|
JPH0329734A
(ja)
|
1989-06-20 |
1991-02-07 |
Kubota Corp |
ラベルプリンタ
|
|
US7144731B2
(en)
|
1989-10-16 |
2006-12-05 |
Amgen Inc. |
SCF antibody compositions and methods of using the same
|
|
US20050276784A1
(en)
|
1990-08-27 |
2005-12-15 |
Solan-Kettering Institute For Cancer Research |
Ligand for the c-kit receptor and methods of use thereof
|
|
DE4205148A1
(de)
|
1991-05-25 |
1993-01-21 |
Boehringer Mannheim Gmbh |
Monoklonale antikoerper gegen c-kit
|
|
WO1994008039A1
(en)
|
1992-10-02 |
1994-04-14 |
Systemix, Inc. |
Method of enrichment for human hematopoietic stem cells using c-kit
|
|
US5821108A
(en)
|
1995-04-07 |
1998-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker
|
|
US6429025B1
(en)
|
1996-06-28 |
2002-08-06 |
Caliper Technologies Corp. |
High-throughput screening assay systems in microscale fluidic devices
|
|
AU9692498A
(en)
|
1997-10-10 |
1999-05-03 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Complex of biotinylated viral vector and ligand for targeted gene delivery
|
|
CA2330208A1
(en)
|
1998-05-29 |
1999-12-02 |
Thomas Jefferson University |
Compositions and methods for use in affecting hematopoietic stem cell populations in mammals
|
|
US6607891B1
(en)
|
1998-07-31 |
2003-08-19 |
Mitsubishi Chemical Corporation |
Method of assaying insulin-like growth factor
|
|
US6989248B2
(en)
|
1999-05-06 |
2006-01-24 |
The Trustees Of Columbia University In The City Of New York |
Methods of use of compounds which inhibit the stem cell signaling pathway
|
|
CA2392490A1
(en)
|
1999-11-24 |
2001-05-31 |
Mcs Micro Carrier Systems Gmbh |
Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
|
|
US20030082155A1
(en)
|
1999-12-06 |
2003-05-01 |
Habener Joel F. |
Stem cells of the islets of langerhans and their use in treating diabetes mellitus
|
|
US7862810B2
(en)
|
2000-07-31 |
2011-01-04 |
New York Medical College |
Methods and compositions for the repair and/or regeneration of damaged myocardium
|
|
US20040003420A1
(en)
|
2000-11-10 |
2004-01-01 |
Ralf Kuhn |
Modified recombinase
|
|
US20050222030A1
(en)
|
2001-02-21 |
2005-10-06 |
Anthony Allison |
Modified annexin proteins and methods for preventing thrombosis
|
|
US20040115184A1
(en)
|
2001-02-27 |
2004-06-17 |
Smith Harold C |
Methods and compositions for modifying apolipoprotein b mrna editing
|
|
ATE421991T1
(de)
|
2001-04-24 |
2009-02-15 |
Ajinomoto Kk |
Stammzellen und verfahren zu deren trennung
|
|
AU2002330714A1
(en)
|
2001-05-30 |
2003-01-02 |
Biomedical Center |
In silico screening for phenotype-associated expressed sequences
|
|
EP2277991A1
(en)
|
2001-08-21 |
2011-01-26 |
Ventana Medical Systems, Inc. |
Method and quantification assay for determining c-kit/SCF/pAKT status
|
|
JP4330995B2
(ja)
|
2001-11-15 |
2009-09-16 |
チルドレンズ メディカル センター コーポレーション |
絨毛膜絨毛、羊水、および胎盤からの胎児性幹細胞を単離、増殖、および分化させる方法、ならびにその治療的使用方法
|
|
AU2003219718A1
(en)
|
2002-02-06 |
2003-09-02 |
Orbus Medical Technologies Inc. |
Medical device with coating that promotes endothelial cell adherence and differentiation
|
|
US20040161419A1
(en)
|
2002-04-19 |
2004-08-19 |
Strom Stephen C. |
Placental stem cells and uses thereof
|
|
ES2438965T3
(es)
|
2002-04-23 |
2014-01-21 |
Roger Williams Hospital |
Composiciones y métodos para administrar células madre
|
|
US20040005623A1
(en)
|
2002-06-10 |
2004-01-08 |
Longley B. Jack |
Method of determining tumor sensitivities to therapeutic drugs
|
|
WO2004002425A2
(en)
|
2002-06-28 |
2004-01-08 |
Bio Transplant, Inc. |
Process for promoting graft acceptance by depletion of hematopoietic stem cells
|
|
US20060034767A1
(en)
|
2002-07-05 |
2006-02-16 |
Roger Williams Medical Center |
Targeting and tracking of cells to specific organs and tissues in vivo
|
|
US20050032122A1
(en)
|
2003-08-06 |
2005-02-10 |
Shiaw-Min Hwang |
Optimizing culture medium for CD34<+> hematopoietic cell expansion
|
|
US20050124896A1
(en)
|
2003-08-25 |
2005-06-09 |
Jacob Richter |
Method for protecting implantable sensors and protected implantable sensors
|
|
BRPI0414698A
(pt)
|
2003-09-23 |
2006-11-28 |
Novartis Ag |
combinação de um inibidor receptor de vegf com um agente quimioterapêutico
|
|
TWI338714B
(en)
|
2003-12-02 |
2011-03-11 |
Cathay General Hospital |
Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid
|
|
US7863043B2
(en)
|
2004-02-11 |
2011-01-04 |
Aldagen, Inc. |
Stem cell populations and methods of use
|
|
US20050187607A1
(en)
|
2004-02-20 |
2005-08-25 |
Akhtar Adil J. |
Drug delivery device
|
|
WO2005100999A2
(en)
|
2004-04-08 |
2005-10-27 |
Cornell Research Foundation, Inc. |
Functional immunohistochemical cell cycle analysis as a prognostic indicator for cancer
|
|
EP1797200A2
(en)
|
2004-09-10 |
2007-06-20 |
The Regents of the University of Colorado |
Early detection of hemangiosarcoma and angiosarcoma
|
|
WO2006062946A2
(en)
|
2004-12-06 |
2006-06-15 |
University Of Florida Research Foundation, Inc. |
Incorporation of bone marrow derived stem cells in tumors
|
|
CA2593549C
(en)
|
2005-01-07 |
2016-04-26 |
Wake Forest University Health Sciences |
Regeneration of pancreatic islets by amniotic fluid stem cell therapy
|
|
US20080248503A1
(en)
|
2005-02-16 |
2008-10-09 |
Rich Ivan N |
Methods of Screening Compounds to Predict Toxicity and Residual Proliferative and Differentiation Capacity of the Lympho-Hematopoietic System
|
|
US20060222634A1
(en)
|
2005-03-31 |
2006-10-05 |
Clarke Diana L |
Amnion-derived cell compositions, methods of making and uses thereof
|
|
CA2606081C
(en)
|
2005-04-26 |
2013-09-17 |
Markus M. Heiss |
