|
US4911920A
(en)
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
JPH0832707B2
(ja)
|
1986-02-05 |
1996-03-29 |
富山化学工業株式会社 |
新規なセフアロスポリン類およびその塩
|
|
ATE141502T1
(de)
|
1991-01-15 |
1996-09-15 |
Alcon Lab Inc |
Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
|
|
US5212162A
(en)
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
DE69232557T2
(de)
|
1991-05-20 |
2002-10-24 |
Rhone-Poulenc Rorer International (Holdings) Inc., Greenville |
Aromatische oligomere verbindungen als imitatoren bioaktives makromoleküle
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
JP2000507955A
(ja)
|
1996-04-03 |
2000-06-27 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシル―タンパク質転移酵素の阻害剤
|
|
JP2000256286A
(ja)
|
1999-03-11 |
2000-09-19 |
Kaken Pharmaceut Co Ltd |
アルキルアミン誘導体
|
|
CA2385747A1
(en)
|
1999-09-17 |
2001-03-22 |
Gavin C. Hirst |
Pyrazolopyrimidines as therapeutic agents
|
|
US6887870B1
(en)
|
1999-10-12 |
2005-05-03 |
Bristol-Myers Squibb Company |
Heterocyclic sodium/proton exchange inhibitors and method
|
|
WO2002000651A2
(en)
|
2000-06-27 |
2002-01-03 |
Bristol-Myers Squibb Pharma Company |
Factor xa inhibitors
|
|
NZ526472A
(en)
|
2000-12-21 |
2004-04-30 |
Vertex Pharma |
Pyrazole compounds useful as protein kinase inhibitors
|
|
EP1217000A1
(en)
|
2000-12-23 |
2002-06-26 |
Aventis Pharma Deutschland GmbH |
Inhibitors of factor Xa and factor VIIa
|
|
MY139563A
(en)
|
2002-09-04 |
2009-10-30 |
Bristol Myers Squibb Co |
Heterocyclic aromatic compounds useful as growth hormone secretagogues
|
|
US20070111967A1
(en)
|
2003-07-09 |
2007-05-17 |
Miller David J |
Organosilicon compounds and their use
|
|
BRPI0511676A
(pt)
|
2004-05-29 |
2008-01-08 |
7Tm Pharma As |
uso medicinal de ligandos receptores
|
|
WO2006091898A2
(en)
|
2005-02-25 |
2006-08-31 |
Adenosine Therapeutics, Llc |
Pyrazolyl substituted xanthines
|
|
JP2009501733A
(ja)
|
2005-07-20 |
2009-01-22 |
メルク フロスト カナダ リミテツド |
ステアロイルコエンザイムａデルタ−９デサチュラーゼの阻害剤としてのヘテロ芳香族化合物
|
|
KR20080080584A
(ko)
|
2005-11-30 |
2008-09-04 |
버텍스 파마슈티칼스 인코포레이티드 |
ｃ-Ｍｅｔ의 억제제 및 이의 용도
|
|
SI1981519T1
(en)
*
|
2005-12-29 |
2018-05-31 |
Dyax Corp. |
INHIBITION PROTEAZE
|
|
EP1849781A1
(en)
|
2006-04-28 |
2007-10-31 |
Laboratorios del Dr. Esteve S.A. |
Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments
|
|
JP5322935B2
(ja)
*
|
2006-07-31 |
2013-10-23 |
アクティベサイト ファーマシューティカルズ インコーポレイティッド |
血漿カリクレインの阻害薬
|
|
EP1908762A2
(en)
|
2006-10-04 |
2008-04-09 |
Speedel Experimenta AG |
Organic compounds
|
|
EP1908471A1
(en)
|
2006-10-04 |
2008-04-09 |
Speedel Experimenta AG |
Tetrahydropyridines as renin inhibitors
|
|
WO2008059854A1
(en)
|
2006-11-16 |
2008-05-22 |
Astellas Pharma Inc. |
Piperidine derivatives or salts thereof
|
|
EP1974729A1
(en)
|
2007-03-28 |
2008-10-01 |
Santhera Pharmaceuticals (Schweiz) AG |
Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
|
|
JP5539864B2
(ja)
|
2007-06-12 |
2014-07-02 |
アカオゲン，インコーポレーテッド |
