|
GB939516A
(en)
|
1961-05-29 |
1963-10-16 |
British Drug Houses Ltd |
Sulphonyl ureas
|
|
US3702849A
(en)
|
1967-10-26 |
1972-11-14 |
Pfizer |
4-(isoquinolin-1-yl) piperazine-1-carboxylic acid esters
|
|
US3752660A
(en)
|
1971-03-15 |
1973-08-14 |
Allied Chem |
Chlorophenoxyacetyloxazolidone herbicides and preparation thereof
|
|
EP0094498A3
(en)
|
1982-05-06 |
1985-04-03 |
American Cyanamid Company |
Antiatherosclerotic 1-piperazine derivatives
|
|
US4439606A
(en)
|
1982-05-06 |
1984-03-27 |
American Cyanamid Company |
Antiatherosclerotic 1-piperazinecarbonyl compounds
|
|
US4656181A
(en)
|
1982-11-24 |
1987-04-07 |
Cermol S.A. |
Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
|
|
JPS59163372A
(ja)
|
1983-03-09 |
1984-09-14 |
Showa Denko Kk |
ピラゾ−ル誘導体とその製造法及び除草剤
|
|
JPS60193955A
(ja)
|
1984-03-13 |
1985-10-02 |
Mitsui Toatsu Chem Inc |
環式不飽和アミド置換エ−テル化合物及びその製造方法
|
|
JPS6143190A
(ja)
*
|
1984-08-06 |
1986-03-01 |
Mitsui Petrochem Ind Ltd |
ピリドピリミジン誘導体およびその製法
|
|
US4911920A
(en)
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5010175A
(en)
|
1988-05-02 |
1991-04-23 |
The Regents Of The University Of California |
General method for producing and selecting peptides with specific properties
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
US5925525A
(en)
|
1989-06-07 |
1999-07-20 |
Affymetrix, Inc. |
Method of identifying nucleotide differences
|
|
IE66205B1
(en)
|
1990-06-14 |
1995-12-13 |
Paul A Bartlett |
Polypeptide analogs
|
|
US5650489A
(en)
|
1990-07-02 |
1997-07-22 |
The Arizona Board Of Regents |
Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
|
|
JP2594486B2
(ja)
|
1991-01-15 |
1997-03-26 |
アルコン ラボラトリーズ インコーポレイテッド |
局所的眼薬組成物
|
|
US5212162A
(en)
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
US6017696A
(en)
|
1993-11-01 |
2000-01-25 |
Nanogen, Inc. |
Methods for electronic stringency control for molecular biological analysis and diagnostics
|
|
US6051380A
(en)
|
1993-11-01 |
2000-04-18 |
Nanogen, Inc. |
Methods and procedures for molecular biological analysis and diagnostics
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
US5288514A
(en)
|
1992-09-14 |
1994-02-22 |
The Regents Of The University Of California |
Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5605798A
(en)
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
|
US5858659A
(en)
|
1995-11-29 |
1999-01-12 |
Affymetrix, Inc. |
Polymorphism detection
|
|
US6045996A
(en)
|
1993-10-26 |
2000-04-04 |
Affymetrix, Inc. |
Hybridization assays on oligonucleotide arrays
|
|
US6068818A
(en)
|
1993-11-01 |
2000-05-30 |
Nanogen, Inc. |
Multicomponent devices for molecular biological analysis and diagnostics
|
|
US5538848A
(en)
|
1994-11-16 |
1996-07-23 |
Applied Biosystems Division, Perkin-Elmer Corp. |
Method for detecting nucleic acid amplification using self-quenching fluorescence probe
