|
JPS5892644A
(ja)
|
1981-11-26 |
1983-06-02 |
Taiho Yakuhin Kogyo Kk |
新規なニトロ安息香酸アミド誘導体およびそれを含有する放射線増感剤
|
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
JP2528107B2
(ja)
|
1985-03-15 |
1996-08-28 |
サマ−トン，ジエ−ムス |
ポリヌクレオチド測定試薬と方法
|
|
US4866132A
(en)
|
1986-04-17 |
1989-09-12 |
The Research Foundation Of State University Of New York |
Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom
|
|
US5616584A
(en)
|
1986-09-25 |
1997-04-01 |
Sri International |
1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
|
|
US4921963A
(en)
|
1987-04-13 |
1990-05-01 |
British Columbia Cancer Foundation |
Platinum complexes with one radiosensitizing ligand
|
|
JPH0819111B2
(ja)
|
1987-10-22 |
1996-02-28 |
ポーラ化成工業株式会社 |
２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
|
|
US4828971A
(en)
|
1988-03-24 |
1989-05-09 |
Eastman Kodak Company |
Thermally processable element comprising a backing layer
|
|
CA1251835A
(en)
|
1988-04-05 |
1989-03-28 |
Wai-Cheung Tang |
Dielectric image-resonator multiplexer
|
|
US5256334A
(en)
|
1988-09-08 |
1993-10-26 |
The Research Foundation Of The State University Of New York |
Homogeneous radiopaque polymer-organobismuth composites
|
|
WO1991004753A1
(en)
|
1989-10-02 |
1991-04-18 |
Cetus Corporation |
Conjugates of antisense oligonucleotides and therapeutic uses thereof
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
AU649074B2
(en)
|
1990-10-12 |
1994-05-12 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Modified ribozymes
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
JPH07509444A
(ja)
|
1991-11-26 |
1995-10-19 |
アルカーメス・インコーポレーテツド |
トランスフェリンセレプター特異的抗体−神経薬又は診断薬複合体の製造法
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
EP0654993A1
(en)
|
1992-08-17 |
1995-05-31 |
Quadra Logic Technologies Inc. |
Method for destroying or inhibiting growth of unwanted cells or tissues
|
|
US5346981A
(en)
|
1993-01-13 |
1994-09-13 |
Miles Inc. |
Radiopaque polyurethanes
|
|
KR100361933B1
(ko)
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
|
US5599796A
(en)
|
1993-12-02 |
1997-02-04 |
Emory University |
Treatment of urogenital cancer with boron neutron capture therapy
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
CA2192203A1
(en)
|
1994-06-17 |
1995-12-28 |
Werner Hofheinz |
N,n'-bis(quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials
|
|
US5716824A
(en)
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
|
WO1996019487A1
(en)
|
1994-12-22 |
1996-06-27 |
Nissan Chemical Industries, Ltd. |
Organobismuth derivatives and process for producing the same
|
|
US5700825A
(en)
|
1995-03-31 |
1997-12-23 |
Florida State University |
Radiosensitizing diamines and their pharmaceutical preparations
|
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
AU1430097A
(en)
|
1996-01-16 |
1997-08-11 |
Ribozyme Pharmaceuticals, Inc. |
Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
|
|
CA2249195A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
CA2274587A1
(en)
|
1996-12-10 |
1998-06-18 |
Genetrace Systems Inc. |
Releasable nonvolatile mass-label molecules
|
|
US20030073207A1
(en)
|
1997-01-31 |
2003-04-17 |
Saghir Akhtar |
Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
CA2323757C
(en)
|
1998-04-02 |
2011-08-02 |
Genentech, Inc. |
Antibody variants and fragments thereof
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
CA2326823A1
(en)
|
1998-04-20 |
1999-10-28 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
GB9816575D0
(en)
|
1998-07-31 |
1998-09-30 |
Zeneca Ltd |
Novel compounds
|
|
ES2260570T3
(es)
|
1998-08-27 |
2006-11-01 |
Spirogen Limited |
Pirrolobenziodiazepinas dimericas.
