CN113286880A - 调控基因组的方法和组合物 - Google Patents

调控基因组的方法和组合物 Download PDF

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Publication number
CN113286880A
CN113286880A CN201980069630.5A CN201980069630A CN113286880A CN 113286880 A CN113286880 A CN 113286880A CN 201980069630 A CN201980069630 A CN 201980069630A CN 113286880 A CN113286880 A CN 113286880A
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sequence
rna
dna
polypeptide
template rna
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J.R.鲁本斯
G.A.冯马尔扎恩
R.J.西托里克
B.E.斯坦伯格
D.李
W.E.萨洛蒙
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Flagship Pioneering Innovations VI Inc
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201980069630.5A 2018-08-28 2019-08-28 调控基因组的方法和组合物 Pending CN113286880A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862723886P 2018-08-28 2018-08-28
US62/723,886 2018-08-28
US201862725778P 2018-08-31 2018-08-31
US62/725,778 2018-08-31
US201962850883P 2019-05-21 2019-05-21
US62/850,883 2019-05-21
US201962864924P 2019-06-21 2019-06-21
US62/864,924 2019-06-21
PCT/US2019/048607 WO2020047124A1 (en) 2018-08-28 2019-08-28 Methods and compositions for modulating a genome

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CN113286880A true CN113286880A (zh) 2021-08-20

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US (2) US12031129B2 (https=)
EP (1) EP3844272A1 (https=)
JP (2) JP7680351B2 (https=)
KR (1) KR20210049859A (https=)
CN (1) CN113286880A (https=)
AU (1) AU2019327449B2 (https=)
BR (1) BR112021003380A2 (https=)
CA (1) CA3109953A1 (https=)
IL (1) IL280947A (https=)
WO (1) WO2020047124A1 (https=)

Cited By (3)

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WO2024131786A1 (zh) * 2022-12-19 2024-06-27 北京干细胞与再生医学研究院 一种在基因组插入大片段dna的系统
WO2025011467A1 (zh) * 2023-07-10 2025-01-16 北京干细胞与再生医学研究院 工程化的哺乳动物基因写入系统
CN119343448A (zh) * 2023-04-11 2025-01-21 北京星辰集因科技有限责任公司 一种非ltr逆转录转座子系统及其用途

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