JP2020505327A - Ｅｇｆｒタンパク質分解標的化キメラ分子およびその関連する使用方法 - Google Patents

Ｅｇｆｒタンパク質分解標的化キメラ分子およびその関連する使用方法 Download PDF

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JP2020505327A
JP2020505327A JP2019534368A JP2019534368A JP2020505327A JP 2020505327 A JP2020505327 A JP 2020505327A JP 2019534368 A JP2019534368 A JP 2019534368A JP 2019534368 A JP2019534368 A JP 2019534368A JP 2020505327 A JP2020505327 A JP 2020505327A
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alkyl
optionally substituted
substituted
aryl
group
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JP2020505327A5 (https=
Inventor
クルー，アンドリュー・ピィ
ジマーマン，カート
ワン，ジン
バーリン，マイケル
ドン，ハンチン
イーシェンコ，アレクセイ
チエン，イミン
クルーズ，クレイグ・エム
ジェイミー−フィゲロア，サウル
バーズレム，ジョージ
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Yale University
Arvinas Operations Inc
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Yale University
Arvinas Operations Inc
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2019534368A 2016-12-23 2017-12-22 Ｅｇｆｒタンパク質分解標的化キメラ分子およびその関連する使用方法 Pending JP2020505327A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662438901P 2016-12-23 2016-12-23
US62/438,901 2016-12-23
US201762563494P 2017-09-26 2017-09-26
US62/563,494 2017-09-26
PCT/US2017/068308 WO2018119441A1 (en) 2016-12-23 2017-12-22 Egfr proteolysis targeting chimeric molecules and associated methods of use

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JP2020505327A true JP2020505327A (ja) 2020-02-20
JP2020505327A5 JP2020505327A5 (https=) 2021-02-04

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US (3) US10994015B2 (https=)
EP (1) EP3559002A4 (https=)
JP (1) JP2020505327A (https=)
KR (1) KR20190101406A (https=)
CN (1) CN110753693A (https=)
AU (1) AU2017382406A1 (https=)
BR (1) BR112019012682A2 (https=)
CA (1) CA3047586A1 (https=)
CO (1) CO2019007892A2 (https=)
IL (1) IL267398A (https=)
MX (1) MX2019007646A (https=)
RU (1) RU2019121527A (https=)
WO (1) WO2018119441A1 (https=)

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JP2021521163A (ja) * 2018-04-09 2021-08-26 上海科技大学Ｓｈａｎｇｈａｉ Ｔｅｃｈ Ｕｎｉｖｅｒｓｉｔｙ 標的タンパク質分解化合物、その抗腫瘍応用、その中間体および中間体の応用
JP2023520940A (ja) * 2020-04-09 2023-05-22 ユーブラス バイオセラピューティクス インコーポレーテッド 標的プロテアーゼ分解（ｔｅｄ）プラットフォーム
JP2023527396A (ja) * 2020-05-28 2023-06-28 ブリストル－マイヤーズ スクイブ カンパニー ガレクチン－３阻害剤
JP2023541612A (ja) * 2020-09-11 2023-10-03 ジェイツーエイチ バイオテック インコーポレイテッド Ｅｇｆｒ突然変異癌の抑制用化合物及びその医薬用途
JP2024516518A (ja) * 2021-04-23 2024-04-16 シャンハイ リーディングタック ファーマシューティカル カンパニー，リミテッド Ｓｏｓ１分解剤及びその製造方法並びに応用
JP2024526096A (ja) * 2021-06-22 2024-07-17 エルジー・ケム・リミテッド タンパク質キナーゼ阻害剤としての新規な化合物
JP2024540511A (ja) * 2021-11-17 2024-10-31 ティーワイケー メディシンズ インコーポレーテッド Ｅｇｆｒタンパク質分解用化合物及びその使用

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US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
WO2016197114A1 (en) 2015-06-05 2016-12-08 Arvinas, Inc. Tank-binding kinase-1 protacs and associated methods of use
EP3319944A4 (en) 2015-07-10 2019-04-24 Arvinas, Inc. MDM2-BASED MODULATORS OF PROTEOLYSIS AND RELATED USE METHODS
US10772962B2 (en) 2015-08-19 2020-09-15 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
US20170281784A1 (en) 2016-04-05 2017-10-05 Arvinas, Inc. Protein-protein interaction inducing technology
AU2017254713C1 (en) * 2016-04-22 2021-04-29 Dana-Farber Cancer Institute, Inc. Bifunctional molecules for degradation of EGFR and methods of use
ES2990061T3 (es) 2016-05-10 2024-11-28 C4 Therapeutics Inc Degronímeros espirocíclicos para la degradación de proteínas diana
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
EP3454856B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
US20180072711A1 (en) 2016-09-15 2018-03-15 Arvinas, Inc. Indole derivatives as estrogen receptor degraders
KR20190084063A (ko) 2016-10-28 2019-07-15 이칸 스쿨 오브 메디슨 엣 마운트 시나이 Ｅｚｈ２-매개성 암 치료용 조성물 및 방법
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