|
|
GB9818730D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
US6849272B1
(en)
|
1999-04-21 |
2005-02-01 |
Massachusetts Institute Of Technology |
Endosomolytic agents and cell delivery systems
|
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
DE10100586C1
(de)
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
|
US7829693B2
(en)
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
CA2328356A1
(en)
|
1999-12-22 |
2001-06-22 |
Itty Atcravi |
Recreational vehicles
|
|
AU767394C
(en)
|
1999-12-29 |
2005-04-21 |
Immunogen, Inc. |
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
|
KR20080023768A
(ko)
|
2000-03-30 |
2008-03-14 |
화이트헤드 인스티튜트 포 바이오메디칼 리서치 |
Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
|
|
EP2796553B1
(en)
|
2000-03-30 |
2019-06-19 |
Whitehead Institute for Biomedical Research |
RNA sequence-specific mediators of RNA interference
|
|
AU5752601A
(en)
|
2000-05-04 |
2001-11-12 |
Avi Biopharma Inc |
Splice-region antisense composition and method
|
|
CN100523215C
(zh)
|
2000-12-01 |
2009-08-05 |
马普科技促进协会 |
介导rna干涉的小rna分子
|
|
US8546143B2
(en)
|
2001-01-09 |
2013-10-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
DE10133858A1
(de)
|
2001-07-12 |
2003-02-06 |
Aventis Pharma Gmbh |
Synthetische doppelsträngige Oligonucleotide zur gezielten Hemmung der Genexpression
|
|
AU2002368077B2
(en)
|
2001-07-12 |
2010-03-04 |
Jefferson Foote |
Super humanized antibodies
|
|
US6942972B2
(en)
|
2001-10-24 |
2005-09-13 |
Beckman Coulter, Inc. |
Efficient synthesis of protein-oligonucleotide conjugates
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
EP1432724A4
(en)
|
2002-02-20 |
2006-02-01 |
Sirna Therapeutics Inc |
RNA inhibition mediated inhibition of MAP KINASE GENES
|
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US20040023220A1
(en)
|
2002-07-23 |
2004-02-05 |
Lawrence Greenfield |
Integrated method for PCR cleanup and oligonucleotide removal
|
|
ES2369542T3
(es)
|
2002-07-31 |
2011-12-01 |
Seattle Genetics, Inc. |
Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa.
|
|
EP1857547B2
(en)
|
2002-08-05 |
2020-12-02 |
Silence Therapeutics GmbH |
Further novel forms of interfering RNA molecules
|
|
US7923547B2
(en)
|
2002-09-05 |
2011-04-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
EP2305813A3
(en)
|
2002-11-14 |
2012-03-28 |
Dharmacon, Inc. |
Fuctional and hyperfunctional sirna
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
|
US20070167384A1
(en)
|
2003-04-02 |
2007-07-19 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
|
EP1608733B1
(en)
|
2003-04-02 |
2011-12-07 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
|
US20040224893A1
(en)
|
2003-05-06 |
2004-11-11 |
Li-Hsien Wang |
Methods of using IL-1 antagonists to treat neointimal hyperplasia
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
CA2528012C
(en)
|
2003-06-02 |
2015-11-24 |
University Of Massachusetts |
Methods and compositions for controlling efficacy of rna silencing
|
|
CA2527958C
(en)
|
2003-06-02 |
2014-04-08 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of rnai
|
|
ES2905724T3
(es)
|
2003-06-13 |
2022-04-11 |
