JP2021534798A5 - - Google Patents
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- Publication number
- JP2021534798A5 JP2021534798A5 JP2021511605A JP2021511605A JP2021534798A5 JP 2021534798 A5 JP2021534798 A5 JP 2021534798A5 JP 2021511605 A JP2021511605 A JP 2021511605A JP 2021511605 A JP2021511605 A JP 2021511605A JP 2021534798 A5 JP2021534798 A5 JP 2021534798A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- polypeptide
- sequence
- domain
- template rna
- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025011363A JP2025063317A (ja) | 2018-08-28 | 2025-01-27 | ゲノムを調節するための方法及び組成物 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862723886P | 2018-08-28 | 2018-08-28 | |
| US62/723,886 | 2018-08-28 | ||
| US201862725778P | 2018-08-31 | 2018-08-31 | |
| US62/725,778 | 2018-08-31 | ||
| US201962850883P | 2019-05-21 | 2019-05-21 | |
| US62/850,883 | 2019-05-21 | ||
| US201962864924P | 2019-06-21 | 2019-06-21 | |
| US62/864,924 | 2019-06-21 | ||
| PCT/US2019/048607 WO2020047124A1 (en) | 2018-08-28 | 2019-08-28 | Methods and compositions for modulating a genome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025011363A Division JP2025063317A (ja) | 2018-08-28 | 2025-01-27 | ゲノムを調節するための方法及び組成物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021534798A JP2021534798A (ja) | 2021-12-16 |
| JPWO2020047124A5 JPWO2020047124A5 (https=) | 2022-09-06 |
| JP2021534798A5 true JP2021534798A5 (https=) | 2022-09-06 |
| JP7680351B2 JP7680351B2 (ja) | 2025-05-20 |
Family
ID=67997683
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021511605A Active JP7680351B2 (ja) | 2018-08-28 | 2019-08-28 | ゲノムを調節するための方法及び組成物 |
| JP2025011363A Pending JP2025063317A (ja) | 2018-08-28 | 2025-01-27 | ゲノムを調節するための方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025011363A Pending JP2025063317A (ja) | 2018-08-28 | 2025-01-27 | ゲノムを調節するための方法及び組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12031129B2 (https=) |
| EP (1) | EP3844272A1 (https=) |
| JP (2) | JP7680351B2 (https=) |
| KR (1) | KR20210049859A (https=) |
| CN (1) | CN113286880A (https=) |
| AU (1) | AU2019327449B2 (https=) |
| BR (1) | BR112021003380A2 (https=) |
| CA (1) | CA3109953A1 (https=) |
| IL (1) | IL280947A (https=) |
| WO (1) | WO2020047124A1 (https=) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| MX2019015505A (es) | 2017-06-30 | 2020-07-28 | Inscripta Inc | Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados. |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
| US10526598B2 (en) | 2018-04-24 | 2020-01-07 | Inscripta, Inc. | Methods for identifying T-cell receptor antigens |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| CN113286880A (zh) | 2018-08-28 | 2021-08-20 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US11001831B2 (en) | 2019-03-25 | 2021-05-11 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| AU2020288623A1 (en) | 2019-06-06 | 2022-01-06 | Inscripta, Inc. | Curing for recursive nucleic acid-guided cell editing |
| WO2020252361A1 (en) * | 2019-06-12 | 2020-12-17 | Emendobio Inc. | Novel genome editing tool |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| JP7831937B2 (ja) | 2019-09-03 | 2026-03-17 | クリエイト・メディシンズ，インコーポレーテッド | ゲノム組込みのための方法および組成物 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US11203762B2 (en) | 2019-11-19 | 2021-12-21 | Inscripta, Inc. | Methods for increasing observed editing in bacteria |
| EP4069851A4 (en) | 2019-12-18 | 2023-11-22 | Inscripta, Inc. | Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells |
| IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
| JP2023516692A (ja) * | 2020-03-04 | 2023-04-20 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ゲノムを調節するための方法及び組成物 |