Combination of the application of antibodies for immunostimulation together with glucocorticoids
|
|
JP4268209B2
(ja)
|
2005-07-20 |
2009-05-27 |
ソウル ナショナル ユニバーシティ インダストリー ファウンデーション |
子宮内膜細胞を用いた造血幹細胞または前駆細胞の培養及び増殖方法
|
|
ES2577535T3
(es)
|
2005-10-21 |
2016-07-15 |
Regents Of The University Of California |
Mutaciones del oncogén de C-kit en melanomas
|
|
CN101316590B
(zh)
|
2005-11-07 |
2011-08-03 |
卫材R&D管理有限公司 |
血管生成抑制剂和c-kit激酶抑制剂的组合使用
|
|
US20090304625A1
(en)
|
2006-01-18 |
2009-12-10 |
Ahsan Husain |
Modulators of cardiac cell hypertrophy and hyperplasia
|
|
US20070254319A1
(en)
|
2006-04-07 |
2007-11-01 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Identification of a constitutively resistant cancer stem cell
|
|
TWI395754B
(zh)
|
2006-04-24 |
2013-05-11 |
Amgen Inc |
人類化之c-kit抗體
|
|
US8568286B2
(en)
|
2006-06-14 |
2013-10-29 |
Cardiac Pacemakers, Inc. |
Methods to position therapeutic agents using a magnetic field
|
|
ES2882360T3
(es)
|
2006-11-03 |
2021-12-01 |
Univ Leland Stanford Junior |
Inmunoempobrecimiento selectivo de un nicho de células madre endógenas para injerto
|
|
WO2008115300A1
(en)
|
2006-12-01 |
2008-09-25 |
Apocell, Inc. |
C-kit phosphorylation in cancer
|
|
WO2008076143A1
(en)
|
2006-12-18 |
2008-06-26 |
Osi Pharmaceuticals, Inc. |
Combination of igfr inhibitor and anti-cancer agent
|
|
WO2008085951A2
(en)
|
2007-01-04 |
2008-07-17 |
Vivek Mittal |
Treatment of tumors by ablating bone marrow-derived endothelial progenitor cells
|
|
DE102007008650B4
(de)
|
2007-02-20 |
2012-06-06 |
Charité - Universitätsmedizin Berlin |
Zellen zur Therapie des Herzens
|
|
BRPI0807966A2
(pt)
|
2007-03-01 |
2014-06-10 |
Cryo Cell Int |
Aquisição, isolação e criopreservação de células endometriais/menstruais
|
|
US9200253B1
(en)
|
2007-08-06 |
2015-12-01 |
Anthrogenesis Corporation |
Method of producing erythrocytes
|
|
US8431162B2
(en)
|
2007-10-30 |
2013-04-30 |
University Of Louisville Research Foundation, Inc. |
Subpopulations of bone marrow-derived adherent stem cells and methods of use therefor
|
|
US20090169613A1
(en)
|
2007-11-09 |
2009-07-02 |
Reznik Boris N |
Targeting of tumor stem cells through selective silencing of boris expression
|
|
MX2011004165A
(es)
|
2008-10-22 |
2011-08-08 |
Genentech Inc |
Celulas madre de prostata y sus usos.
|
|
AU2010229924B2
(en)
|
2009-03-24 |
2016-07-21 |
Plus Therapeutics Inc. |
Devices and methods of cell capture and analysis
|
|
WO2010136508A2
(en)
|
2009-05-28 |
2010-12-02 |
Glaxo Group Limited |
Stem cell targeting
|
|
EP2259065A1
(en)
|
2009-06-03 |
2010-12-08 |
Erasmus University Medical Center Rotterdam |
Methods, reagents and kits for flow cytometric immunophenotyping
|
|
WO2013166281A1
(en)
|
2012-05-02 |
2013-11-07 |
Cedars-Sinai Medical Center |
Bi-functional compositions for targeting cells to diseased tissues and methods of using same
|
|
US20110104787A1
(en)
|
2009-11-05 |
2011-05-05 |
President And Fellows Of Harvard College |
Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
|
|
US9149544B2
(en)
|
2009-11-06 |
2015-10-06 |
The Penn State Research Foundation |
Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo
|
|
US8518716B2
(en)
|
2009-11-30 |
2013-08-27 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Soluble CD117 (sc-kit) for diagnosis of preeclampsia and eclampsia
|
|
WO2011073521A1
(en)
|
2009-12-15 |
2011-06-23 |
Petri Salven |
Methods for enriching adult-derived endothelial progenitor cells and uses thereof
|
|
US20130011380A1
(en)
|
2009-12-18 |
2013-01-10 |
Blau Helen M |
Use of Cytidine Deaminase-Related Agents to Promote Demethylation and Cell Reprogramming
|
|
CN102822676B
(zh)
|
2010-01-12 |
2015-02-18 |
雀巢产品技术援助有限公司 |
用于预测三阴性乳腺癌对疗法的应答的方法
|
|
US20130109048A1
(en)
|
2010-07-09 |
2013-05-02 |
Ecole Polytechnique Federale De Lausanne (Epfl) |
Method for in-vitro monitoring of neuronal disorders and use thereof
|
|
EP2624847B1
(en)
|
2010-10-05 |
2017-09-13 |
AAL Scientifics, Inc. |
Human lung stem cells and uses thereof
|
|
WO2012068248A2
(en)
|
2010-11-16 |
2012-05-24 |
Ingeneron, Inc. |
Methods for preserving target cells
|
|
WO2012068243A2
(en)
|
2010-11-16 |
2012-05-24 |
Ingeneron, Inc. |
Methods for obtaining target cells
|
|
WO2012135844A2
(en)
|
2011-04-01 |
2012-10-04 |
Cornell University |
Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers
|
|
US20120264710A1
(en)
|
2011-04-15 |
2012-10-18 |
Marit Liland Sandvold |
Systems and Methods for Detecting hENT1 Expression in Hematological Disorders
|
|
EP2706881B1
(en)
|
2011-05-11 |
2018-07-25 |
StemRad Ltd. |
Radiation protection device and methods thereof
|
|
AR086044A1
(es)
|
2011-05-12 |
2013-11-13 |
Imclone Llc |
Anticuerpos que se unen especificamente a un dominio extracelular de c-kit y usos de los mismos
|
|
WO2012171112A1
(en)
|
2011-06-14 |
2012-12-20 |
Mcmaster University |
Isolated embryonic stem cells that express lineage markers and associated methods
|
|
CN102876666B
(zh)
|
2011-07-15 |
2015-02-04 |
内蒙古弘泰医学科技有限公司 |
Rna胞体及其用途
|
|
CN103088008B
(zh)
|
2011-10-31 |
2014-08-20 |
中国科学院微生物研究所 |
胞苷脱氨酶及其编码基因和它们的应用
|
|
RU2650811C2
(ru)
|
2012-02-24 |
2018-04-17 |
Фред Хатчинсон Кэнсер Рисерч Сентер |
Композиции и способы лечения гемоглобинопатии
|
|
KR101384360B1
(ko)
|
2012-05-04 |
2014-04-14 |
아주대학교산학협력단 |
Scf 또는 이의 수용체를 억제하는 물질을 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물
|
|
EP3241902B1
(en)
|
2012-05-25 |
2018-02-28 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
US9102936B2
(en)
|
2012-06-11 |
2015-08-11 |
Agilent Technologies, Inc. |