Alnylam Europe Ag |
Acido ribonucleico bicatenario con elevada eficacia en un organismo
|
|
GB0416511D0
(en)
|
2003-10-22 |
2004-08-25 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
US8133733B2
(en)
|
2003-10-24 |
2012-03-13 |
Gencia Corporation |
Nonviral vectors for delivering polynucleotides to target tissues
|
|
ES2605443T3
(es)
|
2003-11-06 |
2017-03-14 |
Seattle Genetics, Inc. |
Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
|
|
US8389710B2
(en)
|
2004-02-27 |
2013-03-05 |
Operational Technologies Corporation |
Therapeutic nucleic acid-3′-conjugates
|
|
EP1723152B1
(en)
|
2004-03-09 |
2015-02-11 |
Spirogen Sàrl |
Pyrrolobenzodiazepines
|
|
CA2559955C
(en)
|
2004-03-15 |
2016-02-16 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded rna
|
|
EP1765847A4
(en)
|
2004-05-27 |
2010-10-20 |
Alnylam Pharmaceuticals Inc |
NUCLEASERESISTENT DOUBLE-STRANDED RIBONUCLEIC ACID
|
|
ES2627917T3
(es)
|
2004-06-28 |
2017-08-01 |
The University Of Western Australia |
Oligonucleótidos no codificantes para la inducción de la omisión exónica y métodos de uso de los mismos
|
|
JP2008519863A
(ja)
|
2004-11-12 |
2008-06-12 |
シアトル ジェネティクス インコーポレイティッド |
Ｎ末端にアミノ安息香酸単位を有するオーリスタチン
|
|
US7429482B2
(en)
|
2005-01-13 |
2008-09-30 |
United States Of America As Represented By The Department Of Veterans Affairs |
Screening tools for discovery of novel anabolic agents
|
|
ES2338696T3
(es)
|
2005-04-21 |
2010-05-11 |
Spirogen Limited |
Pirrolobenzodiazepinas.
|
|
BRPI0611474A2
(pt)
|
2005-05-26 |
2010-09-14 |
Ensemble Discovery Corp |
biodetecção por quìmica modelada com ácido nucléico
|
|
WO2007008848A2
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
|
|
CN101287835A
(zh)
|
2005-08-17 |
2008-10-15 |
株式会社百奥尼 |
用于siRNA细胞内输送的siRNA-亲水性聚合物结合物及其方法
|
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
DK1813614T3
(da)
|
2006-01-25 |
2012-01-23 |
Sanofi Sa |
Cytotoksiske midler, der omfatter nye tomaymycinderivater
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
LT2735568T
(lt)
|
2006-05-10 |
2017-11-27 |
Sarepta Therapeutics, Inc. |
Oligonukleotido analogai, turintys katijonines jungtis tarp subvienetų
|
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
|
WO2012024613A1
(en)
|
2010-08-19 |
2012-02-23 |
Wintrance Corporation |
Synergistic biomolecule-polymer conjugates
|
|
US8598333B2
(en)
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
|
US7521232B2
(en)
|
2006-05-31 |
2009-04-21 |
Icx Nomadics, Inc. |
Emissive species for clinical imaging
|
|
BRPI0714381A2
(pt)
|
2006-07-10 |
2013-03-05 |
Biogen Idec Inc |
composiÇÕes e mÉtodos para inibir crescimento de cÂnceres deficientes em smad4
|
|
JP6047270B2
(ja)
|
2006-08-11 |
2016-12-21 |
バイオマリン テクノロジーズ ベー．フェー． |
Ｄｎａリピートの不安定性に関連した遺伝的障害を治療するための方法及び手段
|
|
CN101500548A
(zh)
|
2006-08-18 |
2009-08-05 |
弗·哈夫曼-拉罗切有限公司 |
用于体内递送多核苷酸的多缀合物
|
|
EP2148886B1
(en)
|
2007-05-10 |
2014-02-19 |
R & D Biopharmaceuticals Gmbh |
Tubulysine derivatives
|
|
PT2019104E
(pt)
|
2007-07-19 |
2013-12-03 |
Sanofi Sa |
Agentes citotóxicos compreendendo novos derivados de tomaimicina e sua utilização terapêutica
|
|
EP3121281B1
(en)
|
2007-08-27 |