|
|
IL111730A
(en)
|
1993-11-29 |
1998-12-06 |
Fujisawa Pharmaceutical Co |
Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
|
|
EP0754240B1
(en)
|
1994-02-07 |
2003-08-20 |
Beckman Coulter, Inc. |
Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis
|
|
US5593853A
(en)
|
1994-02-09 |
1997-01-14 |
Martek Corporation |
Generation and screening of synthetic drug libraries
|
|
US5539083A
(en)
|
1994-02-23 |
1996-07-23 |
Isis Pharmaceuticals, Inc. |
Peptide nucleic acid combinatorial libraries and improved methods of synthesis
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
WO1996013262A1
(en)
|
1994-10-27 |
1996-05-09 |
Merck & Co., Inc. |
Muscarine antagonists
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
JP3053222B2
(ja)
|
1995-04-20 |
2000-06-19 |
ファイザー・インコーポレーテッド |
Ｍｍｐおよびｔｎｆ抑制剤としてのアリールスルホニルヒドロキサム酸誘導体
|
|
FR2734816B1
(fr)
|
1995-05-31 |
1997-07-04 |
Adir |
Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
EP2258726A1
(en)
|
1995-06-14 |
2010-12-08 |
The Regents of the University of California |
High affinity human antibodies to c-erbB-2
|
|
ATE225343T1
(de)
|
1995-12-20 |
2002-10-15 |
Hoffmann La Roche |
Matrix-metalloprotease inhibitoren
|
|
US6011029A
(en)
|
1996-02-26 |
2000-01-04 |
Bristol-Myers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
TR199900066T2
(xx)
|
1996-07-18 |
1999-04-21 |
Pfizer Inc. |
Matriks metalloproteazlar�n fosfinat bazl� inhibit�rleri
|
|
SK21499A3
(en)
|
1996-08-23 |
2000-05-16 |
Pfizer |
Arylsulfonylamino hydroxamic acid derivatives
|
|
US5777324A
(en)
|
1996-09-19 |
1998-07-07 |
Sequenom, Inc. |
Method and apparatus for maldi analysis
|
|
US6077864A
(en)
|
1997-01-06 |
2000-06-20 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
DE69817801T2
(de)
|
1997-02-03 |
2004-03-11 |
Pfizer Products Inc., Groton |
Arylsulfonylhydroxamsäurederivate
|
|
GB9702194D0
(en)
|
1997-02-04 |
1997-03-26 |
Lilly Co Eli |
Sulphonide derivatives
|
|
BR9807824A
(pt)
|
1997-02-07 |
2000-03-08 |
Pfizer |
Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
|
|
EP0960098A1
(en)
|
1997-02-11 |
1999-12-01 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
JP2001511766A
(ja)
|
1997-02-17 |
2001-08-14 |
藤沢薬品工業株式会社 |
新規アミノピペラジン誘導体
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
US6002008A
(en)
|
1997-04-03 |
1999-12-14 |
American Cyanamid Company |
Substituted 3-cyano quinolines
|
|
US5919626A
(en)
|
1997-06-06 |
1999-07-06 |
Orchid Bio Computer, Inc. |
Attachment of unmodified nucleic acids to silanized solid phase surfaces
|
|
WO1998057948A1
(en)
|
1997-06-17 |
1998-12-23 |
Schering Corporation |
Novel n-substituted urea inhibitors of farnesyl-protein transferase
|
|
TR200000368T2
(tr)
|
1997-08-08 |
2000-07-21 |
Pfizer Products Inc. |
Ariloksiariarilsülfonilamino hidroksamik asit türevleri.
