JP2025063317A5 - - Google Patents
Info
- Publication number
- JP2025063317A5 JP2025063317A5 JP2025011363A JP2025011363A JP2025063317A5 JP 2025063317 A5 JP2025063317 A5 JP 2025063317A5 JP 2025011363 A JP2025011363 A JP 2025011363A JP 2025011363 A JP2025011363 A JP 2025011363A JP 2025063317 A5 JP2025063317 A5 JP 2025063317A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- polypeptide
- acid sequence
- rna
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862723886P | 2018-08-28 | 2018-08-28 | |
| US62/723,886 | 2018-08-28 | ||
| US201862725778P | 2018-08-31 | 2018-08-31 | |
| US62/725,778 | 2018-08-31 | ||
| US201962850883P | 2019-05-21 | 2019-05-21 | |
| US62/850,883 | 2019-05-21 | ||
| US201962864924P | 2019-06-21 | 2019-06-21 | |
| US62/864,924 | 2019-06-21 | ||
| PCT/US2019/048607 WO2020047124A1 (en) | 2018-08-28 | 2019-08-28 | Methods and compositions for modulating a genome |
| JP2021511605A JP7680351B2 (ja) | 2018-08-28 | 2019-08-28 | ゲノムを調節するための方法及び組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021511605A Division JP7680351B2 (ja) | 2018-08-28 | 2019-08-28 | ゲノムを調節するための方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025063317A JP2025063317A (ja) | 2025-04-15 |
| JP2025063317A5 true JP2025063317A5 (https=) | 2025-09-02 |
Family
ID=67997683
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021511605A Active JP7680351B2 (ja) | 2018-08-28 | 2019-08-28 | ゲノムを調節するための方法及び組成物 |
| JP2025011363A Pending JP2025063317A (ja) | 2018-08-28 | 2025-01-27 | ゲノムを調節するための方法及び組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021511605A Active JP7680351B2 (ja) | 2018-08-28 | 2019-08-28 | ゲノムを調節するための方法及び組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12031129B2 (https=) |
| EP (1) | EP3844272A1 (https=) |
| JP (2) | JP7680351B2 (https=) |
| KR (1) | KR20210049859A (https=) |
| CN (1) | CN113286880A (https=) |
| AU (1) | AU2019327449B2 (https=) |
| BR (1) | BR112021003380A2 (https=) |
| CA (1) | CA3109953A1 (https=) |
| IL (1) | IL280947A (https=) |
| WO (1) | WO2020047124A1 (https=) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| JP2020530979A (ja) | 2017-06-30 | 2020-11-05 | インスクリプタ, インコーポレイテッド | 自動細胞処理方法、モジュール、機器及びシステム |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US10557216B2 (en) | 2018-04-24 | 2020-02-11 | Inscripta, Inc. | Automated instrumentation for production of T-cell receptor peptide libraries |
| US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| EP3844272A1 (en) | 2018-08-28 | 2021-07-07 | Flagship Pioneering Innovations VI, LLC | Methods and compositions for modulating a genome |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US11001831B2 (en) | 2019-03-25 | 2021-05-11 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| AU2020288623A1 (en) | 2019-06-06 | 2022-01-06 | Inscripta, Inc. | Curing for recursive nucleic acid-guided cell editing |
| US20220298495A1 (en) * | 2019-06-12 | 2022-09-22 | Emendobio Inc. | Novel genome editing tool |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| CN114981409A (zh) | 2019-09-03 | 2022-08-30 | 美洛德生物医药公司 | 用于基因组整合的方法和组合物 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US11203762B2 (en) | 2019-11-19 | 2021-12-21 | Inscripta, Inc. | Methods for increasing observed editing in bacteria |
| AU2020407048A1 (en) | 2019-12-18 | 2022-06-09 | Inscripta, Inc. | Cascade/dCas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells |
| BR112022017713A2 (pt) * | 2020-03-04 | 2022-11-16 | Flagship Pioneering Innovations Vi Llc | Métodos e composições para modular um genoma |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| KR20230053735A (ko) | 2020-03-04 | 2023-04-21 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈의 조정을 위한 개선된 방법 및 조성물 |
| CA3174553A1 (en) * | 2020-03-05 | 2021-09-10 | Flagship Pioneering Innovations Vi, Llc | Host defense suppressing methods and compositions for modulating a genome |
| JP2023518395A (ja) | 2020-03-19 | 2023-05-01 | インテリア セラピューティクス,インコーポレイテッド | 指向性ゲノム編集のための方法及び組成物 |
| EP4133069A2 (en) * | 2020-04-08 | 2023-02-15 | Astrazeneca AB | Compositions and methods for improved site-specific modification |
| US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| WO2021248102A1 (en) * | 2020-06-05 | 2021-12-09 | Flagship Pioneering Innovations Vi, Llc | Template guide rna molecules |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| US11299731B1 (en) | 2020-09-15 | 2022-04-12 | Inscripta, Inc. | CRISPR editing to embed nucleic acid landing pads into genomes of live cells |
| EP4232583A1 (en) | 2020-10-21 | 2023-08-30 | Massachusetts Institute of Technology | Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste) |
| EP4256040A4 (en) * | 2020-12-07 | 2025-11-12 | Inscripta Inc | NUCLEIC ACID-GUIDED GARN STABILIZATION IN NICKASE EDITION |
| AU2021415461A1 (en) | 2021-01-04 | 2023-08-17 | Inscripta, Inc. | Mad nucleases |
| CN116745428A (zh) * | 2021-01-14 | 2023-09-12 | 加利福尼亚大学董事会 | 位点特异性基因修饰 |
| CN112708636A (zh) * | 2021-01-22 | 2021-04-27 | 彭双红 | 基因转录框架、载体系统、基因组序列编辑方法及应用 |
| US20240132916A1 (en) * | 2021-02-09 | 2024-04-25 | The Broad Institute, Inc. | Nuclease-guided non-ltr retrotransposons and uses thereof |
| US11884924B2 (en) | 2021-02-16 | 2024-01-30 | Inscripta, Inc. | Dual strand nucleic acid-guided nickase editing |
| WO2022183210A1 (en) * | 2021-02-26 | 2022-09-01 | Flagship Pioneering Innovations Vi, Llc | Tissue-specific methods and compositions for modulating a genome |
| AU2022240747A1 (en) * | 2021-03-19 | 2023-10-05 | Flagship Pioneering Innovations Vi, Llc | Ltr transposon compositions and methods |
| EP4314289A1 (en) | 2021-03-26 | 2024-02-07 | Flagship Pioneering Innovations VII, LLC | Production of circular polyribonucleotides in a prokaryotic system |
| WO2022204460A1 (en) | 2021-03-26 | 2022-09-29 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for producing circular polyribonucleotides |
| EP4314281A1 (en) | 2021-03-26 | 2024-02-07 | Flagship Pioneering Innovations VII, LLC | Production of circular polyribonucleotides in a eukaryotic system |
| BR112023023642A2 (pt) | 2021-05-11 | 2024-01-30 | Myeloid Therapeutics Inc | Métodos e composições para integração genômica |
| TW202332686A (zh) | 2021-07-23 | 2023-08-16 | 美商旗艦先鋒創新有限責(Vii))公司 | 用於真菌控制的組成物和相關方法 |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| CN118119704A (zh) * | 2021-09-08 | 2024-05-31 | 宏基因组学公司 | 用于转座货物核苷酸序列的系统和方法 |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| JP2024534856A (ja) * | 2021-09-08 | 2024-09-26 | メタゲノミ,インク. | レトロトランスポゾン及びその機能的断片を含む系、組成物、及び方法 |
| MX2024003262A (es) | 2021-09-17 | 2024-06-19 | Flagship Pioneering Innovations Vi Llc | Composiciones y metodos para producir poliribonucleotidos circulares. |