2021-03-31 |
1Globe Health Institute LLC |
Compositions of asymmetric interfering rna and uses thereof
|
|
EP2190995A2
(en)
|
2007-09-18 |
2010-06-02 |
Intradigm Corporation |
Compositions comprising k-ras sirna and methods of use
|
|
JP5723154B2
(ja)
|
2007-09-19 |
2015-05-27 |
アプライド バイオシステムズ リミテッド ライアビリティー カンパニー |
ＲＮＡｉにおけるオフターゲット表現型の影響を減少させるためのＳｉＲＮＡ配列非依存性修飾フォーマットおよびその安定化型
|
|
NZ584793A
(en)
|
2007-10-26 |
2012-05-25 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
US20110081362A1
(en)
|
2008-01-31 |
2011-04-07 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
|
US20110065774A1
(en)
|
2008-01-31 |
2011-03-17 |
Alnylam Pharmaceuticals |
Chemically modified oligonucleotides and uses thereof
|
|
LT2237799T
(lt)
|
2008-02-01 |
2019-07-25 |
Ascendis Pharma A/S |
Provaistas, apimantis besiskaidantį linkerį
|
|
EP3643782A1
(en)
|
2008-02-11 |
2020-04-29 |
Phio Pharmaceuticals Corp. |
Modified rnai polynucleotides and uses thereof
|
|
WO2009117531A1
(en)
|
2008-03-18 |
2009-09-24 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
US8575123B2
(en)
|
2008-04-11 |
2013-11-05 |
Tekmira Pharmaceuticals Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
US8703921B2
(en)
|
2008-04-15 |
2014-04-22 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Compositions and methods for delivering inhibitory oligonucleotides
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US20110130346A1
(en)
|
2008-05-30 |
2011-06-02 |
Isis Innovation Limited |
Peptide conjugates for delvery of biologically active compounds
|
|
GB0813432D0
(en)
|
2008-07-22 |
2008-08-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
AU2009279458B2
(en)
|
2008-08-08 |
2015-07-02 |
Code Biotherapeutics, Inc. |
Long-acting DNA dendrimers and methods thereof
|
|
ES2915692T3
(es)
|
2008-08-13 |
2022-06-24 |
California Inst Of Techn |
Nanopartículas portadoras y composiciones, métodos y sistemas relacionados
|
|
EP2690175B1
(en)
|
2008-09-02 |
2016-12-28 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for combined inhibition of mutant EGFR gene and IL-6 expression
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
EP2342340A1
(en)
|
2008-09-22 |
2011-07-13 |
Rxi Pharmaceuticals Corporation |
Rna interference in skin indications
|
|
EP3133160B1
(en)
|
2008-10-24 |
2018-12-12 |
Sarepta Therapeutics, Inc. |
Exon skipping compositions for dmd
|
|
SI2607484T1
(sl)
|
2008-10-27 |
2016-11-30 |
Biomarin Technologies B.V. |
Metode in sredstva za učinkovito preskakovanje eksona 45 v pre-mRNA Duchennove mišične distrofije
|
|
BRPI0923225A2
(pt)
|
2008-12-02 |
2016-10-04 |
Chiralgen Ltd |
metodo para sintese de acidos nucleicos modificados no atomo de fosforo
|
|
CA3014224C
(en)
|
2009-02-05 |
2022-05-24 |
Immunogen, Inc. |
Condensed benzodiazepine-indoline derivatives and processes to prepare said derivatives
|
|
WO2010093788A2
(en)
|
2009-02-11 |
2010-08-19 |
Dicerna Pharmaceuticals, Inc. |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
US8481698B2
(en)
|
2009-03-19 |
2013-07-09 |
The President And Fellows Of Harvard College |
Parallel proximity ligation event analysis
|
|
WO2010115033A2
(en)
|
