JP2022519761A5 - - Google Patents
Info
- Publication number
- JP2022519761A5 JP2022519761A5 JP2021546890A JP2021546890A JP2022519761A5 JP 2022519761 A5 JP2022519761 A5 JP 2022519761A5 JP 2021546890 A JP2021546890 A JP 2021546890A JP 2021546890 A JP2021546890 A JP 2021546890A JP 2022519761 A5 JP2022519761 A5 JP 2022519761A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- base editor
- adenosine deaminase
- alpha
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024208066A JP2025037975A (ja) | 2019-02-13 | 2024-11-29 | アルファ－１アンチトリプシン不全を治療するための組成物および方法 |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962805271P | 2019-02-13 | 2019-02-13 | |
| US201962805238P | 2019-02-13 | 2019-02-13 | |
| US62/805,238 | 2019-02-13 | ||
| US62/805,271 | 2019-02-13 | ||
| US201962852224P | 2019-05-23 | 2019-05-23 | |
| US201962852228P | 2019-05-23 | 2019-05-23 | |
| US62/852,224 | 2019-05-23 | ||
| US62/852,228 | 2019-05-23 | ||
| US201962931722P | 2019-11-06 | 2019-11-06 | |
| US62/931,722 | 2019-11-06 | ||
| US201962941569P | 2019-11-27 | 2019-11-27 | |
| US62/941,569 | 2019-11-27 | ||
| US202062966526P | 2020-01-27 | 2020-01-27 | |
| US62/966,526 | 2020-01-27 | ||
| PCT/US2020/018195 WO2020168135A1 (en) | 2019-02-13 | 2020-02-13 | Compositions and methods for treating alpha-1 antitrypsin deficiency |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024208066A Division JP2025037975A (ja) | 2019-02-13 | 2024-11-29 | アルファ－１アンチトリプシン不全を治療するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022519761A JP2022519761A (ja) | 2022-03-24 |
| JP2022519761A5 true JP2022519761A5 (https=) | 2023-10-03 |
| JP7646554B2 JP7646554B2 (ja) | 2025-03-17 |
Family
ID=72044596
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021546890A Active JP7646554B2 (ja) | 2019-02-13 | 2020-02-13 | アルファ－１アンチトリプシン不全を治療するための組成物および方法 |
| JP2024208066A Pending JP2025037975A (ja) | 2019-02-13 | 2024-11-29 | アルファ－１アンチトリプシン不全を治療するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024208066A Pending JP2025037975A (ja) | 2019-02-13 | 2024-11-29 | アルファ－１アンチトリプシン不全を治療するための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230101597A1 (https=) |
| EP (1) | EP3923994A4 (https=) |
| JP (2) | JP7646554B2 (https=) |
| KR (1) | KR20210126680A (https=) |
| CN (2) | CN120138046A (https=) |
| AU (1) | AU2020223314A1 (https=) |
| CA (1) | CA3128878A1 (https=) |
| WO (1) | WO2020168135A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019265019B2 (en) | 2018-05-11 | 2025-11-06 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| AU2020215730A1 (en) | 2019-01-31 | 2021-07-29 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
| JP7693552B2 (ja) * | 2019-02-13 | 2025-06-17 | ビーム セラピューティクス インク． | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
| CN120174005A (zh) | 2019-02-13 | 2025-06-20 | 比姆医疗股份有限公司 | 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞 |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| WO2021189110A1 (en) * | 2020-03-25 | 2021-09-30 | University Of Tasmania | Dna altering proteins and uses therefor |
| CA3196831A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| CA3198671A1 (en) * | 2020-10-14 | 2022-04-21 | Beam Therapeutics Inc. | Compositions and methods for treating glycogen storage disease type 1a |
| CN112553246A (zh) * | 2020-12-08 | 2021-03-26 | 安徽省农业科学院水稻研究所 | 一种基于CRISPR-SaCas9系统的高效基因组编辑载体及其应用 |
| WO2022150372A1 (en) * | 2021-01-05 | 2022-07-14 | Horizon Discovery Ltd. | Guide rna designs and complexes for type v cas systems |
| EP4396354A4 (en) * | 2021-09-26 | 2025-12-03 | Wave Life Sciences Ltd | OLIGONUCLEOTIDE COMPOSITIONS AND ASSOCIATED PROCESSES |
| CN114634923B (zh) * | 2022-04-07 | 2024-02-23 | 尧唐(上海)生物科技有限公司 | 腺苷脱氨酶、碱基编辑器融合蛋白、碱基编辑器系统及用途 |
| KR20250126155A (ko) * | 2022-11-04 | 2025-08-22 | 라이프 에디트 테라퓨틱스, 인크. | 내부 삽입 부위를 갖는 진화된 아데닌 데아미나제 및 rna-가이드 뉴클레아제 융합 단백질 및 사용 방법 |
| WO2025202473A1 (en) * | 2024-03-28 | 2025-10-02 | Revvity Discovery Limited | A nucleic acid deaminase, a base editor and uses thereof |
| CN119162157B (zh) * | 2024-11-14 | 2025-06-03 | 锐正基因(苏州)有限公司 | 用于碱基编辑的脱氨酶及其变体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3019595A4 (en) * | 2013-07-09 | 2016-11-30 | THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS | |
| BR112017007765B1 (pt) * | 2014-10-14 | 2023-10-03 | Halozyme, Inc | Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo |
| IL310721B2 (en) * | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| US11512311B2 (en) * | 2016-03-25 | 2022-11-29 | Editas Medicine, Inc. | Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency |
| CN110214183A (zh) * | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| KR102622411B1 (ko) * | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| US11866697B2 (en) * | 2017-05-18 | 2024-01-09 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| KR102761791B1 (ko) * | 2017-06-26 | 2025-02-05 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법 |
| CA3108281A1 (en) * | 2018-08-03 | 2020-02-06 | Beam Therapeutics Inc. | Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence |
| AU2020344547A1 (en) * | 2019-09-09 | 2022-03-24 | Beam Therapeutics Inc. | Novel nucleobase editors and methods of using same |
-
2020
- 2020-02-13 KR KR1020217029279A patent/KR20210126680A/ko active Pending
- 2020-02-13 CN CN202510196898.2A patent/CN120138046A/zh active Pending
- 2020-02-13 CN CN202080028286.8A patent/CN114072180B/zh active Active
- 2020-02-13 CA CA3128878A patent/CA3128878A1/en active Pending
- 2020-02-13 JP JP2021546890A patent/JP7646554B2/ja active Active
- 2020-02-13 WO PCT/US2020/018195 patent/WO2020168135A1/en not_active Ceased
- 2020-02-13 AU AU2020223314A patent/AU2020223314A1/en active Pending
- 2020-02-13 US US17/430,665 patent/US20230101597A1/en active Pending
- 2020-02-13 EP EP20755500.4A patent/EP3923994A4/en active Pending
-
2024
- 2024-11-29 JP JP2024208066A patent/JP2025037975A/ja active Pending