| CA3235625A1 (en) | 2021-10-18 | 2023-04-27 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
| EP4419669A1 (en) * | 2021-10-19 | 2024-08-28 | Massachusetts Institute Of Technology | Genomic editing with site-specific retrotransposons |
| EP4426828A1 (en) | 2021-11-01 | 2024-09-11 | Tome Biosciences, Inc. | Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo |
| WO2023108153A2 (en) | 2021-12-10 | 2023-06-15 | Flagship Pioneering Innovations Vi, Llc | Cftr-modulating compositions and methods |
| EP4453201A1 (en) | 2021-12-22 | 2024-10-30 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for purifying polyribonucleotides |
| AU2022420615A1 (en) | 2021-12-22 | 2024-07-04 | Tome Biosciences, Inc. | Co-delivery of a gene editor construct and a donor template |
| WO2023205744A1 (en) | 2022-04-20 | 2023-10-26 | Tome Biosciences, Inc. | Programmable gene insertion compositions |
| KR20250006975A (ko) * | 2022-05-02 | 2025-01-13 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 부위 특이적 게놈 변형을 위한 다성분 시스템 |
| WO2023215831A1 (en) | 2022-05-04 | 2023-11-09 | Tome Biosciences, Inc. | Guide rna compositions for programmable gene insertion |
| WO2023225670A2 (en) | 2022-05-20 | 2023-11-23 | Tome Biosciences, Inc. | Ex vivo programmable gene insertion |
| US20250319115A1 (en) | 2022-05-25 | 2025-10-16 | Flagship Pioneering Innovations Vii, Llc | Compositions and Methods for Modulating Cytokines |
| AU2023276757A1 (en) | 2022-05-25 | 2024-11-21 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulation of tumor suppressors and oncogenes |
| CA3254388A1 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | COMPOSITIONS AND METHODS OF MODULATING TRAFFIC FACTORS |
| CN119563038A (zh) | 2022-05-25 | 2025-03-04 | 旗舰创业创新七公司 | 用于调节免疫应答的组合物和方法 |
| WO2023230570A2 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulating genetic drivers |
| WO2023230524A1 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vi, Llc | Compositions of secretory and/or catalytic cells and methods using the same |
| JP2025525569A (ja) | 2022-07-18 | 2025-08-05 | レナゲード セラピューティクス マネージメント インコーポレイテッド | 遺伝子編集成分、システム、及び使用方法 |
| WO2024020587A2 (en) | 2022-07-22 | 2024-01-25 | Tome Biosciences, Inc. | Pleiopluripotent stem cell programmable gene insertion |
| WO2024086586A2 (en) * | 2022-10-18 | 2024-04-25 | Flagship Pioneering Innovations Vi, Llc | Improved gene editing systems utilizing trans recruiting components |
| EP4612296A1 (en) | 2022-10-31 | 2025-09-10 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for purifying polyribonucleotides |
| TW202434728A (zh) | 2022-11-08 | 2024-09-01 | 美商旗艦先鋒創新有限責任公司 | 用於產生環狀多核糖核苷酸的組成物和方法 |
| EP4630542A2 (en) * | 2022-12-09 | 2025-10-15 | Metagenomi, Inc. | Retrotransposon compositions and methods of use |
| CN120418275A (zh) * | 2022-12-19 | 2025-08-01 | 北京干细胞与再生医学研究院 | 一种在基因组插入大片段dna的系统 |
| WO2024138194A1 (en) | 2022-12-22 | 2024-06-27 | Tome Biosciences, Inc. | Platforms, compositions, and methods for in vivo programmable gene insertion |
| WO2024175780A1 (en) | 2023-02-23 | 2024-08-29 | Micropep Technologies S.A. | Micropeptides to improve plant immunity and application thereof |
| CN121358494A (zh) | 2023-03-15 | 2026-01-16 | 旗舰创业创新第六有限责任公司 | 免疫原性组合物及其用途 |