Method of adaptor-dimer subtraction using a CRISPR CAS6 protein
|
|
US20150160226A1
(en)
|
2012-06-14 |
2015-06-11 |
Erasmus University Medical Center Rotterdam |
Method, reagents, and kits for detecting minimal residual disease
|
|
DK3431497T3
(da)
|
2012-06-27 |
2022-10-10 |
Univ Princeton |
Spaltede inteiner, konjugater og anvendelser deraf
|
|
SI2890780T1
(sl)
|
2012-08-29 |
2020-11-30 |
Sangamo Therapeutics, Inc. |
Postopki in sestavki za zdravljenje genetskega stanja
|
|
JP2015529466A
(ja)
|
2012-09-14 |
2015-10-08 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
鎌状赤血球症の幹細胞遺伝子治療のためのレンチウイルスベクター
|
|
WO2014043442A1
(en)
|
2012-09-14 |
2014-03-20 |
Children's Medical Center Corporation |
Inhibition of viral infection-triggered asthma with c-kit inhibitor
|
|
EP2908913B1
(en)
|
2012-10-17 |
2018-10-03 |
Cedars-Sinai Medical Center |
Molecular signatures of ovarian cancer
|
|
WO2014066271A1
(en)
|
2012-10-22 |
2014-05-01 |
Becton, Dickinson And Company |
Non-b-lineage cells capable of producing antibody
|
|
WO2014066545A1
(en)
|
2012-10-26 |
2014-05-01 |
Cedars-Sinai Medical Center |
Therapeutic cells depleted of specific subpopulations of cells for use in tissue repair of regeneration
|
|
TW201427667A
(zh)
|
2012-11-20 |
2014-07-16 |
Celgene Avilomics Res Inc |
治療和布魯頓(bruton’s)酪胺酸激酶相關之疾病或失調的方法
|
|
EP3363902B1
(en)
|
2012-12-06 |
2019-11-27 |
Sigma Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
DK2931897T3
(en)
|
2012-12-12 |
2018-02-05 |
Broad Inst Inc |
CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS
|
|
DK2931898T3
(en)
|
2012-12-12 |
2016-06-20 |
Massachusetts Inst Technology |
CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
|
|
CA2895155C
(en)
|
2012-12-17 |
2021-07-06 |
President And Fellows Of Harvard College |
Rna-guided human genome engineering
|
|
US20210137991A1
(en)
|
2013-02-08 |
2021-05-13 |
Themba Inc. |
Gene editing for autoimmune disorders
|
|
WO2014153114A1
(en)
|
2013-03-14 |
2014-09-25 |
Fred Hutchinson Cancer Research Center |
Compositions and methods to modify cells for therapeutic objectives
|
|
AU2014227653B2
(en)
|
2013-03-15 |
2017-04-20 |
The General Hospital Corporation |
Using RNA-guided foki nucleases (RFNs) to increase specificity for RNA-guided genome editing
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
WO2014141306A2
(en)
|
2013-03-15 |
2014-09-18 |
Rajiv Gandhi Centre For Biotechnology |
Methods and materials for identifying therapeutic response in chronic myeloid leukemia
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
WO2014186686A2
(en)
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
EP3004370B1
(en)
*
|
2013-06-05 |
2024-08-21 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
US20160122405A1
(en)
|
2013-06-06 |
2016-05-05 |
President And Fellows Of Harvard College |
Homeodomain fusion proteins and uses thereof
|
|
JP2016528890A
(ja)
*
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いるゲノム編集の治療用の使用
|
|
SMT202100691T1
(it)
|
2013-07-11 |
2022-01-10 |
Modernatx Inc |
Composizioni 5 comprendenti polinucleotidi sintetici che codificano proteine correlate a crispr e sgrna sintetici e metodi d'uso
|
|
FR3008408B1
(fr)
|
2013-07-11 |
2018-03-09 |
Mc Saf |
Nouveaux conjugues anticorps-medicament et leur utilisation en therapie
|
|
WO2015021426A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
A crispr/cas system-based novel fusion protein and its application in genome editing
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
AU2014346559B2
(en)
|
2013-11-07 |
2020-07-09 |
Editas Medicine,Inc. |
CRISPR-related methods and compositions with governing gRNAs
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
|
AU2014361781B2
(en)
|
2013-12-12 |
2021-04-01 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
|
|
US9994831B2
(en)
|
2013-12-12 |
2018-06-12 |
The Regents Of The University Of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
WO2015148512A1
(en)
|
2014-03-24 |
2015-10-01 |
Qt Holdings Corp |
Shaped articles including hydrogels and methods of manufacture and use thereof
|
|
US10369104B2
(en)
|
2014-04-01 |
2019-08-06 |
Children's Hospital Los Angeles |
Targeted polymerized nanoparticles for cancer treatment
|
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
FI3656869T4
(fi)
|
2014-08-26 |
2025-06-04 |
Univ Leland Stanford Junior |
Kantasolujen siirrostaminen kantasoluihin kohdentuvan aineen ja immunoregulatorista signaalia moduloivan aineen yhdistelmän kanssa
|
|
EP3633032A3
(en)
|
2014-08-28 |
2020-07-29 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
|
EP2995948A1
(en)
|
2014-09-09 |
2016-03-16 |
Ecole Polytechnique Federale de Lausanne (EPFL) |
Methods and compounds useful in hematopoietic stem cell medicine
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
ES2753391T3
(es)
|
2014-10-14 |
2020-04-08 |
Halozyme Inc |
Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas
|
|
US10258697B2
(en)
|
2014-10-29 |
2019-04-16 |
Massachusetts Eye And Ear Infirmary |
Efficient delivery of therapeutic molecules in vitro and in vivo
|
|
US10920215B2
(en)
|
2014-11-04 |
2021-02-16 |
National University Corporation Kobe University |
Method for modifying genome sequence to introduce specific mutation to targeted DNA sequence by base-removal reaction, and molecular complex used therein
|
|
EP3224617A1
(en)
|
2014-11-26 |
2017-10-04 |
Oxford University Innovation Limited |
Detection of acute myeloid leukaemia (aml) leukaemic stem cells (lsc)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