2009-04-02 |
2010-10-07 |
Regents Of The University Of Minnesota |
Nucleotide repeat expansion-associated polypeptides and uses thereof
|
|
CN102459595A
(zh)
|
2009-04-24 |
2012-05-16 |
普罗森那技术公司 |
用于治疗dmd的包含肌苷的寡核苷酸
|
|
WO2010129666A1
(en)
|
2009-05-05 |
2010-11-11 |
Altermune Technologies, Llc |
Chemically programmable immunity
|
|
EP2437785B1
(en)
|
2009-06-04 |
2015-02-25 |
Novartis AG |
METHODS FOR IDENTIFICATION OF SITES FOR IgG CONJUGATION
|
|
US20110269665A1
(en)
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
US9050375B2
(en)
|
2009-07-06 |
2015-06-09 |
Hoffmann-La Roche, Inc. |
Bi-specific digoxigenin binding antibodies
|
|
IT1394860B1
(it)
|
2009-07-22 |
2012-07-20 |
Kemotech S R L |
Composti farmaceutici
|
|
EP2456470A1
(en)
|
2009-07-22 |
2012-05-30 |
Cenix Bioscience GmbH |
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
|
|
EP2473607A2
(en)
|
2009-08-31 |
2012-07-11 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Exon skipping therapy for functional amelioration of semi functional dystrophin in becker and duchenne muscular dystrophy
|
|
MX2012004029A
(es)
|
2009-10-07 |
2012-05-08 |
Macrogenics Inc |
Polipeptidos que contienen la region fc que exhiben funcion efectora mejorada debido a alteraciones del grado de fucosilacion, y metodos para su uso.
|
|
HUE040445T2
(hu)
|
2009-11-12 |
2019-03-28 |
Univ Western Australia |
Antiszensz molekulák és eljárások betegségek kezelésére
|
|
SG183273A1
(en)
|
2010-02-12 |
2012-09-27 |
Solulink Inc |
Preparation and/or purification of oligonucleotide conjugates
|
|
CN103068405A
(zh)
|
2010-04-15 |
2013-04-24 |
西雅图基因公司 |
靶向吡咯并苯并二氮杂卓结合物
|
|
MX368648B
(es)
|
2010-04-15 |
2019-10-09 |
Seattle Genetics Inc |
Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
|
|
WO2011139702A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
|
KR101981705B1
(ko)
|
2010-05-28 |
2019-05-24 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
IT1400425B1
(it)
|
2010-06-08 |
2013-05-31 |
Amsterdam Molecular Therapeutics Bv |
Modified snrnas for use in therapy.
|
|
JP2013531981A
(ja)
|
2010-06-11 |
2013-08-15 |
アンチセンス・ファーマ・ゲーエムベーハー |
選択的オリゴヌクレオチド修飾の方法
|
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
|
ES2756326T3
(es)
|
2010-07-19 |
2020-04-27 |
Ionis Pharmaceuticals Inc |
Modulación de la expresión de distrofia miotónica-proteína quinasa (DMPK)
|
|
EP2606152B2
(en)
*
|
2010-08-18 |
2025-03-12 |
Fred Hutchinson Cancer Center |
Methods for determining the presence or risk of developing facioscapulohumeral dystrophy (fshd)
|
|
EP3118316A1
(en)
*
|
2010-09-02 |
2017-01-18 |
Université de Mons |
Agents useful in treating facioscapulohumeral muscular dystrophy
|
|
WO2012058210A1
(en)
|
2010-10-29 |
2012-05-03 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
|
|
US9090629B2
(en)
|
2010-11-03 |
2015-07-28 |
Immunogen, Inc. |
Cytotoxic agents comprising new ansamitocin derivatives
|
|
US8501930B2
(en)
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
|
MX347298B
(es)
|
2010-12-29 |
2017-04-21 |
Arrowhead Res Corp |
Conjugados de suministro de polinucleotidos in vivo que tienen acoplamientos sensibles a enzima.
