JP2008523041A5 - - Google Patents

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Publication number
JP2008523041A5
JP2008523041A5 JP2007544984A JP2007544984A JP2008523041A5 JP 2008523041 A5 JP2008523041 A5 JP 2008523041A5 JP 2007544984 A JP2007544984 A JP 2007544984A JP 2007544984 A JP2007544984 A JP 2007544984A JP 2008523041 A5 JP2008523041 A5 JP 2008523041A5
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JP
Japan
Prior art keywords
alkyl
amino
independently selected
alkoxy
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007544984A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008523041A (ja
JP5197014B2 (ja
Filing date
Publication date
Priority claimed from GB0427138A external-priority patent/GB0427138D0/en
Priority claimed from GB0516435A external-priority patent/GB0516435D0/en
Application filed filed Critical
Priority claimed from PCT/GB2005/004743 external-priority patent/WO2006061638A2/en
Publication of JP2008523041A publication Critical patent/JP2008523041A/ja
Publication of JP2008523041A5 publication Critical patent/JP2008523041A5/ja
Application granted granted Critical
Publication of JP5197014B2 publication Critical patent/JP5197014B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007544984A 2004-12-10 2005-12-09 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体 Expired - Lifetime JP5197014B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0427138.3 2004-12-10
GB0427138A GB0427138D0 (en) 2004-12-10 2004-12-10 Therapeutic compounds
GB0516435.5 2005-08-11
GB0516435A GB0516435D0 (en) 2005-08-11 2005-08-11 Therapeutic compounds
PCT/GB2005/004743 WO2006061638A2 (en) 2004-12-10 2005-12-09 Heterocycle derivatives as histone deacetylase (hdac) inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012251740A Division JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

Publications (3)

Publication Number Publication Date
JP2008523041A JP2008523041A (ja) 2008-07-03
JP2008523041A5 true JP2008523041A5 (https=) 2010-12-02
JP5197014B2 JP5197014B2 (ja) 2013-05-15

Family

ID=36424637

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007544984A Expired - Lifetime JP5197014B2 (ja) 2004-12-10 2005-12-09 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体
JP2012251740A Expired - Lifetime JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012251740A Expired - Lifetime JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

Country Status (7)