US10676737B2
(en)
|
2014-12-17 |
2020-06-09 |
Proqr Therapeutics Ii B.V. |
Targeted RNA editing
|
|
AU2016225178B2
(en)
|
2015-02-23 |
2022-05-05 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2016135559A2
(en)
|
2015-02-23 |
2016-09-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
EP3265559B1
(en)
|
2015-03-03 |
2021-01-06 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
CN107614531A
(zh)
|
2015-03-18 |
2018-01-19 |
纪念斯隆凯特琳癌症中心 |
在造血和淋巴恶性肿瘤中靶向cd99的组合物和方法
|
|
HK1249534A1
(zh)
|
2015-04-06 |
2018-11-02 |
哈佛大学校长及研究员协会 |
用於非清髓性预处理的组合物和方法
|
|
CA2985615A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
CN106011104B
(zh)
|
2015-05-21 |
2019-09-27 |
清华大学 |
利用拆分Cas系统进行基因编辑和表达调控方法
|
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US11479793B2
(en)
|
2015-07-15 |
2022-10-25 |
Rutgers, The State University Of New Jersey |
Nuclease-independent targeted gene editing platform and uses thereof
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017048969A1
(en)
|
2015-09-17 |
2017-03-23 |
The Regents Of The University Of California |
Variant cas9 polypeptides comprising internal insertions
|
|
EP3356520B1
(en)
|
2015-10-02 |
2022-03-23 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Lentiviral protein delivery system for rna-guided genome editing
|
|
JP7109784B2
(ja)
|
2015-10-23 |
2022-08-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
遺伝子編集のための進化したCas9蛋白質
|
|
ES2942309T3
(es)
|
2015-11-04 |
2023-05-31 |
Vertex Pharma |
Materiales y métodos para el tratamiento de hemoglobinopatías
|
|
CA2999649A1
(en)
|
2015-11-06 |
2017-05-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of glycogen storage disease type 1a
|
|
CA3006618A1
(en)
|
2015-12-01 |
2017-06-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of alpha-1 antitrypsin deficiency
|
|
MX2018011114A
(es)
|
2016-03-14 |
2019-02-20 |
Editas Medicine Inc |
Métodos y composiciones relacionadas con crispr/cas para el tratamiento de beta hemoglobinopatías.
|
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
TWI773666B
(zh)
|
2016-03-30 |
2022-08-11 |
美商英特利亞醫療公司 |
Crispr/cas 組分之脂質奈米粒子調配物
|
|
JP2019103391A
(ja)
|
2016-04-14 |
2019-06-27 |
国立大学法人 東京医科歯科大学 |
単球系統のみに分化するヒト単球前駆細胞およびその単離方法
|
|
AU2017250295B2
(en)
|
2016-04-14 |
2022-08-25 |
Fred Hutchinson Cancer Center |
Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
|
|
US20200263190A1
(en)
|
2016-04-19 |
2020-08-20 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
CN110382692A
(zh)
|
2016-04-19 |
2019-10-25 |
博德研究所 |
新型crispr酶以及系统
|
|
WO2017191503A1
(en)
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
FR3051555B1
(fr)
|
2016-05-20 |
2018-05-11 |
Horiba Abx Sas |
Detection de la maladie residuelle du myelome multiple
|
|
AU2017268839A1
(en)
|
2016-05-27 |
2018-11-29 |
Laboratoire Francais Du Fractionnement Et Des Biotechnologies |
Combination of anti-CD20 antibody, P13 kinase-delta selective inhibitor, and BTK inhibitor to treat B-cell proliferative disorders
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
BR112018076306A2
(pt)
|
2016-06-17 |
2019-03-26 |
Magenta Therapeutics, Inc. |
composições e métodos para a supressão de células cd117+
|
|
CN109641051A
(zh)
|
2016-06-17 |
2019-04-16 |
美真达治疗公司 |
用于耗尽细胞的组合物和方法
|
|
WO2018020323A2
(en)
|
2016-07-25 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of fatty acid disorders
|
|
NZ750256A
(en)
|
2016-08-03 |
2026-02-27 |
Dipersio John F |
Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
|
|
KR102547316B1
(ko)
|
2016-08-03 |
2023-06-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
WO2018035388A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
EP3500663A1
(en)
|
2016-08-29 |
2019-06-26 |
PDI Pharm Development International AG |
Provision of a therapeutically active cell product
|
|
US10941402B2
(en)
|
2016-09-01 |
2021-03-09 |
Proqr Therapeutics Ii B.V. |
Chemically modified single-stranded RNA-editing oligonucleotides
|
|
US11590098B2
(en)
|
2016-09-06 |
2023-02-28 |
Mayo Foundation For Medical Education And Research |
Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
|
|
EP3526320A1
(en)
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
|
AU2017355218B2
(en)
|
2016-11-02 |
2024-02-22 |
Universität Basel |
Immunologically discernible cell surface variants for use in cell therapy
|
|
WO2018085516A2
(en)
|
2016-11-02 |
2018-05-11 |
Aal Scientifics, Inc. |
Non-mesenchymal human lung stem cells and methods of their use for treating respiratory diseases
|
|
WO2018089664A1
(en)
|
2016-11-11 |
2018-05-17 |
The Regents Of The University Of California |
Variant rna-guided polypeptides and methods of use
|
|
CN107043779B
(zh)
|
2016-12-01 |
2020-05-12 |
中国农业科学院作物科学研究所 |
一种CRISPR/nCas9介导的定点碱基替换在植物中的应用
|
|
AU2017374044B2
(en)
|
2016-12-08 |
2023-11-30 |
Intellia Therapeutics, Inc. |
Modified guide RNAs
|
|
AU2017379073B2
(en)
|
2016-12-22 |
2023-12-14 |
Intellia Therapeutics, Inc. |
Compositions and methods for treating alpha-1 antitrypsin deficiency
|
|
EP3559223A1
(en)
|
2016-12-23 |
2019-10-30 |
President and Fellows of Harvard College |
Gene editing of pcsk9
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
WO2018119604A1
(zh)
|
2016-12-26 |
2018-07-05 |
深圳市汇顶科技股份有限公司 |
指纹辨识系统
|
|
WO2018129129A1
(en)
|
2017-01-05 |
2018-07-12 |
Rutgers, The State University Of New Jersey |
Targeted gene editing platform independent of dna double strand break and uses thereof
|
|
MX395639B
(es)
|
2017-01-20 |
2025-03-25 |
Heidelberg Pharma Res Gmbh |
Composiciones y métodos para el agotamiento de células cd137+.
