JP2007536891A5 - - Google Patents
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- Publication number
- JP2007536891A5 JP2007536891A5 JP2005510086A JP2005510086A JP2007536891A5 JP 2007536891 A5 JP2007536891 A5 JP 2007536891A5 JP 2005510086 A JP2005510086 A JP 2005510086A JP 2005510086 A JP2005510086 A JP 2005510086A JP 2007536891 A5 JP2007536891 A5 JP 2007536891A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cancer
- protein
- sequence
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 20
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 125000000539 amino acid group Chemical group 0.000 claims description 8
- 239000013604 expression vector Substances 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 8
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 8
- 230000001093 anti-cancer Effects 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 201000007983 brain glioma Diseases 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 description 3
- 101000830565 Homo sapiens Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 description 3
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 description 3
- 108700012411 TNFSF10 Proteins 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 102000044949 human TNFSF10 Human genes 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2003/000928 WO2005042744A1 (en) | 2003-11-03 | 2003-11-03 | A recombinant protein with cancer suppression action, its encoding gene and use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007536891A JP2007536891A (ja) | 2007-12-20 |
| JP2007536891A5 true JP2007536891A5 (https=) | 2010-02-12 |
| JP4688678B2 JP4688678B2 (ja) | 2011-05-25 |
Family
ID=34529378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005510086A Expired - Lifetime JP4688678B2 (ja) | 2003-11-03 | 2003-11-03 | 抗癌作用を有する組換えタンパク質、それをコードする遺伝子、及びそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7666989B2 (https=) |
| EP (1) | EP1688498B1 (https=) |
| JP (1) | JP4688678B2 (https=) |
| CN (1) | CN100549175C (https=) |
| AT (1) | ATE501256T1 (https=) |
| AU (1) | AU2003280921B2 (https=) |
| BR (1) | BRPI0318594B8 (https=) |
| CA (1) | CA2544473C (https=) |
| DE (1) | DE60336353D1 (https=) |
| NZ (1) | NZ547274A (https=) |
| WO (1) | WO2005042744A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060241051A1 (en) | 2002-12-26 | 2006-10-26 | Chieko Kitada | Metastin derivatives and use thereof |
| AR049938A1 (es) | 2004-06-25 | 2006-09-13 | Takeda Pharmaceutical | Derivados de metastina y utilizacion de los mismos |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
| TWI404726B (zh) | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
| WO2009131191A1 (ja) * | 2008-04-24 | 2009-10-29 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| HRP20150664T1 (hr) | 2010-12-03 | 2015-07-31 | Adamed Sp. Z O.O. | Antikancerogeni fuzijski protein |
| PL219845B1 (pl) | 2011-01-05 | 2015-07-31 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Przeciwnowotworowe białko fuzyjne |
| PL394618A1 (pl) | 2011-04-19 | 2012-10-22 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe bialko fuzyjne |
| CN103534273B (zh) * | 2011-09-16 | 2020-05-12 | 北京沙东生物技术有限公司 | 环化变构trail/apo2l及其编码基因与应用 |
| PL397167A1 (pl) | 2011-11-28 | 2013-06-10 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe bialko fuzyjne |
| PL223487B1 (pl) | 2011-12-28 | 2016-10-31 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Przeciwnowotworowe białko fuzyjne |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| AU708239B2 (en) * | 1995-06-29 | 1999-07-29 | Immunex Corporation | Cytokine that induces apoptosis |
| KR20010019100A (ko) * | 1999-08-25 | 2001-03-15 | 황규언 | 인간 유래 세포소멸인자 ｔｒａｉｌ의 결정화에 의한 3차원 구조 |
| US6900185B1 (en) * | 2000-04-12 | 2005-05-31 | University Of Iowa Research Foundation | Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer |
| KR100436089B1 (ko) * | 2000-07-06 | 2004-06-14 | 설대우 | 분비성 재조합 트라이머형의 트레일 단백질 생산을 위한 디엔에이 카세트, 테트라사이클린/독시사이클린-유도성아데노-관련 바이러스 벡터, 이 둘의 조합, 및 이들을이용한 유전자 치료 |
| CN1205335C (zh) * | 2001-11-30 | 2005-06-08 | 中国人民解放军第二军医大学 | 肿瘤凋亡诱导配体基因、基因表达蛋白及其制备方法 |
-
2003
- 2003-11-03 DE DE60336353T patent/DE60336353D1/de not_active Expired - Lifetime
- 2003-11-03 EP EP03770858A patent/EP1688498B1/en not_active Expired - Lifetime
- 2003-11-03 AU AU2003280921A patent/AU2003280921B2/en not_active Expired
- 2003-11-03 AT AT03770858T patent/ATE501256T1/de not_active IP Right Cessation
- 2003-11-03 NZ NZ547274A patent/NZ547274A/en not_active IP Right Cessation
- 2003-11-03 CN CNB2003801106041A patent/CN100549175C/zh not_active Expired - Lifetime
- 2003-11-03 WO PCT/CN2003/000928 patent/WO2005042744A1/zh not_active Ceased
- 2003-11-03 US US10/577,535 patent/US7666989B2/en not_active Expired - Lifetime
- 2003-11-03 BR BRPI0318594A patent/BRPI0318594B8/pt not_active IP Right Cessation
- 2003-11-03 CA CA2544473A patent/CA2544473C/en not_active Expired - Lifetime
- 2003-11-03 JP JP2005510086A patent/JP4688678B2/ja not_active Expired - Lifetime
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