| CA3174483A1 (en) | 2020-03-04 | 2021-09-10 | Flagship Pioneering Innovations Vi, Llc | Improved methods and compositions for modulating a genome |
| AU2021232069A1 (en) * | 2020-03-05 | 2022-11-03 | Flagship Pioneering Innovations Vi, Llc | Host defense suppressing methods and compositions for modulating a genome |
| AU2021236683A1 (en) | 2020-03-19 | 2022-11-17 | Intellia Therapeutics, Inc. | Methods and compositions for directed genome editing |
| CN115427566A (zh) * | 2020-04-08 | 2022-12-02 | 阿斯利康(瑞典)有限公司 | 用于改善的位点特异性修饰的组合物和方法 |
| US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| WO2021248102A1 (en) * | 2020-06-05 | 2021-12-09 | Flagship Pioneering Innovations Vi, Llc | Template guide rna molecules |
| EP4185600A4 (en) | 2020-07-24 | 2024-12-04 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| WO2022060749A1 (en) | 2020-09-15 | 2022-03-24 | Inscripta, Inc. | Crispr editing to embed nucleic acid landing pads into genomes of live cells |
| EP4232583A1 (en) | 2020-10-21 | 2023-08-30 | Massachusetts Institute of Technology | Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste) |
| CN116848240A (zh) * | 2020-12-07 | 2023-10-03 | 因思科瑞普特公司 | 核酸引导的切口酶编辑中的gRNA稳定 |
| AU2021415461A1 (en) | 2021-01-04 | 2023-08-17 | Inscripta, Inc. | Mad nucleases |
| KR20230131229A (ko) * | 2021-01-14 | 2023-09-12 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 부위 특이적 유전자 변형 |
| CN112708636A (zh) * | 2021-01-22 | 2021-04-27 | 彭双红 | 基因转录框架、载体系统、基因组序列编辑方法及应用 |
| US20240132916A1 (en) * | 2021-02-09 | 2024-04-25 | The Broad Institute, Inc. | Nuclease-guided non-ltr retrotransposons and uses thereof |
| US11884924B2 (en) | 2021-02-16 | 2024-01-30 | Inscripta, Inc. | Dual strand nucleic acid-guided nickase editing |
| US20240042058A1 (en) * | 2021-02-26 | 2024-02-08 | Flagship Pioneering Innovations Vi, Llc | Tissue-specific methods and compositions for modulating a genome |
| CA3214277A1 (en) * | 2021-03-19 | 2022-09-22 | Flagship Pioneering Innovations Vi, Llc | Ltr transposon compositions and methods |
| AR125217A1 (es) | 2021-03-26 | 2023-06-28 | Flagship Pioneering Innovations Vii Llc | Producción de polirribonucleótidos circulares en un sistema procariota |
| EP4314289A1 (en) | 2021-03-26 | 2024-02-07 | Flagship Pioneering Innovations VII, LLC | Production of circular polyribonucleotides in a prokaryotic system |
| WO2022204464A1 (en) | 2021-03-26 | 2022-09-29 | Flagship Pioneering Innovations Vii, Llc | Production of circular polyribonucleotides in a eukaryotic system |
| AU2022272235A1 (en) | 2021-05-11 | 2023-12-21 | Create Medicines, Inc. | Methods and compositions for genomic integration |
| AU2022315304A1 (en) | 2021-07-23 | 2024-02-08 | Flagship Pioneering Innovations Vii, Llc | Compositions for fungal control and related methods |
| MX2024003006A (es) * | 2021-09-08 | 2024-03-25 | Metagenomi Inc | Sistemas, composiciones y metodos que implican retrotransposones y fragmentos funcionales de estos. |
| JP2024533311A (ja) | 2021-09-08 | 2024-09-12 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ゲノムを調節するための方法及び組成物 |
| KR20240099164A (ko) | 2021-09-08 | 2024-06-28 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | Pah-조절 조성물 및 방법 |
| WO2023039434A1 (en) * | 2021-09-08 | 2023-03-16 | Metagenomi, Inc. | Systems and methods for transposing cargo nucleotide sequences |
| ES2994006T3 (en) | 2021-09-17 | 2025-01-16 | Flagship Pioneering Innovations Vi Llc | Compositions and methods for producing circular polyribonucleotides |
| JP2024538144A (ja) | 2021-10-18 | 2024-10-18 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ポリリボヌクレオチドを精製するための組成物及び方法 |
