JP5197014B2 - ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体 - Google Patents

ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体 Download PDF

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JP5197014B2
JP5197014B2 JP2007544984A JP2007544984A JP5197014B2 JP 5197014 B2 JP5197014 B2 JP 5197014B2 JP 2007544984 A JP2007544984 A JP 2007544984A JP 2007544984 A JP2007544984 A JP 2007544984A JP 5197014 B2 JP5197014 B2 JP 5197014B2
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amino
alkyl
imidazol
methyl
ium
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JP2008523041A (ja
JP2008523041A5 (https=
Inventor
アテンニ，バルバラ
フエリグノ，フエデリカ
ジヨーンズ，フイリツプ
インジエニト，ラフアエル
キンツエル，オラフ
リヤウヘル・ブフイ，ラウラ
オントリア・オントリア，ヘスス・マリア
ペスカトーレ，ジヨバンナ
ローリー，マイケル
スカルペツリ，リタ
シユルツ，カルステン
Original Assignee
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ
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Priority claimed from GB0427138A external-priority patent/GB0427138D0/en
Priority claimed from GB0516435A external-priority patent/GB0516435D0/en
Application filed by イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ filed Critical イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
JP2007544984A 2004-12-10 2005-12-09 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体 Expired - Lifetime JP5197014B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0427138.3 2004-12-10
GB0427138A GB0427138D0 (en) 2004-12-10 2004-12-10 Therapeutic compounds
GB0516435.5 2005-08-11
GB0516435A GB0516435D0 (en) 2005-08-11 2005-08-11 Therapeutic compounds
PCT/GB2005/004743 WO2006061638A2 (en) 2004-12-10 2005-12-09 Heterocycle derivatives as histone deacetylase (hdac) inhibitors

Related Child Applications (1)

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JP2012251740A Division JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

Publications (3)

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JP2008523041A JP2008523041A (ja) 2008-07-03
JP2008523041A5 JP2008523041A5 (https=) 2010-12-02
JP5197014B2 true JP5197014B2 (ja) 2013-05-15

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JP2007544984A Expired - Lifetime JP5197014B2 (ja) 2004-12-10 2005-12-09 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体
JP2012251740A Expired - Lifetime JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

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JP2012251740A Expired - Lifetime JP5878859B2 (ja) 2004-12-10 2012-11-16 ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤としての複素環誘導体

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Country Link
US (1) US7863294B2 (https=)
EP (1) EP1828171B1 (https=)
JP (2) JP5197014B2 (https=)
AU (1) AU2005313108B2 (https=)
CA (1) CA2590811C (https=)
ES (1) ES2462341T3 (https=)
WO (1) WO2006061638A2 (https=)

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WO2005117553A2 (en) 2004-05-27 2005-12-15 The Regents Of The University Of Colorado Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
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GB0522130D0 (en) * 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007070816A2 (en) * 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Thiophene derivatives as factor xia inhibitors
EP1981854B1 (en) 2005-12-14 2011-06-01 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
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WO2009042646A1 (en) * 2007-09-24 2009-04-02 Curis, Inc. Anti-proliferative agents
WO2010056549A1 (en) * 2008-10-29 2010-05-20 Sirtris Pharmaceuticals, Inc. Pyridine, bicyclic pyridine and related analogs as sirtuin modulators
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CN103221047B (zh) 2010-01-13 2014-12-17 坦颇罗制药股份有限公司 化合物和方法
JP2013517279A (ja) * 2010-01-13 2013-05-16 テンペロ、ファーマシューティカルズ、インコーポレイテッド 化合物及び方法
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