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
US6903118B1
(en)
|
1997-12-17 |
2005-06-07 |
Klinge Pharma Gmbh |
Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
|
|
DE19756236A1
(de)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
|
|
BR9813835A
(pt)
|
1997-12-22 |
2000-10-10 |
Du Pont Pharm Co |
Composto, composição farmacêutica e método de tratamento ou prevenção de uma desordem tromboembólica
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
EP1090293B2
(en)
|
1998-06-24 |
2019-01-23 |
Illumina, Inc. |
Decoding of array sensors with microspheres
|
|
DE69915004T2
(de)
|
1998-11-05 |
2004-09-09 |
Pfizer Products Inc., Groton |
5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate
|
|
US6429027B1
(en)
|
1998-12-28 |
2002-08-06 |
Illumina, Inc. |
Composite arrays utilizing microspheres
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
CA2384838C
(en)
|
1999-09-13 |
2006-07-18 |
Nugen Technologies, Inc. |
Methods and compositions for linear isothermal amplification of polynucleotide sequences
|
|
TWI271406B
(en)
|
1999-12-13 |
2007-01-21 |
Eisai Co Ltd |
Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
|
|
BR0109165A
(pt)
|
2000-03-13 |
2003-04-22 |
American Cyanamid Co |
Método de tratamento de pólipos colÈnicos
|
|
AU2001245863A1
(en)
|
2000-03-21 |
2001-10-03 |
The Procter & Gamble Company |
Heterocyclic side chain containing metalloprotease inhibitors
|
|
JP2003535860A
(ja)
|
2000-06-05 |
2003-12-02 |
ドン・ア・ファーム・カンパニー・リミテッド |
新規なオキサゾリジノン誘導体及びその製造方法
|
|
TWI227231B
(en)
|
2000-07-12 |
2005-02-01 |
Novartis Ag |
4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3
|
|
EA005809B1
(ru)
|
2000-08-18 |
2005-06-30 |
Милленниум Фармасьютикалз, Инк. |
Производные хиназолина в качестве ингибиторов киназы
|
|
US6890747B2
(en)
|
2000-10-23 |
2005-05-10 |
Warner-Lambert Company |
Phosphoinositide 3-kinases
|
|
US7429599B2
(en)
|
2000-12-06 |
2008-09-30 |
Signal Pharmaceuticals, Llc |
Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
|
|
US20020169300A1
(en)
|
2001-01-30 |
2002-11-14 |
Waterman Marian L. |
Method of detection and treatment of colon cancer by analysis of beta-catenin-sensitive isoforms of lymphoid enhancer factor-1
|
|
WO2002080928A1
(en)
|
2001-04-03 |
2002-10-17 |
Merck & Co., Inc. |
N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
|
|
US7074801B1
(en)
|
2001-04-26 |
2006-07-11 |
Eisai Co., Ltd. |
Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
|
|
JP2002371078A
(ja)
|
2001-06-12 |
2002-12-26 |
Sankyo Co Ltd |
キノリン誘導体及びキノロン誘導体
|
|
JP2005502623A
(ja)
|
2001-07-02 |
2005-01-27 |
ノボ ノルディスク アクティーゼルスカブ |
置換ピペラジンおよびジアゼパン
|
|
WO2003053958A1
(en)
|
2001-12-20 |
2003-07-03 |
Celltech R & D Limited |
Quinazolinedione derivatives
|
|
EP1348434A1
(en)
|
2002-03-27 |
2003-10-01 |
Fujisawa Deutschland GmbH |
Use of pyridyl amides as inhibitors of angiogenesis
|
|
US20050256159A1
(en)
|
2002-10-11 |
2005-11-17 |
Astrazeneca Ab |
1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors
|
|
JP4608852B2
(ja)
|
2002-10-15 |
2011-01-12 |
チッソ株式会社 |
液晶性ビニルケトン誘導体およびその重合体
|
|