抗菌剤
|
|
WO2009023179A2
(en)
|
2007-08-10 |
2009-02-19 |
Genelabs Technologies, Inc. |
Nitrogen containing bicyclic chemical entities for treating viral infections
|
|
KR100994115B1
(ko)
|
2008-08-18 |
2010-11-15 |
삼성모바일디스플레이주식회사 |
광효율 개선층을 구비한 유기 발광 소자
|
|
US20100160369A1
(en)
|
2008-12-04 |
2010-06-24 |
Exelixis, Inc. |
S1P1 Agonists and Methods of Making And Using
|
|
US20100204265A1
(en)
|
2009-02-09 |
2010-08-12 |
Genelabs Technologies, Inc. |
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
|
|
US8455476B2
(en)
|
2009-04-22 |
2013-06-04 |
Janssen Pharmaceutica, Nv |
Azetidinyl diamides as monoacylglycerol lipase inhibitors
|
|
MX2011012037A
(es)
|
2009-05-13 |
2012-02-28 |
Amgen Inc |
Compuestos de heteroarilo como inhibidores de pikk.
|
|
AR076928A1
(es)
|
2009-05-28 |
2011-07-20 |
Otsuka Pharma Co Ltd |
Derivados de 3h-pirido[4, 3-d]pirimidin-4-ona, un metodo para su preparacion, composiciones farmaceuticas que los comprenden y su uso en la manufactura de un medicamento para el tratamiento o prevencion de enfermedades relacionadas con el estres.
|
|
US9394279B2
(en)
|
2009-06-11 |
2016-07-19 |
Abbvie Inc. |
Anti-viral compounds
|
|
US8937150B2
(en)
|
2009-06-11 |
2015-01-20 |
Abbvie Inc. |
Anti-viral compounds
|
|
GB201007187D0
(en)
|
2010-04-29 |
2010-06-09 |
Iti Scotland Ltd |
Ubiquitination modulators
|
|
WO2012016133A2
(en)
|
2010-07-29 |
2012-02-02 |
President And Fellows Of Harvard College |
Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
|
|
EP2627178B1
(en)
|
2010-10-11 |
2018-05-02 |
Merck Sharp & Dohme Corp. |
Quinazolinone-type compounds as crth2 antagonists
|
|
US9273028B2
(en)
|
2010-10-29 |
2016-03-01 |
Biogen Ma Inc. |
Heterocyclic tyrosine kinase inhibitors
|
|
JP2012111731A
(ja)
|
2010-11-26 |
2012-06-14 |
Otsuka Pharmaceut Co Ltd |
医薬
|
|
SI2651939T1
(sl)
|
2010-12-13 |
2015-07-31 |
Array Biopharma, Inc. |
SUBSTITUIRANE N-(1H-INDAZOL-4-IL)IMIDAZO(1,2-a)PIRIDIN-3-KARBOKSAMIDNE SPOJINE KOT INHIBITORJI RECEPTORSKE TIROZINSKE KINAZE TIPA III
|
|
US8883793B2
(en)
|
2010-12-29 |
2014-11-11 |
Development Center For Biotechnology |
Tubulin inhibitors and methods of using the same
|
|
WO2012129562A2
(en)
|
2011-03-24 |
2012-09-27 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
WO2012142308A1
(en)
*
|
2011-04-13 |
2012-10-18 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
JP2014514302A
(ja)
|
2011-04-13 |
2014-06-19 |
メルク・シャープ・アンド・ドーム・コーポレーション |
Ｂａｃｅ阻害薬としての５−置換されたイミノチアジン類およびそれのモノおよびジオキシド、組成物およびそれらの使用
|
|
GB2494851A
(en)
|
2011-07-07 |
2013-03-27 |
Kalvista Pharmaceuticals Ltd |
Plasma kallikrein inhibitors
|
|
WO2013052526A1
(en)
|
2011-10-06 |
2013-04-11 |
Merck Sharp & Dohme Corp. |
Triazolyl pde10 inhibitors
|
|
WO2013081094A1
(ja)
|
2011-11-30 |
2013-06-06 |
東レ株式会社 |
イミダゾ［１，２－ａ］ピリジン誘導体及びその医薬用途
|
|
MX352861B
(es)
|
2011-12-30 |
2017-12-13 |
Ptc Therapeutics Inc |
Compuestos para tratar la atrofia muscular espinal.
