Vented drug reservoir unit |
CA2625954C (en) * | 2005-11-02 | 2014-06-17 | Prosthesica Ag | Implantable infusion device with advanceable and retractable needle |
US9248317B2 (en) | 2005-12-02 | 2016-02-02 | Ulthera, Inc. | Devices and methods for selectively lysing cells |
US7885793B2 (en) | 2007-05-22 | 2011-02-08 | International Business Machines Corporation | Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution |
US9636035B2 (en) * | 2005-12-14 | 2017-05-02 | Scibase Ab | Medical apparatus for determination of biological conditions using impedance measurements |
JP4402648B2 (ja) * | 2005-12-16 | 2010-01-20 | オリンパス株式会社 | 被検体内導入装置 |
US7736310B2 (en) | 2006-01-30 | 2010-06-15 | Abbott Diabetes Care Inc. | On-body medical device securement |
EP1815790A1 (de) * | 2006-02-04 | 2007-08-08 | Roche Diagnostics GmbH | Stechgerät mit Impedanzmesseinrichtung |
US11318249B2 (en) | 2006-02-09 | 2022-05-03 | Deka Products Limited Partnership | Infusion pump assembly |
EP1993633B1 (en) * | 2006-02-09 | 2016-11-09 | Deka Products Limited Partnership | Pumping fluid delivery systems and methods using force application assembly |
US8419708B2 (en) | 2006-02-10 | 2013-04-16 | Hisamitsu Pharmaceuticals Co., Inc. | Transdermal drug administration apparatus having microneedles |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
US7981034B2 (en) | 2006-02-28 | 2011-07-19 | Abbott Diabetes Care Inc. | Smart messages and alerts for an infusion delivery and management system |
CA2647362C (en) | 2006-03-14 | 2014-10-14 | University Of Southern California | Mems device and method for delivery of therapeutic agents |
US9119945B2 (en) * | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US7918814B2 (en) * | 2006-05-02 | 2011-04-05 | Georgia Tech Research Corporation | Method for drug delivery to ocular tissue using microneedle |
US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
US7621895B2 (en) * | 2006-05-17 | 2009-11-24 | Abbott Cardiovascular Systems Inc. | Needle array devices and methods |
US20070276318A1 (en) * | 2006-05-26 | 2007-11-29 | Mit, Llp | Iontosonic-microneedle applicator apparatus and methods |
US20090171269A1 (en) * | 2006-06-29 | 2009-07-02 | Abbott Diabetes Care, Inc. | Infusion Device and Methods Therefor |
US9119582B2 (en) | 2006-06-30 | 2015-09-01 | Abbott Diabetes Care, Inc. | Integrated analyte sensor and infusion device and methods therefor |
US20090326441A1 (en) * | 2006-08-01 | 2009-12-31 | Agency For Science ,Technology And Research | Ultrasonic Enhanced Microneedles |
US8932216B2 (en) | 2006-08-07 | 2015-01-13 | Abbott Diabetes Care Inc. | Method and system for providing data management in integrated analyte monitoring and infusion system |
US8206296B2 (en) | 2006-08-07 | 2012-06-26 | Abbott Diabetes Care Inc. | Method and system for providing integrated analyte monitoring and infusion system therapy management |
JP2010502267A (ja) * | 2006-08-28 | 2010-01-28 | エージェンシー・フォー・サイエンス・テクノロジー・アンド・リサーチ | マイクロニードルおよびマイクロニードルの製造方法 |
WO2008027218A2 (en) * | 2006-08-29 | 2008-03-06 | Alza Corporation | Drug electrotransport with hydration measurement of hydratable reservoir |
WO2008036043A1 (en) * | 2006-09-18 | 2008-03-27 | Agency For Science, Technology And Research | Needle structures and methods for fabricating needle structures |
WO2008041183A2 (en) | 2006-10-05 | 2008-04-10 | Technion Research & Development Foundation Ltd. | Microtubes and methods of producing same |
EP2084802B1 (en) * | 2006-10-25 | 2019-03-06 | Roche Diabetes Care GmbH | Uninterruptible power supply for a medical appliance |
EP2076172A4 (en) * | 2006-10-27 | 2012-03-21 | Aretais Inc | USE OF COHERENT RAMAN PROCEDURES FOR MEDICAL DIAGNOSTIC AND THERAPEUTIC PURPOSES AND CALIBRATION METHOD THEREFOR |
US10525246B2 (en) * | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
US8845530B2 (en) * | 2007-01-02 | 2014-09-30 | Isense Corporation | Resposable biosensor assembly and method of sensing |
FR2912919B1 (fr) * | 2007-02-22 | 2009-05-01 | Bernard Perriere | Dispositif d'injection miniaturise a usage medical |
US20080249469A1 (en) * | 2007-03-22 | 2008-10-09 | Ponnambalam Selvaganapathy | Method and apparatus for active control of drug delivery using electro-osmotic flow control |
GB2448493B (en) * | 2007-04-16 | 2009-10-14 | Dewan Fazlul Hoque Chowdhury | Microneedle transdermal delivery device |
AU2008241470B2 (en) | 2007-04-16 | 2013-11-07 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
WO2008137956A2 (en) | 2007-05-07 | 2008-11-13 | Vascular Pathways, Inc. | Intravenous catheter insertion and blood sample devices and method of use |
WO2008154338A1 (en) * | 2007-06-07 | 2008-12-18 | Piezo Resonance Innovations, Inc. | Eye surgical tool |
US20100137429A1 (en) * | 2007-06-21 | 2010-06-03 | Fujimoto Co., Ltd. | Composition for transdermal or transmucosal administration |
US8641618B2 (en) | 2007-06-27 | 2014-02-04 | Abbott Diabetes Care Inc. | Method and structure for securing a monitoring device element |
US8085151B2 (en) | 2007-06-28 | 2011-12-27 | Abbott Diabetes Care Inc. | Signal converting cradle for medical condition monitoring and management system |
US8328738B2 (en) | 2007-06-29 | 2012-12-11 | Actuated Medical, Inc. | Medical tool for reduced penetration force with feedback means |
US9987468B2 (en) | 2007-06-29 | 2018-06-05 | Actuated Medical, Inc. | Reduced force device for intravascular access and guidewire placement |
US8160900B2 (en) | 2007-06-29 | 2012-04-17 | Abbott Diabetes Care Inc. | Analyte monitoring and management device and method to analyze the frequency of user interaction with the device |
US10219832B2 (en) | 2007-06-29 | 2019-03-05 | Actuated Medical, Inc. | Device and method for less forceful tissue puncture |
US8043229B2 (en) * | 2007-06-29 | 2011-10-25 | Actuated Medical, Inc. | Medical tool for reduced penetration force |
US7828771B2 (en) * | 2007-07-26 | 2010-11-09 | Entra Pharmaceuticals, Inc. | Systems and methods for delivering drugs |
SG183726A1 (en) * | 2007-08-14 | 2012-09-27 | Hutchinson Fred Cancer Res | Needle array assembly and method for delivering therapeutic agents |
JP5411138B2 (ja) * | 2007-08-24 | 2014-02-12 | エイジェンシー フォー サイエンス, テクノロジー アンド リサーチ | 皮膚貫通検出システム |
WO2009029572A1 (en) * | 2007-08-24 | 2009-03-05 | Deka Products Limited Partnership | Microneedle systems and apparatus |
US9096845B2 (en) * | 2007-08-29 | 2015-08-04 | Technion Research & Development Foundation Limited | Encapsulation of bacteria and viruses in electrospun fibers |
US20090088682A1 (en) * | 2007-09-28 | 2009-04-02 | Seattle Medical Technologies | Wearable infusion device |
