JP2020079275A - 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法 - Google Patents
受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法 Download PDFInfo
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Abstract
Description
本願は2014年8月8日出願のU.S.仮特許出願No.62/035274の優先権を主張し、その開示はその全体が参照によって組み込まれる。
本開示の製剤は、水に可溶でないかまたは不十分に水に可溶であることを特徴とする治療薬剤の高濃度(約1mg/mL〜約300mg/mL)を達成するように製剤される。
本開示は、パゾパニブの医薬的に許容される塩の安定な溶液医薬製剤を調製および/または製造する方法を提供する。
本開示はパゾパニブの二価塩の製剤を調製するための方法を提供する。方法は、(a)パゾパニブの二価塩を1つ以上の製剤薬剤の溶液中に溶解するステップを包含する。方法に用いられる製剤薬剤は複合体化薬剤、可溶化薬剤、および緩衝薬剤を包含するが、これに限定されることはない。二価塩を製剤薬剤の溶液中に溶解した後の溶液のpHは、放出の前および/もしくは後の製剤中の二価塩の安定性、放出の前および/もしくは後の製剤中の二価塩の可溶性、送達デバイスからの製剤中の二価塩の放出速度、ならびに/または後眼部内への放出時のパゾパニブの治療有効性を維持するために、最適pHに調整される。医薬的に許容される塩は、パゾパニブの二価ハロゲン化物塩、例えばパゾパニブの二価塩化物塩、パゾパニブの二価臭化物塩、パゾパニブの二価ヨウ化物塩、またはパゾパニブの二価フッ化物塩である。本開示はパゾパニブの二価塩化物塩を調製する方法を提供する。
本開示は、治療薬剤の一価塩の安定なおよび/または可溶な製剤を調製するための方法を提供する。一価塩は水溶液に高度に不溶であり、保存の間ならびに/または標的部位への製剤の送達前および/もしくは後に沈澱しやすい。本開示は、一価塩を可溶化する容易さを増大させるおよび/または溶液中の一価の安定性を増大させる方法を提供する。方法は製剤中の一価塩の増大した可溶性および/または安定性を提供し、その結果、塩は、保存の間にならびに/または標的部位への送達の前および/もしくは後に、長期間溶解したままである。
本開示は、37℃においてPDSによってレシーバ液(PBS緩衝液)中に放出される治療薬剤の量によって測定される治療薬剤放出速度を提供する。治療薬剤放出試験は、インキュベータ内で37℃に維持された硝子体に相当する液中にPDSによって放出される治療薬剤の量を測定することによって行われる。PDSはリン酸緩衝生理食塩水を含有する容器内に浮かべられる。定期的に、PDSは新しい容器に移され、治療薬剤の濃度が前の容器の液中で測定される。速度は、サンプル収集の時間によって除算した放出された治療薬剤の量から計算される。累積的な放出のパーセントは、治療デバイス(PDS)内に当初充填された治療薬剤の量によって除算した治療薬剤の累積的な量から計算される。半減期は4週間の累積的な放出のパーセントから計算される。本開示は大量の緩衝溶液中への小量の製剤の放出時の条件を提供する。薬物が希釈(放出)によって沈澱する場合には、これは送達デバイスの目詰まりおよび/または薬物の損失を引き起こし得る。なぜなら、固体薬物がレシーバ液中で測定可能でなくなるからである。その上、薬物がインビボでアクセス不可能であるので、沈澱は活性成分による有効な処置を妨げる。
本開示は、本開示の安定な製剤のいずれか1つが、治療デバイスのリザーバチャンバー内に含有されるキットであって、リザーバチャンバーが眼の硝子体内における治療薬剤の制御放出のための多孔質構造に連結されている、前記キットを提供する。