|
|
JP6404717B2
(ja)
|
2012-03-02 |
2018-10-17 |
ジェネンテック， インコーポレイテッド |
アミドスピロ環状アミド及びスルホンアミド誘導体
|
|
JP6280546B2
(ja)
|
2012-06-26 |
2018-02-14 |
デル マー ファーマシューティカルズ |
ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
|
|
AR096393A1
(es)
|
2013-05-23 |
2015-12-30 |
Bayer Cropscience Ag |
Compuestos heterocíclicos pesticidas
|
|
CA2920815C
(en)
|
2013-08-14 |
2021-09-21 |
Kalvista Pharmaceuticals Limited |
Inhibitors of plasma kallikrein
|
|
CA2928867A1
(en)
|
2013-10-30 |
2015-05-07 |
Bayer Pharma Aktiengesellschaft |
Substituted oxopyridine derivatives
|
|
WO2015095449A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount rna transcripts
|
|
EP3087067B1
(en)
|
2013-12-26 |
2018-10-24 |
Takeda Pharmaceutical Company Limited |
4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (magl) inhibitors
|
|
BR112016015449A8
(pt)
|
2013-12-30 |
2020-06-09 |
Lifesci Pharmaceuticals Inc |
compostos inibidores terapêuticos, composição farmacêutica os compreendendo e uso dos mesmos
|
|
US9611252B2
(en)
|
2013-12-30 |
2017-04-04 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
TW201613917A
(en)
|
2014-06-06 |
2016-04-16 |
Biogen Ma Inc |
ATX modulating agents
|
|
MX381342B
(es)
*
|
2014-07-16 |
2025-03-12 |
Lifesci Pharmaceuticals Inc |
Compuestos terapeuticos inhibidores.
|
|
WO2016029146A1
(en)
|
2014-08-22 |
2016-02-25 |
University Of Washington |
Specific inhibitors of methionyl-trna synthetase
|
|
GB201421083D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
Enzyme inhibitors
|
|
GB201421088D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
New enzyme inhibitors
|
|
GB201421085D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
New enzyme inhibitors
|
|
CN105777632A
(zh)
|
2015-01-09 |
2016-07-20 |
成都贝斯凯瑞生物科技有限公司 |
芳环并氮杂环衍生物及其应用
|
|
AU2016247768B2
(en)
|
2015-04-17 |
2019-03-07 |
Corteva Agriscience Llc |
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
|
|
WO2017001936A2
(en)
|
2015-07-01 |
2017-01-05 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
WO2017001926A2
(en)
|
2015-07-01 |
2017-01-05 |
Lifesci Pharmaceuticals, Inc |
Therapeutic inhibitory compounds
|
|
EP3386504A4
(en)
|
2015-12-11 |
2019-05-22 |
Lifesci Pharmaceuticals, Inc. |
THERAPEUTIC INHIBITOR COMPOUNDS
|
|
CN109152784B
(zh)
|
2016-03-16 |
2021-12-28 |
库拉肿瘤学公司 |
经取代的menin-mll抑制剂及使用方法
|
|
GB201609519D0
(en)
|
2016-05-31 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of n-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyr idin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide
|
|
IL263235B
(en)
|
2016-05-31 |
2022-07-01 |
Kalvista Pharmaceuticals Ltd |
History of pyrazoles as plasma kallikrein inhibitors
|
