ATE246489T1 - Implantierbares diffusionabgabesystem - Google Patents

Implantierbares diffusionabgabesystem

Info

Publication number
ATE246489T1
ATE246489T1 AT98911690T AT98911690T ATE246489T1 AT E246489 T1 ATE246489 T1 AT E246489T1 AT 98911690 T AT98911690 T AT 98911690T AT 98911690 T AT98911690 T AT 98911690T AT E246489 T1 ATE246489 T1 AT E246489T1
Authority
AT
Austria
Prior art keywords
beneficial agent
delivery system
delivering
reservoir
capillary channel
Prior art date
Application number
AT98911690T
Other languages
English (en)
Inventor
Wouter E Roorda
Keith E Dionne
James E Brown
Jeremy C Wright
Craig R Davis
Steven J Prestrelski
Stelios T Tzannis
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE246489T1 publication Critical patent/ATE246489T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
AT98911690T 1997-03-31 1998-03-17 Implantierbares diffusionabgabesystem ATE246489T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4219697P 1997-03-31 1997-03-31
PCT/US1998/005138 WO1998043611A1 (en) 1997-03-31 1998-03-17 Diffusional implantable delivery system

Publications (1)

Publication Number Publication Date
ATE246489T1 true ATE246489T1 (de) 2003-08-15

Family

ID=21920574

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03075231T ATE333266T1 (de) 1997-03-31 1998-03-17 Diffusionsgesteuertes implantierbares verabreichungssystem
AT98911690T ATE246489T1 (de) 1997-03-31 1998-03-17 Implantierbares diffusionabgabesystem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03075231T ATE333266T1 (de) 1997-03-31 1998-03-17 Diffusionsgesteuertes implantierbares verabreichungssystem

Country Status (16)