治療デバイスは多くの構成および物理的属性を包含し、例えば治療デバイスの物理的特徴は、視力が損なわれないような縫合、位置、および大きさの治療薬剤送達デバイス(ポート送達システム(PDS))ならびに生体適合性材料の少なくとも1つを含む。例えば、デバイスは、約0.005ccから約0.2cc、例えば約0.01ccから約0.1ccのリザーバ容量と約2cc以下のデバイス容積とを含む。0.1ccよりも大きいデバイス容積では硝子体手術が行われる。治療デバイスの長さは患者の視力に干渉せず、眼に関してインプラントされるデバイスの場所だけでなくデバイスの形状にも依存する。デバイスの長さはデバイスが挿入される角度にもまた依存する。例えば、デバイスの長さは約4から6mmを含む。眼の直径は約24mmなので、強膜から硝子体内に約6mm以下延びるデバイスは患者の視力に最小限の影響を及ぼす。
本開示の薬物送達製剤は、眼の硝子体における治療薬剤の制御放出のための治療薬剤送達システム中の多孔質構造に連結されたリザーバチャンバー内に含有され、多孔質構造からの製剤の制御放出は、リザーバチャンバー内の治療薬剤の濃度よりも少なくとも2桁低い硝子体内の治療薬剤の濃度を生ずる。リザーバチャンバーは再充填可能であり、デバイスが眼に挿入された後に製剤を再充填される。
本明細書および付随する請求項においてはいくつもの用語に言及がなされ、それらは次の意味を有すると定義される。本明細書の全てのパーセンテージ、比、および割合は、別様に指定されない限り重量による。全ての温度は別様に指定されない限りセルシウス度(℃)である。
1.低い水可溶性を有する治療薬剤の医薬的に許容される塩と1つ以上の製剤薬剤との安定な医薬製剤であって、医薬的に許容される塩が一価または二価塩であり、1つ以上の製剤薬剤が、複合体化薬剤、可溶化薬剤、および任意に緩衝薬剤を含み、治療薬剤の塩が製剤中において溶存している、前記医薬製剤。
ここで、塩は一価塩であり、方法は、(a)塩基によって塩を処理すること、(b)塩基処理した塩を1つ以上の製剤薬剤の溶液中に溶解すること、ここで製剤薬剤は複合体化薬剤、可溶化薬剤、および任意に緩衝薬剤を含む、ならびに(c)酸によってpHを約2以下のpHに調整すること、ここで、塩基処理は製剤中の総塩含量を増大させ、酸によってpHを調整することは製剤中の塩の可溶性を増大させる、
を含む前記方法。
ここで、製剤のpHが任意に調整される、
請求項24の方法。
ならびに、前記複合体化薬剤の量の約2倍を超える量を低粘度の溶液に添加および溶解することをさらに含む、
請求項24の方法。
方法が、多孔質構造に連結したリザーバチャンバーを含む硝子体内送達デバイスから、低い水可溶性を有する治療薬剤の医薬的に許容される塩と1つ以上の製剤薬剤との安定な医薬製剤を送達することを含み、
製剤がデバイスのリザーバ内に含有され、
多孔質構造によるリザーバからの製剤の制御放出が、硝子体内の治療薬剤の半減期を増大させ;
前記方法。
製剤中のパゾパニブ1HClの安定性が、ジメチルスルホキシド(DMSO)からの凍結乾燥によりパゾパニブ1HClの少なくとも約70%の結晶質相A形を結晶質相G形に変換することによって増大し;
製剤が、希釈されたときおよび/または硝子体内への送達時もしくはその間に少なくとも50日間沈澱しない、
前記製剤。
製剤中のパゾパニブ1HClの安定性が、トリフルオロエタノール(TFE)からの凍結乾燥によりパゾパニブ1HClの結晶質相A形を部分的にまたは完全に非晶質および/または微結晶質の相に変換することによって増大し、
製剤が、希釈されたときおよび/または硝子体内への送達時もしくはその間に少なくとも50日間沈澱しない、
前記製剤。