|
|
JP7321934B2
(ja)
|
2017-01-30 |
2023-08-07 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
幹細胞移植のための非遺伝毒性移植前処置レジメン
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018152197A1
(en)
|
2017-02-15 |
2018-08-23 |
Massachusetts Institute Of Technology |
Dna writers, molecular recorders and uses thereof
|
|
SG11201907870VA
(en)
|
2017-02-28 |
2019-09-27 |
Vor Biopharma Inc |
Compositions and methods for inhibition of lineage specific proteins
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
US12485186B2
(en)
|
2017-03-31 |
2025-12-02 |
The Children's Medical Center Corporation |
Antibody-mediated conditioning with immunosuppression to enable allogeneic transplantation
|
|
CN106916852B
(zh)
|
2017-04-13 |
2020-12-04 |
上海科技大学 |
一种碱基编辑系统及其构建和应用方法
|
|
DK3609540T5
(da)
|
2017-04-14 |
2024-09-02 |
Bolt Biotherapeutics Inc |
Fremgangsmåde til immunkonjugatsyntese
|
|
WO2018195545A2
(en)
|
2017-04-21 |
2018-10-25 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
WO2018213708A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
EP3625342B1
(en)
|
2017-05-18 |
2022-08-24 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US20200172895A1
(en)
|
2017-05-25 |
2020-06-04 |
The General Hospital Corporation |
Using split deaminases to limit unwanted off-target base editor deamination
|
|
IT201700062176A1
(it)
|
2017-06-07 |
2018-12-07 |
Univ Degli Studi Milano |
Metodo per l’isolamento di sottopopolazioni di progenitori cellulari cardiaci e relativi usi in campo medico
|
|
AU2018290843B2
(en)
|
2017-06-26 |
2025-04-24 |
Massachusetts Institute Of Technology |
CRISPR/Cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
|
WO2019005886A1
(en)
|
2017-06-26 |
2019-01-03 |
The Broad Institute, Inc. |
CRISPR / CAS-CYTIDINE DEAMINASE COMPOSITIONS, SYSTEMS AND METHODS FOR TARGETED EDITING OF NUCLEIC ACIDS
|
|
WO2019003193A1
(en)
|
2017-06-30 |
2019-01-03 |
Novartis Ag |
METHODS FOR TREATING DISEASES USING GENE EDITING SYSTEMS
|
|
US11168322B2
(en)
|
2017-06-30 |
2021-11-09 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
WO2019018383A1
(en)
|
2017-07-18 |
2019-01-24 |
Calimmune, Inc. |
COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES
|
|
WO2019023347A1
(en)
|
2017-07-26 |
2019-01-31 |
Forty Seven, Inc. |
ANTI-SIRP-ALPHA ANTIBODIES AND ASSOCIATED METHODS
|
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
|
CN118530967A
(zh)
|
2017-08-23 |
2024-08-23 |
通用医疗公司 |
具有改变的PAM特异性的工程化的CRISPR-Cas9核酸酶
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
US10849924B2
(en)
|
2017-09-26 |
2020-12-01 |
New York Medical College |
Compositions and methods for restoring endothelial glycocalyx
|
|
EP4389889A3
(en)
|
2017-10-06 |
2024-09-04 |
Oregon Health & Science University |
Compositions and methods for editing rna
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
US20200237743A1
(en)
|
2017-10-17 |
2020-07-30 |
Rhizen Pharmaceuticals Sa |
Crac channel modulators for treating esophageal cancer
|
|
CA3079897A1
(en)
|
2017-10-24 |
2019-05-02 |
Magenta Therapeutics, Inc. |
Compositions and methods for the depletion of cd117+ cells
|
|
WO2019084053A1
(en)
|
2017-10-24 |
2019-05-02 |
Magenta Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS
|
|
CA3079215A1
(en)
|
2017-10-24 |
2019-05-02 |
Magenta Therapeutics, Inc. |
Compositions and methods for the depletion of cd117+ cells
|
|
WO2019082124A1
(en)
|
2017-10-26 |
2019-05-02 |
Rhizen Pharmaceuticals Sa |
COMPOSITION AND METHOD FOR THE TREATMENT OF LARGE B-CELL DIFFUSED LYMPHOMA
|
|
WO2019081982A1
(en)
|
2017-10-26 |
2019-05-02 |
Crispr Therapeutics Ag |
SUBSTANCES AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
|
|
AU2018360367A1
(en)
|
2017-10-30 |
2020-05-28 |
Rhizen Pharmaceuticals Sa |
Calcium release-activated calcium channel modulators for treating hematological and solid cancers
|
|
CN111770776A
(zh)
|
2017-12-06 |
2020-10-13 |
瑞真药业公司 |
治疗外周t细胞淋巴瘤和皮肤t细胞淋巴瘤的组合物和方法
|
|
WO2019113437A1
(en)
|
2017-12-08 |
2019-06-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Hematopoietic stem cell engraftment
|
|