|
|
BR112013020273A2
(pt)
|
2011-02-08 |
2016-10-18 |
Charlotte Mecklenburg Hospital |
oligonucleotídeos antissenso
|
|
WO2012125850A1
(en)
|
2011-03-16 |
2012-09-20 |
Amgen Inc. |
Fc variants
|
|
US9045750B2
(en)
|
2011-03-18 |
2015-06-02 |
Yuelong Ma |
Humanized lewis-Y specific antibody-based delivery of dicer substrate siRNA (D-siRNA) against STAT3
|
|
LT2691417T
(lt)
|
2011-03-29 |
2018-10-25 |
Roche Glycart Ag |
Antikūno fc variantai
|
|
WO2012177837A2
(en)
|
2011-06-21 |
2012-12-27 |
Immunogen, Inc. |
Novel maytansinoid derivatives with peptide linker and conjugates thereof
|
|
CA2839593A1
(en)
|
2011-07-15 |
2013-01-24 |
Sarepta Therapeutics, Inc. |
Methods and compositions for manipulating translation of protein isoforms from alternative initiation start sites
|
|
CN107365339A
(zh)
|
2011-07-19 |
2017-11-21 |
波涛生命科学有限公司 |
合成官能化核酸的方法
|
|
CA2842798C
(en)
*
|
2011-07-25 |
2021-02-23 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of dux4
|
|
US10023861B2
(en)
|
2011-08-29 |
2018-07-17 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
US9593141B2
(en)
|
2011-11-09 |
2017-03-14 |
President And Fellows Of Harvard College |
Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics
|
|
US9796974B2
(en)
|
2011-11-18 |
2017-10-24 |
Alnylam Pharmaceuticals, Inc. |
Modified RNAi agents
|
|
BR112014013526A8
(pt)
|
2011-12-05 |
2017-06-13 |
Igenica Biotherapeutics Inc |
conjugados de anticorpo-fármaco e compostos, composições e métodos relacionados
|
|
TW201333040A
(zh)
|
2012-01-06 |
2013-08-16 |
Bioalliance Cv |
抗－輸鐵蛋白受器之抗體及其使用方法
|
|
US10010623B2
(en)
|
2012-02-16 |
2018-07-03 |
Ucl Business Plc |
Lysosome-cleavable linker
|
|
RU2582259C2
(ru)
|
2012-02-24 |
2016-04-20 |
Алтеоген Инк. |
Модифицированные антитела, с которыми связан мотив, включающий остаток цистеина, конъюгаты этих модифицированных антител с лекарственными веществами и способ их получения
|
|
AR090905A1
(es)
|
2012-05-02 |
2014-12-17 |
Merck Sharp & Dohme |
Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica
|
|
CN104583406A
(zh)
|
2012-05-02 |
2015-04-29 |
诺华股份有限公司 |
治疗kras相关疾病的有机组合物
|
|
CN104640572B
(zh)
|
2012-05-15 |
2018-04-27 |
索伦托医疗有限公司 |
药物偶联物，偶联方法，及其用途
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
DK2872147T3
(da)
|
2012-07-13 |
2023-02-20 |
Wave Life Sciences Ltd |
Fremgangsmåde til fremstilling af kirale oligonukleotider
|
|
JP2015529073A
(ja)
|
2012-08-20 |
2015-10-05 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
生物可逆性基を有するポリヌクレオチド
|
|
KR102058381B1
(ko)
|
2012-08-24 |
2019-12-24 |
강원대학교산학협력단 |
인간 ｌ１ｃａｍ에 대한 인간화 항체 및 그의 제조 방법
|
|
DK2839860T3
(da)
|
2012-10-12 |
2019-06-17 |
Medimmune Ltd |
Pyrrolobenzodiazepiner og konjugater deraf
|
|
CA2889044A1
(en)
|
2012-11-15 |
2014-05-22 |
Roche Innovation Center Copenhagen A/S |
Anti apob antisense conjugate compounds
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
KR20210132742A
(ko)
|
2012-12-21 |
2021-11-04 |
알트루바이오 인코퍼레이티드 |
친수성 자기-희생 링커 및 그것의 포합체
|
|
US9481905B2
(en)
|
2013-02-19 |
2016-11-01 |
Orizhan Bioscience Limited |
Method of using neutrilized DNA (N-DNA) as surface probe for high throughput detection platform
|
|
MX363787B
(es)
|
2013-03-13 |
2019-04-03 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de los mismos.