| EP4680750A1 (en) | 2023-03-15 | 2026-01-21 | Flagship Pioneering Innovations VI, LLC | Compositions comprising polyribonucleotides and uses thereof |
| WO2024212753A1 (en) * | 2023-04-11 | 2024-10-17 | Beijing Astragenomics Technology Co., Ltd. | Non-ltr retrotransposon system and use thereof |
| TW202449159A (zh) | 2023-04-19 | 2024-12-16 | 美商旗艦先鋒創新有限責任(Vii)公司 | 用於產生文庫之組合物及方法 |
| WO2024234006A1 (en) | 2023-05-11 | 2024-11-14 | Tome Biosciences, Inc. | Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs) |
| WO2025006419A1 (en) | 2023-06-26 | 2025-01-02 | Flagship Pioneering Innovations Vii, Llc | Engineered plasmodia and related methods |
| CN119286819A (zh) * | 2023-07-10 | 2025-01-10 | 北京干细胞与再生医学研究院 | 工程化的哺乳动物基因写入系统 |
| KR20250027489A (ko) * | 2023-08-16 | 2025-02-26 | 기초과학연구원 | 단일가닥 절단 활성을 가지는 CRISPR/Cas 시스템과 PARP 억제제를 이용하는 세포 사멸 방법 |
| AU2024335327A1 (en) | 2023-09-01 | 2026-03-26 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025050069A1 (en) | 2023-09-01 | 2025-03-06 | Tome Biosciences, Inc. | Programmable gene insertion using engineered integration enzymes |
| WO2025085519A1 (en) * | 2023-10-16 | 2025-04-24 | Typewriter Therapeutics, Inc. | R2 retrotransposons for gene writing |
| WO2025128545A1 (en) * | 2023-12-11 | 2025-06-19 | Aera Therapeutics, Inc. | Engineered mobile genetic element systems |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025132815A1 (en) | 2023-12-20 | 2025-06-26 | Novozymes A/S | Novel cas nucleases and polynucleotides encoding the same |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025217194A1 (en) * | 2024-04-09 | 2025-10-16 | Typewriter Therapeutics, Inc. | Repeat dosing of retrotransposons |
| WO2025224182A2 (en) | 2024-04-23 | 2025-10-30 | Basecamp Research Ltd | Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo |
| WO2026062521A2 (en) | 2024-09-18 | 2026-03-26 | Institute Of Molecular And Clinical Ophthalmology Basel (Iob) | Methods and compounds for promoting survival of photoreceptors |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030121063A1 (en) | 1995-11-16 | 2003-06-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods of use of mammalian retrotransposons |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| CN1342758A (zh) * | 2000-09-12 | 2002-04-03 | 上海博德基因开发有限公司 | 一种新的多肽——逆转录酶9.24和编码这种多肽的多核苷酸 |
| JP2002291473A (ja) * | 2001-04-02 | 2002-10-08 | New Industry Research Organization | レトロトランスポゾン、プロモーター活性を有するdna断片、及びその利用 |
| US20060183226A1 (en) * | 2002-01-31 | 2006-08-17 | Haruhiko Fujiwara | Methods for retrotransposing long interspersed elements (lines) |
| WO2004072290A1 (en) | 2003-02-07 | 2004-08-26 | The Administrators Of The Tulane Educational Fund | Mammalian retrotransposable elements |
| US9267932B2 (en) * | 2003-05-28 | 2016-02-23 | The Johns Hopkins University | Synthetic mammalian retrotransposon gene |
| JPWO2005054463A1 (ja) * | 2003-11-21 | 2007-12-06 | 財団法人大阪産業振興機構 | レトロトランスポゾンを用いた哺乳動物のゲノム改変技術の開発 |
| AU2005331864A1 (en) * | 2005-05-14 | 2006-11-23 | Fudan University | Piggybac as a tool for genetic manipulation and analysis in vertebrates |
| US20110171729A1 (en) | 2006-05-04 | 2011-07-14 | Ab Maxis Inc. | Method for Producing Stable Mammalian Cell Lines Producing High Levels of Recombinant Proteins |
| US8598328B2 (en) * | 2006-12-13 | 2013-12-03 | National University Corporation Nagoya University | Tol1 factor transposase and DNA introduction system using the same |
