JP2002529066A5 - - Google Patents
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- Publication number
- JP2002529066A5 JP2002529066A5 JP2000581045A JP2000581045A JP2002529066A5 JP 2002529066 A5 JP2002529066 A5 JP 2002529066A5 JP 2000581045 A JP2000581045 A JP 2000581045A JP 2000581045 A JP2000581045 A JP 2000581045A JP 2002529066 A5 JP2002529066 A5 JP 2002529066A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polynucleotide
- ctgf
- guc
- cag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/187,478 US6348329B1 (en) | 1998-11-06 | 1998-11-06 | Nucleic acids encoding rat connective tissue growth factor (CTGF) and methods of use |
| US09/187,478 | 1998-11-06 | ||
| US09/292,036 | 1999-04-14 | ||
| US09/292,036 US6358741B1 (en) | 1998-11-06 | 1999-04-14 | Connective tissue growth factor (CTGF) and methods of use |
| PCT/US1999/026189 WO2000027868A2 (en) | 1998-11-06 | 1999-11-05 | Connective tissue growth factor (ctgf) and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002529066A JP2002529066A (ja) | 2002-09-10 |
| JP2002529066A5 true JP2002529066A5 (https=) | 2007-01-11 |
| JP4698837B2 JP4698837B2 (ja) | 2011-06-08 |
Family
ID=22689164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000581045A Expired - Lifetime JP4698837B2 (ja) | 1998-11-06 | 1999-11-05 | 結合組織成長因子（ｃｔｇｆ）および使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US6348329B1 (https=) |
| JP (1) | JP4698837B2 (https=) |
| KR (1) | KR20010102943A (https=) |
| HK (1) | HK1039342A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1682699A (en) * | 1997-12-25 | 1999-07-19 | Japan Tobacco Inc. | Monoclonal antibody against connective tissue growth factor and medicinal uses thereof |
| US7115390B1 (en) * | 1998-12-14 | 2006-10-03 | Fibrogen, Inc. | Connective tissue growth factor fragments and methods and uses thereof |
| CN1170849C (zh) * | 1998-12-14 | 2004-10-13 | 迈阿密大学 | 结缔组织生长因子片段及其方法和用途 |
| US6444657B1 (en) * | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
| US6965025B2 (en) * | 2001-12-10 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of connective tissue growth factor expression |
| US7351407B2 (en) | 2002-04-30 | 2008-04-01 | Alcon, Inc. | Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (CTGF) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
| EP1925306A3 (en) | 2002-04-30 | 2008-09-17 | Alcon, Inc. | Agents which Regulate, Inhibit, or Modulate the Activity and/or Expression of Connective Tissue Growth Factor (CTGF) to Lower Intraocular Pressure |
| US20060074018A1 (en) * | 2002-06-04 | 2006-04-06 | Metabolex Inc | Methods of diagnosing & treating diabetes and insulin resistance |
| US7405274B2 (en) | 2003-06-04 | 2008-07-29 | Fibrogen, Inc. | Connective tissue growth factor antibodies |
| WO2005033136A1 (en) * | 2003-09-29 | 2005-04-14 | Children's Hospital, Inc. | Unique integrin binding site in connective tissue growth factor (ctgf) |
| CN101884789A (zh) * | 2004-02-11 | 2010-11-17 | 法布罗根股份有限公司 | Ctgf作为糖尿病肾病的治疗靶点 |
| TWI386225B (zh) * | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術 |
| US20060275797A1 (en) * | 2005-03-21 | 2006-12-07 | Alcon Manufacturing, Ltd. | Use of agents which inhibit connective tissue growth factor (CTGF) binding and signaling via the TrkA/p75NTR receptor complex for the prevention and treatment of CTGF-mediated ocular disorders |
| US20100034892A1 (en) | 2006-08-30 | 2010-02-11 | The Trustees Of Columbia University In The City Of New York | Treatment for bone formation disorders by growth factor delivery |
| US8946172B2 (en) * | 2008-08-25 | 2015-02-03 | Excaliard Pharmaceuticals, Inc. | Method for reducing scarring during wound healing using antisense compounds directed to CTGF |
| NZ601660A (en) | 2008-08-25 | 2014-05-30 | Excaliard Pharmaceuticals Inc | Antisense oligonucleotides directed against connective tissue growth factor and uses thereof |
| EP2448971A1 (en) | 2009-07-02 | 2012-05-09 | Fibrogen, Inc. | Methods for treatment of muscular dystrophy |
| US20120244169A1 (en) | 2009-11-06 | 2012-09-27 | Fibrogen, Inc. | Treatment for Radiation-Induced Disorders |
| US20140134181A1 (en) | 2010-11-05 | 2014-05-15 | Kenneth E. Lipson | Treatment Method For Lung Remodeling Diseases |
| PT2670411T (pt) | 2011-02-02 | 2019-06-18 | Excaliard Pharmaceuticals Inc | Compostos anti sentido visando um fator de crescimento do tecido conetivo (ctfg) para utilização num método de tratamento de queloides ou cicatrizes hipertróficas |
| US8802839B2 (en) | 2011-07-15 | 2014-08-12 | Fibrogen, Inc. | Connective tissue growth factor antisense oligonucleotides |
| US11299537B2 (en) | 2015-12-10 | 2022-04-12 | Fibrogen, Inc. | Methods for treatment of motor neuron diseases |
| US20200369759A1 (en) | 2019-05-23 | 2020-11-26 | Fibrogen, Inc. | Methods of treatment of muscular dystrophies |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5094941A (en) | 1987-12-31 | 1992-03-10 | Zymogenetics, Inc. | Monoclonal antibodies to PDGF |
| US5147294A (en) | 1990-10-01 | 1992-09-15 | Trustees Of Boston University | Therapeutic method for reducing chronic pain in a living subject |
| EP0566673A1 (en) | 1990-12-21 | 1993-10-27 | Creative Biomolecules, Inc. | Biosynthetic pdgf antagonists |
| US5770209A (en) | 1991-08-30 | 1998-06-23 | University Of South Florida | Acceleration of wound healing using connective tissue growth factor |
| US5408040A (en) | 1991-08-30 | 1995-04-18 | University Of South Florida | Connective tissue growth factor(CTGF) |
| US5596090A (en) * | 1992-07-24 | 1997-01-21 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human VCAM-1 RNA |
| US5916756A (en) | 1993-12-14 | 1999-06-29 | University Of South Florida | Assay of connective tissue growth factor for detection of cell proliferative disorders |
| JP4537507B2 (ja) * | 1997-12-25 | 2010-09-01 | アムジェン インコーポレイテッド | 結合組織増殖因子に対するモノクローナル抗体及びその医薬用途 |
| AU1682699A (en) * | 1997-12-25 | 1999-07-19 | Japan Tobacco Inc. | Monoclonal antibody against connective tissue growth factor and medicinal uses thereof |
-
1998
- 1998-11-06 US US09/187,478 patent/US6348329B1/en not_active Expired - Lifetime
-
1999
- 1999-04-14 US US09/292,036 patent/US6358741B1/en not_active Expired - Lifetime
- 1999-11-05 KR KR1020017005703A patent/KR20010102943A/ko not_active Withdrawn
- 1999-11-05 HK HK02100878.5A patent/HK1039342A1/zh unknown
- 1999-11-05 JP JP2000581045A patent/JP4698837B2/ja not_active Expired - Lifetime
-
2002
- 2002-02-19 US US10/080,173 patent/US20020115156A1/en not_active Abandoned
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