JP2021518159A5 - - Google Patents
Info
- Publication number
- JP2021518159A5 JP2021518159A5 JP2020573079A JP2020573079A JP2021518159A5 JP 2021518159 A5 JP2021518159 A5 JP 2021518159A5 JP 2020573079 A JP2020573079 A JP 2020573079A JP 2020573079 A JP2020573079 A JP 2020573079A JP 2021518159 A5 JP2021518159 A5 JP 2021518159A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- letters represent
- lna
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642934P | 2018-03-14 | 2018-03-14 | |
| US62/642,934 | 2018-03-14 | ||
| PCT/US2019/022351 WO2019178411A1 (en) | 2018-03-14 | 2019-03-14 | Inhibitors of micro-rna 22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021518159A JP2021518159A (ja) | 2021-08-02 |
| JP2021518159A5 true JP2021518159A5 (https=) | 2022-03-16 |
| JP7318166B2 JP7318166B2 (ja) | 2023-08-01 |
Family
ID=67908026
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573079A Active JP7318166B2 (ja) | 2018-03-14 | 2019-03-14 | マイクロｒｎａ２２の阻害剤 |
| JP2020549635A Pending JP2021518841A (ja) | 2018-03-14 | 2019-03-14 | マイクロｒｎａと肥満症 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020549635A Pending JP2021518841A (ja) | 2018-03-14 | 2019-03-14 | マイクロｒｎａと肥満症 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11753639B2 (https=) |
| EP (2) | EP3765610A4 (https=) |
| JP (2) | JP7318166B2 (https=) |
| KR (2) | KR20200131287A (https=) |
| CN (2) | CN112119159B (https=) |
| AU (2) | AU2019234917B2 (https=) |
| BR (2) | BR112020018705A2 (https=) |
| CA (2) | CA3093572A1 (https=) |
| ES (1) | ES3001019T3 (https=) |
| RU (2) | RU2020131372A (https=) |
| SG (2) | SG11202008925VA (https=) |
| WO (2) | WO2019178410A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200131287A (ko) | 2018-03-14 | 2020-11-23 | 베스 이스라엘 데코니스 메디칼 센터 | 마이크로-rna 22의 억제제 |
| CN110609142A (zh) * | 2019-10-09 | 2019-12-24 | 广州医科大学附属第二医院 | 一种检测外周血fto蛋白与自身调控元件结合能力的方法与应用 |
| CN115029347B (zh) * | 2022-05-11 | 2024-02-20 | 珠海中科先进技术研究院有限公司 | 识别和调控肝肾细胞纤维化的分子监测序列、重组质粒、抑制病毒 |
| CN116082447A (zh) * | 2022-09-09 | 2023-05-09 | 湖南大学 | 一种多肽及其制备方法 |
| CN117304258B (zh) * | 2022-09-09 | 2024-09-24 | 湖南大学 | 一种多肽的用途 |
| EP4353823A1 (en) * | 2022-10-12 | 2024-04-17 | Resalis Therapeutics S.r.l. | Inhibitors of micro-rna 22 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5840710A (en) | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
| US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
| CA2294988C (en) | 1997-07-01 | 2015-11-24 | Isis Pharmaceuticals Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
| JP2002516256A (ja) | 1998-05-26 | 2002-06-04 | アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド | 二環式糖成分を有する新規ヌクレオシド |
| US6838283B2 (en) | 1998-09-29 | 2005-01-04 | Isis Pharmaceuticals Inc. | Antisense modulation of survivin expression |
| US6693187B1 (en) | 2000-10-17 | 2004-02-17 | Lievre Cornu Llc | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge |
| CA2487274A1 (en) | 2002-05-06 | 2003-11-13 | Nucleonics Inc. | Spermine chemically linked to lipids and cell-specific targeting molecules as a transfection agent |
