JP4610193B2 - 吸引機構を有する経皮的輸送装置 - Google Patents
吸引機構を有する経皮的輸送装置 Download PDFInfo
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- JP4610193B2 JP4610193B2 JP2003539746A JP2003539746A JP4610193B2 JP 4610193 B2 JP4610193 B2 JP 4610193B2 JP 2003539746 A JP2003539746 A JP 2003539746A JP 2003539746 A JP2003539746 A JP 2003539746A JP 4610193 B2 JP4610193 B2 JP 4610193B2
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- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
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- A61M2005/1581—Right-angle needle-type devices
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0266—Shape memory materials
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
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- A—HUMAN NECESSITIES
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- A61M2230/00—Measuring parameters of the user
- A61M2230/65—Impedance, e.g. conductivity, capacity
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
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- Vascular Medicine (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Diabetes (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- External Artificial Organs (AREA)
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Description
2H2O(l)→O2(g)+4H+(aq)+4e−
他方は以下に示す陰極で生じる還元反応である。
2H2O(l)+2e−→H2(g)+OH−
電子数の釣り合いを保つため、陰極での還元反応は陽極での酸化反応の2倍生じなければならない。したがって、陰極での還元反応を2倍して2つの酸化および還元反応を足し合わせると、全体としての反応は、
6H2O(l)+4e−
→2H2(g)+O2(g)+4H+(aq)+4OH−(aq)+4e−
となる。H+とOH−がH2Oを形成し、さらに等式の両辺に現れるイオン種を相殺すると、全体として正味の反応は、
6H2O(l)→2H2(g)+O2(g)
となる。
ngc=nge/(eNA)=7.784×10−6mol/C
ここで、ngeは、上記反応系に投入された電子1個当たりに生成される気体のモル数、すなわち4分の3(3/4)であり、eは1個の電子の電荷であり、NAはアボガドロ定数である。この変換は、例えば3桁を超える大きな体積変化を引き起こし、この体積変化が、リザーバ46から薬を吐出するために利用される。水の水素および酸素への変換が生じると、体積膨張によってフレキシブル膜48が押されて、リザーバ46から薬および任意の担体あるいはその他の化合物や溶媒が、微細針14を通して放出される。
11 接続具
12 投薬器
14 微細針
16 電池
18 プロセッサ
20 ハウジング
22 表示器
24 通信カード
26 電磁石
28 真空ポンプ
30 アクチュエータ
32 インピーダンス・センサ
34 スピーカ
37 圧力センサ
62 先端
Claims (16)
- 特定成分の物質を収容する貯留室と、
前記貯留室と生体との間で輸送される際に前記物質が通過するボアをそれぞれ有し、経皮的輸送装置が前記生体の体表面に置かれたとき前記体表面と平行な面にほぼ整列する端部を有し、前記面とほぼ垂直な軸を中心として回転する1本以上の針と、
前記針が前記面とほぼ平行な方向に沿って移動するときに、前記体表面の一部分を前記面よりも上方に吸引して、前記針の端部が前記体表面の前記一部分を貫通するようにする吸引力を発生させる真空発生器と、
を備えた経皮的輸送装置。 - 請求項1において、前記真空発生器による真空を利用して、前記輸送装置を前記体表面に固定する経皮的輸送装置。
- 請求項2において、前記針が皮膚を貫通した後に前記真空吸引が停止される経皮的輸送装置。
- 請求項3において、前記1本以上の針によって前記体表面に取り付けられている経皮的輸送装置。
- 請求項1において、前記1本以上の針が0〜90°の挿入角度に合わせた向きに設定されている経皮的輸送装置。
- 請求項1において、前記1本以上の針が所定の深さよりも深く貫入しないようにするための機械ストッパが設けられている経皮的輸送装置。
- 物質が通過するボアを有し、一端部が経皮的輸送装置が生体の体表面に置かれたときに前記体表面よりも上方に位置し、前記一端部が前記面とほぼ垂直な軸を中心として回転する針と、
前記針が前記面に沿って移動するときに、前記体表面の一部分を前記一端部よりも上方に吸引して、前記針の一端部が前記体表面の前記一部分を貫通することを可能にする吸引力を発生させる真空発生器と、
を備えた経皮的輸送装置。 - 請求項7において、前記針を前記体表面に挿入することで前記体表面の一部に付着し、この付着は前記真空発生器を停止した後も持続する経皮的輸送装置。
- 生体の体表面に物質を輸送する経皮的輸送装置であって、
前記体表面の一部分を体表面よりも上方に吸引する真空発生器と、
前記体表面とほぼ垂直な軸を中心として回転し、回転時に一端部が前記体表面における吸引された部分を貫通する1本以上の針と、
を備えた経皮的輸送装置。 - 請求項9において、前記1本以上の針が0〜90°の挿入角度に合わせた向きに設定されている経皮的輸送装置。
- 請求項9において、前記1本以上の針によって前記体表面に取り付けられている経皮的輸送装置。
- 請求項9において、さらに、前記1本以上の針の挿入深さを制御する機械ストッパを備えた経皮的輸送装置。
- 生体の体表面に物質を輸送する経皮的輸送装置であって、