US8439940B2 (en) | 2010-12-22 | 2013-05-14 | Cabochon Aesthetics, Inc. | Dissection handpiece with aspiration means for reducing the appearance of cellulite |
WO2010042045A1 (en) | 2008-10-10 | 2010-04-15 | Milux Holding S.A. | A system, an apparatus, and a method for treating a sexual dysfunctional female patient |
CN103961792B (zh) * | 2007-12-17 | 2016-09-21 | 新世界药品有限公司 | 整合的真皮内递送、诊断和通讯系统 |
ES2425769T5 (es) | 2007-12-20 | 2017-07-28 | University Of Southern California | Aparato para la administración de agentes terapéuticos |
WO2009088956A2 (en) | 2007-12-31 | 2009-07-16 | Deka Products Limited Partnership | Infusion pump assembly |
FI20075978A0 (fi) * | 2007-12-31 | 2007-12-31 | Katja Paassilta | Järjestely ja menetelmä |
JP5634269B2 (ja) | 2007-12-31 | 2014-12-03 | デカ・プロダクツ・リミテッド・パートナーシップ | 注入ポンプアセンブリ |
US11357910B2 (en) | 2007-12-31 | 2022-06-14 | Deka Products Limited Partnership | Pump assembly with switch |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US8961448B2 (en) * | 2008-01-28 | 2015-02-24 | Peter Forsell | Implantable drainage device |
CA2749782C (en) | 2008-01-29 | 2021-06-15 | Milux Holding S.A. | Apparatus for treating obesity |
WO2009104174A2 (en) * | 2008-02-21 | 2009-08-27 | Technion Research & Development Foundation Ltd . | A method of attaching a cell-of-interest to a microtube |
WO2009108836A1 (en) * | 2008-02-29 | 2009-09-03 | Path Scientific, Llc | Unitized painfree blood glucose measuring device |
JP2009222474A (ja) * | 2008-03-14 | 2009-10-01 | Panasonic Corp | 微量液体供給装置および微量液体供給方法 |
US8486278B2 (en) | 2008-05-08 | 2013-07-16 | Minipumps, Llc | Drug-delivery pumps and methods of manufacture |
US9333297B2 (en) | 2008-05-08 | 2016-05-10 | Minipumps, Llc | Drug-delivery pump with intelligent control |
EP2898911A1 (en) | 2008-05-08 | 2015-07-29 | MiniPumps, LLC | Implantable pumps and cannulas therefor |
WO2009142741A1 (en) | 2008-05-21 | 2009-11-26 | Theraject, Inc. | Method of manufacturing solid solution peforator patches and uses thereof |
US8591410B2 (en) | 2008-05-30 | 2013-11-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing glycemic control |
US8924159B2 (en) | 2008-05-30 | 2014-12-30 | Abbott Diabetes Care Inc. | Method and apparatus for providing glycemic control |
US8592424B2 (en) | 2008-06-30 | 2013-11-26 | Afgin Pharma Llc | Topical regional neuro-affective therapy |
CN101960144A (zh) * | 2008-07-08 | 2011-01-26 | 松下电器产业株式会社 | 使用了导电性高分子的流体运送装置 |
US8868176B2 (en) * | 2008-07-22 | 2014-10-21 | New York University | Microelectrode-equipped subdural therapeutic agent delivery strip |
WO2010023666A2 (en) * | 2008-08-28 | 2010-03-04 | Medingo Ltd. | Device and method for enhanced subcutaneous insulin absorption |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
CA2737461A1 (en) | 2008-09-19 | 2010-03-25 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
EP3851076A1 (en) | 2008-10-10 | 2021-07-21 | MedicalTree Patent Ltd. | An improved artificial valve |
HUE056076T2 (hu) | 2008-10-10 | 2022-01-28 | Medicaltree Patent Ltd | Szívsegítõ készülék és rendszer |
EP2349385B1 (en) | 2008-10-10 | 2019-12-11 | MedicalTree Patent Ltd. | Heart help device, system and method |
CA2776467A1 (en) | 2008-10-10 | 2010-04-15 | Peter Forsell | Fastening means for implantable medical control assembly |
US20210378811A1 (en) * | 2008-10-10 | 2021-12-09 | Peter Forsell | Fastening means for implantable medical control assembly |
EP2349170B1 (en) | 2008-10-10 | 2023-09-27 | Implantica Patent Ltd. | Apparatus for the treatment of female sexual dysfunction |
US9168364B2 (en) | 2008-11-04 | 2015-10-27 | Janisys Limited | Transfer device for transferring a substance between the device and a subject |
JP5690739B2 (ja) | 2008-12-02 | 2015-03-25 | アラーガン、インコーポレイテッドAllergan,Incorporated | 注射装置 |
US20110301628A1 (en) * | 2008-12-05 | 2011-12-08 | Yossi Gross | Techniques for use with a nail penetration device |
US9358375B2 (en) | 2008-12-19 | 2016-06-07 | Janisys Limited | Fluid transfer device and an active substance cartridge for the fluid transfer device, and a method for controlling the pressure at which an active substance is delivered to a subject from a fluid transfer device |
US20100187132A1 (en) * | 2008-12-29 | 2010-07-29 | Don Alden | Determination of the real electrochemical surface areas of screen printed electrodes |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
WO2010101626A1 (en) | 2009-03-02 | 2010-09-10 | Seventh Sense Biosystems, Inc. | Techniques and devices associated with blood sampling |
US20110105951A1 (en) * | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin |
US9119578B2 (en) | 2011-04-29 | 2015-09-01 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
US20110172508A1 (en) * | 2010-01-13 | 2011-07-14 | Seventh Sense Biosystems, Inc. | Sampling device interfaces |
US8781576B2 (en) * | 2009-03-17 | 2014-07-15 | Cardiothrive, Inc. | Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current |
WO2010107707A2 (en) | 2009-03-17 | 2010-09-23 | Savage Walter T | External defibrillator |
DE102009002019A1 (de) | 2009-03-31 | 2010-10-07 | Robert Bosch Gmbh | Applikator zur Behandlung von Haut |
EP2425209A4 (en) | 2009-04-29 | 2013-01-09 | Abbott Diabetes Care Inc | METHOD AND SYSTEM FOR REAL-TIME CALIBRATION OF AN ANALYTICAL SENSOR WITH RETROACTIVE FILLING |
EP2424610A2 (en) * | 2009-04-29 | 2012-03-07 | Janisys Limited | A micro-needle device and apparatus and a method for applying a micro-needle element to a site on the skin of a subject |
WO2010145908A1 (en) * | 2009-05-20 | 2010-12-23 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
US9949812B2 (en) | 2009-07-17 | 2018-04-24 | Peter Forsell | Vaginal operation method for the treatment of anal incontinence in women |
US10952836B2 (en) | 2009-07-17 | 2021-03-23 | Peter Forsell | Vaginal operation method for the treatment of urinary incontinence in women |
EP3284494A1 (en) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
CA2769102C (en) | 2009-07-31 | 2017-09-19 | 3M Innovative Properties Company | Hollow microneedle arrays |
US9358064B2 (en) | 2009-08-07 | 2016-06-07 | Ulthera, Inc. | Handpiece and methods for performing subcutaneous surgery |
US11096708B2 (en) | 2009-08-07 | 2021-08-24 | Ulthera, Inc. | Devices and methods for performing subcutaneous surgery |
EP2467797B1 (en) | 2009-08-18 | 2017-07-19 | MiniPumps, LLC | Electrolytic drug-delivery pump with adaptive control |
US8758271B2 (en) | 2009-09-01 | 2014-06-24 | Massachusetts Institute Of Technology | Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties |
US20110060202A1 (en) * | 2009-09-08 | 2011-03-10 | Seth Adrian Miller | Dehydration detector using micro-needles |
WO2011029828A1 (en) * | 2009-09-10 | 2011-03-17 | Sanofi-Aventis Deutschland Gmbh | Medicament container |