| EP2055784A1 (en) | 2007-10-31 | 2009-05-06 | Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer | Controlled activation of non-LTR retrotransposons in mammals |
| US8889394B2 (en) | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
| AU2010325563B2 (en) * | 2009-11-27 | 2017-02-02 | Basf Plant Science Company Gmbh | Chimeric endonucleases and uses thereof |
| AU2012220596B2 (en) * | 2011-02-23 | 2016-05-12 | Board Of Regents | Use of template switching for DNA synthesis |
| US20140113375A1 (en) | 2012-10-21 | 2014-04-24 | Lixin Liu | Transient Expression And Reverse Transcription Aided Genome Alteration System |
| CN113355357B (zh) | 2012-12-12 | 2024-12-03 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| US20140186843A1 (en) | 2012-12-12 | 2014-07-03 | Massachusetts Institute Of Technology | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| RU2662932C2 (ru) | 2013-03-14 | 2018-07-31 | Карибо Биосайенсиз, Инк. | Композиции и способы с участием нуклеиновых кислот, нацеленных на нуклеиновые кислоты |
| US20140349400A1 (en) | 2013-03-15 | 2014-11-27 | Massachusetts Institute Of Technology | Programmable Modification of DNA |
| DK3456831T3 (da) * | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| EP3155116A4 (en) | 2014-06-10 | 2017-12-27 | Massachusetts Institute Of Technology | Method for gene editing |
| EP3183358B1 (en) | 2014-08-19 | 2020-10-07 | President and Fellows of Harvard College | Rna-guided systems for probing and mapping of nucleic acids |
| EP3188763B1 (en) | 2014-09-02 | 2020-05-13 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification |
| WO2016065364A1 (en) | 2014-10-24 | 2016-04-28 | Life Technologies Corporation | Compositions and methods for enhancing homologous recombination |
| KR102531016B1 (ko) * | 2014-11-21 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물 |
| CN108026526B (zh) | 2015-06-09 | 2023-05-12 | 爱迪塔斯医药公司 | 用于改善移植的crispr/cas相关方法和组合物 |
| WO2016205728A1 (en) | 2015-06-17 | 2016-12-22 | Massachusetts Institute Of Technology | Crispr mediated recording of cellular events |
| EP3356520B1 (en) | 2015-10-02 | 2022-03-23 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Lentiviral protein delivery system for rna-guided genome editing |
| US11427837B2 (en) | 2016-01-12 | 2022-08-30 | The Regents Of The University Of California | Compositions and methods for enhanced genome editing |
| GB201602473D0 (en) * | 2016-02-11 | 2016-03-30 | Horizon Discovery Ltd | Replicative transposon system |
| US20170275665A1 (en) | 2016-02-24 | 2017-09-28 | Board Of Regents, The University Of Texas System | Direct crispr spacer acquisition from rna by a reverse-transcriptase-cas1 fusion protein |
| US11447768B2 (en) | 2016-03-01 | 2022-09-20 | University Of Florida Research Foundation, Incorporated | Molecular cell diary system |
| LT3436077T (lt) * | 2016-03-30 | 2025-06-25 | Intellia Therapeutics, Inc. | Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams |
| WO2017173004A1 (en) * | 2016-03-30 | 2017-10-05 | Mikuni Takayasu | A method for in vivo precise genome editing |
| EP3443088B1 (en) | 2016-04-13 | 2024-09-18 | Editas Medicine, Inc. | Grna fusion molecules, gene editing systems, and methods of use thereof |