Country Link
US (1) US5972369A (de)
EP (1) EP0973499B1 (de)
JP (1) JP2001518880A (de)
KR (1) KR100523199B1 (de)
CN (2) CN1138579C (de)
AT (2) ATE333266T1 (de)
AU (1) AU729870B2 (de)
CA (1) CA2284058C (de)
DE (2) DE69835305T2 (de)
DK (1) DK0973499T3 (de)
ES (1) ES2205462T3 (de)
HK (1) HK1027756A1 (de)
IL (2) IL159636A0 (de)
NZ (1) NZ500018A (de)
PT (1) PT973499E (de)
WO (1) WO1998043611A1 (de)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US20060280774A1 (en) * 1995-06-02 2006-12-14 Allergan, Inc. Compositions and methods for treating glaucoma
US6994851B1 (en) 1997-07-10 2006-02-07 Mannkind Corporation Method of inducing a CTL response
US6977074B2 (en) 1997-07-10 2005-12-20 Mannkind Corporation Method of inducing a CTL response
US6187330B1 (en) 1998-01-30 2001-02-13 Scios Inc. Controlled release delivery of peptide or protein
UA81216C2 (en) * 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
CN1292721C (zh) 1999-10-21 2007-01-03 爱尔康公司 药物释放装置
US7943162B2 (en) 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
WO2001032199A1 (en) * 1999-11-05 2001-05-10 Rogoff Joseph A Secretin and secretin pharmaceuticals for treating lactose intolerance
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US7179483B2 (en) 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
EP1280486B1 (de) 2000-04-26 2010-11-17 Watson Pharmaceuticals, Inc. Verminderung der nebenwirkungen bei der oxybutynin-therapie
US20030124177A1 (en) * 2000-04-26 2003-07-03 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
US7029694B2 (en) 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
WO2001088231A2 (en) * 2000-05-14 2001-11-22 The Uab Research Foundation Method and device for controlling crystal growth
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
ATE435237T1 (de) * 2000-08-09 2009-07-15 Maruho Kk Durch homogene bluttransfusion induziertes protein und für dieses kodierende dna
CA2420038C (en) * 2000-08-30 2010-11-09 John Hopkins University Devices for intraocular drug delivery
DE60114229T2 (de) 2000-11-29 2006-07-06 Allergan, Inc., Irvine Verhinderung von transplantatabstossung im auge
ATE506929T1 (de) 2001-06-12 2011-05-15 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
CN100349562C (zh) 2001-07-23 2007-11-21 爱尔康公司 眼部药物输送装置
EP1409065B1 (de) 2001-07-23 2007-01-17 Alcon, Inc. Vorrichtung zur freisetzung eines ophthalmischen arzneimittels
KR101127502B1 (ko) * 2002-03-11 2012-03-23 알콘, 인코퍼레이티드 이식 가능한 약물 전달 시스템
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20060172972A1 (en) * 2002-12-20 2006-08-03 Chakshu Research Inc Formulation and method for administration of ophthalmologically active agents
US20060166879A1 (en) * 2002-12-20 2006-07-27 Chakshu Research Inc Treatment of conditions associated with the presence of macromolecular aggregates, particularly ophthalmic disorders
CN1753683B (zh) * 2002-12-20 2010-05-26 视可舒研究公司 预防和治疗不良眼部病症的眼用制剂
US20060177430A1 (en) * 2002-12-20 2006-08-10 Chakshu Research Inc Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer
US20050048099A1 (en) * 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
WO2004098565A2 (en) 2003-05-02 2004-11-18 Surmodics, Inc. Implantable controlled release bioactive agent delivery device
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US7651596B2 (en) 2005-04-08 2010-01-26 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
WO2005011520A2 (en) 2003-07-25 2005-02-10 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
WO2005079257A2 (en) * 2004-02-12 2005-09-01 Dexcom, Inc. Biointerface with macro- and micro- architecture
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
WO2006023130A2 (en) * 2004-08-12 2006-03-02 Surmodics, Inc. Biodegradable controlled release bioactive agent delivery device
WO2006039459A1 (en) * 2004-09-30 2006-04-13 Bausch & Lomb Incorporated Capsule for encasing tablets for surgical insertion into the human body
EP1827462A4 (de) * 2004-11-24 2012-01-04 Therakine Ltd Implantat für die intraokulare arzneimittelabgabe
US7514256B2 (en) * 2005-02-11 2009-04-07 Emilio Barbera-Guillem Bioreactor for selectively controlling the molecular diffusion between fluids
US7699863B2 (en) * 2005-03-01 2010-04-20 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
US7785291B2 (en) * 2005-03-01 2010-08-31 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
US20060233858A1 (en) * 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
WO2007011843A2 (en) * 2005-07-15 2007-01-25 Chakshu Research Inc. Prevention and treatment of ophthalmic complications of diabetes
GB0523638D0 (en) 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
US7887508B2 (en) * 2006-03-14 2011-02-15 The University Of Southern California MEMS device and method for delivery of therapeutic agents
WO2007120381A2 (en) 2006-04-14 2007-10-25 Dexcom, Inc. Analyte sensor
US8333997B2 (en) * 2006-06-21 2012-12-18 Albert Einstein College Of Medicine Of Yeshiva University Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof
US8802128B2 (en) * 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20070298073A1 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
EP1905466B1 (de) * 2006-09-28 2017-05-31 Brainlab AG Bestimmung eines injektionsbereichs in einer heterogenen körperstruktur
US8501029B2 (en) * 2006-10-30 2013-08-06 Agilent Technologies, Inc. Micromachined titanium for high pressure microfluidic applications
US8562558B2 (en) 2007-06-08 2013-10-22 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US9452258B2 (en) 2007-10-09 2016-09-27 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
CN102047101A (zh) 2008-03-28 2011-05-04 德克斯康公司 用于连续的分析物传感器的聚合物膜
US10780241B2 (en) * 2008-08-21 2020-09-22 Vero Biotech LLC Devices and methods for minimizing and treating high-altitude sickness
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8399006B2 (en) 2009-01-29 2013-03-19 Forsight Vision4, Inc. Posterior segment drug delivery
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
EP2369320A1 (de) * 2010-03-22 2011-09-28 Boehringer Ingelheim International GmbH Verfahren zur simulation von feinleckagen an flüssigkeitsbefüllten behältern
WO2011139594A2 (en) * 2010-04-27 2011-11-10 Medtronic, Inc. Artificial bursa for intra-articular drug delivery
CN103153316B (zh) 2010-08-05 2015-08-19 弗赛特影像4股份有限公司 组合药物递送方法和设备
PL2600930T3 (pl) 2010-08-05 2021-09-06 Forsight Vision4, Inc. Urządzenie wstrzykujące do dostarczania leku
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US20140033800A1 (en) 2010-11-11 2014-02-06 Forsight Vision4, Inc. Methods and apparatus to determine diffusion properties of porous structures for drug delivery
EP2640360A2 (de) 2010-11-19 2013-09-25 Forsight Vision4, Inc. Therapeutische wirkstoffformulierungen für implantierte vorrichtungen
WO2012088306A2 (en) * 2010-12-22 2012-06-28 Psivida Us, Inc. Two-piece injectable drug delivery device with heat-cured seal
US8992503B2 (en) 2011-03-27 2015-03-31 Microsert Ltd. Miniature implanted drug delivery devices and inserter systems for introducing such devices
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
US20130053666A1 (en) 2011-08-26 2013-02-28 Dexcom, Inc. Polymer membranes for continuous analyte sensors
ES2864203T3 (es) 2011-09-16 2021-10-13 Forsight Vision4 Inc Aparato de intercambio de fluido
US9814867B2 (en) 2011-12-05 2017-11-14 Nano Precision Medical, Inc. Device having titania nanotube membrane for drug delivery
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US9101707B2 (en) 2012-04-27 2015-08-11 Gregory Zeltser Implantable bioartificial perfusion system
CA2874824C (en) 2012-06-01 2021-10-26 Surmodics, Inc. Apparatus and methods for coating balloon catheters
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2013183058A2 (en) 2012-06-07 2013-12-12 Tulip Medical Ltd. Expanded device
US9788765B2 (en) 2012-09-28 2017-10-17 Dexcom, Inc. Zwitterion surface modifications for continuous sensors
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2014152959A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
EP2978393B1 (de) 2013-03-28 2023-12-27 ForSight Vision4, Inc. Augenimplantat zur abgabe von therapeutischen substanzen
ES2926480T3 (es) 2013-12-05 2022-10-26 Epitomee Medical Ltd Dispositivos y sistemas retentivos para la liberación in situ de principios activos farmacéuticos
US9770412B2 (en) 2014-01-23 2017-09-26 Nano Precision Medical, Inc. Implant device for drug delivery
WO2015196055A1 (en) * 2014-06-19 2015-12-23 California Institute Of Technology Small molecule transport device for drug delivery or waste removal
RU2695563C2 (ru) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Способ и устройство для доставки глазного имплантата
RU2017105844A (ru) 2014-08-08 2018-09-11 Форсайт Вижн4, Инк. Стабильные и растворимые составы ингибиторов рецепторных тирозинкиназ и способы их получения
JP7037360B2 (ja) 2014-11-10 2022-03-16 フォーサイト・ビジョン フォー・インコーポレーテッド 拡張可能な薬物送達デバイス
EP3377009B1 (de) 2015-11-20 2020-10-28 ForSight Vision4, Inc. Poröse strukturen für arzneimittelabgabevorrichtungen mit verlängerter freisetzung
EP4218566A1 (de) 2015-12-30 2023-08-02 Dexcom, Inc. Enzymimmobilisierte haftschicht für analytsensoren
EP3439591B1 (de) 2016-04-05 2020-09-23 ForSight Vision4, Inc. Implantierbare okulare arzneimittelabgabevorrichtungen
WO2017218354A1 (en) * 2016-06-13 2017-12-21 Nano Precision Medical, Inc. Drug delivery device
US20190117131A1 (en) 2017-10-24 2019-04-25 Dexcom, Inc. Pre-connected analyte sensors
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
KR20200093581A (ko) 2017-11-21 2020-08-05 포사이트 비젼4, 인크. 확장 가능한 포트 전달 시스템을 위한 유체 교환 기기 및 사용 방법
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
JP2024510494A (ja) 2021-03-19 2024-03-07 デックスコム・インコーポレーテッド 分析物センサ用薬物放出膜
CA3230350A1 (en) 2021-09-15 2023-03-23 Shanger Wang Bioactive releasing membrane for analyte sensor