US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
US8685038B2 (en) | 2009-12-07 | 2014-04-01 | Incube Labs, Llc | Iontophoretic apparatus and method for marking of the skin |
WO2011084511A1 (en) | 2009-12-15 | 2011-07-14 | Massachusetts Institute Of Technology | Jet injector use in oral evaluation |
US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
CN102811754B (zh) * | 2010-01-13 | 2017-05-17 | 第七感生物系统有限公司 | 流体的快速输送和/或抽出 |
EP3243435A1 (en) * | 2010-01-13 | 2017-11-15 | Seventh Sense Biosystems, Inc. | Sampling device interfaces |
WO2011094573A1 (en) | 2010-01-28 | 2011-08-04 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
US8366667B2 (en) * | 2010-02-11 | 2013-02-05 | Baxter International Inc. | Flow pulsatility dampening devices |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8285328B2 (en) | 2010-04-20 | 2012-10-09 | Minipumps, Llc | Remote-controlled drug pump devices |
CN102985131B (zh) | 2010-04-28 | 2016-06-29 | 金伯利-克拉克环球有限公司 | 用于递送siRNA的医疗装置 |
JP5860453B2 (ja) | 2010-04-28 | 2016-02-16 | キンバリー クラーク ワールドワイド インコーポレイテッド | 表面にナノ構造体を含む複合マイクロニードルアレイ |
US9629979B2 (en) * | 2010-04-28 | 2017-04-25 | Sanovas, Inc. | Pressure/Vacuum actuated catheter drug delivery probe |
US9586044B2 (en) | 2010-04-28 | 2017-03-07 | Kimberly-Clark Worldwide, Inc. | Method for increasing the permeability of an epithelial barrier |
PT2563450T (pt) | 2010-04-28 | 2017-08-28 | Kimberly Clark Co | Dispositivo para entrega de medicação para a artrite reumatóide |
AU2011248108B2 (en) | 2010-05-04 | 2016-05-26 | Corium Pharma Solutions, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US8337457B2 (en) | 2010-05-05 | 2012-12-25 | Springleaf Therapeutics, Inc. | Systems and methods for delivering a therapeutic agent |
US11925779B2 (en) | 2010-05-14 | 2024-03-12 | C. R. Bard, Inc. | Catheter insertion device including top-mounted advancement components |
US9872971B2 (en) | 2010-05-14 | 2018-01-23 | C. R. Bard, Inc. | Guidewire extension system for a catheter placement device |
US9950139B2 (en) | 2010-05-14 | 2018-04-24 | C. R. Bard, Inc. | Catheter placement device including guidewire and catheter control elements |
US8932258B2 (en) | 2010-05-14 | 2015-01-13 | C. R. Bard, Inc. | Catheter placement device and method |
US10384039B2 (en) | 2010-05-14 | 2019-08-20 | C. R. Bard, Inc. | Catheter insertion device including top-mounted advancement components |
US9125625B2 (en) | 2010-06-10 | 2015-09-08 | The Regents Of The University Of California | Textile-based printable electrodes for electrochemical sensing |
WO2011163347A2 (en) | 2010-06-23 | 2011-12-29 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
US9227021B2 (en) | 2010-06-29 | 2016-01-05 | Genesis Biosystems, Inc. | Microneedle roller (MNR) infusion system |
US20120016308A1 (en) | 2010-07-16 | 2012-01-19 | Seventh Sense Biosystems, Inc. | Low-pressure packaging for fluid devices |
US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
US9420952B2 (en) | 2010-07-27 | 2016-08-23 | Carefusion 303, Inc. | Temperature probe suitable for axillary reading |
US9585620B2 (en) | 2010-07-27 | 2017-03-07 | Carefusion 303, Inc. | Vital-signs patch having a flexible attachment to electrodes |
US9017255B2 (en) | 2010-07-27 | 2015-04-28 | Carefusion 303, Inc. | System and method for saving battery power in a patient monitoring system |
US8814792B2 (en) | 2010-07-27 | 2014-08-26 | Carefusion 303, Inc. | System and method for storing and forwarding data from a vital-signs monitor |
US9055925B2 (en) | 2010-07-27 | 2015-06-16 | Carefusion 303, Inc. | System and method for reducing false alarms associated with vital-signs monitoring |
US9357929B2 (en) | 2010-07-27 | 2016-06-07 | Carefusion 303, Inc. | System and method for monitoring body temperature of a person |
US9615792B2 (en) | 2010-07-27 | 2017-04-11 | Carefusion 303, Inc. | System and method for conserving battery power in a patient monitoring system |
DE102010038733A1 (de) * | 2010-07-30 | 2012-02-02 | Robert Bosch Gmbh | Modulare Mikronadel-Transportvorrichtung |
WO2012021801A2 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
US9173994B2 (en) * | 2010-08-20 | 2015-11-03 | Purdue Research Foundation | Touch-actuated micropump for transdermal drug delivery and method of use |
WO2012042517A1 (en) | 2010-09-27 | 2012-04-05 | Steadymed, Ltd. | Size-efficient drug-delivery device |
WO2012048277A2 (en) | 2010-10-07 | 2012-04-12 | Massachusetts Institute Of Technology | Injection methods using a servo-controlled needle-free injector |
US8821434B2 (en) | 2010-10-07 | 2014-09-02 | Massachusetts Institute Of Technology | Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system |
JP5996544B2 (ja) | 2010-10-15 | 2016-09-21 | クリアサイド・バイオメディカル・インコーポレーテッドClearside Biomedical Incorporated | 眼球アクセス用装置 |
WO2012058192A1 (en) * | 2010-10-26 | 2012-05-03 | 7944942 Canada Inc. | Automatic medication injection device |
US9017289B2 (en) | 2010-11-03 | 2015-04-28 | Covidien Lp | Transdermal fluid delivery device |
US8808202B2 (en) | 2010-11-09 | 2014-08-19 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
US8368285B2 (en) | 2010-12-17 | 2013-02-05 | Massachusette Institute Of Technology | Electrochemical actuators |
US8690833B2 (en) | 2011-01-31 | 2014-04-08 | Vascular Pathways, Inc. | Intravenous catheter and insertion device with reduced blood spatter |
WO2012108956A2 (en) | 2011-02-09 | 2012-08-16 | Becton, Dickinson And Company | Improvements in infusion systems |
WO2012154277A1 (en) | 2011-02-25 | 2012-11-15 | C.R. Bard, Inc. | Medical component insertion device including a retractable needle |
US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
WO2012139593A2 (en) * | 2011-04-15 | 2012-10-18 | Rigshospitalet Copenhagen University Hospital | System and method for injecting a substance into a human body |
BR112013027010A2 (pt) * | 2011-04-19 | 2016-12-27 | Invisiderm Llc | método de produzir substâncias com gás supersaturado, dispositivo para sua entrega trasdérmica, e seus usos |
US20140163456A1 (en) * | 2011-04-19 | 2014-06-12 | Invisiderm, Llc | Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof |
EP3106092A3 (en) | 2011-04-29 | 2017-03-08 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
KR102237667B1 (ko) * | 2011-04-29 | 2021-04-12 | 세븐쓰 센스 바이오시스템즈, 인크. | 유체들의 전달 및/또는 수용 |
US20130158468A1 (en) * | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
USD903101S1 (en) | 2011-05-13 | 2020-11-24 | C. R. Bard, Inc. | Catheter |
US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
WO2013006643A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