Country Link
US (1) US7863294B2 (https=)
EP (1) EP1828171B1 (https=)
JP (2) JP5197014B2 (https=)
AU (1) AU2005313108B2 (https=)
CA (1) CA2590811C (https=)
ES (1) ES2462341T3 (https=)
WO (1) WO2006061638A2 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017321B2 (en) 2004-01-23 2011-09-13 The Regents Of The University Of Colorado, A Body Corporate Gefitinib sensitivity-related gene expression and products and methods related thereto
WO2005117553A2 (en) 2004-05-27 2005-12-15 The Regents Of The University Of Colorado Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
GB0518237D0 (en) 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0522130D0 (en) * 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007070816A2 (en) * 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Thiophene derivatives as factor xia inhibitors
EP1981854B1 (en) 2005-12-14 2011-06-01 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
GB0526107D0 (en) * 2005-12-22 2006-02-01 Angeletti P Ist Richerche Bio Therapeutic Compounds
WO2009042646A1 (en) * 2007-09-24 2009-04-02 Curis, Inc. Anti-proliferative agents
WO2010056549A1 (en) * 2008-10-29 2010-05-20 Sirtris Pharmaceuticals, Inc. Pyridine, bicyclic pyridine and related analogs as sirtuin modulators
GB0900484D0 (en) 2009-01-13 2009-02-11 Angeletti P Ist Richerche Bio Therapeutic agent
GB0916608D0 (en) 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2011047156A1 (en) 2009-10-15 2011-04-21 Hercules Technology Management Co V, Inc. Sepiapterin reductase inhibitors for the treatment of pain
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
JP2013517281A (ja) * 2010-01-13 2013-05-16 テンペロ、ファーマシューティカルズ、インコーポレイテッド 化合物及び方法
CN103221047B (zh) 2010-01-13 2014-12-17 坦颇罗制药股份有限公司 化合物和方法
JP2013517279A (ja) * 2010-01-13 2013-05-16 テンペロ、ファーマシューティカルズ、インコーポレイテッド 化合物及び方法
WO2011130163A1 (en) * 2010-04-12 2011-10-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
AR082498A1 (es) * 2010-08-20 2012-12-12 Gruenenthal Gmbh Derivados ciclicos de carboxamida y urea sustituidos como ligandos del receptor de vainiloide
WO2012062462A1 (en) * 2010-11-10 2012-05-18 Grünenthal GmbH Substituted heteroaromatic carboxamide and urea derivatives as vanilloid receptor ligands
WO2013006408A1 (en) * 2011-07-01 2013-01-10 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013005798A1 (ja) * 2011-07-06 2013-01-10 持田製薬株式会社 新規含窒素複素環誘導体
WO2013009827A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009830A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009810A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009812A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc Methods of treatment
ITRM20120405A1 (it) * 2012-08-09 2014-02-10 C N C C S Scarl Collezione Naziona Le Dei Compost Compounds for use in the treatment of disorders that are ameliorated by inhibition of hdac
ES2691643T3 (es) 2012-08-24 2018-11-28 Board Of Regents, The University Of Texas System Moduladores heterocíclicos de la actividad de HIF para el tratamiento de enfermedades
ITRM20120530A1 (it) * 2012-10-31 2014-05-01 C N C C S S C A R L Collezione Na Zionale Dei Co Compounds for use in the treatment of parasitic diseases
CN103588761B (zh) * 2013-10-22 2015-05-27 湖南大学 N-[1-(苯并呋喃-5-基)-2-氧代乙基]苯并吡喃-4-酰胺的制备与应用
KR20180002729A (ko) 2015-05-07 2018-01-08 씨에이치디아이 파운데이션, 인코포레이티드 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법
EA035592B1 (ru) 2015-05-07 2020-07-13 Сиэйчдиай Фаундэйшн, Инк. Ингибиторы деацетилаз гистонов и композиции и способы их применения
US11352326B2 (en) * 2016-11-16 2022-06-07 The General Hospital Corporation Myeloperoxidase imaging agents
CN107226791B (zh) * 2017-06-13 2020-07-10 贵州医科大学 氮氧化物作为新型组蛋白去乙酰化酶抑制剂的抗肿瘤应用
JP7330168B2 (ja) * 2017-08-31 2023-08-21 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント インデン誘導体およびその使用
WO2020028150A1 (en) 2018-08-01 2020-02-06 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
EP3876928B1 (en) * 2018-11-08 2024-10-23 Merck Sharp & Dohme LLC Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
US12365674B2 (en) 2019-01-15 2025-07-22 Merck Sharp & Dohme Llc Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection
WO2020190827A1 (en) 2019-03-21 2020-09-24 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
CN110776521A (zh) * 2019-10-24 2020-02-11 秦源生物医药科技(上海)有限公司 一种1,2,4-三唑-1,3,4-噻二唑类化合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0946587A2 (en) * 1996-12-16 1999-10-06 Fujisawa Pharmaceutical Co., Ltd. New amide compounds
US6852725B1 (en) 1998-06-12 2005-02-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S. A. S. Imidazolyl derivatives
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
WO2002010140A2 (en) 2000-08-01 2002-02-07 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Imidazolyl derivatives
AU2003900608A0 (en) * 2003-02-11 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Hdac inhibitor
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
WO2006005941A1 (en) 2004-07-12 2006-01-19 Istituto Di Ricerche Di Biologia Molecolare P Angeletti S.P.A. Amide derivatives as inhibitors of histone deacetylase
WO2006005955A1 (en) 2004-07-12 2006-01-19 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Amide derivatives as inhibitors of histone deacetylase
GB0522130D0 (en) 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0526107D0 (en) 2005-12-22 2006-02-01 Angeletti P Ist Richerche Bio Therapeutic Compounds

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