WO2019118516A1
(en)
|
2017-12-11 |
2019-06-20 |
Editas Medicine, Inc. |
Cpf1-related methods and compositions for gene editing
|
|
WO2019126709A1
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Cas12b systems, methods, and compositions for targeted dna base editing
|
|
CN109957569B
(zh)
|
2017-12-22 |
2022-10-25 |
苏州齐禾生科生物科技有限公司 |
基于cpf1蛋白的碱基编辑系统和方法
|
|
GB201802201D0
(en)
|
2018-02-09 |
2018-03-28 |
Ultrahuman Five Ltd |
Binding agents
|
|
CA3093289A1
(en)
|
2018-03-07 |
2019-09-12 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
ES3042632T3
(en)
|
2018-03-13 |
2025-11-24 |
Amgen Inc |
Methods for the preparation of trypsin-resistant polypeptides for mass spectrometric analysis
|
|
IL277106B2
(en)
|
2018-03-13 |
2024-03-01 |
Amgen Inc |
Sequential digestion of polypeptides for mass spectrometric analysis
|
|
WO2019178426A1
(en)
|
2018-03-14 |
2019-09-19 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
AU2019234922A1
(en)
|
2018-03-14 |
2020-10-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
WO2019183000A1
(en)
|
2018-03-19 |
2019-09-26 |
University Of Massachusetts |
Modified guide rnas for crispr genome editing
|
|
CA3097044A1
(en)
|
2018-04-17 |
2019-10-24 |
The General Hospital Corporation |
Sensitive in vitro assays for substrate preferences and sites of nucleic acid binding, modifying, and cleaving agents
|
|
JP7558929B2
(ja)
|
2018-05-11 |
2024-10-01 |
ビーム セラピューティクス インク. |
プログラム可能塩基エディターシステムを用いて病原性変異を抑制する方法
|
|
AU2019266327B2
(en)
|
2018-05-11 |
2025-11-06 |
Beam Therapeutics Inc. |
Methods of editing single nucleotide polymorphism using programmable base editor systems
|
|
CN121555430A
(zh)
|
2018-05-11 |
2026-02-24 |
比姆医疗股份有限公司 |
使用可编程碱基编辑器系统取代病原性氨基酸的方法
|
|
EP3820487A4
(en)
|
2018-05-14 |
2022-03-09 |
Themba Inc. |
Gene editing for autoimmune disorders
|
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
|
WO2019234694A2
(en)
|
2018-06-07 |
2019-12-12 |
Magenta Therapeutics, Inc. |
Therapeutic methods using antibody drug conjugates (adcs)
|
|
AU2019316094B2
(en)
|
2018-08-03 |
2026-02-19 |
Beam Therapeutics Inc. |
Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
|
|
EP3841203A4
(en)
|
2018-08-23 |
2022-11-02 |
The Broad Institute Inc. |
CAS9 VARIANTS WITH NON-CANONICAL PAM SPECIFICITIES AND THEIR USES
|
|
WO2020047326A2
(en)
|
2018-08-31 |
2020-03-05 |
ALX Oncology Inc. |
Decoy polypeptides
|
|
KR20210055733A
(ko)
|
2018-09-07 |
2021-05-17 |
빔 테라퓨틱스, 인크. |
핵염기 편집 시스템을 전달하기 위한 조성물 및 방법
|
|
GB201815670D0
(en)
|
2018-09-26 |
2018-11-07 |
Univ Oxford Innovation Ltd |
Protein editing
|
|
CN109295186B
(zh)
|
2018-09-30 |
2023-10-03 |
中山大学 |
一种基于全基因组测序检测腺嘌呤单碱基编辑系统脱靶效应的方法及其在基因编辑中的应用
|
|
CN113302493A
(zh)
|
2018-10-01 |
2021-08-24 |
小利兰·斯坦福大学托管委员会 |
同时解析多种抗体同种型的高特异性和灵敏度免疫吸附诊断测定
|
|
KR102716514B1
(ko)
|
2018-10-10 |
2024-10-15 |
주식회사 노벨티노빌리티 |
신규 항-c-KIT 항체
|
|
CN113330026A
(zh)
|
2018-10-23 |
2021-08-31 |
美真达治疗公司 |
Fc沉默的抗体药物缀合物(ADC)及其用途
|
|
US20200376135A1
(en)
|
2018-10-23 |
2020-12-03 |
Magenta Therapeutics, Inc. |
Fc silenced antibody drug conjugates (adcs) and uses thereof
|
|
JP2022512781A
(ja)
|
2018-10-30 |
2022-02-07 |
マジェンタ セラピューティクス インコーポレイテッド |
同種造血幹細胞移植の方法
|
|
CN119684457A
(zh)
|
2018-11-26 |
2025-03-25 |
四十七有限责任公司 |
针对c-kit的人源化抗体
|
|
US20220023348A1
(en)
|
2018-11-28 |
2022-01-27 |
Forty Seven, Inc. |
Genetically modified hspcs resistant to ablation regime
|
|
US20220047637A1
(en)
|
2018-11-29 |
2022-02-17 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
AU2019396614B2
(en)
|
2018-12-14 |
2025-07-10 |
Amgen Inc. |
System suitability method for use with protein concentration determination by slope
|
|
KR20210121113A
(ko)
|
2019-01-31 |
2021-10-07 |
빔 테라퓨틱스, 인크. |
비-표적 탈아미노화가 감소된 핵염기 편집기 및 핵염기 편집기를 특성규명하기 위한 분석
|
|
EP3918077A4
(en)
|
2019-01-31 |
2023-03-29 |
Beam Therapeutics, Inc. |
NUCLEOBASE EDITORS WITH REDUCED OFF-TARGET DEAMINATION AND METHODS OF USING THEM TO MODIFY A NUCLEOBASE TARGET SEQUENCE
|
|
US11946040B2
(en)
|
2019-02-04 |
2024-04-02 |
The General Hospital Corporation |
Adenine DNA base editor variants with reduced off-target RNA editing