| EP4166660A1 (en) | 2016-04-29 | 2023-04-19 | BASF Plant Science Company GmbH | Improved methods for modification of target nucleic acids using fused guide rna - donor molecules |
| US20190345483A1 (en) | 2016-05-12 | 2019-11-14 | President And Fellows Of Harvard College | AAV Split Cas9 Genome Editing and Transcriptional Regulation |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018045321A1 (en) | 2016-09-02 | 2018-03-08 | North Carolina State University | Methods and compositions for modification of plastid genomes |
| ES2985812T3 (es) | 2016-09-09 | 2024-11-07 | The Board Of Trustees Of The Leland Stanfordjunior Univ | Edición genómica de precisión de alto rendimiento |
| US20190330620A1 (en) | 2016-10-14 | 2019-10-31 | Emendobio Inc. | Rna compositions for genome editing |
| EP4545649A3 (en) | 2016-11-11 | 2025-06-04 | Bio-Rad Laboratories, Inc. | Methods for processing nucleic acid samples |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| EP3630849A4 (en) | 2017-05-25 | 2021-01-13 | The General Hospital Corporation | BIPARTITE BASIC EDITOR (BBE) AND TYPE II-C-CAS9 ZINC FINGER EDITOR ARCHITECTURES |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| JP2021530212A (ja) | 2018-07-13 | 2021-11-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | レトロトランスポゾンベースの送達媒体及びその使用方法 |
| EP3844272A1 (en) | 2018-08-28 | 2021-07-07 | Flagship Pioneering Innovations VI, LLC | Methods and compositions for modulating a genome |
| JP7658579B2 (ja) | 2018-10-19 | 2025-04-08 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 操作された長鎖散在反復エレメント(line)トランスポゾンおよびそれらの使用方法 |
| WO2020186262A1 (en) | 2019-03-14 | 2020-09-17 | Cornell University | Compositions and methods for gene targeting using crispr-cas and transposons |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US20220298495A1 (en) | 2019-06-12 | 2022-09-22 | Emendobio Inc. | Novel genome editing tool |
| JP7759311B2 (ja) | 2019-07-19 | 2025-10-23 | フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー | リコンビナーゼ組成物及び使用方法 |
| US20220411768A1 (en) | 2019-10-21 | 2022-12-29 | The Trustees Of Columbia University In The City Of New York | Methods of performing rna templated genome editing |
| CA3162499A1 (en) | 2019-11-22 | 2021-05-27 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| US20230348939A1 (en) | 2020-03-04 | 2023-11-02 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| KR20230053735A (ko) | 2020-03-04 | 2023-04-21 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈의 조정을 위한 개선된 방법 및 조성물 |
| BR112022017713A2 (pt) | 2020-03-04 | 2022-11-16 | Flagship Pioneering Innovations Vi Llc | Métodos e composições para modular um genoma |
| CA3174553A1 (en) | 2020-03-05 | 2021-09-10 | Flagship Pioneering Innovations Vi, Llc | Host defense suppressing methods and compositions for modulating a genome |
| WO2021248102A1 (en) | 2020-06-05 | 2021-12-09 | Flagship Pioneering Innovations Vi, Llc | Template guide rna molecules |
| WO2022183210A1 (en) | 2021-02-26 | 2022-09-01 | Flagship Pioneering Innovations Vi, Llc | Tissue-specific methods and compositions for modulating a genome |
| AU2022240747A1 (en) | 2021-03-19 | 2023-10-05 | Flagship Pioneering Innovations Vi, Llc | Ltr transposon compositions and methods |
| EP4347859A4 (en) | 2021-05-26 | 2025-07-02 | Flagship Pioneering Innovations Vi Llc | INTEGRASE COMPOSITIONS AND METHODS |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| IL311219A (en) | 2021-09-08 | 2024-05-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for genome modulation |