| EP2302055B1 (en) * | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| US20070213292A1 (en) * | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| KR101485071B1 (ko) * | 2005-12-12 | 2015-01-26 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 마이크로 ｒｎａ를 이용한 근육 세포 증식 및 분화 조절방법과 근육 세포 치료방법 및 유전자 발현 억제방법그리고 마이크로 ｒｎａ 분자의 발현용 벡터와 이를 이용한키트 및 미오사이트 |
| AU2013254923A1 (en) * | 2006-04-03 | 2013-11-28 | Santaris Pharma A/S | Pharmaceutical compositions comprising anti-miRNA antisense oligonucleotide |
| EP2007888A2 (en) | 2006-04-03 | 2008-12-31 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| EP2623599B1 (en) * | 2007-10-04 | 2019-01-02 | Roche Innovation Center Copenhagen A/S | Micromirs |
| EP2419537B1 (en) * | 2009-04-13 | 2014-01-29 | Somagenics, Inc. | Methods and compositions for detection of small rnas |
| SG176716A1 (en) * | 2009-06-08 | 2012-01-30 | Miragen Therapeutics | CHEMICAL MODIFICATION MOTIFS FOR miRNA INHIBITORS AND MIMETICS |
| UY33807A (es) * | 2010-12-17 | 2012-07-31 | Sanofi Sa | miRNAs como indicadores del estado tisular o de enfermedades como osteoartritis |
| CA2832899A1 (en) | 2011-04-12 | 2012-10-18 | Beth Israel Deaconess Medical Center, Inc. | Micro-rna inhibitors and their uses in disease |
| JP6092655B2 (ja) * | 2012-02-23 | 2017-03-08 | 善基 村上 | テスト体液サンプルの分類方法 |
| US9034839B2 (en) | 2012-04-20 | 2015-05-19 | Aptamir Therapeutics, Inc. | miRNA modulators of thermogenesis |
| WO2013181613A1 (en) * | 2012-05-31 | 2013-12-05 | Research Development Foundation | Mirna for the diagnosis and treatment of autoimmune and inflammatory disease |
| CN107236735B (zh) * | 2012-06-21 | 2019-11-08 | 米拉根医疗股份有限公司 | 包含锁核酸基序的基于寡核苷酸的抑制剂 |
| US9822358B2 (en) | 2013-10-18 | 2017-11-21 | Beth Israel Deaconess Medical Center | Treatment of cancers with micro-RNA inhibitors |
| CA2935426C (en) * | 2014-01-30 | 2023-07-25 | F. Hoffmann-La Roche Ag | Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target |
| WO2016127002A1 (en) | 2015-02-04 | 2016-08-11 | Bristol-Myers Squibb Company | Lna oligonucleotides with alternating flanks |
| WO2016149358A1 (en) * | 2015-03-16 | 2016-09-22 | Duncan Ross | Method of treatment comprising membrane-enclosed vesicle |
| WO2017187426A1 (en) * | 2016-04-29 | 2017-11-02 | Aptamir Therapeutics, Inc. | Inhibition of mir-22 mirna by apt-110 |
| CN107432933A (zh) * | 2017-07-13 | 2017-12-05 | 中南大学湘雅三医院 | miR‑22作为靶位点在制备膀胱癌的化疗增敏治疗药物中的应用 |
| WO2019053235A1 (en) * | 2017-09-15 | 2019-03-21 | Genfit | NON-INVASIVE DIAGNOSIS OF NON ALCOHOLIC LIVER DISEASES, NON ALCOHOLIC STHEATHEPATITIS AND / OR HEPATIC FIBROSIS |
| KR20200131287A (ko) | 2018-03-14 | 2020-11-23 | 베스 이스라엘 데코니스 메디칼 센터 | 마이크로-rna 22의 억제제 |
| WO2019217907A1 (en) * | 2018-05-11 | 2019-11-14 | The Regents Of The University Of California | Methods and compositions for the treatment of hepatic and metabolic diseases |
-
2019
- 2019-03-14 KR KR1020207029242A patent/KR20200131287A/ko not_active Withdrawn
- 2019-03-14 RU RU2020131372A patent/RU2020131372A/ru unknown
- 2019-03-14 RU RU2020132725A patent/RU2020132725A/ru unknown
- 2019-03-14 CA CA3093572A patent/CA3093572A1/en active Pending