EP1597256A1
(en)
|
2003-02-21 |
2005-11-23 |
Pfizer Inc. |
N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors
|
|
PL1633724T3
(pl)
|
2003-03-12 |
2011-10-31 |
Kudos Pharm Ltd |
Pochodne ftalazynonu
|
|
US20050119266A1
(en)
|
2003-10-01 |
2005-06-02 |
Yan Shi |
Pyrrolidine and piperidine derivatives as factor Xa inhibitors
|
|
SE0302811D0
(sv)
|
2003-10-23 |
2003-10-23 |
Astrazeneca Ab |
Novel compounds
|
|
JP4923380B2
(ja)
|
2003-12-22 |
2012-04-25 |
Ｊｎｃ株式会社 |
低屈折率異方性化合物、組成物およびそれらの重合体または重合体組成物
|
|
GEP20084439B
(en)
|
2004-01-23 |
2008-07-25 |
Amgen Inc |
Nitrogen-containing heterocyclic derivatives and pharmaceutical use thereof
|
|
WO2005082892A2
(en)
|
2004-02-17 |
2005-09-09 |
Dr. Reddy's Laboratories Ltd. |
Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
|
|
US7368445B2
(en)
|
2004-03-01 |
2008-05-06 |
Eli Lilly And Company |
Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms
|
|
EP1736465A4
(en)
|
2004-03-31 |
2009-06-17 |
Ajinomoto Kk |
ANILINE DERIVATIVES
|
|
US20060167044A1
(en)
|
2004-12-20 |
2006-07-27 |
Arnaiz Damian O |
Piperidine derivatives and their use as anti-inflammatory agents
|
|
GB0428475D0
(en)
|
2004-12-30 |
2005-02-02 |
4 Aza Bioscience Nv |
Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
|
|
US20090264415A2
(en)
|
2004-12-30 |
2009-10-22 |
Steven De Jonghe |
Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment
|
|
TW200643015A
(en)
|
2005-03-11 |
2006-12-16 |
Akzo Nobel Nv |
2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives
|
|
US7579368B2
(en)
|
2005-03-16 |
2009-08-25 |
Hoffman-La Roche Inc. |
Cis-imidazolines
|
|
JP2007016011A
(ja)
|
2005-06-10 |
2007-01-25 |
Nippon Soda Co Ltd |
抗酸化活性を有する新規な含窒素ヘテロ環化合物、及び該化合物を含有する抗酸化薬
|
|
JP2008543888A
(ja)
|
2005-06-24 |
2008-12-04 |
ギリアード サイエンシーズ， インコーポレイテッド |
ピリド（３，２−ｄ）ピリミジン、およびＣ型肝炎を治療するのに有用な医薬組成物
|
|
AU2006303955A1
(en)
|
2005-10-11 |
2007-04-26 |
Intermune, Inc. |
Inhibitors of viral replication
|
|
JP2009519349A
(ja)
|
2005-12-15 |
2009-05-14 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｃｂ２受容体を変調する化合物
|
|
PE20070978A1
(es)
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
|
US8097617B2
(en)
|
2006-03-31 |
2012-01-17 |
Novartis Ag |
Organic compounds
|
|
WO2007116313A2
(en)
|
2006-04-12 |
2007-10-18 |
Pfizer Limited |
Pyrrolidine derivatives as modulators of chemokine ccr5 receptors
|
|
EP2038255A2
(en)
|
2006-06-16 |
2009-03-25 |
High Point Pharmaceuticals, LLC |
Pharmaceutical use of substituted piperidine carboxamides
|
|
BRPI0713328A2
(pt)
|
2006-06-22 |
2012-10-30 |
Biovitrum Ab |
derivados de piridina e pirazina como inibidores de cinase mnk
|
|
FR2903101B1
(fr)
|
2006-06-30 |
2008-09-26 |
Servier Lab |
Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
WO2008009078A2
(en)
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
|
|
EP1903038A1
(de)
|
2006-09-07 |
2008-03-26 |
Bayer Schering Pharma Aktiengesellschaft |
N-(1-Hetaryl-piperidin-4-yl)-(het)arylamide als EP2-Rezeptor Modulatoren
|
|
EP2061462A2
(en)
|
2006-09-15 |
2009-05-27 |
Schering Corporation |
Treating pain, diabetes and lipid metabolism disorders