|
GB201609607D0
(en)
|
2016-06-01 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
|
|
GB201609603D0
(en)
|
2016-06-01 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
|
|
CN110022875A
(zh)
|
2016-07-11 |
2019-07-16 |
莱福斯希医药公司 |
治疗性抑制化合物
|
|
WO2018015818A2
(en)
|
2016-07-15 |
2018-01-25 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
US10280172B2
(en)
*
|
2016-09-29 |
2019-05-07 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
US11111245B2
(en)
|
2017-02-01 |
2021-09-07 |
Aucentra Therapeutics Pty Ltd |
Derivatives of N-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents
|
|
WO2018161033A1
(en)
|
2017-03-02 |
2018-09-07 |
Wright, Adrian |
Small molecule ire1-alpha inhibitors
|
|
MX2019011511A
(es)
|
2017-03-30 |
2019-11-18 |
Hoffmann La Roche |
Naftiridinas como inhibidores de cinasa 1 progenitora hematopoyetica (hpk1).
|
|
WO2018229543A2
(en)
|
2017-06-14 |
2018-12-20 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
PE20200696A1
(es)
|
2017-06-22 |
2020-06-16 |
Curadev Pharma Ltd |
Moduladores de moleculas pequenas de sting humana
|
|
JP7210540B2
(ja)
*
|
2017-08-04 |
2023-01-23 |
武田薬品工業株式会社 |
血漿カリクレインの阻害剤およびその使用
|
|
GB201719881D0
(en)
|
2017-11-29 |
2018-01-10 |
Kalvista Pharmaceuticals Ltd |
Solid forms of plasma kallikrein inhibitor and salts thereof
|
|
GB201719882D0
(en)
|
2017-11-29 |
2018-01-10 |
Kalvista Pharmaceuticals Ltd |
Solid forms of a plasma kallikrein inhibitor and salts thereof
|
|
KR20200143376A
(ko)
|
2018-03-13 |
2020-12-23 |
샤이어 휴먼 지네틱 테라피즈 인크. |
혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도
|
|
TW202116753A
(zh)
|
2019-07-11 |
2021-05-01 |
大陸商南京征祥醫藥有限公司 |
以噌啉作為hpk1的抑制劑
|
|
EP4031547B1
(en)
|
2019-09-18 |
2024-07-17 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors and uses thereof
|
|
CN114667289B
(zh)
|
2019-09-18 |
2025-08-26 |
武田药品工业有限公司 |
杂芳基血浆激肽释放酶抑制剂
|
|
CN114516867B
(zh)
|
2020-04-28 |
2023-09-15 |
江南大学 |
一类含氧五元杂环化合物、合成方法、药物组合物及用途
|
|
US20240199612A1
(en)
|
2021-02-23 |
2024-06-20 |
Shire Human Genetic Therapies, Inc. |
Imidazopyridinyl inhibitors of plasma kallikrein
|
|
US20240226106A1
(en)
|
2021-03-17 |
2024-07-11 |
Shire Human Genetic Therapies, Inc. |
Inhibitors of plasma kallikrein
|
|
BR112023018619A2
(pt)
|
2021-03-17 |
2023-11-28 |
Takeda Pharmaceuticals Co |
Inibidores de heteroaril de calicreína plasmática
|
|
CN117396473A
(zh)
|
2021-03-17 |
2024-01-12 |
武田药品工业株式会社 |
血浆激肽释放酶的咪唑并吡啶基抑制剂
|
|
US20240382482A1
(en)
|
2021-03-17 |
2024-11-21 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors
|
|
EP4308564A1
(en)
|
2021-03-17 |
2024-01-24 |
Takeda Pharmaceutical Company Limited |
Polycyclic inhibitors of plasma kallikrein
|