|
|
US9217148B2
(en)
|
2013-03-14 |
2015-12-22 |
Sarepta Therapeutics, Inc. |
Exon skipping compositions for treating muscular dystrophy
|
|
EP3964237B1
(en)
|
2013-03-15 |
2026-02-18 |
Regeneron Pharmaceuticals, Inc. |
Biologically active molecules, conjugates thereof, and therapeutic uses
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
HK1220154A1
(zh)
|
2013-03-15 |
2017-04-28 |
Sarepta Therapeutics, Inc. |
改进的用於治疗肌营养不良的组合物
|
|
CN109234274B
(zh)
|
2013-03-27 |
2021-09-21 |
伊萨纳治疗有限公司 |
修饰的TGF-β寡核苷酸
|
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
|
WO2014169049A1
(en)
|
2013-04-09 |
2014-10-16 |
Duke University |
2' fluoro-modified rnas as immunostimulators
|
|
GB2529356B
(en)
|
2013-04-28 |
2020-12-23 |
Genequantum Healthcare Co Ltd |
Novel linkers, coupling intermediates, conjugates, preparation method and application thereof
|
|
SG11201509566RA
(en)
|
2013-05-20 |
2015-12-30 |
Genentech Inc |
Anti-transferrin receptor antibodies and methods of use
|
|
EP3004174B1
(en)
|
2013-05-31 |
2019-04-17 |
Zymeworks Inc. |
Heteromultimers with reduced or silenced effector function
|
|
US11229711B2
(en)
|
2013-06-06 |
2022-01-25 |
Magenta Therapeutics, Inc. |
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
US20140363454A1
(en)
|
2013-06-06 |
2014-12-11 |
Igenica Biotherapeutics, Inc. |
Antibody-Drug Conjugates, Compositions and Methods of Use
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
EP2845607A1
(en)
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
|
PT3057585T
(pt)
|
2013-10-15 |
2020-10-21 |
Seagen Inc |
Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando
|
|
AU2014337317A1
(en)
|
2013-10-15 |
2016-09-15 |
Sorrento Therapeutics Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
WO2015069587A2
(en)
|
2013-11-06 |
2015-05-14 |
Merck Sharp & Dohme Corp. |
Peptide containing conjugates for dual molecular delivery of oligonucleotides
|
|
US10378017B2
(en)
|
2013-12-02 |
2019-08-13 |
Brandeis University |
High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides
|
|
EP3094728B1
(en)
|
2014-01-16 |
2022-03-09 |
Wave Life Sciences Ltd. |
Chiral design
|
|
US10358643B2
(en)
|
2014-01-30 |
2019-07-23 |
Hoffmann-La Roche, Inc. |
Poly oligomer compound with biocleavable conjugates
|
|
PT3159409T
(pt)
|
2014-06-17 |
2020-01-21 |
Nippon Shinyaku Co Ltd |
Ácido nucleico anti-sentido para utilização no tratamento da distrofia muscular de duchenne
|
|
TWI695011B
(zh)
|
2014-06-18 |
2020-06-01 |
美商梅爾莎納醫療公司 |
抗ｈｅｒ２表位之單株抗體及其使用之方法
|
|
US10988764B2
(en)
|
2014-06-23 |
2021-04-27 |
Monsanto Technology Llc |
Compositions and methods for regulating gene expression via RNA interference
|
|
IL316808A
(en)
|
2014-08-20 |
2025-01-01 |
Alnylam Pharmaceuticals Inc |
Modified double-stranded RNA materials and their uses
|
|
JP6779876B2
(ja)
|
2014-11-19 |
2020-11-04 |
ジェネンテック， インコーポレイテッド |
抗トランスフェリン受容体抗体及びその使用方法
|
|
US10538763B2
(en)
*
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
EP3286318A2
(en)
|
2015-04-22 |
2018-02-28 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
|
US20180344817A1
(en)
|
2015-05-01 |
2018-12-06 |
Precision Biosciences, Inc. |