次の例は、本開示の製剤を調製し、硝子体内送達時の硝子体におけるそれらの特徴を評価する方法を提供する。
調製の方法 パゾパニブ2HCl製剤
調製の方法 パゾパニブ1HCl製剤−凍結乾燥なし
治療薬剤、例えばパゾパニブ1HClの高濃度製剤を、医薬活性成分を分散液中において塩基、例えばNaOHと室温で約30分撹拌および/または振とうすることによって調製した。分散液の組成は例えば1N NaOH中に約275mg/mLであった。
より容易な製剤プロセスのためだけでなく、安定性改善のために、1つ以上の製剤薬剤中への可溶化前にパゾパニブ1HClの凍結乾燥を行った。凍結乾燥はトリフルオロエタノール(TFE)、トリフルオロエタノール−水(90−10)混合物、またはジメチルスルホキシド(DMSO)から行った。凍結乾燥は高度に結晶質の薬物をほぼ非晶質の固体(これはより好ましい可溶性特性を有する)に移行させると考えられる。XRPD分析を行って、2HCl、1HCl、および1HClの凍結乾燥した薬物生成物の結晶質構造を比較した。結果を表3に示す。凍結乾燥方法は表4にまとめられている。
約60mg/mLのパゾパニブ1HClの結晶質形態をトリフルオロエタノール中で調製した。約1%から約30%の水(例えば約20%)の水をもまたトリフルオロエタノール中の治療薬剤溶液の溶液に追加した。それから、溶液を(追加される水ありまたはなしで)当分野における標準的な条件下で凍結乾燥した。溶液を35℃〜50℃(例えば約40℃)で約12時間から約24時間または約50℃〜65℃で(例えば約60℃で)約4時間から約8時間乾燥した。
インキュベータ内で37℃に維持された硝子体に相当する液中にPDSによって放出される治療薬剤の量を測定することによって、治療薬剤放出試験を行った。PDSを、リン酸緩衝生理食塩水を含有する容器内に浮かべた。定期的に、PDSを新しい容器に移し、治療薬剤の濃度を前の容器の液中で測定した。速度は、サンプル収集の時間によって除算した放出された治療薬剤の量から計算した。累積的な放出のパーセントは、治療デバイス(PDS)内に当初充填された治療薬剤の量によって除算した治療薬剤の累積的な量から計算した。半減期は4週間の累積的な放出のパーセントから計算した。
1. CAPTISOL(登録商標)中のパゾパニブ2HCl(サンプル1)(PA−96):
・ 製剤は60.0mg/mLパゾパニブ、2.2:1のCAPTISOL(登録商標)、1%PVP、6mg/mlヒスチジンHCl、pH6.5であった
・ 半減期=53日;
2. CAPTISOL(登録商標)中のパゾパニブ1HCl(サンプル2)(PA−110):
・ 製剤は60.0mg/mLパゾパニブ、2.2:1のCAPTISOL(登録商標)、1%PVP、6mg/mlヒスチジンHCl、pH6.5であった
・ 半減期=99日;放出の間に可視的な薬物沈澱
3. パゾパニブ1HCl−TFEから凍結乾燥(PAL−18)
・ 製剤は36mg/mLパゾパニブ、4:1のCAPTISOL(登録商標)、1%PVP、25mg/mlヒスチジンHCl、pH6.5であった
・ 半減期=45日
4. パゾパニブ1HCl−DMSOから凍結乾燥(PAD−5)
・ 製剤は50mg/mLパゾパニブ、3:1のCAPTISOL(登録商標)、1%PVP、6mg/mlヒスチジンHCl、pH3.4であった
・ 半減期=45日
沈澱試験−比較結果:この試験は、薬物放出時の、すなわち小量の製剤が大量の緩衝溶液中に放出されるときの条件をモデル化する目的で行った。モデルにおいて、薬物が希釈(放出)によって沈澱する場合には、これがデバイスの目詰まりおよび/または薬物の損失を引き起こし得る。なぜなら、レシーバ液中の固体薬物は測定可能ではないであろうからである(また、これはインビボ条件下で放出されるときに恐らくアクセス可能でもないであろう)。試験を行うために、製剤を(約0.1%アジ化ナトリウムを含む)リン酸緩衝生理食塩水溶液によって330倍希釈した。例えば3μLの製剤を1mLのPBS緩衝液に加える。溶液は37℃サーモスタット内に保ち、結晶成長/沈澱の出現を定期的にチェックした。表5にまとめられているように、異なる薬物ソースから調製された製剤は、希釈時の沈澱に対して異なる安定性を示した。