|
|
KR20210126680A
(ko)
|
2019-02-13 |
2021-10-20 |
빔 테라퓨틱스, 인크. |
알파-1 항트립신 결핍증을 치료하기 위한 조성물 및 방법
|
|
US20220235347A1
(en)
|
2019-02-13 |
2022-07-28 |
Beam Therapeutics Inc. |
Compositions and methods for treating hemoglobinopathies
|
|
US20220098593A1
(en)
|
2019-02-13 |
2022-03-31 |
Beam Therapeutics Inc. |
Splice acceptor site disruption of a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
|
|
US20220127594A1
(en)
|
2019-02-13 |
2022-04-28 |
Beam Therapeutics Inc. |
Compositions and methods for treating glycogen storage disease type 1a
|
|
KR20210139265A
(ko)
|
2019-02-13 |
2021-11-22 |
빔 테라퓨틱스, 인크. |
표적 서열에서 핵염기를 변형하기 위한 아데노신 데아미나제 염기 편집기 및 이의 사용 방법
|
|
WO2020168122A1
(en)
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
|
|
AU2020223306A1
(en)
|
2019-02-13 |
2021-08-05 |
Beam Therapeutics Inc. |
Methods of editing a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN113993550A
(zh)
|
2019-04-24 |
2022-01-28 |
美真达治疗公司 |
用于基因疗法的调理方法
|
|
JP2022529727A
(ja)
|
2019-04-24 |
2022-06-23 |
マジェンタ セラピューティクス インコーポレイテッド |
Anti-cd117 とその使用
|
|
SG11202110287QA
(en)
|
2019-04-24 |
2021-10-28 |
Heidelberg Pharma Res Gmbh |
Amatoxin antibody-drug conjugates and uses thereof
|
|
CA3134319A1
(en)
|
2019-04-24 |
2020-10-29 |
Rahul Palchaudhuri |
Anti-cd117 antibodies and uses thereof
|
|
EP3958909A4
(en)
|
2019-04-24 |
2024-01-10 |
Magenta Therapeutics, Inc. |
ANTI-CD117 ANTIBODY DRUG CONJUGATES AND USES THEREOF
|
|
EP3958899A4
(en)
|
2019-04-24 |
2023-08-02 |
Magenta Therapeutics, Inc. |
ANTI-CD117 ANTIBODY-DRUG CONJUGATES AND THEIR USES
|
|
EP3959242A4
(en)
|
2019-04-24 |
2023-09-13 |
Magenta Therapeutics, Inc. |
ANTRACYCLINE ANTIBODY-DRUG CONJUGATES AND THEIR USES
|
|
US20220211885A1
(en)
|
2019-04-25 |
2022-07-07 |
Actinium Pharmaceuticals, Inc. |
Compositions and methods of immunodepletion for the treatment of malignant and non-malignant hematological diseases
|
|
CN110042124A
(zh)
|
2019-04-25 |
2019-07-23 |
国家卫生健康委科学技术研究所 |
基因组碱基编辑增加人红细胞中胎儿血红蛋白水平的试剂盒及应用
|
|
US20220387622A1
(en)
|
2019-05-21 |
2022-12-08 |
Beam Therapeutics Inc. |
Methods of editing a single nucleotide polymorphism using programmable base editor systems
|
|
EP3976658A4
(en)
|
2019-05-24 |
2023-06-07 |
Forty Seven, Inc. |
Regimes for co-administration of immunotherapeutic agents against c-kit and cd47
|
|
WO2020248064A1
(en)
|
2019-06-12 |
2020-12-17 |
Ontario Institute For Cancer Research (Oicr) |
Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof
|
|
KR102258713B1
(ko)
|
2019-07-31 |
2021-05-31 |
한양대학교 산학협력단 |
사이토신 염기교정용 조성물 및 이의 용도
|
|
WO2021022044A1
(en)
|
2019-07-31 |
2021-02-04 |
Forty Seven, Inc. |
Depletion regimes for engineered t-cell or nk-cell therapy
|
|
US20230017979A1
(en)
|
2019-08-29 |
2023-01-19 |
Beam Therapeutics Inc. |
Compositions and methods for non-toxic conditioning
|
|
GB201912681D0
(en)
|
2019-09-04 |
2019-10-16 |
Eth Zuerich |
Bispecific binding agent that binds to cd117/c-kit and cd3
|
|
CN114667149A
(zh)
|
2019-09-09 |
2022-06-24 |
比姆医疗股份有限公司 |
新型核碱基编辑器及其使用方法
|
|
ES2960527T3
(es)
|
2019-09-13 |
2024-03-05 |
Miltenyi Biotec Bv & Co Kg |
Método para la generación de una composición celular de células progenitoras dopaminérgicas del mesencéfalo ventral
|
|
CA3154648A1
(en)
|
2019-09-16 |
2021-03-25 |
Opsidio, LLC |
Anti-stem cell factor antibodies and methods of use thereof
|
|
JP7814052B2
(ja)
|
2019-09-17 |
2026-02-16 |
ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー |
標的ゲノム修飾のための高度に効率的なrna-アプタマー動員媒介性dna塩基エディターおよびそれらの使用
|
|
CN112125915A
(zh)
|
2019-09-18 |
2020-12-25 |
四川百利药业有限责任公司 |
一种喜树碱衍生物及其偶联物
|
|
WO2021067233A1
(en)
|
2019-09-30 |
2021-04-08 |
The Children's Medical Center Corporation |
Bcl11a guide and base editor delivery
|
|
AU2020370110A1
(en)
|
2019-10-21 |
2022-05-26 |
Rhizen Pharmaceuticals Ag |
Compositions comprising a DHODH inhibitor for the treatment of acute myeloid leukemia
|
|
NL2024163B1
(en)
|
2019-11-05 |
2021-07-20 |
Univ Of Salamanca |
Means and methods for multiparameter cytometry-based leukocyte subsetting.