前記体表面の少なくとも一部分を体表面よりも上方に吸引する真空発生器と、
前記体表面とほぼ垂直な軸を中心として回転する複数の針とを備え、
前記複数の針の少なくとも1本の一端部が、回転時に前記体表面における吸引された部分を貫通する経皮的輸送装置。 - 請求項13において、前記真空発生器が前記体表面の複数部分を前記体表面よりも上方に吸引し、前記複数の針のそれぞれが前記体表面における吸引された各部分を貫通する経皮的輸送装置。
- 請求項13において、前記複数の針によって前記体表面に取り付けられている経皮的輸送装置。
- 請求項15において、前記真空発生器を停止した後も前記体表面に保持される経皮的輸送装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33842501P | 2001-10-26 | 2001-10-26 | |
US39948902P | 2002-07-29 | 2002-07-29 | |
PCT/US2002/033830 WO2003037407A1 (en) | 2001-10-26 | 2002-10-22 | Transdermal transport device with suction |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2009114992A Division JP2009219888A (ja) | 2001-10-26 | 2009-05-11 | 吸引機構を有する経皮的輸送装置 |
Publications (2)
Publication Number | Publication Date |
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JP2005507716A JP2005507716A (ja) | 2005-03-24 |
JP4610193B2 true JP4610193B2 (ja) | 2011-01-12 |
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ID=26991185
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003539742A Pending JP2005525141A (ja) | 2001-10-26 | 2002-10-18 | 微細針輸送装置 |
JP2003539743A Expired - Fee Related JP4612304B2 (ja) | 2001-10-26 | 2002-10-21 | 微細針経皮的輸送装置 |
JP2003539746A Expired - Fee Related JP4610193B2 (ja) | 2001-10-26 | 2002-10-22 | 吸引機構を有する経皮的輸送装置 |
JP2003539745A Pending JP2005507715A (ja) | 2001-10-26 | 2002-10-22 | 電気分解式アクチュエータを有する経皮的輸送装置 |
JP2003539744A Expired - Fee Related JP4610192B2 (ja) | 2001-10-26 | 2002-10-22 | インピーダンス・センサ |
JP2005304325A Pending JP2006081918A (ja) | 2001-10-26 | 2005-10-19 | 蒸気発生式アクチュエータを有する経皮的輸送装置 |
JP2009114991A Pending JP2009219887A (ja) | 2001-10-26 | 2009-05-11 | インピーダンス・センサ |
JP2009114989A Pending JP2009219886A (ja) | 2001-10-26 | 2009-05-11 | 微細針輸送装置 |
JP2009114992A Pending JP2009219888A (ja) | 2001-10-26 | 2009-05-11 | 吸引機構を有する経皮的輸送装置 |
JP2009114990A Pending JP2009240790A (ja) | 2001-10-26 | 2009-05-11 | 微細針経皮的輸送装置 |
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JP2003539742A Pending JP2005525141A (ja) | 2001-10-26 | 2002-10-18 | 微細針輸送装置 |
JP2003539743A Expired - Fee Related JP4612304B2 (ja) | 2001-10-26 | 2002-10-21 | 微細針経皮的輸送装置 |
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JP2003539745A Pending JP2005507715A (ja) | 2001-10-26 | 2002-10-22 | 電気分解式アクチュエータを有する経皮的輸送装置 |
JP2003539744A Expired - Fee Related JP4610192B2 (ja) | 2001-10-26 | 2002-10-22 | インピーダンス・センサ |
JP2005304325A Pending JP2006081918A (ja) | 2001-10-26 | 2005-10-19 | 蒸気発生式アクチュエータを有する経皮的輸送装置 |
JP2009114991A Pending JP2009219887A (ja) | 2001-10-26 | 2009-05-11 | インピーダンス・センサ |
JP2009114989A Pending JP2009219886A (ja) | 2001-10-26 | 2009-05-11 | 微細針輸送装置 |
JP2009114992A Pending JP2009219888A (ja) | 2001-10-26 | 2009-05-11 | 吸引機構を有する経皮的輸送装置 |
JP2009114990A Pending JP2009240790A (ja) | 2001-10-26 | 2009-05-11 | 微細針経皮的輸送装置 |
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EP (5) | EP1439871B1 (ja) |
JP (10) | JP2005525141A (ja) |
AT (3) | ATE420680T1 (ja) |
AU (3) | AU2002353840B2 (ja) |
CA (5) | CA2464483C (ja) |
DE (3) | DE60230896D1 (ja) |
WO (5) | WO2003037403A1 (ja) |
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