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE267665C (de) *
US34365A (en) * 1862-02-11 Improvement in machines for cutting veneers
US3760806A (en) * 1971-01-13 1973-09-25 Alza Corp Helical osmotic dispenser with non-planar membrane
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3760984A (en) * 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4142526A (en) * 1974-12-23 1979-03-06 Alza Corporation Osmotic releasing system with means for changing release therefrom
US4160452A (en) * 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
DE2721752C2 (de) * 1977-05-13 1983-12-29 Siemens AG, 1000 Berlin und 8000 München In einen menschlichen oder tierischen Körper implantierbares Gerät zur Infusion einer medizinischen Flüssigkeit
US4468220A (en) * 1982-04-05 1984-08-28 Milliken Research Corporation Low flow constant rate pump
US4720384A (en) * 1985-05-03 1988-01-19 E. I. Du Pont De Nemours And Company Manufacture of hollow fine tubular drug delivery systems
US4802885A (en) * 1986-06-17 1989-02-07 Medical Engineering Corporation Self sealing subcutaneous infusion and withdrawal device
US4838862A (en) * 1986-08-04 1989-06-13 Pharmetrix Corp. Portable controlled release osmotic infusion device
US5322691A (en) * 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4994273A (en) * 1987-11-02 1991-02-19 Merck & Co., Inc. Solubility modulated drug delivery device
US4931050A (en) * 1988-04-13 1990-06-05 Shiley Infusaid Inc. Constant pressure variable flow pump
NZ228382A (en) * 1989-03-17 1992-08-26 Carter Holt Harvey Plastic Pro Drug administering coil-like device for insertion in body cavity of animal
FR2649617A1 (fr) * 1989-07-12 1991-01-18 Veprol Dispositif de delivrance d'un principe actif pharmacologique par pompage electrolytique
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5180591A (en) * 1990-07-11 1993-01-19 Alza Corporation Delivery device with a protective sleeve
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5516522A (en) * 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
EP1238656A1 (de) * 1996-02-02 2002-09-11 ALZA Corporation Implantierbares System mit verzögerter Wirkstofffreisetzung