|
|
JP2010520876A
(ja)
|
2007-03-09 |
2010-06-17 |
アストラゼネカ・アクチエボラーグ |
ピペラジンおよびピペリジンｍＧｌｕＲ５増強剤
|
|
US8445679B2
(en)
|
2007-04-16 |
2013-05-21 |
Abbvie Inc. |
7-substituted indole MCL-1 inhibitors
|
|
CA2991818C
(en)
|
2008-03-28 |
2022-10-11 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for nucleic acid sequencing
|
|
EP2133334A1
(en)
|
2008-06-09 |
2009-12-16 |
DAC S.r.l. |
Heterocyclic derivatives as HDAC inhibitors
|
|
CA2733533C
(en)
|
2008-08-25 |
2013-12-17 |
Irm Llc |
Hedgehog pathway modulators
|
|
RU2011123647A
(ru)
|
2008-11-10 |
2012-12-20 |
Вертекс Фармасьютикалз Инкорпорейтед |
Соединения, полезные в качестве ингибиторов atr киназы
|
|
WO2010087399A1
(ja)
|
2009-01-30 |
2010-08-05 |
第一三共株式会社 |
ウロテンシンｉｉ受容体拮抗薬
|
|
AU2010238732B2
(en)
|
2009-04-22 |
2015-06-11 |
Janssen Pharmaceutica Nv |
Azetidinyl diamides as monoacylglycerol lipase inhibitors
|
|
WO2010141817A1
(en)
|
2009-06-05 |
2010-12-09 |
Janssen Pharmaceutica Nv |
Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
|
|
EP2270002A1
(en)
|
2009-06-18 |
2011-01-05 |
Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg |
Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders
|
|
EP2448581B1
(en)
|
2009-06-29 |
2016-12-07 |
Agios Pharmaceuticals, Inc. |
Therapeutic compositions and related methods of use
|
|
WO2011016559A1
(ja)
|
2009-08-07 |
2011-02-10 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
KR101256018B1
(ko)
|
2009-08-20 |
2013-04-18 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
|
|
RU2595718C2
(ru)
|
2009-09-09 |
2016-08-27 |
Селджен Авиломикс Рисерч,Инк. |
Ингибиторы pi3-киназы и их применение
|
|
CA2785499C
(en)
|
2009-12-22 |
2017-05-02 |
Vertex Pharmaceuticals Incorporated |
Isoindolinone inhibitors of phosphatidylinositol 3-kinase
|
|
CN102812167A
(zh)
|
2009-12-30 |
2012-12-05 |
阿维拉制药公司 |
蛋白的配体-介导的共价修饰
|
|
US8722663B2
(en)
|
2010-01-29 |
2014-05-13 |
Otsuka Pharmaceutical Co., Ltd. |
Di-substituted pyridine derivatives as anticancers
|
|
US20110217309A1
(en)
|
2010-03-03 |
2011-09-08 |
Buck Elizabeth A |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
GB201004200D0
(en)
|
2010-03-15 |
2010-04-28 |
Univ Basel |
Spirocyclic compounds and their use as therapeutic agents and diagnostic probes
|
|
SG183855A1
(en)
|
2010-03-16 |
2012-10-30 |
Merck Patent Gmbh |
Morpholinylquinazolines
|
|
WO2011136264A1
(ja)
|
2010-04-28 |
2011-11-03 |
第一三共株式会社 |
［５，６］複素環化合物
|
|
TW201202230A
(en)
|
2010-05-24 |
2012-01-16 |
Mitsubishi Tanabe Pharma Corp |
Novel quinazoline compound
|
|
WO2011153553A2
(en)
|
2010-06-04 |
2011-12-08 |
The Regents Of The University Of California |
Methods and compositions for kinase inhibition
|
|
CN103119439A
(zh)
|
2010-06-08 |
2013-05-22 |
纽亘技术公司 |
用于多重测序的方法和组合物
|
|
US8658131B2
(en)
|
2010-06-21 |
2014-02-25 |
Washington University |
Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand
|
|
MX342879B
(es)
|
2010-07-30 |
2016-10-14 |
Oncotherapy Science Inc * |
Derivados de quinolina e inhibidores de cinasa de cremallera de leucina embrionica materna que los contienen.