|
|
CN114938630A
(zh)
|
2019-11-15 |
2022-08-23 |
尼奥普罗根公司 |
用于心脏修复的永生化心脏干细胞
|
|
EP3825330A1
(en)
|
2019-11-19 |
2021-05-26 |
International-Drug-Development-Biotech |
Anti-cd117 antibodies and methods of use thereof
|
|
KR102772859B1
(ko)
|
2019-11-25 |
2025-02-27 |
주식회사 노벨티노빌리티 |
c-kit에 대한 항체 및 이의 용도
|
|
WO2021123397A1
(en)
|
2019-12-20 |
2021-06-24 |
Biogemma |
IMPROVING EFFICIENCY OF BASE EDITING USING TypeV CRISPR ENZYMES
|
|
WO2021158999A1
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Gene editing methods for treating spinal muscular atrophy
|
|
WO2021158921A2
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
|
CA3170326A1
(en)
|
2020-02-13 |
2021-08-19 |
Beam Therapeutics Inc. |
Compositions and methods for engraftment of base edited cells
|
|
US20230313234A1
(en)
|
2020-03-04 |
2023-10-05 |
Suzhou Qi Biodesign Biotechnology Company Limited |
Improved cytosine base editing system
|
|
GB202003129D0
(en)
|
2020-03-04 |
2020-04-15 |
Hansa Biopharma AB |
Conditioning regimen for transplant of stem cells
|
|
WO2021188590A2
(en)
|
2020-03-16 |
2021-09-23 |
Magenta Therapeutics, Inc. |
T-cell bispecific binding proteins
|
|
AU2021236683A1
(en)
|
2020-03-19 |
2022-11-17 |
Intellia Therapeutics, Inc. |
Methods and compositions for directed genome editing
|
|
WO2021207651A2
(en)
|
2020-04-09 |
2021-10-14 |
Verve Therapeutics, Inc. |
Chemically modified guide rnas for genome editing with cas12b
|
|
WO2021211734A1
(en)
|
2020-04-15 |
2021-10-21 |
The Regents Of The University Of California |
Compositions and methods for treatment
|
|
WO2021228944A1
(en)
|
2020-05-13 |
2021-11-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Base editing approaches for the treatment of betahemoglobinopathies
|
|
WO2021239308A1
(en)
|
2020-05-27 |
2021-12-02 |
Universität Zürich |
Viral vectors expressing therapeutic proteins specifically in myeloid cells and microglia
|
|
CA3186295A1
(en)
|
2020-06-08 |
2021-12-16 |
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. |
Camptothecin drug having high-stability hydrophilic connecting unit and conjugate thereof
|
|
EP4179079A1
(en)
|
2020-07-10 |
2023-05-17 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
|
CA3184988A1
(en)
|
2020-07-13 |
2022-01-20 |
Ahmed Mamai |
Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof
|
|
JP2023534693A
(ja)
|
2020-07-15 |
2023-08-10 |
ライフエディット セラピューティクス,インコーポレイティド |
ウラシル安定化タンパク質並びにその活性断片及びバリアント並びに使用方法
|
|
AU2021324891A1
(en)
|
2020-08-14 |
2023-04-06 |
Orchard Therapeutics (Europe) Limited |
Compositions and methods for treating or preventing hereditary angioedema
|
|
EP4199968A1
(en)
|
2020-08-20 |
2023-06-28 |
Ambrx, Inc. |
Antibody-tlr agonist conjugates, methods and uses thereof
|
|
WO2022043538A1
(en)
|
2020-08-29 |
2022-03-03 |
argenx BV |
Method of treatment of patients having reduced sensitivity to a bcl-2 inhibitor
|
|
TWI910226B
(zh)
|
2020-09-11 |
2026-01-01 |
美商生命編輯治療學公司 |
Dna修飾酶及活性片段,及其變異體與使用方法
|
|
CA3192224A1
(en)
|
2020-09-11 |
2022-03-17 |
Jyun-Liang LIN |
Base editing enzymes
|
|
US20230383277A1
(en)
|
2020-10-14 |
2023-11-30 |
Beam Therapeutics Inc. |
Compositions and methods for treating glycogen storage disease type 1a
|
|
WO2022081828A1
(en)
|
2020-10-16 |
2022-04-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Hematopoietic stem cell engraftment with a combination of agents
|
|
IT202000028688A1
(it)
|
2020-11-27 |
2022-05-27 |
Consiglio Nazionale Ricerche |
Varianti della citidina deaminasi per l’editazione di basi
|
|
CN114752629B
(zh)
|
2020-12-28 |
2025-08-19 |
华东师范大学 |
一种针对细胞中单个或多个基因进行基因编辑的方法、产品和应用
|
|
EP4274897A4
(en)
|
2021-01-08 |
2025-03-05 |
The General Hospital Corporation |
GENOMEDITING APPROACHES TO THE TREATMENT OF SPINAL MUSCLE ATROPHY
|
|
US20240360414A1
(en)
|
2021-01-15 |
2024-10-31 |
St. Jude Children's Research Hospital, Inc. |
Systems and Methods for Base Editing Of HBG1/2 Gene Promoter and Fetal Hemoglobin Induction
|
|
US20240327859A1
(en)
|
2021-07-02 |
2024-10-03 |
University Of Maryland, College Park |
Cytidine deaminases and methods of genome editing using the same
|
|
US20240352439A1
(en)
|
2021-09-03 |
2024-10-24 |
The University Of Chicago |
Polypeptides and methods for modifying nucleic acids
|
|
AU2022349449A1
(en)
|
2021-09-22 |
2024-04-18 |
Verve Therapeutics, Inc. |
Gene editing of pcsk9 or angptl3 and compositions and methods of using same for treatment of disease
|
|
WO2023047338A1
(en)
|
2021-09-24 |
2023-03-30 |
Crispr Therapeutics Ag |
PRODRUG INCORPORATED sgRNA SYNTHESIS
|
|
WO2023125814A1
(zh)
|
2021-12-29 |
2023-07-06 |
华东师范大学 |
腺嘌呤脱氨酶及其应用
|
|
CN119013310A
(zh)
|
2022-02-17 |
2024-11-22 |
正序(上海)生物科技有限公司 |
具有改善的编辑精确度的突变的胞嘧啶脱氨酶
|
|
EP4540378A1
(en)
|
2022-06-20 |
2025-04-23 |
CRISPR Therapeutics AG |
Base editing proteins and uses thereof
|
|
AU2023288909A1
(en)
|
2022-06-23 |
2025-01-09 |
Basf Agricultural Solutions Us Llc |
Diversifying base editing
|