| EP4419669A1 (en) * | 2021-10-19 | 2024-08-28 | Massachusetts Institute Of Technology | Genomic editing with site-specific retrotransposons |
| KR20240099393A (ko) | 2021-11-01 | 2024-06-28 | 톰 바이오사이언시스, 인코포레이티드 | 유전자 편집 기구와 핵산 카고의 동시 전달을 위한 단일 작제물 플랫폼 |
| EP4444362A4 (en) | 2021-12-10 | 2026-04-01 | Flagship Pioneering Innovations Vi Llc | CFTR COMPOSITIONS AND MODULATION METHODS |
| WO2023122764A1 (en) | 2021-12-22 | 2023-06-29 | Tome Biosciences, Inc. | Co-delivery of a gene editor construct and a donor template |
| KR20240117149A (ko) | 2021-12-22 | 2024-07-31 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 폴리리보뉴클레오티드를 정제하기 위한 조성물 및 방법 |
| WO2023205744A1 (en) | 2022-04-20 | 2023-10-26 | Tome Biosciences, Inc. | Programmable gene insertion compositions |
| CN119630786A (zh) * | 2022-05-02 | 2025-03-14 | 加利福尼亚大学董事会 | 用于位点特异性基因组修饰的多组件系统 |
| WO2023215831A1 (en) | 2022-05-04 | 2023-11-09 | Tome Biosciences, Inc. | Guide rna compositions for programmable gene insertion |
| WO2023225670A2 (en) | 2022-05-20 | 2023-11-23 | Tome Biosciences, Inc. | Ex vivo programmable gene insertion |
| US20250320254A1 (en) | 2022-05-25 | 2025-10-16 | Flagship Pioneering Innovations Vii, Llc | Compositions and Methods for Modulating Circulating Factors |
| CA3253328A1 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | Compositions and Modulation Methods of Genetic Drivers |
| JP2025517969A (ja) | 2022-05-25 | 2025-06-12 | フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー | 腫瘍抑制因子及び癌遺伝子の調節のための組成物及び方法 |
| WO2023230524A1 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vi, Llc | Compositions of secretory and/or catalytic cells and methods using the same |
| EP4641202A3 (en) | 2022-05-25 | 2026-01-21 | Flagship Pioneering Innovations VII, LLC | Compositions and methods for modulation of immune responses |
| US20250319115A1 (en) | 2022-05-25 | 2025-10-16 | Flagship Pioneering Innovations Vii, Llc | Compositions and Methods for Modulating Cytokines |
| JP2025525569A (ja) | 2022-07-18 | 2025-08-05 | レナゲード セラピューティクス マネージメント インコーポレイテッド | 遺伝子編集成分、システム、及び使用方法 |
| WO2024020587A2 (en) | 2022-07-22 | 2024-01-25 | Tome Biosciences, Inc. | Pleiopluripotent stem cell programmable gene insertion |
| WO2024086586A2 (en) * | 2022-10-18 | 2024-04-25 | Flagship Pioneering Innovations Vi, Llc | Improved gene editing systems utilizing trans recruiting components |
| AU2023372397A1 (en) | 2022-10-31 | 2025-05-08 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
| EP4615465A1 (en) | 2022-11-08 | 2025-09-17 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for producing circular polyribonucleotides |
| EP4630542A2 (en) * | 2022-12-09 | 2025-10-15 | Metagenomi, Inc. | Retrotransposon compositions and methods of use |
| CN118222533A (zh) * | 2022-12-19 | 2024-06-21 | 北京干细胞与再生医学研究院 | 一种在基因组插入大片段dna的系统 |
| WO2024138194A1 (en) | 2022-12-22 | 2024-06-27 | Tome Biosciences, Inc. | Platforms, compositions, and methods for in vivo programmable gene insertion |
| IL322884A (en) | 2023-02-23 | 2025-10-01 | Micropep Tech S A | Antifungal peptides for controlling plant pathogens |
| WO2024192420A1 (en) | 2023-03-15 | 2024-09-19 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising polyribonucleotides and uses thereof |
| EP4680276A1 (en) | 2023-03-15 | 2026-01-21 | Flagship Pioneering Innovations VI, LLC | Immunogenic compositions and uses thereof |
| US20250236890A1 (en) * | 2023-04-11 | 2025-07-24 | Beijing Astragenomics Technology Co., Ltd. | Non-ltr retrotransposon system and use thereof |
| US20240352485A1 (en) | 2023-04-19 | 2024-10-24 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for the production of libraries |