AU2012326664A1 (en) | 2011-09-02 | 2014-04-03 | North Carolina State University | Microneedle arrays for biosensing and drug delivery |
EP3574950B1 (en) | 2011-10-27 | 2021-02-17 | Sorrento Therapeutics, Inc. | Transdermal delivery of high viscosity bioactive agents |
US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
PL3542851T3 (pl) | 2011-10-27 | 2022-04-25 | Sorrento Therapeutics, Inc. | Wszczepialne urządzenia do dostarczania środków biologicznie czynnych |
CN104023760A (zh) | 2011-10-28 | 2014-09-03 | 普莱萨格生命科学公司 | 药物递送方法 |
US9317656B2 (en) | 2011-11-23 | 2016-04-19 | Abbott Diabetes Care Inc. | Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof |
DK2791160T3 (da) | 2011-12-16 | 2022-05-30 | Modernatx Inc | Modificerede mrna-sammensætninger |
DE102011089723A1 (de) * | 2011-12-23 | 2013-06-27 | Robert Bosch Gmbh | Mikronadelarray-Applikator und Verfahren zur Applikation eines Mikronadelarrays |
US10130800B2 (en) | 2012-01-27 | 2018-11-20 | Invisiderm, Llc | Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof |
EP2825106B1 (en) * | 2012-03-13 | 2019-05-08 | Becton Dickinson France | Injection device having a miniaturized drug delivery portion |
US10071209B2 (en) | 2012-03-15 | 2018-09-11 | Steadymed Ltd. | Enhanced infusion-site pain-reduction for drug-delivery devices |
ES2715311T3 (es) | 2012-03-19 | 2019-06-03 | Steadymed Ltd | Mecanismo de conexión de fluido para bombas tipo parche |
KR20130114996A (ko) * | 2012-04-10 | 2013-10-21 | 삼성디스플레이 주식회사 | 표시 장치 및 그 제조방법 |
EP4112112A1 (en) | 2012-05-01 | 2023-01-04 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Tip-loaded microneedle arrays for transdermal insertion |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
KR102370581B1 (ko) * | 2012-07-06 | 2022-03-03 | 더 제너럴 하스피탈 코포레이션 | 피부과 치료를 위한 방법 및 장치 |
US9782538B2 (en) | 2012-09-27 | 2017-10-10 | Becton, Dickinson And Company | Angled inserter for drug infusion |
KR20210133321A (ko) | 2012-11-08 | 2021-11-05 | 클리어사이드 바이오메디컬, 인코포레이드 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
KR102265808B1 (ko) | 2012-12-21 | 2021-06-16 | 코리움, 인크. | 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법 |
WO2014113089A2 (en) | 2013-01-17 | 2014-07-24 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
CN108607150B (zh) | 2013-01-30 | 2021-01-12 | 血管通路股份有限公司 | 用于静脉穿刺和导管放置的系统和方法 |
CN105073179B (zh) * | 2013-02-28 | 2019-03-19 | 索伦托治疗有限公司 | 经皮药物递送装置 |
JP6487899B2 (ja) | 2013-03-12 | 2019-03-20 | コリウム インターナショナル, インコーポレイテッド | 微小突起アプリケータ |
US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
JP6098250B2 (ja) * | 2013-03-14 | 2017-03-22 | セイコーエプソン株式会社 | 液体輸送装置 |
US10080839B2 (en) | 2013-03-14 | 2018-09-25 | Becton, Dickinson And Company | Angled inserter for drug infusion |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
EP4194028A1 (en) * | 2013-03-15 | 2023-06-14 | Corium Pharma Solutions, Inc. | Multiple impact microprojection applicators |
US9821113B2 (en) | 2013-03-15 | 2017-11-21 | Becton, Dickinson And Company | Automatic angled infusion set assembly |
EP2968736A4 (en) * | 2013-03-15 | 2016-11-09 | Amgen Inc | ADJUSTABLE TO A BODY SHAPE AUTO INJECTOR DEVICE |
US9603995B2 (en) | 2013-03-15 | 2017-03-28 | Tandem Diabetes Care. Inc. | Device and method for setting therapeutic parameters for an infusion device |
JP2016514133A (ja) | 2013-03-15 | 2016-05-19 | コリウム インターナショナル, インコーポレイテッド | ポリマーを含まない微細構造物を含むマイクロアレイ、製造方法および使用方法 |
MX2015012933A (es) | 2013-03-15 | 2016-09-19 | Corium Int Inc | Micrordenamiento para suministro de agente terapeutico y metodos de uso. |
EP4378444A3 (en) | 2013-05-03 | 2024-07-03 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US20140350516A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Mechanical syringe accessory |
US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
US10149973B2 (en) | 2013-06-14 | 2018-12-11 | Cardiothrive, Inc. | Multipart non-uniform patient contact interface and method of use |
US9656094B2 (en) | 2013-06-14 | 2017-05-23 | Cardiothrive, Inc. | Biphasic or multiphasic pulse generator and method |
US10279189B2 (en) | 2013-06-14 | 2019-05-07 | Cardiothrive, Inc. | Wearable multiphasic cardioverter defibrillator system and method |
US9833630B2 (en) | 2013-06-14 | 2017-12-05 | Cardiothrive, Inc. | Biphasic or multiphasic pulse waveform and method |
US9907970B2 (en) | 2013-06-14 | 2018-03-06 | Cardiothrive, Inc. | Therapeutic system and method using biphasic or multiphasic pulse waveform |
US9616243B2 (en) | 2013-06-14 | 2017-04-11 | Cardiothrive, Inc. | Dynamically adjustable multiphasic defibrillator pulse system and method |
JP6038311B2 (ja) * | 2013-06-18 | 2016-12-07 | 久光製薬株式会社 | アプリケータ |
JP6038310B2 (ja) | 2013-06-19 | 2016-12-07 | 久光製薬株式会社 | アプリケータ |
US20150027241A1 (en) * | 2013-07-23 | 2015-01-29 | Diba Industries, Inc. | Piercing probes with offset conical piercing tip and fluid-sampling systems comprising the piercing probes |
US10299793B2 (en) | 2013-10-23 | 2019-05-28 | Valtech Cardio, Ltd. | Anchor magazine |
US20160367638A1 (en) | 2013-12-19 | 2016-12-22 | Crystal BYERS | LEPTIN mRNA COMPOSITIONS AND FORMULATIONS |
WO2015119906A1 (en) | 2014-02-05 | 2015-08-13 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
GB201403773D0 (en) * | 2014-03-04 | 2014-04-16 | Univ Cardiff | Microneedle based cell delivery |
US10279106B1 (en) | 2014-05-08 | 2019-05-07 | Tandem Diabetes Care, Inc. | Insulin patch pump |
US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
JP6822843B2 (ja) | 2014-06-03 | 2021-01-27 | アムジエン・インコーポレーテツド | 薬物送達装置によって収集されたデータを遠隔で処理するためのシステム及び方法 |
CN106794321A (zh) | 2014-06-20 | 2017-05-31 | 科尼尔赛德生物医学公司 | 可变直径插管以及用于控制对药剂递送的插入深度的方法 |
US10321858B2 (en) | 2014-08-18 | 2019-06-18 | Proteadx, Inc. | Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems |
EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
WO2016037127A1 (en) | 2014-09-05 | 2016-03-10 | C.R. Bard, Inc. | Catheter insertion device including retractable needle |
EP3193973A1 (en) * | 2014-09-15 | 2017-07-26 | Sanofi | Medicament delivery device with rotatable housing on a base |
DE102014219719B4 (de) * | 2014-09-29 | 2018-05-03 | Ipr Intelligente Peripherien Für Roboter Gmbh | Nadelgreifer |
US10226585B2 (en) | 2014-10-01 | 2019-03-12 | Allergan, Inc. | Devices for injection and dosing |
USD750223S1 (en) | 2014-10-14 | 2016-02-23 | Clearside Biomedical, Inc. | Medical injector for ocular injection |
CN105873514B (zh) * | 2014-10-27 | 2018-10-26 | 深圳市光聚通讯技术开发有限公司 | 动态血糖采集装置及主机 |
JP6716566B2 (ja) | 2014-12-19 | 2020-07-01 | アムジエン・インコーポレーテツド | 近接センサ付き薬物送達装置 |
WO2016100055A1 (en) | 2014-12-19 | 2016-06-23 | Amgen Inc. | Drug delivery device with live button or user interface field |