|
|
KR20130101040A
(ko)
|
2010-09-03 |
2013-09-12 |
얀센 파마슈티카 엔.브이. |
모노아실글리세롤 리파아제 억제제로서의 다이-아제티디닐 다이아미드
|
|
US8883791B2
(en)
|
2010-09-29 |
2014-11-11 |
Intervet Inc. |
N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
|
|
BR112013009858A2
(pt)
|
2010-10-22 |
2016-07-26 |
Janssen Pharmaceutica Nv |
diamidas de piperidin-4-il-azetidina como inibidores de monoacilglicerol lipase
|
|
EP2635279A4
(en)
|
2010-11-05 |
2014-10-29 |
Glaxosmithkline Ip No 2 Ltd |
CHEMICAL COMPOUNDS
|
|
US9260484B2
(en)
|
2011-06-15 |
2016-02-16 |
Ohio State Innovation Foundation |
Small molecule composite surfaces as inhibitors of protein-protein interactions
|
|
MX2013015204A
(es)
|
2011-06-29 |
2014-02-17 |
Otsuka Pharma Co Ltd |
Quinazolinas como compuestos terapeuticos, y metodos de uso relacionados.
|
|
CN103087077B
(zh)
|
2011-11-03 |
2016-05-18 |
上海希迈医药科技有限公司 |
噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
JP2013107855A
(ja)
|
2011-11-22 |
2013-06-06 |
Mitsubishi Tanabe Pharma Corp |
医薬組成物
|
|
US9745631B2
(en)
|
2011-12-20 |
2017-08-29 |
Dana-Farber Cancer Institute, Inc. |
Methods for diagnosing and treating oncogenic kras-associated cancer
|
|
WO2013096151A1
(en)
|
2011-12-22 |
2013-06-27 |
Glaxosmithkline Llc |
Chemical compounds
|
|
EP2802579B1
(en)
|
2012-01-13 |
2016-04-13 |
Bristol-Myers Squibb Company |
Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors
|
|
WO2013140148A1
(en)
|
2012-03-19 |
2013-09-26 |
Imperial Innovations Limited |
Quinazoline compounds and their use in therapy
|
|
WO2013155077A1
(en)
|
2012-04-09 |
2013-10-17 |
Board Of Regents,The University Of Texas System |
Response markers for src inhibitor therapies
|
|
US20150087628A1
(en)
|
2012-04-10 |
2015-03-26 |
The Regents Of The University Of California |
Compositions and methods for treating cancer
|
|
KR20150006477A
(ko)
|
2012-05-09 |
2015-01-16 |
그래댈리스, 인코포레이티드 |
단일-뉴클레오타이드 ｋｒａｓ 돌연변이에 특이적인 이-기능성 짧은-헤어핀 ｒｎａ (ｂｉ-ｓｈｒｎａ)
|
|
JO3300B1
(ar)
|
2012-06-06 |
2018-09-16 |
Novartis Ag |
مركبات وتركيبات لتعديل نشاط egfr
|
|
KR102163776B1
(ko)
|
2012-07-11 |
2020-10-12 |
블루프린트 메디신즈 코포레이션 |
섬유아세포 성장인자 수용체의 저해제
|
|
TW201414737A
(zh)
|
2012-07-13 |
2014-04-16 |
必治妥美雅史谷比公司 |
作爲激酶抑制劑之咪唑并三□甲腈
|
|
CA2882879A1
(en)
|
2012-08-24 |
2014-02-27 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
US20150283142A1
(en)
|
2013-03-15 |
2015-10-08 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
BR112015011456A2
(pt)
|
2012-11-20 |
2017-07-11 |
Genentech Inc |
compostos de aminopirimidina como inibidores de egfr mutantes contendo t790m
|
|
US9695179B2
(en)
|
2013-03-14 |
2017-07-04 |
Convergene Llc |
Methods and compositions for inhibition of bromodomain-containing proteins
|
|
US9745319B2
(en)
|
2013-03-15 |
2017-08-29 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the GTPase K-Ras G12C
|
|
US9227978B2
(en)
|
2013-03-15 |
2016-01-05 |
Araxes Pharma Llc |
Covalent inhibitors of Kras G12C
|
|
EA201591532A1
(ru)
|
2013-03-15 |
2016-03-31 |
Эпизим, Инк. |
Ингибиторы carm1 и их применение
|
|
WO2014201435A1