本明細書において参照される特許文献および科学論文のそれぞれの開示全体は、全ての目的について参照によって組み込まれる。本開示において、ホスト文献は十分な正確さで同定されており、本開示に関わる情報は参照の文脈に基づいて解釈される。公報および特許文献の引用は、いずれもしかるべき先行技術であるという承認として意図されておらず、その内容または日付についてもいかなる承認にもならない。本発明はここで書面による明細書として記載されたが、当業者は、本発明が種々の態様で実施され得、先述の記載および例が、付随する請求項の限定のためでなく例示の目的であるということを認めるであろう。
本発明はその発明の詳細な説明と関連して記載されたが、先述の記載により、添付の請求項の範囲によって定義される本発明の範囲を限定せず、例示することが意図されている。他の側面、利点、および改変は次の請求項の範囲内である。
Claims (38)
- 低い水可溶性を有する治療薬剤の医薬的に許容される塩と1つ以上の製剤薬剤とを含む、安定な医薬製剤であって、
医薬的に許容される塩が一価または二価塩であり、ならびに
1つ以上の製剤薬剤が、複合体化薬剤、可溶化薬剤、および/または緩衝薬剤を含み;
治療薬剤の塩が製剤中において溶存している、
前記医薬製剤。 - 治療薬剤の医薬的に許容される塩がパゾパニブの塩である、請求項1に記載の製剤。
- 医薬的に許容される塩がパゾパニブの一価または二価ハロゲン化物塩である、請求項2に記載の製剤。
- 一価または二価塩が塩化物塩である、請求項3に記載の製剤。
- 一価塩が製剤中において約60mg/mLの濃度まで安定である、請求項4に記載の製剤。
- 二価塩が製剤中において約70mg/mlの濃度まで安定である、請求項4に記載の製剤。
- 一価塩が治療薬剤の凍結乾燥した一価塩である、請求項4に記載の製剤。
- 一価塩がジメチルスルホキシド(DMSO)、トリフルオロエタノール(TFE)、またはトリフルオロエタノール−水混合物と凍結乾燥される、請求項7に記載の製剤。
- 複合体化薬剤が、2−ヒドロキシプロピル−β−シクロデキストリン、メチル−β−シクロデキストリン、ランダムメチル化β−シクロデキストリン、エチル化β−シクロデキストリン、トリアセチル−β−シクロデキストリン、ペルアセチル化β−シクロデキストリン、カルボキシメチル−β−シクロデキストリン、ヒドロキシエチル−β−シクロデキストリン、2−ヒドロキシ−3−(トリメチルアンモニオ)プロピル−β−シクロデキストリン、グルコシル−β−シクロデキストリン、マルトシル−β−シクロデキストリン、スルホブチルエーテル−β−シクロデキストリン、分岐β−シクロデキストリン、ヒドロキシプロピル−γ−シクロデキストリン、ランダムメチル化γ−シクロデキストリン、トリメチル−γ−シクロデキストリン、およびそのいずれかの組み合わせ(単数または複数)からなる群から選択されるシクロデキストリンである、請求項1に記載の製剤。
- 可溶化薬剤がポリ(ビニルピロリドン)(PVP)である、請求項1に記載の製剤。
- 緩衝薬剤がヒスチジンHClである、請求項1に記載の製剤。
- 低い水可溶性を有する治療薬剤の医薬的に許容される塩の安定な溶液医薬製剤を調製する方法であって、
塩が一価塩であり、