EP3238352A4 (en) | 2014-12-23 | 2018-08-22 | Axell Wireless Ltd. | Harmonizing noise aggregation and noise management in distributed antenna system |
EP3045185A1 (en) * | 2015-01-16 | 2016-07-20 | Sanofi-Aventis Deutschland GmbH | Connector for a container filled with a liquid medicament |
JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | 薬剤送達方法及びシステム |
JP6484345B2 (ja) | 2015-02-17 | 2019-03-20 | アムジエン・インコーポレーテツド | 固定及び/または戻りが真空によって支援された薬物送達装置 |
WO2016145230A1 (en) | 2015-03-10 | 2016-09-15 | Unger Jacob G | Multiple needle injector |
EP3267875A4 (en) | 2015-03-12 | 2018-12-05 | Chrono Therapeutics Inc. | Craving input and support system |
WO2016149673A1 (en) | 2015-03-18 | 2016-09-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
USD903100S1 (en) | 2015-05-01 | 2020-11-24 | C. R. Bard, Inc. | Catheter placement device |
JP6784352B2 (ja) * | 2015-05-11 | 2020-11-11 | 国立大学法人 東京医科歯科大学 | インスリン送達用デバイス |
US11040176B2 (en) | 2015-05-15 | 2021-06-22 | C. R. Bard, Inc. | Catheter placement device including an extensible needle safety component |
US10463847B2 (en) | 2015-06-11 | 2019-11-05 | Steadymed Ltd. | Infusion set |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US10940292B2 (en) | 2015-07-08 | 2021-03-09 | Actuated Medical, Inc. | Reduced force device for intravascular access and guidewire placement |
US11793543B2 (en) | 2015-09-18 | 2023-10-24 | Obvius Robotics, Inc. | Device and method for automated insertion of penetrating member |
WO2017066768A1 (en) | 2015-10-16 | 2017-04-20 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices |
US11744889B2 (en) | 2016-01-05 | 2023-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
EP3413851B1 (en) | 2016-02-10 | 2023-09-27 | Clearside Biomedical, Inc. | Packaging |
US10980992B2 (en) * | 2016-02-19 | 2021-04-20 | North Carolina State University | Methods and compositions related to physiologically responsive microneedle delivery systems |
CA3018223A1 (en) | 2016-03-28 | 2017-10-05 | Ichor Medical Systems, Inc. | Method and apparatus for delivery of therapeutic agents |
CN109310827B (zh) | 2016-04-08 | 2021-09-07 | 阿勒根公司 | 抽吸和注射装置 |
EP3452165A1 (en) | 2016-05-02 | 2019-03-13 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
NL2016807B1 (en) * | 2016-05-20 | 2017-11-27 | Uprax | System and method for applying microneedles |
EP3458141A1 (en) * | 2016-05-20 | 2019-03-27 | Uprax Microsolutions B.V. | System and method for applying microneedles |
US10220195B2 (en) * | 2016-06-08 | 2019-03-05 | Eclipse Medcorp, Llc | Radio frequency needling device for use with disposable needle cartridges |
IL305537A (en) | 2016-08-12 | 2023-10-01 | Clearside Biomedical Inc | Devices and methods for adjusting the insertion depth of a drug administration needle |
EP4424355A2 (en) | 2016-09-12 | 2024-09-04 | C. R. Bard, Inc. | Blood control for a catheter insertion device |
US11241563B2 (en) | 2016-12-22 | 2022-02-08 | Johnson & Johnson Consumer Inc. | Microneedle arrays and methods for making and using |
EP3338832A1 (en) * | 2016-12-23 | 2018-06-27 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device |
EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
EP3585471A4 (en) | 2017-03-01 | 2021-03-10 | C.R. Bard, Inc. | CATHETER INTRODUCTION DEVICE |
USD867582S1 (en) | 2017-03-24 | 2019-11-19 | Allergan, Inc. | Syringe device |
WO2018191361A1 (en) | 2017-04-13 | 2018-10-18 | Teleflex Medical Incorporated | Catheter insertion device |
US11045142B1 (en) | 2017-04-29 | 2021-06-29 | Biolinq, Inc. | Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry |
WO2018204515A1 (en) | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
CN109833562B (zh) * | 2017-11-27 | 2024-03-15 | 苏州纳通生物纳米技术有限公司 | 一种一次性自毁式振动头组件以及应用该组件的促渗仪 |
US10828500B2 (en) | 2017-12-22 | 2020-11-10 | Cardiothrive, Inc. | External defibrillator |
CN111818953A (zh) * | 2018-01-07 | 2020-10-23 | 亚夫拉罕·阿米尔 | 用于皮肤改善的高负载微针和组合物 |
US11389626B2 (en) | 2018-03-07 | 2022-07-19 | Bard Access Systems, Inc. | Guidewire advancement and blood flashback systems for a medical device insertion system |
US11090506B2 (en) * | 2018-05-15 | 2021-08-17 | Omm Imports, Inc. | Disposable product cap and assembly having a manually usable thermo-optical device for skin care |
AU2019279884A1 (en) | 2018-05-29 | 2020-12-10 | Morningside Venture Investments Limited | Drug delivery methods and systems |
JP7476119B2 (ja) | 2018-06-29 | 2024-04-30 | ジョンソン アンド ジョンソン コンシューマー インコーポレイテッド | 活性物質の送達のための三次元マイクロ流体デバイス |
USD921884S1 (en) | 2018-07-27 | 2021-06-08 | Bard Access Systems, Inc. | Catheter insertion device |
FR3084578B1 (fr) * | 2018-08-03 | 2024-01-12 | Pkvitality | Gestion enfoncement de microaiguilles |
WO2020172567A1 (en) | 2019-02-22 | 2020-08-27 | Deka Products Limited Partnership | Infusion set and inserter assembly systems and methods |
WO2020188484A1 (en) * | 2019-03-19 | 2020-09-24 | King Abdullah University Of Science And Technology | Miniaturized delivery system and method |
US11590332B2 (en) * | 2019-04-17 | 2023-02-28 | Path Scientific, Llc | Precision microneedling device and methods of use |
GB201908043D0 (en) * | 2019-06-05 | 2019-07-17 | Lekkos Vasileios | Transdermal patch for therapeutic uses |
KR102279603B1 (ko) * | 2019-06-11 | 2021-07-20 | (주)비올 | 바늘 조립체, 이를 포함하는 피부 자극기 및 그 제조 방법 |
CN114364976A (zh) * | 2019-07-12 | 2022-04-15 | 曲莱博医疗有限公司 | 电化学fet传感器 |
WO2021020730A2 (ko) * | 2019-07-26 | 2021-02-04 | 주식회사 림사이언스 | 의료용 니들을 가압하는 장치 |
WO2021034862A1 (en) | 2019-08-19 | 2021-02-25 | Becton, Dickinson And Company | Midline catheter placement device |
US20220379022A1 (en) * | 2019-10-30 | 2022-12-01 | Thermalin, Inc. | Agent delivery systems, devices, and methods |
EP4108286A4 (en) * | 2020-02-20 | 2024-03-13 | Jubilee Biotech Co., Ltd. | APPLICATOR FOR ADMINISTRATION OF DRUGS AND MICRO-NEEDLE PATCH USED THEREFOR |
DK4048152T3 (da) | 2020-07-29 | 2024-03-11 | Biolinq Incorporated | System til kontinuerlig analytovervågning med mikronålsindretning |
CN112370653B (zh) * | 2020-11-12 | 2022-08-30 | 深圳市圣通生物科技有限公司 | 一种喷淋消毒式纳米微针中胚层导入美容仪 |
WO2022187821A1 (en) * | 2021-03-01 | 2022-09-09 | Bluexthermal, Inc. | Device and method for thermal modulation of tissue |
US11510602B1 (en) | 2021-11-08 | 2022-11-29 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US12029562B2 (en) | 2021-04-14 | 2024-07-09 | Satio, Inc. | Dermal patch system |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
WO2022240700A1 (en) | 2021-05-08 | 2022-11-17 | Biolinq Incorporated | Fault detection for microneedle array based continuous analyte monitoring device |
US12059371B2 (en) | 2022-01-04 | 2024-08-13 | Bluexthermal, Inc. | Ocular region heat transfer devices and associated systems and methods |