| WO2024234006A1 (en) | 2023-05-11 | 2024-11-14 | Tome Biosciences, Inc. | Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs) |
| WO2025006419A1 (en) | 2023-06-26 | 2025-01-02 | Flagship Pioneering Innovations Vii, Llc | Engineered plasmodia and related methods |
| CN119286819A (zh) * | 2023-07-10 | 2025-01-10 | 北京干细胞与再生医学研究院 | 工程化的哺乳动物基因写入系统 |
| CN121712890A (zh) * | 2023-08-16 | 2026-03-20 | 基础科学研究院 | 使用具有单链断裂活性的CRISPR/Cas系统和PARP抑制剂的细胞死亡方法 |
| WO2025050069A1 (en) | 2023-09-01 | 2025-03-06 | Tome Biosciences, Inc. | Programmable gene insertion using engineered integration enzymes |
| AU2024335327A1 (en) | 2023-09-01 | 2026-03-26 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025085519A1 (en) * | 2023-10-16 | 2025-04-24 | Typewriter Therapeutics, Inc. | R2 retrotransposons for gene writing |
| WO2025128545A1 (en) * | 2023-12-11 | 2025-06-19 | Aera Therapeutics, Inc. | Engineered mobile genetic element systems |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025132815A1 (en) | 2023-12-20 | 2025-06-26 | Novozymes A/S | Novel cas nucleases and polynucleotides encoding the same |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025217194A1 (en) * | 2024-04-09 | 2025-10-16 | Typewriter Therapeutics, Inc. | Repeat dosing of retrotransposons |
| WO2025224182A2 (en) | 2024-04-23 | 2025-10-30 | Basecamp Research Ltd | Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo |
| WO2026062521A2 (en) | 2024-09-18 | 2026-03-26 | Institute Of Molecular And Clinical Ophthalmology Basel (Iob) | Methods and compounds for promoting survival of photoreceptors |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030121063A1 (en) | 1995-11-16 | 2003-06-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods of use of mammalian retrotransposons |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| CN1342758A (zh) * | 2000-09-12 | 2002-04-03 | 上海博德基因开发有限公司 | 一种新的多肽——逆转录酶9.24和编码这种多肽的多核苷酸 |
| JP2002291473A (ja) * | 2001-04-02 | 2002-10-08 | New Industry Research Organization | レトロトランスポゾン、プロモーター活性を有するｄｎａ断片、及びその利用 |
| US20060183226A1 (en) * | 2002-01-31 | 2006-08-17 | Haruhiko Fujiwara | Methods for retrotransposing long interspersed elements (lines) |
| US20070037759A1 (en) | 2003-02-07 | 2007-02-15 | Administrators Of The Tulane Educational Fund, The | Mammalian retrotransposable elements |
| CA2526860A1 (en) * | 2003-05-28 | 2005-06-02 | The Johns Hopkins University | Synthetic mammalian retrotransposon gene |
| US20080104723A1 (en) * | 2003-11-21 | 2008-05-01 | Osaka Industrial Promojtion Organization C/O Mydom | Development of Mammalian Genome Modification Technique Using Retrotransposon |
| CN101297031B (zh) * | 2005-05-14 | 2013-06-05 | 复旦大学 | 在脊椎动物中作为遗传操作和分析工具的piggyBac |
| JP2009535065A (ja) | 2006-05-04 | 2009-10-01 | アブマクシス・インコーポレイテツド | 組換えタンパク質の高レベルを産生する安定した哺乳動物細胞系を作製するための方法 |
| US8598328B2 (en) * | 2006-12-13 | 2013-12-03 | National University Corporation Nagoya University | Tol1 factor transposase and DNA introduction system using the same |
| EP2055784A1 (en) | 2007-10-31 | 2009-05-06 | Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer | Controlled activation of non-LTR retrotransposons in mammals |
| US8889394B2 (en) | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
| US10316304B2 (en) | 2009-11-27 | 2019-06-11 | Basf Plant Science Company Gmbh | Chimeric endonucleases and uses thereof |
| KR101911969B1 (ko) * | 2011-02-23 | 2018-10-25 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | Ｄｎａ 합성을 위한 주형 스위칭의 용도 |
| US20140113375A1 (en) | 2012-10-21 | 2014-04-24 | Lixin Liu | Transient Expression And Reverse Transcription Aided Genome Alteration System |