方法が、(a)有機溶媒中の塩の有機溶液を調製すること;(b)有機溶液を凍結乾燥し、それによって治療薬剤の凍結乾燥した塩を調製すること;(c)可溶化薬剤および緩衝薬剤を水に溶解し、それによって溶液を調製すること、(d)複合体化薬剤を溶液中に溶解し、それによって低粘度の溶液を調製すること、ならびに(e)凍結乾燥した塩を溶液に添加および混合して、約常温以上で一価塩を溶液中に溶解し、それによって安定な溶液医薬製剤を調製することを含む、
前記方法。 - 方法が、ステップ(e)後に、複合体化薬剤の量の約2倍を超える量を添加および溶解することをさらに含む、請求項12に記載の方法。
- 有機溶媒がジメチルスルホキシド(DMSO)、トリフルオロエタノール(TFE)、またはトリフルオロエタノール−水混合物である、請求項12に記載の方法。
- DMSO中での凍結乾燥が、治療薬剤の塩の1つの結晶質形態を別の結晶質形態に変換する、請求項14に記載の方法。
- DMSO中での凍結乾燥が、治療薬剤の塩の結晶質相A形を少なくとも70%の結晶質相G形を含有する材料に変換し、これはXRPDによって決定される、請求項14に記載の方法。
- TEE中での凍結乾燥が、治療薬剤の塩の結晶質相A形を部分的なまたは完全な非晶質相に変換する、請求項14に記載の方法。
- 安定な溶液医薬製剤を調製する間にpHが調整される、請求項12に記載の方法。
- 安定な溶液医薬製剤を調製する間にpHが調整されない、請求項12に記載の方法。
- 可溶化薬剤がポリ(ビニルピロリドン)(PVP)である、請求項12に記載の方法。
- 緩衝薬剤がヒスチジンHClである、請求項12に記載の方法。
- 複合体化薬剤が、2−ヒドロキシプロピル−β−シクロデキストリン、メチル−β−シクロデキストリン、ランダムメチル化β−シクロデキストリン、エチル化β−シクロデキストリン、トリアセチル−β−シクロデキストリン、ペルアセチル化β−シクロデキストリン、カルボキシメチル−β−シクロデキストリン、ヒドロキシエチル−β−シクロデキストリン、2−ヒドロキシ−3−(トリメチルアンモニオ)プロピル−β−シクロデキストリン、グルコシル−β−シクロデキストリン、マルトシル−β−シクロデキストリン、スルホブチルエーテル−β−シクロデキストリン、分岐β−シクロデキストリン、ヒドロキシプロピル−γ−シクロデキストリン、ランダムメチル化γ−シクロデキストリン、トリメチル−γ−シクロデキストリン、およびそのいずれかの組み合わせ(単数または複数)からなる群から選択されるシクロデキストリンである、請求項12に記載の方法。
- 治療薬剤の医薬的に許容される塩がパゾパニブの塩である、請求項12に記載の方法。
- 一価塩がハロゲン化物である、請求項12に記載の方法。
- ハロゲン化物が塩化物である、請求項12に記載の方法。
- 凍結乾燥した塩が、ステップ(e)において約37℃から約50℃の間の温度で溶液中に溶解される、請求項12に記載の方法。
- 方法が、約常温以上で、水を加えながら、少なくとも可溶化薬剤、緩衝薬剤、複合体化薬剤、および凍結乾燥した塩を連続的に混合することをさらに含む、請求項13に記載の方法。
- 製剤のpHが塩基によって約6〜7に調整される、請求項27に記載の方法。
- 後眼部の眼科疾患または障害を処置および/または改善する方法であって、
方法が、低い水可溶性を有する治療薬剤の医薬的に許容される塩と1つ以上の製剤薬剤との安定な医薬製剤を、多孔質構造に連結したリザーバチャンバーを含む硝子体内送達デバイスから送達することを含み、
製剤がデバイスのリザーバ内に含有され、および
多孔質構造によるリザーバからの製剤の制御放出が硝子体内の治療薬剤の半減期を増大させ;
医薬的に許容される塩が一価または二価塩であり、ならびに
1つ以上の製剤薬剤が複合体化薬剤、可溶化薬剤、および緩衝薬剤を含み;
治療薬剤の塩が製剤中において溶存している、