CN115177258B (zh) * | 2022-06-07 | 2024-08-20 | 东华大学 | 一种自锁导电心肌补片及其制备方法 |
EP4295873A1 (en) * | 2022-06-21 | 2023-12-27 | National University of Ireland Galway | An infusion catheter system |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3537A (en) * | 1844-04-13 | X g gupping instrument | ||
US3659A (en) * | 1844-07-11 | Machine for hulling and pearling rice | ||
US447225A (en) * | 1891-02-24 | Machine for attaching stays to the corners of boxes | ||
US1934043A (en) | 1929-05-17 | 1933-11-07 | Standard Oil Dev Co | Process of improvement of lubricating oils |
DE596981C (de) * | 1931-10-30 | 1934-05-12 | Mario Demarchi Dr | Injektionsspritze |
FR757501A (fr) | 1932-09-23 | 1933-12-28 | Dispositif automatique pour la manceuvre des seringues d'injection | |
US2088780A (en) * | 1936-10-09 | 1937-08-03 | Sigurd E Follese | Massage device |
US2763935A (en) | 1954-06-11 | 1956-09-25 | Purdne Res Foundation | Determining depth of layers of fat and of muscle on an animal body |
US2945496A (en) * | 1958-08-18 | 1960-07-19 | Fosdal Alfred | Dental instrument for immobilizing tissue |
DE1115722B (de) | 1960-04-30 | 1961-10-26 | Hoechst Ag | Metallanode fuer die elektrolytische Abscheidung von Chlor |
GB1128329A (en) * | 1964-12-23 | 1968-09-25 | Nat Res Dev | Electrodes for making electrical contact to the living body of a mammal |
US3568735A (en) * | 1968-06-26 | 1971-03-09 | Cooke Eng Co | Laboratory microtitration dispensing apparatus |
US3568732A (en) | 1969-02-28 | 1971-03-09 | Kelly James A Jun | Splice straightener for aerial conductors |
US3659600A (en) * | 1970-02-24 | 1972-05-02 | Estin Hans H | Magnetically operated capsule for administering drugs |
US3727614A (en) | 1971-05-13 | 1973-04-17 | Merck & Co Inc | Multiple dosage inoculator |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3738493A (en) * | 1971-09-24 | 1973-06-12 | Analytical Instr Spec | Apparatus for simultaneous application of samples to thin layer chromatography plates |
BE795384A (fr) * | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
CH557178A (de) | 1972-08-10 | 1974-12-31 | Siemens Ag | Geraet fuer die zufuehrung von medikamenten. |
US3923060A (en) * | 1974-04-23 | 1975-12-02 | Jr Everett H Ellinwood | Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means |
US4140109A (en) * | 1977-10-17 | 1979-02-20 | Savic Michael I | Impedance-based method and apparatus for monitoring cryodestruction in controlled cryosurgery |
FR2460343A1 (fr) | 1979-06-29 | 1981-01-23 | Solvay | Cathode pour la production electrolytique d'hydrogene |
JPS5683360A (en) * | 1979-12-10 | 1981-07-07 | Olympus Optical Co | Pneumoperitoneum needle |
US4447225A (en) * | 1982-03-22 | 1984-05-08 | Taff Barry E | Multidose jet injector |
US4619652A (en) | 1982-12-23 | 1986-10-28 | Alza Corporation | Dosage form for use in a body mounted pump |
US4505710A (en) | 1983-05-13 | 1985-03-19 | Collins Earl R | Implantable fluid dispensing system |
DE3502913C1 (de) * | 1985-01-29 | 1986-07-03 | Günter Prof. Dr.rer.nat. 5100 Aachen Rau | Messaufnehmer zur nichtinvasiven Erfassung elektrophysiologischer Groessen |
US4777599A (en) * | 1985-02-26 | 1988-10-11 | Gillette Company | Viscoelastometry of skin using shear wave propagation |
FR2594341B1 (fr) * | 1986-02-14 | 1990-08-10 | Charton Jean Pierre | Appareil injecteur pour la pratique de la mesotherapie |
AT384737B (de) * | 1986-04-04 | 1987-12-28 | Thoma Dipl Ing Dr Techn Herwig | Vorrichtung zur stroemungskonstanten abgabe fluessiger arzneimittel |
EP0260953B1 (en) * | 1986-09-18 | 1994-03-30 | Paul G. Yock | Device for use in the cannulation of blood vessels |
CA1283827C (en) * | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
US4808156A (en) * | 1987-03-09 | 1989-02-28 | Dean Consuelo M | Cannular instrument and method for inserting a cannular instrument into a vein |
US6056716A (en) * | 1987-06-08 | 2000-05-02 | D'antonio Consultants International Inc. | Hypodermic fluid dispenser |
DD262803A1 (de) | 1987-08-05 | 1988-12-14 | Transform Roentgen Matern Veb | Injektionseinrichtung |
US5312486A (en) | 1987-12-24 | 1994-05-17 | Frank Meyer | Water-containing, hardenable foam compositions with inorganic components and process for their preparation |
US4989614A (en) * | 1988-02-23 | 1991-02-05 | Vance Products Incorporated | Fine-needle aspiration cell sampling methods |
CA2008262A1 (en) * | 1989-01-30 | 1990-07-30 | John A. Gilly | Clinical applicator |
US5425706A (en) | 1989-02-24 | 1995-06-20 | S. I. Scientific Innovations Ltd. | Dispensing device particularly useful for dispensing nutritional liquids |
US5062834A (en) | 1989-02-24 | 1991-11-05 | Product Development (S.G.Z.) Ltd | Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate |
JPH0648975B2 (ja) * | 1989-10-02 | 1994-06-29 | 俊郎 樋口 | 微小インジェクション装置及びそのインジェクション制御方法 |
US5262128A (en) * | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
US6090790A (en) * | 1989-12-14 | 2000-07-18 | Eriksson; Elof | Gene delivery by microneedle injection |
US5697901A (en) * | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
US5092901A (en) * | 1990-06-06 | 1992-03-03 | The Royal Institution For The Advancement Of Learning (Mcgill University) | Shape memory alloy fibers having rapid twitch response |
US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
TW279133B (ja) * | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
US5156591A (en) * | 1990-12-13 | 1992-10-20 | S. I. Scientific Innovations Ltd. | Skin electrode construction and transdermal drug delivery device utilizing same |
US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US5279547A (en) * | 1991-01-03 | 1994-01-18 | Alcon Surgical Inc. | Computer controlled smart phacoemulsification method and apparatus |
SE9101022D0 (sv) * | 1991-01-09 | 1991-04-08 | Paal Svedman | Medicinsk suganordning |
US5312456A (en) | 1991-01-31 | 1994-05-17 | Carnegie Mellon University | Micromechanical barb and method for making the same |
US5533995A (en) * | 1991-11-13 | 1996-07-09 | Elan Corporation, Plc | Passive transdermal device with controlled drug delivery |
US6048337A (en) * | 1992-01-07 | 2000-04-11 | Principal Ab | Transdermal perfusion of fluids |
WO1993013718A1 (en) * | 1992-01-21 | 1993-07-22 | Valleylab, Inc. | Electrosurgical control for a trocar |
US5252023A (en) * | 1992-02-10 | 1993-10-12 | Kelly Kevin M | Lifting apparatus |
JP2572823Y2 (ja) * | 1992-02-13 | 1998-05-25 | 株式会社アドバンス | 簡易採血器 |
WO1993020784A1 (en) * | 1992-04-10 | 1993-10-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A microneedle for injection of ocular blood vessels |