- 2019-03-14 ES ES19768368T patent/ES3001019T3/es active Active
- 2019-03-14 KR KR1020207029243A patent/KR20200132920A/ko not_active Withdrawn
- 2019-03-14 JP JP2020573079A patent/JP7318166B2/ja active Active
- 2019-03-14 WO PCT/US2019/022350 patent/WO2019178410A1/en not_active Ceased
- 2019-03-14 CA CA3093844A patent/CA3093844A1/en active Pending
- 2019-03-14 EP EP19768285.9A patent/EP3765610A4/en active Pending
- 2019-03-14 CN CN201980032204.4A patent/CN112119159B/zh active Active
- 2019-03-14 SG SG11202008925VA patent/SG11202008925VA/en unknown
- 2019-03-14 SG SG11202008921YA patent/SG11202008921YA/en unknown
- 2019-03-14 BR BR112020018705-4A patent/BR112020018705A2/pt not_active Application Discontinuation
- 2019-03-14 BR BR112020018752-6A patent/BR112020018752A2/pt not_active Application Discontinuation
- 2019-03-14 US US16/979,777 patent/US11753639B2/en active Active
- 2019-03-14 AU AU2019234917A patent/AU2019234917B2/en active Active
- 2019-03-14 AU AU2019234916A patent/AU2019234916B2/en active Active
- 2019-03-14 CN CN201980018587.XA patent/CN111918968B/zh active Active
- 2019-03-14 WO PCT/US2019/022351 patent/WO2019178411A1/en not_active Ceased
- 2019-03-14 JP JP2020549635A patent/JP2021518841A/ja active Pending
- 2019-03-14 US US16/979,782 patent/US11499152B2/en active Active
- 2019-03-14 EP EP19768368.3A patent/EP3765619B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021518159A5 (https=) | ||
| Mundt et al. | Complete nucleotide sequences of 5′-and 3′-noncoding regions of both genome segments of different strains of infectious bursal disease virus | |
| Lin et al. | Sequence comparisons of a highly virulent infectious bursal disease virus prevalent in Japan | |
| Soto‐Rifo et al. | The role of the DEAD‐box RNA helicase DDX3 in mRNA metabolism | |
| Jeong et al. | Characterization of the DNA nucleotide sequences in the genome of red sea bream iridoviruses isolated in Korea | |
| Dodson et al. | Specialized nucleoprotein structures at the origin of replication of bacteriophage lambda: localized unwinding of duplex DNA by a six-protein reaction. | |
| JP2023543803A5 (https=) | ||
| JP2024530487A5 (https=) | ||
| EP4089175A1 (en) | Genome engineering with type i crispr systems in eukaryotic cells | |
| JP2021534798A5 (https=) | ||
| JP2022519761A5 (https=) | ||
| Klovins et al. | A long-range interaction in Qβ RNA that bridges the thousand nucleotides between the M-site and the 3′ end is required for replication | |
| JP2019536425A5 (https=) | ||
| JP2024511163A5 (https=) | ||
| JP2015532097A5 (https=) | ||
| JP2012136542A5 (https=) | ||
| JP2008533988A5 (https=) | ||
| Prevelige et al. | Building the machines: scaffolding protein functions during bacteriophage morphogenesis | |
| Goodman et al. | The nucleotide sequence at the 5′-terminus of the Qβ RNA minus strand | |
| JP2023511991A5 (https=) | ||
| RU2022103641A (ru) | Искусственная модификация генома для регуляции экспрессии гена | |
| JP2021505129A5 (https=) | ||
| RU2020131372A (ru) | ИНГИБИТОРЫ микроРНК 22 | |
| JP2024511131A5 (https=) | ||
| JP2021522825A5 (https=) |