Precise deletion of chromosomal sequences in vivo and treatment of nucleotide repeat expansion disorders using engineered nucleases
|
|
KR102644053B1
(ko)
|
2015-05-19 |
2024-03-06 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
펩티드 올리고뉴클레오티드 콘주게이트
|
|
AU2016282334B2
(en)
|
2015-06-24 |
2022-07-21 |
F. Hoffmann-La Roche Ag |
Anti-transferrin receptor antibodies with tailored affinity
|
|
WO2017007886A2
(en)
|
2015-07-08 |
2017-01-12 |
Idera Pharmaceuticals, Inc. |
Compositions for inhibiting dux4 gene expression and uses thereof
|
|
JP6749589B2
(ja)
*
|
2015-07-31 |
2020-09-02 |
国立大学法人北海道大学 |
抗Ｅｖａ１タンパク質抗体
|
|
WO2017148880A1
(en)
|
2016-03-01 |
2017-09-08 |
F. Hoffmann-La Roche Ag |
Obinutuzumab variants having altered cell death induction
|
|
KR102775461B1
(ko)
*
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
JP2019516679A
(ja)
|
2016-05-04 |
2019-06-20 |
ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． |
生物活性剤に関する方法および組成物
|
|
DK3473270T5
(da)
|
2016-06-20 |
2024-09-09 |
Genahead Bio Inc |
Konjugat af antistof-lægemiddel
|
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
|
CN110234762A
(zh)
|
2016-10-28 |
2019-09-13 |
吉尼松公司 |
用于治疗肌强直性营养不良的组合物和方法
|
|
CN110337493B
(zh)
|
2016-10-28 |
2024-03-12 |
吉尼松公司 |
用于治疗肌强直性营养不良的组合物和方法
|
|
WO2018098328A1
(en)
|
2016-11-23 |
2018-05-31 |
Alnylam Pharmaceuticals, Inc. |
Modified rna agents with reduced off-target effect
|
|
KR20240172236A
(ko)
*
|
2017-01-06 |
2024-12-09 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩티드 조성물 및 엑손 스키핑을 유도하는 방법
|
|
JOP20190187A1
(ar)
|
2017-02-03 |
2019-08-01 |
Novartis Ag |
مترافقات عقار جسم مضاد لـ ccr7
|
|
DK3444010T3
(da)
*
|
2017-08-14 |
2021-03-15 |
Scandiedge Therapeutics Ab |
Pklr-inhibering i behandlingen af nafld og hcc
|
|
SG11202002517RA
(en)
|
2017-09-22 |
2020-04-29 |
Avidity Biosciences Inc |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
|
MA49923A
(fr)
|
2017-10-02 |
2020-06-24 |
Res Inst Nationwide Childrens Hospital |
Système de déciblage de miarn pour interférence spécifique d'un tissu
|
|
SG11202003126VA
(en)
|
2017-10-04 |
2020-05-28 |
Avidity Biosciences Inc |
Nucleic acid-polypeptide compositions and uses thereof
|
|
ES2927715T3
(es)
*
|
2017-10-05 |
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|
|
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(zh)
|
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|
|
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(en)
*
|
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|
|
EP3830259A4
(en)
*
|
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|
|
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(zh)
*
|
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|
|
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(en)
|
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|
|
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(ja)
|
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|
|
TW202104595A
(zh)
|
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|
|
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(ja)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(es)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|