| CA2894684A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes |
| WO2014093718A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| MX374090B (es) | 2013-03-14 | 2025-03-05 | Caribou Biosciences Inc | Composiciones y métodos de ácidos nucleicos dirigidos al ácido nucleico. |
| US20140349400A1 (en) | 2013-03-15 | 2014-11-27 | Massachusetts Institute Of Technology | Programmable Modification of DNA |
| SI2986729T1 (sl) * | 2013-04-16 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Ciljana sprememba genoma podgane |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| WO2015191693A2 (en) | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| EP3183358B1 (en) | 2014-08-19 | 2020-10-07 | President and Fellows of Harvard College | Rna-guided systems for probing and mapping of nucleic acids |
| WO2016036754A1 (en) | 2014-09-02 | 2016-03-10 | The Regents Of The University Of California | Methods and compositions for rna-directed target dna modification |
| US20170306306A1 (en) | 2014-10-24 | 2017-10-26 | Life Technologies Corporation | Compositions and Methods for Enhancing Homologous Recombination |
| ES2731437T3 (es) * | 2014-11-21 | 2019-11-15 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías |
| EP3307887A1 (en) | 2015-06-09 | 2018-04-18 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for improving transplantation |
| WO2016205728A1 (en) | 2015-06-17 | 2016-12-22 | Massachusetts Institute Of Technology | Crispr mediated recording of cellular events |
| EP3356520B1 (en) | 2015-10-02 | 2022-03-23 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Lentiviral protein delivery system for rna-guided genome editing |
| WO2017123609A1 (en) | 2016-01-12 | 2017-07-20 | The Regents Of The University Of California | Compositions and methods for enhanced genome editing |
| GB201602473D0 (en) * | 2016-02-11 | 2016-03-30 | Horizon Discovery Ltd | Replicative transposon system |
| US20170275665A1 (en) | 2016-02-24 | 2017-09-28 | Board Of Regents, The University Of Texas System | Direct crispr spacer acquisition from rna by a reverse-transcriptase-cas1 fusion protein |
| US11447768B2 (en) | 2016-03-01 | 2022-09-20 | University Of Florida Research Foundation, Incorporated | Molecular cell diary system |
| TWI773666B (zh) * | 2016-03-30 | 2022-08-11 | 美商英特利亞醫療公司 | Crispr/cas 組分之脂質奈米粒子調配物 |
| WO2017173004A1 (en) * | 2016-03-30 | 2017-10-05 | Mikuni Takayasu | A method for in vivo precise genome editing |
| EP3443088B1 (en) | 2016-04-13 | 2024-09-18 | Editas Medicine, Inc. | Grna fusion molecules, gene editing systems, and methods of use thereof |
| JP7184648B2 (ja) | 2016-04-29 | 2022-12-06 | ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー | 標的核酸の改変のための改善された方法 |
| WO2017197238A1 (en) | 2016-05-12 | 2017-11-16 | President And Fellows Of Harvard College | Aav split cas9 genome editing and transcriptional regulation |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CA3035229A1 (en) | 2016-09-02 | 2018-03-08 | North Carolina State University | Methods and compositions for modification of plastid genomes |
| EP4431607A3 (en) | 2016-09-09 | 2024-12-11 | The Board of Trustees of the Leland Stanford Junior University | High-throughput precision genome editing |
| US20190330620A1 (en) | 2016-10-14 | 2019-10-31 | Emendobio Inc. | Rna compositions for genome editing |
| KR102709829B1 (ko) | 2016-11-11 | 2024-09-24 | 바이오 래드 래버러토리스 인코오포레이티드 | 핵산 샘플을 프로세싱하는 방법 |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| US20200172895A1 (en) | 2017-05-25 | 2020-06-04 | The General Hospital Corporation | Using split deaminases to limit unwanted off-target base editor deamination |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| JP2021530212A (ja) | 2018-07-13 | 2021-11-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | レトロトランスポゾンベースの送達媒体及びその使用方法 |