| CA3231679A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Hbb-modulating compositions and methods |
| MX2024002988A (es) | 2021-09-08 | 2024-06-11 | Flagship Pioneering Innovations Vi Llc | Composiciones y metodos moduladores de la serpina. |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| WO2023108153A2 (en) | 2021-12-10 | 2023-06-15 | Flagship Pioneering Innovations Vi, Llc | Cftr-modulating compositions and methods |
-
2019
- 2019-08-28 EP EP19770218.6A patent/EP3844272A1/en active Pending
- 2019-08-28 JP JP2021511605A patent/JP7680351B2/ja active Active
- 2019-08-28 AU AU2019327449A patent/AU2019327449B2/en active Active
- 2019-08-28 KR KR1020217008540A patent/KR20210049859A/ko active Pending
- 2019-08-28 BR BR112021003380-7A patent/BR112021003380A2/pt unknown
- 2019-08-28 CN CN201980069630.5A patent/CN113286880A/zh active Pending
- 2019-08-28 CA CA3109953A patent/CA3109953A1/en active Pending
- 2019-08-28 WO PCT/US2019/048607 patent/WO2020047124A1/en not_active Ceased
- 2019-12-06 US US16/706,448 patent/US12031129B2/en active Active
-
2021
- 2021-02-17 IL IL280947A patent/IL280947A/en unknown
-
2024
- 2024-04-01 US US18/623,612 patent/US12398392B2/en active Active
-
2025
- 2025-01-27 JP JP2025011363A patent/JP2025063317A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2025063317A5 (https=) | ||
| JP2021534798A5 (https=) | ||
| US20220378904A1 (en) | Hmpv mrna vaccine composition | |
| Hay et al. | Replication of adenovirus mini-chromosomes | |
| Chen et al. | Sequence of human glucose-6-phosphate dehydrogenase cloned in plasmids and a yeast artificial chromosome | |
| CN114207134A (zh) | 工程化的mRNA序列及其用途 | |
| WO2019036513A1 (en) | STABILIZED NUCLEIC ACIDS ENCODING MESSENGER RIBONUCLEIC ACID (MRNA) | |
| Morin et al. | The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats | |
| AU2023414262B2 (en) | Polynucleotide molecule for preventing or treating hpv infection-related diseases | |
| JP2024511131A5 (https=) | ||
| WO2025102994A1 (zh) | 基于i型内含子的rna体外环化与滚环翻译的方法及其应用 | |
| Liermann et al. | Genetic analysis of the central untranslated genome region and the proximal coding part of the F gene of wild-type and vaccine canine distemper morbilliviruses | |
| TW202114731A (zh) | B型肝炎病毒(HBV)疫苗與靶向HBV之RNAi之組合 | |
| Muhich et al. | The divergent region of the Leishmania tarentolae kinetoplast maxicircle DNA contains a diverse set of repetitive sequences | |
| JPS61501747A (ja) | 核酸配列の検出方法 | |
| WO2022006306A2 (en) | Compositions for genome editing and methods of use thereof | |
| Ling et al. | Sequence and in vitro expression of the phosphoprotein gene of avian pneumovirus | |
| JPH11500905A (ja) | 増幅配列、これらの配列を有するベクター、およびトランスフェクションされた細胞においてヌクレオチド配列を発現させるための組成物、治療用およびワクチン用におけるこれらの使用 | |
| JP2023553422A (ja) | ウイルスゲノムを切断するための組成物及び方法 | |
| JP2023507174A5 (https=) | ||
| CN119432776B (zh) | 一种非洲猪瘟病毒基因的重组病毒及由其制备的疫苗 | |
| Helfman et al. | Redistributive properties of the vesicular stomatitis virus polymerase | |
| AU2020245537B2 (en) | Engineered mRNA sequences and uses thereof | |
| WO2026008078A1 (en) | Methods for kallikrein (klkb1) gene editing | |
| WO2025002331A1 (en) | Engineered rna polynucleotide and preparation method thereof |