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WO1998043611A1 (en) 1998-10-08
CA2284058A1 (en) 1998-10-08
JP2001518880A (ja) 2001-10-16
ATE333266T1 (de) 2006-08-15
IL159636A0 (en) 2004-06-01
HK1027756A1 (en) 2001-01-23
AU729870B2 (en) 2001-02-15
CA2284058C (en) 2007-02-20
CN1138579C (zh) 2004-02-18
DE69816980D1 (de) 2003-09-11
KR20010005834A (ko) 2001-01-15
ES2205462T3 (es) 2004-05-01
DE69835305T2 (de) 2007-07-19
EP0973499B1 (de) 2003-08-06
US5972369A (en) 1999-10-26
CN1500475A (zh) 2004-06-02
AU6558898A (en) 1998-10-22
EP0973499A1 (de) 2000-01-26
CN1305462C (zh) 2007-03-21
NZ500018A (en) 2001-07-27
DE69816980T2 (de) 2004-07-22
KR100523199B1 (ko) 2005-10-21
DE69835305D1 (de) 2006-08-31
PT973499E (pt) 2003-12-31
IL132040A0 (en) 2001-03-19
DK0973499T3 (da) 2003-11-17
IL132040A (en) 2004-07-25
CN1251986A (zh) 2000-05-03

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