(en)
|
2013-06-13 |
2014-12-18 |
Biodesy, Inc. |
Method of screening candidate biochemical entities targeting a target biochemical entity
|
|
KR102581373B1
(ko)
|
2013-07-03 |
2023-09-20 |
카리오팜 쎄라퓨틱스, 인코포레이티드 |
치환된 벤조퓨라닐 및 벤즈옥사졸릴 화합물 및 이의 용도
|
|
PT3049417T
(pt)
|
2013-07-31 |
2019-01-24 |
Merck Patent Gmbh |
Piridinas, pirimidinas e pirazinas, como inibidores de btk e utilizações das mesmas
|
|
CN104418860B
(zh)
|
2013-08-20 |
2016-09-07 |
中国科学院广州生物医药与健康研究院 |
嘧啶并杂环类化合物及其药用组合物和应用
|
|
BR112016008016B8
(pt)
|
2013-10-10 |
2023-09-26 |
Araxes Pharma Llc |
Compostos inibidores de kras g12c, composição farmacêutica compreendendo ditos compostos, métodos para regular a atividade e para preparar uma proteína mutante kras, hras ou nras g12c, método para inibir a proliferação de uma população de células e usos terapêuticos dos ditos compostos
|
|
TWI659021B
(zh)
|
2013-10-10 |
2019-05-11 |
亞瑞克西斯製藥公司 |
Ｋｒａｓ ｇ１２ｃ之抑制劑
|
|
US9376559B2
(en)
|
2013-11-22 |
2016-06-28 |
Exxonmobil Chemical Patents Inc. |
Reverse staged impact copolymers
|
|
WO2015108992A1
(en)
|
2014-01-15 |
2015-07-23 |
Blueprint Medicines Corporation |
Heterobicyclic compounds and their use as fgfr4 receptor inhibitors
|
|
AP2016009297A0
(en)
|
2014-02-03 |
2016-06-30 |
Cadila Healthcare Ltd |
Novel heterocyclic compounds
|
|
RU2741914C2
(ru)
|
2014-03-20 |
2021-01-29 |
Капелла Терапьютикс, Инк. |
Производные бензимидазола как ингибиторы тирозинкиназ erbb для лечения рака
|
|
CN106458974B
(zh)
|
2014-03-24 |
2019-07-16 |
广东众生药业股份有限公司 |
作为smo抑制剂的喹啉衍生物
|
|
EP3148981A4
(en)
|
2014-05-30 |
2017-11-08 |
The Trustees of Columbia University in the City of New York |
Multivalent ras binding compounds
|
|
ES2843973T3
(es)
|
2014-06-27 |
2021-07-21 |
Celgene Corp |
Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3
|
|
WO2016044604A1
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
JO3556B1
(ar)
|
2014-09-18 |
2020-07-05 |
Araxes Pharma Llc |
علاجات مدمجة لمعالجة السرطان
|
|
WO2016049565A1
(en)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Compositions and methods for inhibition of ras
|
|
US9862701B2
(en)
|
2014-09-25 |
2018-01-09 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
US10011600B2
(en)
|
2014-09-25 |
2018-07-03 |
Araxes Pharma Llc |
Methods and compositions for inhibition of Ras
|
|
NZ729966A
(en)
|
2014-10-08 |
2024-02-23 |
Hoffmann La Roche |
Spirodiamine derivatives as aldosterone synthase inhibitors
|
|
CN105837576B
(zh)
|
2015-01-14 |
2019-03-26 |
湖北生物医药产业技术研究院有限公司 |
Btk抑制剂
|
|
AU2016209046A1
(en)
|
2015-01-23 |
2017-07-20 |
Aclaris Therapeutics, Inc. |
Heterocyclic ITK inhibitors for treating inflammation and cancer
|
|
AU2016220219B2
(en)
|
2015-02-17 |
2020-05-14 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
EP3280708B1
(en)
|
2015-04-10 |
2021-09-01 |
Araxes Pharma LLC |
Substituted quinazoline compounds and methods of use thereof
|
|
MX2017013275A
(es)
|
2015-04-15 |
2018-01-26 |
Araxes Pharma Llc |
Inhibidores triciclicos fusionados de kras y metodos de uso de los mismos.