| CN113286880A (zh) | 2018-08-28 | 2021-08-20 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| US20210340562A1 (en) | 2018-10-19 | 2021-11-04 | Board Of Regents, The University Of Texas System | Engineered long interspersed element (line) transposons and methods of use |
| WO2020186262A1 (en) | 2019-03-14 | 2020-09-17 | Cornell University | Compositions and methods for gene targeting using crispr-cas and transposons |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| WO2020252361A1 (en) | 2019-06-12 | 2020-12-17 | Emendobio Inc. | Novel genome editing tool |
| WO2021016075A1 (en) | 2019-07-19 | 2021-01-28 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| US20220411768A1 (en) | 2019-10-21 | 2022-12-29 | The Trustees Of Columbia University In The City Of New York | Methods of performing rna templated genome editing |
| CA3162499A1 (en) | 2019-11-22 | 2021-05-27 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| US20230348939A1 (en) | 2020-03-04 | 2023-11-02 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| JP2023516692A (ja) | 2020-03-04 | 2023-04-20 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ゲノムを調節するための方法及び組成物 |
| CA3174483A1 (en) | 2020-03-04 | 2021-09-10 | Flagship Pioneering Innovations Vi, Llc | Improved methods and compositions for modulating a genome |
| IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
| AU2021232069A1 (en) | 2020-03-05 | 2022-11-03 | Flagship Pioneering Innovations Vi, Llc | Host defense suppressing methods and compositions for modulating a genome |
| WO2021248102A1 (en) | 2020-06-05 | 2021-12-09 | Flagship Pioneering Innovations Vi, Llc | Template guide rna molecules |
| US20240042058A1 (en) | 2021-02-26 | 2024-02-08 | Flagship Pioneering Innovations Vi, Llc | Tissue-specific methods and compositions for modulating a genome |
| CA3214277A1 (en) | 2021-03-19 | 2022-09-22 | Flagship Pioneering Innovations Vi, Llc | Ltr transposon compositions and methods |
| WO2022251356A1 (en) | 2021-05-26 | 2022-12-01 | Flagship Pioneering Innovations Vi, Llc | Integrase compositions and methods |
| MX2024002930A (es) | 2021-09-08 | 2024-05-29 | Flagship Pioneering Innovations Vi Llc | Metodos y composiciones para modular un genoma. |
| AU2022342169A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Hbb-modulating compositions and methods |
| CA3231594A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Serpina-modulating compositions and methods |
| KR20240099164A (ko) | 2021-09-08 | 2024-06-28 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | Pah-조절 조성물 및 방법 |
| JP2024533311A (ja) | 2021-09-08 | 2024-09-12 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ゲノムを調節するための方法及び組成物 |
| EP4444362A4 (en) | 2021-12-10 | 2026-04-01 | Flagship Pioneering Innovations Vi Llc | CFTR COMPOSITIONS AND MODULATION METHODS |
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- 2019-08-28 CN CN201980069630.5A patent/CN113286880A/zh active Pending
- 2019-08-28 BR BR112021003380-7A patent/BR112021003380A2/pt unknown
- 2019-08-28 JP JP2021511605A patent/JP7680351B2/ja active Active
- 2019-08-28 WO PCT/US2019/048607 patent/WO2020047124A1/en not_active Ceased
- 2019-08-28 AU AU2019327449A patent/AU2019327449B2/en active Active
- 2019-08-28 KR KR1020217008540A patent/KR20210049859A/ko active Pending
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- 2019-08-28 EP EP19770218.6A patent/EP3844272A1/en active Pending
- 2019-12-06 US US16/706,448 patent/US12031129B2/en active Active
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