前記方法。 - 疾患または障害が、糖尿病網膜症、加齢黄斑変性(AMD)、異常な脈絡膜血管新生(CNV)、異常な網膜血管新生、ぶどう膜炎、網膜静脈閉塞症、眼外傷、手術誘発性浮腫、手術誘発性血管新生、類嚢胞黄斑浮腫、眼虚血、未熟児網膜症、コーツ病、鎌状赤血球網膜症、および血管新生緑内障から選択される、請求項29に記載の方法。
- リザーバチャンバーが再充填可能であり、デバイスが眼に挿入された後にリザーバチャンバーに製剤が再充填される、請求項29に記載の方法。
- デバイスが眼内に30〜90日の間、または6ヶ月間まで存在した後に、リザーバチャンバーに製剤が再充填される、請求項31に記載の方法。
- 可溶化薬剤がポリ(ビニルピロリドン)(PVP)である、請求項29に記載の方法。
- 緩衝薬剤がヒスチジンHClである、請求項29に記載の方法。
- 複合体化薬剤が、2−ヒドロキシプロピル−β−シクロデキストリン、メチル−β−シクロデキストリン、ランダムメチル化β−シクロデキストリン、エチル化β−シクロデキストリン、トリアセチル−β−シクロデキストリン、ペルアセチル化β−シクロデキストリン、カルボキシメチル−β−シクロデキストリン、ヒドロキシエチル−β−シクロデキストリン、2−ヒドロキシ−3−(トリメチルアンモニオ)プロピル−β−シクロデキストリン、グルコシル−β−シクロデキストリン、マルトシル−β−シクロデキストリン、スルホブチルエーテル−β−シクロデキストリン、分岐β−シクロデキストリン、ヒドロキシプロピル−γ−シクロデキストリン、ランダムメチル化γ−シクロデキストリン、トリメチル−γ−シクロデキストリン、およびそのいずれかの組み合わせ(単数または複数)からなる群から選択されるシクロデキストリンである、請求項29に記載の方法。
- 治療薬剤の医薬的に許容される塩がパゾパニブの塩である、請求項29に記載の方法。
- 一価塩がハロゲン化物である、請求項29に記載の方法。
- ハロゲン化物が塩化物である、請求項37に記載の方法。
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WO2016022750A1 (en) | 2016-02-11 |
SG11201700943TA (en) | 2017-03-30 |
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MY182793A (en) | 2021-02-05 |
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JP2017524034A (ja) | 2017-08-24 |
AU2015301054B2 (en) | 2020-05-14 |
IL250447A0 (en) | 2017-03-30 |
US9474756B2 (en) | 2016-10-25 |
CN107106551A (zh) | 2017-08-29 |
US20170071938A1 (en) | 2017-03-16 |
US20190365757A1 (en) | 2019-12-05 |
BR112017002466A2 (pt) | 2017-12-05 |
RU2017105844A3 (ja) | 2019-03-13 |
CA2957548A1 (en) | 2016-02-11 |
RU2017105844A (ru) | 2018-09-11 |
US10363255B2 (en) | 2019-07-30 |
EP3177289A4 (en) | 2018-03-21 |
KR20170040798A (ko) | 2017-04-13 |
MX2017001818A (es) | 2017-05-30 |
US10765677B2 (en) | 2020-09-08 |
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