US5478328A (en) * | 1992-05-22 | 1995-12-26 | Silverman; David G. | Methods of minimizing disease transmission by used hypodermic needles, and hypodermic needles adapted for carrying out the method |
JPH0698920A (ja) * | 1992-09-21 | 1994-04-12 | Hayashi Shigetada | 鍼灸精密測定器 |
US5354273A (en) * | 1992-12-14 | 1994-10-11 | Mallinckrodt Medical, Inc. | Delivery apparatus with pressure controlled delivery |
US5478323A (en) | 1993-04-02 | 1995-12-26 | Eli Lilly And Company | Manifold for injection apparatus |
IE68890B1 (en) | 1993-04-08 | 1996-07-24 | Elan Med Tech | Intradermal delivery device |
US5335668A (en) * | 1993-04-30 | 1994-08-09 | Medical Scientific, Inc. | Diagnostic impedance measuring system for an insufflation needle |
JP3494183B2 (ja) * | 1993-08-10 | 2004-02-03 | 株式会社アドバンス | 簡易採血装置 |
WO1995007722A1 (en) | 1993-09-14 | 1995-03-23 | North Shore Laboratories Pty. Ltd. | Injection device |
US5389222A (en) * | 1993-09-21 | 1995-02-14 | The United States Of America As Represented By The United States Department Of Energy | Spring-loaded polymeric gel actuators |
US5599345A (en) * | 1993-11-08 | 1997-02-04 | Zomed International, Inc. | RF treatment apparatus |
US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
DE19518932C2 (de) * | 1994-05-23 | 1999-03-18 | Samsung Electro Mech | Vorrichtung zur Perforation der Haut für die Vorbereitung einer transdermalen Medikation |
CA2149836C (en) * | 1994-05-23 | 1999-07-06 | Sang Bae Choi | Perforating device for dermal administration |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
DE4420232A1 (de) | 1994-06-07 | 1995-12-14 | Robert Waltereit | Vorrichtung zur Prüfung der Eindringtiefe einer Kanüle oder Sonde in den Körper eines Patienten |
US5649423A (en) * | 1994-06-07 | 1997-07-22 | Sandia Corporation | Micromechanism linear actuator with capillary force sealing |
US5478315A (en) * | 1994-08-08 | 1995-12-26 | Brothers Family Investments, L.C. | Local anesthetic injection system |
US5432098A (en) * | 1994-10-31 | 1995-07-11 | Dynatech Precision Sampling Corporation | Apparatus, and process, for automatically sampling solids and semi-solids materials for analysis |
IE72524B1 (en) * | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
GB9508606D0 (en) | 1995-04-27 | 1995-06-14 | Svedman Paul | Suction blister sampling |
WO1996037155A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
AU5869796A (en) | 1995-05-22 | 1996-12-11 | Ned A. Godshall | Micromechanical patch for enhancing the delivery of compound s through the skin |
US5827216A (en) | 1995-06-07 | 1998-10-27 | Cormedics Corp. | Method and apparatus for accessing the pericardial space |
US5858001A (en) * | 1995-12-11 | 1999-01-12 | Elan Medical Technologies Limited | Cartridge-based drug delivery device |
JPH09192218A (ja) * | 1996-01-16 | 1997-07-29 | Hitachi Ltd | 血糖値管理システム |
JPH09239031A (ja) * | 1996-03-09 | 1997-09-16 | Honda Electron Co Ltd | 超音波振動子を装着した注射器 |
US5843016A (en) * | 1996-03-18 | 1998-12-01 | Physion S.R.L. | Electromotive drug administration for treatment of acute urinary outflow obstruction |
US6117155A (en) * | 1996-05-01 | 2000-09-12 | Lee; Young H. | Coated needle for use with an intramuscular stimulation treatment device |
US5785688A (en) * | 1996-05-07 | 1998-07-28 | Ceramatec, Inc. | Fluid delivery apparatus and method |
US5954668A (en) * | 1996-06-14 | 1999-09-21 | Medrad, Inc. | Extravasation detector using microwave radiometry |
ES2195151T3 (es) | 1996-06-18 | 2003-12-01 | Alza Corp | Dispositivo de mejora de aporte o de muestreo de agentes transdermicos. |
CA2259437C (en) * | 1996-07-03 | 2006-12-05 | Altea Technologies, Inc. | Multiple mechanical microporation of skin or mucosa |
JPH1043296A (ja) * | 1996-08-05 | 1998-02-17 | Terumo Corp | 薬液注入器具 |
JP4054381B2 (ja) * | 1996-09-17 | 2008-02-27 | デカ・プロダクツ・リミテッド・パートナーシップ | 移送による薬伝達システム |
US6071249A (en) * | 1996-12-06 | 2000-06-06 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
SE9604564D0 (sv) * | 1996-12-12 | 1996-12-12 | Paal Svedman | Sätt och anordning vid avledning av elektriska strömmar |
US6246904B1 (en) * | 1996-12-17 | 2001-06-12 | Alza Corporation | Electrotransport drug delivery reservoirs containing inert fillers |
US5928194A (en) * | 1997-04-07 | 1999-07-27 | Maget; Henri J. R. | Self-contained liquid microdispenser |
US5928207A (en) * | 1997-06-30 | 1999-07-27 | The Regents Of The University Of California | Microneedle with isotropically etched tip, and method of fabricating such a device |
US5972013A (en) | 1997-09-19 | 1999-10-26 | Comedicus Incorporated | Direct pericardial access device with deflecting mechanism and method |
JPH11137684A (ja) * | 1997-11-12 | 1999-05-25 | Hiroshi Oya | 無痛安全注射器 |
CA2311343C (en) * | 1997-11-26 | 2007-05-22 | E-Z-Em, Inc. | Extravasation detection technique |
US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
ATE302041T1 (de) * | 1997-12-11 | 2005-09-15 | Alza Corp | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
DE69806963T2 (de) * | 1997-12-11 | 2002-11-21 | Alza Corp., Mountain View | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
US6126629A (en) * | 1997-12-18 | 2000-10-03 | Bausch & Lomb Surgical, Inc. | Multiple port phaco needle |
US6154673A (en) | 1997-12-30 | 2000-11-28 | Agilent Technologies, Inc. | Multilingual defibrillator |
US6048204A (en) * | 1998-02-03 | 2000-04-11 | Lifecore Biomedical, Inc. | Self tapping screw type dental implant |
US5957895A (en) * | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US5971998A (en) | 1998-03-31 | 1999-10-26 | Donald G. Russell | Support device and method for controlling breast thickness during stereotactic guided needle biopsy |
CA2311487C (en) * | 1998-05-13 | 2004-02-10 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
DE69910003T2 (de) * | 1998-05-13 | 2004-04-22 | Cygnus, Inc., Redwood City | Überwachung physiologischer analyte |
CA2334174A1 (en) | 1998-06-04 | 1999-12-09 | Izrail Tsals | Gas driven drug delivery device |
JP2002517300A (ja) | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
US6678556B1 (en) * | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
GB9815819D0 (en) | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
GB9815820D0 (en) | 1998-07-22 | 1998-09-16 | Secr Defence | Improvements relating to micro-machining |
EP1100566A4 (en) * | 1998-07-27 | 2002-03-20 | Medi Ject Corp | LOADING MECHANISM FOR MEDICAL INJECTOR ASSEMBLY |
CA2344398A1 (en) | 1998-09-18 | 2000-03-30 | The University Of Utah | Surface micromachined microneedles |
DE19843733A1 (de) * | 1998-09-24 | 2000-03-30 | Voith Sulzer Papiertech Patent | Rakelvorrichtung |
US6148232A (en) * | 1998-11-09 | 2000-11-14 | Elecsys Ltd. | Transdermal drug delivery and analyte extraction |