|
|
CA2984183C
(en)
|
2015-05-01 |
2021-11-09 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
EP3356359B1
(en)
|
2015-09-28 |
2021-10-20 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058768A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10858343B2
(en)
|
2015-09-28 |
2020-12-08 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
US10875842B2
(en)
|
2015-09-28 |
2020-12-29 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
WO2017058902A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058915A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058805A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017070256A2
(en)
|
2015-10-19 |
2017-04-27 |
Araxes Pharma Llc |
Method for screening inhibitors of ras
|
|
MX2018004643A
(es)
|
2015-10-21 |
2018-08-01 |
Otsuka Pharma Co Ltd |
Compuestos de benzolactama como inhibidores de la proteina cinasa.
|
|
CA3005089A1
(en)
|
2015-11-16 |
2017-05-26 |
Araxes Pharma Llc |
2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
|
|
WO2017100546A1
(en)
|
2015-12-09 |
2017-06-15 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
|
WO2017172979A1
(en)
|
2016-03-30 |
2017-10-05 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use
|
|
CN105924840A
(zh)
|
2016-06-01 |
2016-09-07 |
扬州兰都塑料科技有限公司 |
一种阻燃电力电缆
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
WO2018064510A1
(en)
|
2016-09-29 |
2018-04-05 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10377743B2
(en)
|
2016-10-07 |
2019-08-13 |
Araxes Pharma Llc |
Inhibitors of RAS and methods of use thereof
|
|
ES2926153T3
(es)
|
2016-11-03 |
2022-10-24 |
Corvus Pharmaceuticals Inc |
Compuestos y métodos para modular la quinasa de células T inducible por interleucina-2
|
|
CN110382483A
(zh)
|
2017-01-26 |
2019-10-25 |
亚瑞克西斯制药公司 |
稠合的n-杂环化合物及其使用方法
|
|
EP3573970A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
|
US11358959B2
(en)
|
2017-01-26 |
2022-06-14 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
US11279689B2
(en)
|
2017-01-26 |
2022-03-22 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
|
|
US11274093B2
(en)
|
2017-01-26 |
2022-03-15 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
JOP20190186A1
(ar)
|
2017-02-02 |
2019-08-01 |
Astellas Pharma Inc |
مركب كينازولين
|
|
JP2020521741A
(ja)
|
2017-05-25 |
2020-07-27 |
アラクセス ファーマ エルエルシー |
がんの処置のための化合物およびその使用の方法
|
|
US11639346B2
(en)
|
2017-05-25 |
2023-05-02 |
Araxes Pharma Llc |
Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
|
|
BR112019024674A2
(pt)
|
2017-05-25 |
2020-06-16 |
Araxes Pharma Llc |
Inibidores covalentes da kras
|
|
JP7266043B2
(ja)
|
2018-05-04 |
2023-04-27 |
アムジエン・インコーポレーテツド |
ＫＲａｓ Ｇ１２Ｃ阻害剤及びそれを使用する方法
|
|
US20210317127A1
(en)
|
2018-08-01 |
2021-10-14 |
Araxes Pharma Llc |
Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
|
|
US20210380595A1
(en)
|
2018-10-24 |
2021-12-09 |
Araxes Pharma Llc |
2-(2-acryloyl-2,6-diazaspiro[3.4]octan-6-yl)-6-(1h-indazol-4-yl)-benzonitrile derivatives and related compounds as inhibitors of g12c mutant kras protein for inhibiting tumor metastasis
|
|
CN113227092A
(zh)
|
2018-11-29 |
2021-08-06 |
亚瑞克西斯制药公司 |
化合物及其用于治疗癌症的使用方法
|
