JP2020528752A5 - - Google Patents
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- JP2020528752A5 JP2020528752A5 JP2020504234A JP2020504234A JP2020528752A5 JP 2020528752 A5 JP2020528752 A5 JP 2020528752A5 JP 2020504234 A JP2020504234 A JP 2020504234A JP 2020504234 A JP2020504234 A JP 2020504234A JP 2020528752 A5 JP2020528752 A5 JP 2020528752A5
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- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims description 40
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims description 40
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 8
- 230000008782 phagocytosis Effects 0.000 claims description 8
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- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 4
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims description 4
- 108010065524 CD52 Antigen Proteins 0.000 claims description 4
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- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 4
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- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 4
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 4
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 4
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- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims description 4
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 4
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- 101150038994 PDGFRA gene Proteins 0.000 claims description 4
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- 210000004027 cell Anatomy 0.000 claims description 4
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- 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 3
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- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 2
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- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 2
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 2
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims description 2
- 101000632467 Homo sapiens Pulmonary surfactant-associated protein D Proteins 0.000 claims description 2
- 101000835928 Homo sapiens Signal-regulatory protein gamma Proteins 0.000 claims description 2
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims description 2
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 2
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- 241000282567 Macaca fascicularis Species 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
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- 108010007100 Pulmonary Surfactant-Associated Protein A Proteins 0.000 claims description 2
- 102100027773 Pulmonary surfactant-associated protein A2 Human genes 0.000 claims description 2
- 102000014128 RANK Ligand Human genes 0.000 claims description 2
- 108010025832 RANK Ligand Proteins 0.000 claims description 2
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims description 2
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 229960000548 alemtuzumab Drugs 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 229960003852 atezolizumab Drugs 0.000 claims description 2
- 229950002916 avelumab Drugs 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 2
- 229960000455 brentuximab vedotin Drugs 0.000 claims description 2
- 229960005395 cetuximab Drugs 0.000 claims description 2
- 229960002204 daratumumab Drugs 0.000 claims description 2
- 230000022811 deglycosylation Effects 0.000 claims description 2
- 229960001251 denosumab Drugs 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 229960004137 elotuzumab Drugs 0.000 claims description 2
- 230000002255 enzymatic effect Effects 0.000 claims description 2
- 230000004761 fibrosis Effects 0.000 claims description 2
- 150000002270 gangliosides Chemical class 0.000 claims description 2
- 229960000578 gemtuzumab Drugs 0.000 claims description 2
- 102000044459 human CD47 Human genes 0.000 claims description 2
- 102000054510 human SIRPG Human genes 0.000 claims description 2
- 210000002540 macrophage Anatomy 0.000 claims description 2
- 201000004792 malaria Diseases 0.000 claims description 2
- 229960000513 necitumumab Drugs 0.000 claims description 2
- 229960003347 obinutuzumab Drugs 0.000 claims description 2
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- 229960002087 pertuzumab Drugs 0.000 claims description 2
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022078181A JP7383074B2 (ja) | 2017-07-26 | 2022-05-11 | 抗ｓｉｒｐ－アルファ抗体及び関連方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537207P | 2017-07-26 | 2017-07-26 | |
| US62/537,207 | 2017-07-26 | ||
| PCT/US2018/043699 WO2019023347A1 (en) | 2017-07-26 | 2018-07-25 | ANTI-SIRP-ALPHA ANTIBODIES AND ASSOCIATED METHODS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022078181A Division JP7383074B2 (ja) | 2017-07-26 | 2022-05-11 | 抗ｓｉｒｐ－アルファ抗体及び関連方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528752A JP2020528752A (ja) | 2020-10-01 |
| JP2020528752A5 true JP2020528752A5 (enExample) | 2021-07-26 |
| JP7122370B2 JP7122370B2 (ja) | 2022-08-19 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020504234A Active JP7122370B2 (ja) | 2017-07-26 | 2018-07-25 | 抗ｓｉｒｐ－アルファ抗体及び関連方法 |
| JP2022078181A Active JP7383074B2 (ja) | 2017-07-26 | 2022-05-11 | 抗ｓｉｒｐ－アルファ抗体及び関連方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022078181A Active JP7383074B2 (ja) | 2017-07-26 | 2022-05-11 | 抗ｓｉｒｐ－アルファ抗体及び関連方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10961318B2 (enExample) |
| EP (1) | EP3658589B1 (enExample) |
| JP (2) | JP7122370B2 (enExample) |
| KR (1) | KR102670957B1 (enExample) |
| CN (1) | CN111448210B (enExample) |
| AU (2) | AU2018308364C1 (enExample) |
| BR (1) | BR112020001653A2 (enExample) |
| CA (1) | CA3071193A1 (enExample) |
| ES (1) | ES2963157T3 (enExample) |
| IL (1) | IL272218A (enExample) |
| MX (1) | MX2020000957A (enExample) |
| PL (1) | PL3658589T3 (enExample) |
| SG (1) | SG11202000658PA (enExample) |
| WO (1) | WO2019023347A1 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RS66062B1 (sr) | 2016-04-14 | 2024-11-29 | Ose Immunotherapeutics | Nova anti-sirpa antitela i njihove terapijske primene |
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| AU2017371070B2 (en) | 2016-12-09 | 2025-01-02 | Alector Llc | Anti-SIRP-alpha antibodies and methods of use thereof |
| US10851164B2 (en) | 2017-04-13 | 2020-12-01 | Aduro Biotech Holdings, Europe B.V. | Anti-SIRPα antibodies |
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| WO2020097193A1 (en) | 2018-11-06 | 2020-05-14 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
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| MX2022002613A (es) | 2019-09-03 | 2022-06-02 | Myeloid Therapeutics Inc | Metodos y composiciones para la integracion del genoma. |
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