US6317630B1 (en) * | 1999-01-29 | 2001-11-13 | Yossi Gross | Drug delivery device |
US6132449A (en) * | 1999-03-08 | 2000-10-17 | Agilent Technologies, Inc. | Extraction and transportation of blood for analysis |
US6319230B1 (en) * | 1999-05-07 | 2001-11-20 | Scimed Life Systems, Inc. | Lateral needle injection apparatus and method |
US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
ATE462468T1 (de) | 1999-06-04 | 2010-04-15 | Georgia Tech Res Inst | Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6607495B1 (en) * | 1999-06-18 | 2003-08-19 | University Of Virginia Patent Foundation | Apparatus for fluid transport and related method thereof |
US6408204B1 (en) * | 1999-07-28 | 2002-06-18 | Medrad, Inc. | Apparatuses and methods for extravasation detection |
CA2390252A1 (en) * | 1999-11-15 | 2001-05-25 | Velcro Industries B.V. | Skin attachment member |
AU2088301A (en) * | 1999-12-16 | 2001-06-25 | Alza Corporation | Device for enhancing transdermal flux of sampled agents |
US7003336B2 (en) * | 2000-02-10 | 2006-02-21 | Medtronic Minimed, Inc. | Analyte sensor method of making the same |
US6572740B2 (en) | 2000-04-13 | 2003-06-03 | Elan Pharma International Limited | Electrolytic cell |
US6565532B1 (en) * | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US6440096B1 (en) * | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
JP2002028247A (ja) * | 2000-07-18 | 2002-01-29 | Japan Science & Technology Corp | 穿刺針による静脈刺入の感知方法及び装置 |
EP2578252B1 (en) | 2000-11-30 | 2019-01-09 | Valeritas, Inc. | Device with substantially freely movable micro-probe over the housing |
WO2002100469A2 (en) | 2001-06-11 | 2002-12-19 | Glaxo Group Limited | Medicament dispenser for containers of varying sizes |
US6835193B2 (en) | 2001-07-10 | 2004-12-28 | Myocardial Therapeutics, Inc. | Methods for controlled depth injections into interior body cavities |
US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
AU2002360712A1 (en) * | 2001-12-21 | 2003-07-30 | The Trustees Of Columbia University In The City Of New York | C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis |
EP1403519A1 (en) * | 2002-09-27 | 2004-03-31 | Novo Nordisk A/S | Membrane pump with stretchable pump membrane |
-
2002
- 2002-09-09 US US10/238,844 patent/US7429258B2/en not_active Expired - Fee Related
- 2002-10-18 CA CA2464483A patent/CA2464483C/en not_active Expired - Fee Related
- 2002-10-18 WO PCT/US2002/033544 patent/WO2003037403A1/en active Application Filing
- 2002-10-18 DE DE60230896T patent/DE60230896D1/de not_active Expired - Lifetime
- 2002-10-18 AT AT02789233T patent/ATE420680T1/de not_active IP Right Cessation
- 2002-10-18 AU AU2002353840A patent/AU2002353840B2/en not_active Ceased
- 2002-10-18 JP JP2003539742A patent/JP2005525141A/ja active Pending
- 2002-10-18 EP EP02789233A patent/EP1439871B1/en not_active Expired - Lifetime
- 2002-10-21 AT AT02782208T patent/ATE386561T1/de not_active IP Right Cessation
- 2002-10-21 US US10/277,724 patent/US20030083618A1/en not_active Abandoned
- 2002-10-21 US US10/278,049 patent/US7364568B2/en not_active Expired - Fee Related
- 2002-10-21 WO PCT/US2002/033794 patent/WO2003037404A1/en active IP Right Grant
- 2002-10-21 US US10/278,050 patent/US7066922B2/en not_active Expired - Lifetime
- 2002-10-21 US US10/277,722 patent/US7645263B2/en not_active Expired - Fee Related
- 2002-10-21 JP JP2003539743A patent/JP4612304B2/ja not_active Expired - Fee Related
- 2002-10-21 DE DE60225172T patent/DE60225172D1/de not_active Expired - Lifetime
- 2002-10-21 EP EP02782208A patent/EP1446176B1/en not_active Expired - Lifetime
- 2002-10-21 CA CA2464485A patent/CA2464485C/en not_active Expired - Fee Related
- 2002-10-22 CA CA002464487A patent/CA2464487A1/en not_active Abandoned
- 2002-10-22 CA CA2464670A patent/CA2464670C/en not_active Expired - Fee Related
- 2002-10-22 EP EP02784221A patent/EP1448253B1/en not_active Expired - Lifetime
- 2002-10-22 WO PCT/US2002/033829 patent/WO2003037406A2/en not_active Application Discontinuation
- 2002-10-22 JP JP2003539746A patent/JP4610193B2/ja not_active Expired - Fee Related
- 2002-10-22 DE DE60230795T patent/DE60230795D1/de not_active Expired - Lifetime
- 2002-10-22 EP EP02789250A patent/EP1443990A1/en not_active Ceased
- 2002-10-22 EP EP02784220A patent/EP1438092A2/en not_active Withdrawn
- 2002-10-22 AU AU2002353855A patent/AU2002353855B2/en not_active Ceased
- 2002-10-22 CA CA2464673A patent/CA2464673C/en not_active Expired - Fee Related
- 2002-10-22 WO PCT/US2002/033830 patent/WO2003037407A1/en active Application Filing
- 2002-10-22 WO PCT/US2002/033823 patent/WO2003037405A1/en active Application Filing
- 2002-10-22 AU AU2002348009A patent/AU2002348009B9/en not_active Ceased
- 2002-10-22 JP JP2003539744A patent/JP4610192B2/ja not_active Expired - Fee Related
- 2002-10-22 AT AT02784221T patent/ATE419885T1/de not_active IP Right Cessation
- 2002-10-22 JP JP2003539745A patent/JP2005507715A/ja active Pending
-
2005
- 2005-10-19 JP JP2005304325A patent/JP2006081918A/ja active Pending
-
2008
- 2008-01-11 US US11/972,726 patent/US7651475B2/en not_active Expired - Fee Related
- 2008-04-29 US US12/150,606 patent/US8246582B2/en not_active Expired - Fee Related
-
2009
- 2009-05-11 JP JP2009114989A patent/JP2009219886A/ja active Pending
- 2009-05-11 JP JP2009114992A patent/JP2009219888A/ja active Pending
- 2009-05-11 JP JP2009114990A patent/JP2009240790A/ja active Pending
- 2009-05-11 JP JP2009114991A patent/JP2009219887A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4612304B2 (ja) | 微細針経皮的輸送装置 | |
AU2002353855A1 (en) | Impedance sensor | |
AU2002348009A1 (en) | Transdermal transport device with suction | |
AU2002353840A1 (en) | Microneedle transport device | |
AU2002348386A1 (en) | Microneedle transdermal transport device | |
AU2002348008A1 (en) | Transdermal transport device with an electrolytic actuator |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051020 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20051020 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20081111 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090116 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090123 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090511 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20091027 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100105 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100113 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100427 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100921 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20101015 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131022 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |