|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US8663624B2
(en)
|
2010-10-06 |
2014-03-04 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
LT3254703T
(lt)
*
|
2011-04-22 |
2020-05-25 |
The Regents Of The University Of California |
Adenoasocijuoto viruso virionai su variantine kapside ir jų panaudojimo būdai
|
|
TWI775096B
(zh)
|
2012-05-15 |
2022-08-21 |
澳大利亞商艾佛蘭屈澳洲私營有限公司 |
使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
ES2701749T3
(es)
|
2012-12-12 |
2019-02-25 |
Broad Inst Inc |
Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
|
|
BR112015013784A2
(pt)
|
2012-12-12 |
2017-07-11 |
Massachusetts Inst Technology |
aplicação, manipulação e otimização de sistemas, métodos e composições para manipulação de sequência e aplicações terapêuticas
|
|
US10266845B2
(en)
*
|
2013-02-08 |
2019-04-23 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
DK2954051T3
(da)
|
2013-02-08 |
2019-07-08 |
Univ Pennsylvania |
Modificeret kapsid til genoverførsel til behandling af nethinden
|
|
JP6591956B2
(ja)
|
2013-03-15 |
2019-10-16 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
Mps1を治療するための組成物および方法
|
|
CA2912525A1
(en)
*
|
2013-05-16 |
2014-11-20 |
Applied Genetic Technologies Corporation |
Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases
|
|
WO2014194132A1
(en)
|
2013-05-31 |
2014-12-04 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
DK3011031T3
(da)
|
2013-06-17 |
2020-12-21 |
Broad Inst Inc |
Fremføring og anvendelse af crispr-cas-systemerne, vektorer og sammensætninger til levermålretning og -terapi
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
JP6625971B2
(ja)
|
2013-06-17 |
2019-12-25 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のためのタンデムガイド系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
KR20250012194A
(ko)
|
2013-06-17 |
2025-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
EP3011030B1
(en)
|
2013-06-17 |
2023-11-08 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
ES2716615T3
(es)
|
2013-06-28 |
2019-06-13 |
Inst Nat Sante Rech Med |
Métodos para expresar un polinucleótido de interés en la retina de un sujeto
|
|
JP6571075B2
(ja)
|
2013-07-08 |
2019-09-04 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
アンチセンスオリゴヌクレオチド介在性エクソンスキッピングを、それを必要とする対象の網膜において行うための方法
|
|
EP3564379A1
(en)
|
2013-09-13 |
2019-11-06 |
California Institute of Technology |
Selective recovery
|
|
IL289736B2
(en)
*
|
2013-12-12 |
2025-09-01 |
Massachusetts Inst Technology |
Administration, use and therapeutic applications of CRISPR–Cas gene editing systems and gene editing preparations
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
WO2015089351A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
KR20160089530A
(ko)
|
2013-12-12 |
2016-07-27 |
더 브로드 인스티튜트, 인코퍼레이티드 |
Hbv 및 바이러스 질병 및 질환을 위한 crisprcas 시스템 및 조성물의 전달,용도 및 치료적 적용
|
|
GB201403684D0
(en)
*
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
US20170007720A1
(en)
*
|
2014-02-21 |
2017-01-12 |
University Of Florida Research Foundation, Inc. |
Methods and compositions for gene delivery to on bipolar cells
|
|
EP3113787B1
(en)
*
|
2014-03-04 |
2019-12-04 |
University of Florida Research Foundation, Inc. |
Improved raav vectors and methods for transduction of photoreceptors and rpe cells
|
|
EP3114227B1
(en)
|
2014-03-05 |
2021-07-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
WO2015138510A1
(en)
|
2014-03-10 |
2015-09-17 |
Editas Medicine., Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
CA3234028A1
(en)
*
|
2014-03-11 |
2015-09-17 |
Wayne State University |
A modified mglur6 promoter and methods of use
|
|
CA2942776C
(en)
|
2014-03-17 |
2023-01-24 |
Adverum Biotechnologies, Inc. |
Polyneucleotide cassette and expression vector for expression of a gene in cone cells using truncated m-opsin promoter
|
|
WO2015148863A2
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3126495A1
(en)
|
2014-04-02 |
2017-02-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
LT3137497T
(lt)
|
2014-05-02 |
2021-07-26 |
Genzyme Corporation |
Aav vektoriai, skirti tinklainės ir cns genų terapijai
|
|
EP3151866B1
(en)
|
2014-06-09 |
2023-03-08 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
EP3188762A4
(en)
*
|
2014-07-31 |
2018-01-10 |
The Board of Regents of the University of Oklahoma |
High isomerohydrolase activity mutants of mammalian rpe65
|
|
EP3194601B1
(en)
*
|
2014-09-16 |
2021-10-27 |
Genzyme Corporation |
Adeno-associated viral vectors for treating myocilin (myoc) glaucoma
|
|
KR20170096998A
(ko)
|
2014-11-05 |
2017-08-25 |
보이저 테라퓨틱스, 인크. |
파킨슨병의 치료를 위한 aadc 폴리뉴클레오티드
|
|
WO2016077687A1
(en)
|
2014-11-14 |
2016-05-19 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
WO2016077689A1
(en)
|
2014-11-14 |
2016-05-19 |
Voyager Therapeutics, Inc. |
Modulatory polynucleotides
|
|
WO2016094783A1
(en)
|
2014-12-12 |
2016-06-16 |
Voyager Therapeutics, Inc. |
Compositions and methods for the production of scaav
|
|
EP3985115A1
(en)
|
2014-12-12 |
2022-04-20 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
EP3702456A1
(en)
|
2014-12-24 |
2020-09-02 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
|
WO2016131009A1
(en)
*
|
2015-02-13 |
2016-08-18 |
University Of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
US10648000B2
(en)
|
2015-02-16 |
2020-05-12 |
University Of Florida Research Foundation, Incorporated |
rAAV vector compositions, methods for targeting vascular endothelial cells and use in treatment of type I diabetes
|
|
ES2920850T3
(es)
*
|
2015-02-20 |
2022-08-10 |
Univ Iowa Res Found |
Procedimientos y composiciones para el tratamiento de enfermedades oculares genéticas
|
|
KR20170137730A
(ko)
*
|
2015-03-02 |
2017-12-13 |
애드베룸 바이오테크놀로지스, 인코포레이티드 |
망막 추상체에 폴리뉴클레오타이드의 유리체 내 전달을 위한 조성물 및 방법
|
|
WO2016154344A1
(en)
*
|
2015-03-24 |
2016-09-29 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
US10081659B2
(en)
|
2015-04-06 |
2018-09-25 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Adeno-associated vectors for enhanced transduction and reduced immunogenicity
|
|
US11180793B2
(en)
|
2015-04-24 |
2021-11-23 |
Editas Medicine, Inc. |
Evaluation of Cas9 molecule/guide RNA molecule complexes
|
|
WO2016183585A1
(en)
*
|
2015-05-14 |
2016-11-17 |
Joslin Diabetes Center, Inc. |
Retinol-binding protein 3 (rbp3) as a protective factor in non-diabetic retinal degeneration
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
TWI813532B
(zh)
|
2015-06-18 |
2023-09-01 |
美商博得學院股份有限公司 |
降低脱靶效應的crispr酶突變
|
|
KR102312253B1
(ko)
*
|
2015-12-04 |
2021-10-15 |
쏘흐본느 유니베흐시테 |
프로모터 및 이의 용도
|
|
WO2017099838A1
(en)
|
2015-12-11 |
2017-06-15 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Gene therapy for combined methylmalonic acidemia/aciduria and hyperhomocysteinemia/homocystinuria, cobalamin c type, and deficiency of mmachc
|
|
WO2017100671A1
(en)
*
|
2015-12-11 |
2017-06-15 |
California Institute Of Technology |
TARGETING PEPTIDES FOR DIRECTING ADENO-ASSOCIATED VIRUSES (AAVs)
|
|
GB2545763A
(en)
|
2015-12-23 |
2017-06-28 |
Adverum Biotechnologies Inc |
Mutant viral capsid libraries and related systems and methods
|
|
EP3411488A1
(en)
|
2016-02-03 |
2018-12-12 |
The Trustees Of The University Of Pennsylvania |
Gene therapy for treating mucopolysaccharidosis type i
|
|
US11512311B2
(en)
|
2016-03-25 |
2022-11-29 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency
|
|
WO2017180936A1
(en)
|
2016-04-15 |
2017-10-19 |
The Trustees Of The University Of Pennsylvania |
Compositions for treatment of wet age-related macular degeneration
|
|
AU2017257169B2
(en)
|
2016-04-29 |
2021-07-08 |
Adverum Biotechnologies, Inc. |
Evasion of neutralizing antibodies by a recombinant adeno-associated virus
|
|
EP3448987A4
(en)
|
2016-04-29 |
2020-05-27 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
WO2017187272A1
(en)
|
2016-04-29 |
2017-11-02 |
Gensight Biologics Sa |
Optogenetic visual restoration using chrimson
|
|
EP3448874A4
(en)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
WO2017192750A1
(en)
*
|
2016-05-04 |
2017-11-09 |
Oregon Health & Science University |
Recombinant adeno-associated viral vectors
|
|
MX2018013463A
(es)
|
2016-05-13 |
2019-07-04 |
4D Molecular Therapeutics Inc |
Capsides variantes de virus adenoasociados y metodos de uso de las mismas.
|
|
CA3024448C
(en)
|
2016-05-18 |
2025-09-09 |
Voyager Therapeutics, Inc. |
MODULATING POLYNUCLEOTIDES
|
|
BR112018073472A2
(pt)
|
2016-05-18 |
2019-08-27 |
Voyager Therapeutics Inc |
composições e métodos de tratamento da doença de huntington
|
|
MA44546B1
(fr)
*
|
2016-06-15 |
2021-03-31 |
Univ California |
Virus adéno-associés variants et procédés d'utilisation
|
|
DK3472317T3
(da)
*
|
2016-06-16 |
2022-05-23 |
Adverum Biotechnologies Inc |
Sammensætninger og fremgangsmåder til reduktion af okulær vaskularisation
|
|
PT3795181T
(pt)
|
2016-06-16 |
2025-11-05 |
Adverum Biotechnologies Inc |
Tratamento de dmi com utilização da variante aav2 com aflibercept
|
|
KR20230039779A
(ko)
*
|
2016-07-29 |
2023-03-21 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
변이체 캡시드를 갖는 아데노-관련된 바이러스 비리온 및 이의 사용 방법
|
|
WO2018026976A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
KR102877327B1
(ko)
|
2016-08-29 |
2025-10-27 |
웨인 스테이트 유니버시티 |
개선된 광 민감성을 갖는 채널옵신 변이체에서의 돌연변이의 확인 및 이의 용도
|
|
JP2019531787A
(ja)
|
2016-08-30 |
2019-11-07 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
生物医学的ターゲティング及びデリバリーの方法並びにそれを実行するための装置及びシステム
|
|
EP3528785A4
(en)
|
2016-10-19 |
2020-12-02 |
Adverum Biotechnologies, Inc. |
MODIFIED AAV CASPIDS AND USES THEREOF
|
|
US11180537B2
(en)
*
|
2016-11-06 |
2021-11-23 |
Nancoscope Technologies LLC |
Optogenetic modulation by Multi-Characteristic Opsins for vision restoration and other applications
|
|
US11236360B2
(en)
|
2016-12-09 |
2022-02-01 |
Regents Of The University Of Minnesota |
Adeno-associated viruses engineered for selectable tropism
|
|
AU2018227483A1
(en)
*
|
2017-02-28 |
2019-09-12 |
Adverum Biotechnologies, Inc. |
Modified AAV capsids and uses thereof
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
KR102616820B1
(ko)
|
2017-03-17 |
2023-12-21 |
애드베룸 바이오테크놀로지스, 인코포레이티드 |
향상된 유전자 발현을 위한 조성물 및 방법
|
|
WO2018189244A1
(en)
*
|
2017-04-11 |
2018-10-18 |
Ruprecht-Karls-Universität Heidelberg |
Adeno-associated virus library
|
|
US11613739B2
(en)
|
2017-04-14 |
2023-03-28 |
Regenxbio Inc. |
Treatment of mucopolysaccharidosis II with recombinant human iduronate-2-sulfatase (IDS) produced by human neural or glial cells
|
|
SG11201909868YA
(en)
|
2017-05-05 |
2019-11-28 |
Voyager Therapeutics Inc |
Compositions and methods of treating huntington's disease
|
|
WO2018204786A1
(en)
|
2017-05-05 |
2018-11-08 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
CN110461368A
(zh)
|
2017-06-30 |
2019-11-15 |
加利福尼亚大学董事会 |
具有变异衣壳的腺相关病毒病毒体及其使用方法
|
|
AU2018298133A1
(en)
|
2017-07-06 |
2020-01-23 |
The Trustees Of The University Of Pennsylvania |
AAV9-mediated gene therapy for treating mucopolysaccharidosis type I
|
|
CA3070087A1
(en)
|
2017-07-17 |
2019-01-24 |
Voyager Therapeutics, Inc. |
Trajectory array guide system
|
|
EP3676373A4
(en)
|
2017-08-28 |
2021-06-09 |
The Regents of The University of California |
Adeno-associated virus capsid variants and methods of use thereof
|
|
DK3684423T5
(da)
|
2017-09-20 |
2024-08-26 |
4D Molecular Therapeutics Inc |
Adeno-associerede virusvariantcapsider og fremgangsmåder til anvendelse deraf
|
|
CA3075656A1
(en)
|
2017-09-29 |
2019-04-04 |
Voyager Therapeutics, Inc. |
Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery
|
|
AU2018350700B2
(en)
*
|
2017-10-16 |
2025-04-24 |
Vigeneron Gmbh |
AAV vectors
|
|
WO2019079240A1
(en)
|
2017-10-16 |
2019-04-25 |
Voyager Therapeutics, Inc. |
TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
|
|
EP4454654A3
(en)
|
2017-10-16 |
2025-02-19 |
Voyager Therapeutics, Inc. |
Treatment of amyotrophic lateral sclerosis (als)
|
|
WO2019079496A2
(en)
|
2017-10-18 |
2019-04-25 |
Regenxbio, Inc. |
FULLY HUMAN ANTIBODY-BASED THERAPEUTIC AGENTS HAVING POST-TRANSLATION MODIFICATION
|
|
EP3697449A1
(en)
|
2017-10-18 |
2020-08-26 |
REGENXBIO Inc. |
Treatment of ocular diseases and metastatic colon cancer with human post-translationally modified vegf-trap
|
|
US11723988B2
(en)
|
2017-10-20 |
2023-08-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising the subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector
|
|
US11851671B2
(en)
|
2017-10-23 |
2023-12-26 |
Regents Of The University Of Minnesota |
Programmable assembly of virus composites for receptor-targeted gene delivery
|
|
JP7184894B2
(ja)
|
2017-11-27 |
2022-12-06 |
4ディー モレキュラー セラピューティクス インコーポレイテッド |
アデノ随伴ウイルス変異キャプシドおよび血管新生の阻害のための使用
|
|
WO2019152843A1
(en)
|
2018-02-01 |
2019-08-08 |
Homology Medicines, Inc. |
Adeno-associated virus compositions for restoring pah gene function and methods of use thereof
|
|
US10610606B2
(en)
|
2018-02-01 |
2020-04-07 |
Homology Medicines, Inc. |
Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
|
|
WO2019157395A1
(en)
*
|
2018-02-08 |
2019-08-15 |
Applied Stemcells, Inc |
Methods for screening variant of target gene
|
|
US11306329B2
(en)
|
2018-02-19 |
2022-04-19 |
City Of Hope |
Adeno-associated virus compositions for restoring F8 gene function and methods of use thereof
|
|
CA3093702A1
(en)
|
2018-03-14 |
2019-09-19 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
JP7425738B2
(ja)
|
2018-04-03 |
2024-01-31 |
ギンコ バイオワークス インコーポレイテッド |
眼組織を標的とするウイルスベクター
|
|
WO2019212922A1
(en)
|
2018-04-29 |
2019-11-07 |
Regenxbio Inc. |
Systems and methods of spectrophotometry for the determination of genome content, capsid content and full/empty ratios of adeno-associated virus particles
|
|
US12365865B2
(en)
|
2018-04-29 |
2025-07-22 |
Regenxbio Inc. |
Scalable clarification process for recombinant AAV production
|
|
BR112020022858A2
(pt)
*
|
2018-05-11 |
2021-02-23 |
Massachusetts Eye And Ear Infirmary |
tropismo específico hepático de vírus adeno-associado
|
|
JP2021523914A
(ja)
|
2018-05-15 |
2021-09-09 |
ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. |
パーキンソン病を治療するための組成物および方法
|
|
US11821009B2
(en)
|
2018-05-15 |
2023-11-21 |
Cornell University |
Genetic modification of the AAV capsid resulting in altered tropism and enhanced vector delivery
|
|
US12070702B2
(en)
|
2018-06-14 |
2024-08-27 |
Regenxbio Inc. |
Anion exchange chromatography for recombinant AAV production
|
|
WO2019240431A1
(ko)
*
|
2018-06-14 |
2019-12-19 |
(주) 에빅스젠 |
세포 투과 펩티드 및 rpe65의 융합 단백질을 포함하는 레버 선천성 흑암시 치료용 약학적 조성물
|
|
CN112703198B
(zh)
|
2018-07-11 |
2025-05-30 |
布里格姆妇女医院 |
用于跨血脑屏障递送试剂的方法和组合物
|
|
AU2019319976B2
(en)
|
2018-08-10 |
2025-08-14 |
Regenxbio Inc. |
Scalable method for recombinant AAV production
|
|
EP3856913A4
(en)
|
2018-09-26 |
2022-10-26 |
California Institute Of Technology |
Adeno-associated virus compositions for targeted gene therapy
|
|
JP7528066B2
(ja)
|
2018-09-28 |
2024-08-05 |
ボイジャー セラピューティクス インコーポレイテッド |
操作されたプロモータを有するフラタキシン発現コンストラクトおよびその使用方法
|
|
AR116569A1
(es)
|
2018-10-01 |
2021-05-19 |
Ultragenyx Pharmaceutical Inc |
Terapia génica para tratar la acidemia propiónica
|
|
EP3861010A1
(en)
|
2018-10-02 |
2021-08-11 |
Voyager Therapeutics, Inc. |
Redirection of tropism of aav capsids
|
|
WO2020081415A1
(en)
|
2018-10-15 |
2020-04-23 |
Regenxbio Inc. |
Method for measuring the infectivity of replication defective viral vectors and viruses
|
|
CA3121177A1
(en)
*
|
2018-12-05 |
2020-06-11 |
Abeona Therapeutics Inc. |
Recombinant adeno-associated viral vector for gene delivery
|
|
EP3893718A4
(en)
|
2018-12-12 |
2022-11-09 |
Tesseract Health, Inc. |
BIOMETRIC IDENTIFICATION SYSTEMS AND RELATED DEVICES
|
|
CN113825521A
(zh)
|
2018-12-21 |
2021-12-21 |
美利坚合众国由健康及人类服务部部长代表 |
腺相关病毒及其用于内耳疗法的用途
|
|
CN110437317B
(zh)
*
|
2019-01-30 |
2023-05-02 |
上海科技大学 |
具有变异衣壳蛋白的腺相关病毒及其用途
|
|
CN113728108A
(zh)
|
2019-02-15 |
2021-11-30 |
桑格摩生物治疗股份有限公司 |
用于生产重组aav的组合物和方法
|
|
JP2022520875A
(ja)
|
2019-02-25 |
2022-04-01 |
ノバルティス アーゲー |
Biettiクリスタリン網膜症を治療するための組成物及び方法
|
|
EP3931334A1
(en)
|
2019-02-25 |
2022-01-05 |
Novartis AG |
Compositions and methods to treat bietti crystalline dystrophy
|
|
US20220047618A1
(en)
|
2019-02-28 |
2022-02-17 |
Regeneron Pharmaceuticals, Inc. |
Adeno-associated virus vectors for the delivery of therapeutics
|
|
CN111621502B
(zh)
*
|
2019-02-28 |
2023-05-02 |
武汉纽福斯生物科技有限公司 |
视网膜劈裂蛋白的编码序列、其表达载体构建及其应用
|
|
JP7597380B2
(ja)
|
2019-03-04 |
2024-12-10 |
アドヴェラム バイオテクノロジーズ, インコーポレイテッド |
対側眼へのaav遺伝子治療の逐次的硝子体内投与
|
|
EP3715358A1
(en)
*
|
2019-03-28 |
2020-09-30 |
Universität zu Köln |
Mutated adeno-associated virus capsid proteins, aav particle comprising the same and liver directed aav vector gene therapy
|
|
CA3135609A1
(en)
|
2019-04-01 |
2020-10-08 |
Tenaya Therapeutics, Inc. |
Adeno-associated virus with engineered capsid
|
|
EP4667578A2
(en)
|
2019-04-03 |
2025-12-24 |
REGENXBIO Inc. |
Gene therapy for eye pathologies
|
|
TW202102526A
(zh)
*
|
2019-04-04 |
2021-01-16 |
美商銳進科斯生物股份有限公司 |
重組腺相關病毒及其用途
|
|
HUE064411T2
(hu)
|
2019-04-11 |
2024-03-28 |
Regenxbio Inc |
Méretkizárásos kromatográfiás módszerek rekombináns adeno-asszociált víruskészítmények jellemzésére
|
|
CN113993552A
(zh)
|
2019-04-19 |
2022-01-28 |
再生生物股份有限公司 |
腺相关病毒载体制剂和方法
|
|
CA3132447A1
(en)
|
2019-04-24 |
2020-10-29 |
Takara Bio Inc. |
Aav mutant having brain-targeting property
|
|
SG11202111414RA
(en)
|
2019-04-24 |
2021-11-29 |
Regenxbio Inc |
Fully-human post-translationally modified antibody therapeutics
|
|
TW202532428A
(zh)
*
|
2019-04-26 |
2025-08-16 |
美商愛德維仁生物科技公司 |
用於玻璃體內遞送之變異體aav蛋白殼
|
|
WO2020222858A1
(en)
*
|
2019-04-27 |
2020-11-05 |
Ocugen, Inc. |
Adeno-associated virus vector mediated gene therapy for ophthalmic diseases
|
|
US11737665B2
(en)
|
2019-06-21 |
2023-08-29 |
Tesseract Health, Inc. |
Multi-modal eye imaging with shared optical path
|
|
AU2020308909A1
(en)
*
|
2019-06-27 |
2022-01-27 |
University Of Florida Research Foundation, Incorporated |
Enhancing AAV-mediated transduction of ocular tissues with hyaluronic acid
|
|
US20220251567A1
(en)
|
2019-07-10 |
2022-08-11 |
Inserm (Institut National De La Santè Et De La Recherche Médicale) |
Methods for the treatment of epilepsy
|
|
AU2020311618B2
(en)
*
|
2019-07-11 |
2025-04-10 |
Centre Hospitalier Universitaire De Nantes |
Chemically-modified adeno-associated virus
|
|
US10653731B1
(en)
|
2019-07-15 |
2020-05-19 |
Vigene Biosciences Inc. |
Recombinantly-modified adeno-associated virus (rAAV) having improved packaging efficiency
|
|
US10801042B1
(en)
|
2019-07-15 |
2020-10-13 |
Vigene Biosciences, Inc. |
Use of ion concentrations to increase the packaging efficiency of recombinant adeno-associated virus
|
|
US10557149B1
(en)
|
2019-07-15 |
2020-02-11 |
Vigene Biosciences, Inc. |
Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus
|
|
WO2021021661A1
(en)
|
2019-07-26 |
2021-02-04 |
Regenxbio Inc. |
Engineered nucleic acid regulatory element and methods of uses thereof
|
|
RU2751592C2
(ru)
|
2019-08-22 |
2021-07-15 |
Общество С Ограниченной Ответственностью "Анабион" |
Выделенный модифицированный белок VP1 капсида аденоассоциированного вируса 5 серотипа (AAV5), капсид и вектор на его основе
|
|
MX2022002366A
(es)
|
2019-08-26 |
2022-07-19 |
Regenxbio Inc |
Tratamiento de la retinopatía diabética con fab anti-vegf completamente humano modificado postraduccionalmente.
|
|
CN114375195A
(zh)
|
2019-09-11 |
2022-04-19 |
阿德夫拉姆生物技术股份有限公司 |
使用编码阿柏西普的aav2变体治疗眼新血管疾病的方法
|
|
CN114729384A
(zh)
*
|
2019-09-12 |
2022-07-08 |
博德研究所 |
工程化腺相关病毒衣壳
|
|
GB201913974D0
(en)
|
2019-09-27 |
2019-11-13 |
King S College London |
Vector
|
|
WO2021067598A1
(en)
|
2019-10-04 |
2021-04-08 |
Ultragenyx Pharmaceutical Inc. |
Methods for improved therapeutic use of recombinant aav
|
|
KR20220081365A
(ko)
|
2019-10-07 |
2022-06-15 |
리젠엑스바이오 인크. |
아데노-연관 바이러스 벡터 약제학적 조성물 및 방법
|
|
WO2021073568A1
(en)
*
|
2019-10-16 |
2021-04-22 |
Wuxi Apptec (Shanghai) Co., Ltd. |
A novel aav variant
|
|
AU2020368539A1
(en)
|
2019-10-16 |
2022-04-28 |
Massachusetts Institute Of Technology |
Engineered muscle targeting compositions
|
|
WO2021084133A1
(en)
*
|
2019-10-31 |
2021-05-06 |
Universität Bern |
Aav vector variants for ocular gene delivery
|
|
IL292605B2
(en)
*
|
2019-11-08 |
2025-09-01 |
Regeneron Pharma |
CRISPR and AAV strategies for treating childhood X-linked retinoschisis
|
|
US20230016983A1
(en)
|
2019-11-19 |
2023-01-19 |
lNSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) |
Antisense oligonucleotides and thier use for the treatment of cancer
|
|
CN115335529A
(zh)
*
|
2019-11-26 |
2022-11-11 |
马萨诸塞大学 |
用于递送kh902(康柏西普)的重组腺相关病毒及其用途
|
|
JP2023503637A
(ja)
|
2019-11-28 |
2023-01-31 |
リジェネックスバイオ インコーポレイテッド |
マイクロジストロフィン遺伝子治療コンストラクト及びその使用
|
|
CN115279400A
(zh)
|
2020-01-10 |
2022-11-01 |
布里格姆妇女医院 |
用于跨血脑屏障递送免疫治疗剂以治疗脑癌的方法和组合物
|
|
TW202140791A
(zh)
|
2020-01-13 |
2021-11-01 |
美商霍蒙拉奇醫藥公司 |
治療苯酮尿症之方法
|
|
WO2021150570A1
(en)
|
2020-01-22 |
2021-07-29 |
Regenxbio Inc. |
Treatment of mucopolysaccharidosis i with fully-human glycosylated human alpha-l-iduronidase (idua)
|
|
AU2021214174A1
(en)
|
2020-01-29 |
2022-08-18 |
Regenxbio Inc. |
Treatment of mucopolysaccharidosis II with recombinant human iduronate-2-sulfatase (IDS) produced by human neural or glial cells
|
|
JP2023512043A
(ja)
|
2020-01-29 |
2023-03-23 |
レジェンクスバイオ インコーポレーテッド |
ムコ多糖症ivaの治療
|
|
BR112022015921A2
(pt)
|
2020-02-14 |
2022-10-04 |
Ultragenyx Pharmaceutical Inc |
Terapia gênica para tratar o transtorno de deficiência de cdkl5
|
|
WO2021188892A1
(en)
|
2020-03-19 |
2021-09-23 |
Ultragenyx Pharmaceutical Inc. |
Compositions and methods for reducing reverse packaging of cap and rep sequences in recombinant aav
|
|
WO2021202532A1
(en)
|
2020-03-31 |
2021-10-07 |
Ultragenyx Pharmaceutical Inc. |
Gene therapy for treating propionic acidemia
|
|
US20230159609A1
(en)
*
|
2020-04-10 |
2023-05-25 |
Sorbonne Université |
G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
|
|
JP2023523211A
(ja)
|
2020-04-24 |
2023-06-02 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
眼科遺伝子治療後の、導入遺伝子産物を発現する形質転換細胞に対する免疫応答の誘導を防止するための方法
|
|
CA3175905A1
(en)
|
2020-04-27 |
2021-11-04 |
David H. Kirn |
Codon optimized gla genes and uses thereof
|
|
PE20230767A1
(es)
|
2020-05-13 |
2023-05-09 |
Voyager Therapeutics Inc |
Redireccion del tropismo de las capsides de aav
|
|
TW202208632A
(zh)
|
2020-05-27 |
2022-03-01 |
美商同源醫藥公司 |
用於恢復pah基因功能的腺相關病毒組成物及其使用方法
|
|
JP2023528801A
(ja)
|
2020-05-29 |
2023-07-06 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
バリアントキャプシドを有するアデノ随伴ウイルスビリオン及びその使用方法
|
|
KR20230050336A
(ko)
|
2020-07-10 |
2023-04-14 |
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸) |
뇌전증을 치료하기 위한 방법과 조성물
|
|
CN117321213A
(zh)
*
|
2020-08-21 |
2023-12-29 |
卡西达公司 |
具有优选表达水平的腺相关病毒组合物
|
|
CN112226461B
(zh)
*
|
2020-08-21 |
2022-04-22 |
华侨大学 |
Cd4阳性细胞特异性基因传递载体及其应用
|
|
US12129287B2
(en)
|
2020-09-14 |
2024-10-29 |
President And Fellows Of Harvard College |
Recombinant adeno associated virus encoding clarin-1 and uses thereof
|
|
EP4214242A1
(en)
|
2020-09-15 |
2023-07-26 |
RegenxBio Inc. |
Vectorized antibodies for anti-viral therapy
|
|
EP4213890A1
(en)
|
2020-09-15 |
2023-07-26 |
RegenxBio Inc. |
Vectorized lanadelumab and administration thereof
|
|
CN113754728B
(zh)
*
|
2020-09-30 |
2022-07-12 |
广州派真生物技术有限公司 |
腺相关病毒突变体及其应用
|
|
JP2023545424A
(ja)
|
2020-10-07 |
2023-10-30 |
リジェネックスバイオ インコーポレイテッド |
ゲル製剤などの脈絡膜上投与用製剤
|
|
JP2023545722A
(ja)
|
2020-10-07 |
2023-10-31 |
リジェネックスバイオ インコーポレイテッド |
遺伝子治療剤の眼送達のためのアデノ随伴ウイルス
|
|
MX2023004035A
(es)
|
2020-10-07 |
2023-07-05 |
Regenxbio Inc |
Formulaciones para la administración supracoroidea tales como formulaciones de viscosidad alta.
|
|
CA3198368A1
(en)
|
2020-10-07 |
2022-04-14 |
Regenxbio Inc. |
Formulations for suprachoroidal administration such as formulations with aggregate formation
|
|
WO2022076750A2
(en)
|
2020-10-07 |
2022-04-14 |
Regenxbio Inc. |
Recombinant adeno-associated viruses for cns or muscle delivery
|
|
AU2021371307A1
(en)
|
2020-10-28 |
2023-06-01 |
Regenxbio, Inc. |
VECTORIZED ANTI-TNF-α ANTIBODIES FOR OCULAR INDICATIONS
|
|
WO2022094157A1
(en)
|
2020-10-28 |
2022-05-05 |
Regenxbio Inc. |
Vectorized anti-cgrp and anti-cgrpr antibodies and administration thereof
|
|
CN116457373A
(zh)
|
2020-10-29 |
2023-07-18 |
再生生物股份有限公司 |
用于眼部适应症的载体化TNF-α拮抗剂
|
|
US20230390418A1
(en)
|
2020-10-29 |
2023-12-07 |
Regenxbio Inc. |
Vectorized factor xii antibodies and administration thereof
|
|
CA3196439A1
(en)
*
|
2020-11-10 |
2022-05-19 |
Avirmax, Inc. |
Engineered viral capsids and methods of use
|
|
WO2022120022A1
(en)
|
2020-12-02 |
2022-06-09 |
Regeneron Pharmaceuticals, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
IL303614A
(en)
|
2020-12-16 |
2023-08-01 |
Regenxbio Inc |
Method of producing a recombinant adeno-associated virus particle
|
|
US20240067678A1
(en)
*
|
2020-12-16 |
2024-02-29 |
Children's Medical Research Institute |
Adeno-associated virus capsids and vectors
|
|
TW202241943A
(zh)
|
2020-12-29 |
2022-11-01 |
美商銳進科斯生物股份有限公司 |
Tau特異性抗體基因療法組合物、方法及其用途
|
|
EP4281568A1
(en)
|
2021-01-21 |
2023-11-29 |
RegenxBio Inc. |
Improved production of recombinant polypeptides and viruses
|
|
WO2022173605A2
(en)
|
2021-02-10 |
2022-08-18 |
Regenxbio Inc. |
Treatment of mucopolysaccharidosis ii with recombinant human iduronate-2-sulfatase (ids)
|
|
CN113121652B
(zh)
*
|
2021-04-19 |
2022-10-11 |
上海信致医药科技有限公司 |
视网膜和肌肉高亲和性腺相关病毒衣壳蛋白及相关应用
|
|
CN113121651B
(zh)
*
|
2021-04-19 |
2023-11-17 |
信念医药科技(上海)有限公司 |
低中和抗体腺相关病毒衣壳蛋白
|
|
WO2022223644A2
(en)
|
2021-04-20 |
2022-10-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Compositions and methods for treating retinal degenerative disorders
|
|
TW202309293A
(zh)
|
2021-04-26 |
2023-03-01 |
美商銳進科斯生物股份有限公司 |
用於治療肌縮蛋白症(dystrophinopathy)之微小肌縮蛋白基因療法給藥
|
|
US20240197915A1
(en)
|
2021-04-27 |
2024-06-20 |
Adverum Biotechnologies, Inc. |
Methods of treating ocular diseases using aav2 variants encoding aflibercept
|
|
US20240218397A1
(en)
|
2021-05-04 |
2024-07-04 |
Regenxbio Inc. |
Novel aav vectors and methods and uses thereof
|
|
EP4337267A1
(en)
|
2021-05-11 |
2024-03-20 |
RegenxBio Inc. |
Treatment of duchenne muscular dystrophy and combinations thereof
|
|
KR20240035759A
(ko)
|
2021-05-26 |
2024-03-18 |
스페어링비젼 |
막대세포-원추세포 이상증(rcd)에서 g-단백질-개폐-k+ 채널-매개 감광성 향상
|
|
AU2022281825A1
(en)
|
2021-05-28 |
2024-01-18 |
Shanghai Regenelead Therapies Co., Ltd. |
Recombinant adeno-associated virus having variant capsid, and application thereof
|
|
WO2022256561A1
(en)
*
|
2021-06-03 |
2022-12-08 |
Dyno Therapeutics, Inc. |
Capsid variants and methods of using the same
|
|
US20250276088A1
(en)
|
2021-07-07 |
2025-09-04 |
Institut National de la Santé et de la Recherche Médicale |
Synergistic combination of rdcfv2 and rdcvf2l for the treatment of tauopathies
|
|
WO2023283649A1
(en)
|
2021-07-08 |
2023-01-12 |
Tenaya Therapeutics, Inc. |
Optimized expression cassettes for gene therapy
|
|
EP4373947A1
(en)
|
2021-07-19 |
2024-05-29 |
New York University |
Auf1 combination therapies for treatment of muscle degenerative disease
|
|
WO2023019168A1
(en)
|
2021-08-11 |
2023-02-16 |
Ultragenyx Pharmaceutical Inc. |
Compositions and methods for treating a muscular dystrophy
|
|
CR20240137A
(es)
|
2021-08-20 |
2024-07-29 |
Biocad Joint Stock Co |
Método para obtener una cápside de virus adenoasociado modificada
|
|
AR126839A1
(es)
|
2021-08-20 |
2023-11-22 |
Llc «Anabion» |
Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 9 (aav9), cápside y vector basado en esta
|
|
AR126840A1
(es)
|
2021-08-20 |
2023-11-22 |
Llc «Anabion» |
Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 5 (aav5), cápside y vector basado en esta
|
|
CN118202060A
(zh)
|
2021-10-05 |
2024-06-14 |
再生生物股份有限公司 |
用于重组aav生产的组合物和方法
|
|
WO2023060113A1
(en)
|
2021-10-05 |
2023-04-13 |
Regenxbio Inc. |
Compositions and methods for recombinant aav production
|
|
EP4413019A2
(en)
|
2021-10-07 |
2024-08-14 |
RegenxBio Inc. |
Recombinant adeno-associated viruses for cns tropic delivery
|
|
US20250001006A1
(en)
|
2021-10-07 |
2025-01-02 |
Regenxbio Inc. |
Recombinant adeno-associated viruses for targeted delivery
|
|
WO2023060264A1
(en)
|
2021-10-08 |
2023-04-13 |
Dyno Therapeutics, Inc. |
Capsid variants and methods of using the same
|
|
US20230338581A1
(en)
|
2021-10-11 |
2023-10-26 |
Sparingvision |
G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
|
|
EP4423285A1
(en)
|
2021-10-28 |
2024-09-04 |
RegenxBio Inc. |
Engineered nucleic acid regulatory elements and methods and uses thereof
|
|
MX2024004936A
(es)
|
2021-11-02 |
2024-05-08 |
Voyager Therapeutics Inc |
Variantes de capsides de aav y sus usos.
|
|
WO2023108507A1
(en)
*
|
2021-12-15 |
2023-06-22 |
National Institute Of Biological Sciences, Beijing |
Recombinant aav vectors and use thereof
|
|
JP2025506383A
(ja)
|
2022-02-02 |
2025-03-11 |
アドヴェラム バイオテクノロジーズ, インコーポレイテッド |
アフリベルセプトをコードするaav2バリアントを使用して眼内血管新生疾患を処置する方法
|
|
JP2025506681A
(ja)
|
2022-02-16 |
2025-03-13 |
アドヴェラム バイオテクノロジーズ, インコーポレイテッド |
組み換えアデノ随伴ウイルスによる血管新生amdにおけるcst変動の低減方法
|
|
CN118715236A
(zh)
*
|
2022-02-17 |
2024-09-27 |
九天生物医药(上海)有限公司 |
具有经修饰的aav衣壳多肽的重组腺相关病毒
|
|
JP2025509328A
(ja)
|
2022-03-07 |
2025-04-11 |
ウルトラジェニックス ファーマシューティカル インコーポレイテッド |
改良されたバッチaav産生システムおよび方法
|
|
EP4493226A1
(en)
|
2022-03-13 |
2025-01-22 |
RegenxBio Inc. |
Modified muscle-specific promoters
|
|
US20250213727A1
(en)
|
2022-03-25 |
2025-07-03 |
Regenxbio Inc. |
Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy
|
|
WO2023196873A1
(en)
|
2022-04-06 |
2023-10-12 |
Regenxbio Inc. |
Pharmaceutical composition comprising a recombinant adeno-associated virus vector with an expression cassette encoding a transgene forsuprachoidal administration
|
|
TW202404651A
(zh)
|
2022-04-06 |
2024-02-01 |
美商銳進科斯生物股份有限公司 |
用於脈絡膜上投與之調配物諸如形成聚集體之調配物
|
|
TW202345913A
(zh)
|
2022-04-06 |
2023-12-01 |
美商銳進科斯生物股份有限公司 |
用於脈絡膜上投與之調配物諸如凝膠調配物
|
|
EP4508062A1
(en)
|
2022-04-11 |
2025-02-19 |
Tenaya Therapeutics, Inc. |
Adeno-associated virus with engineered capsid
|
|
CN116925192B
(zh)
*
|
2022-04-12 |
2025-04-29 |
合肥星眸生物科技有限公司 |
一种融合型腺相关病毒及其应用
|
|
WO2023201277A1
(en)
|
2022-04-14 |
2023-10-19 |
Regenxbio Inc. |
Recombinant adeno-associated viruses for cns tropic delivery
|
|
US20250249127A1
(en)
|
2022-04-14 |
2025-08-07 |
Regenxbio Inc. |
Gene therapy for treating an ocular disease
|
|
CN116970648A
(zh)
*
|
2022-04-24 |
2023-10-31 |
上海朗昇生物科技有限公司 |
新型aav衣壳改造株及其用途
|
|
WO2023215806A2
(en)
|
2022-05-03 |
2023-11-09 |
Regenxbio Inc. |
Vectorized anti-complement antibodies and complement agents and administration thereof
|
|
EP4518973A1
(en)
|
2022-05-03 |
2025-03-12 |
RegenxBio Inc. |
Vectorized anti-tnf-alpha inhibitors for ocular indications
|
|
EP4536694A1
(en)
|
2022-06-07 |
2025-04-16 |
Adverum Biotechnologies, Inc. |
Melanopsin variants for vision restoration
|
|
WO2023239627A2
(en)
|
2022-06-08 |
2023-12-14 |
Regenxbio Inc. |
Methods for recombinant aav production
|
|
EP4558149A1
(en)
|
2022-07-21 |
2025-05-28 |
Institut National de la Santé et de la Recherche Médicale |
Methods and compositions for treating chronic pain disorders
|
|
AU2023323390A1
(en)
|
2022-08-11 |
2025-02-13 |
Institute Of Molecular And Clinical Ophthalmology Basel (Iob) |
Human cone photoreceptor optogenetic constructs
|
|
JP2025527658A
(ja)
|
2022-08-24 |
2025-08-22 |
リジェネックスバイオ インコーポレイテッド |
組換えアデノ随伴ウイルス及びその使用
|
|
IL319873A
(en)
|
2022-09-30 |
2025-05-01 |
Regenxbio Inc |
Treatment of eye diseases with recombinant viral vectors containing anti-VEGF FAB
|
|
JP2025534666A
(ja)
|
2022-10-11 |
2025-10-17 |
リジェネックスバイオ インコーポレイテッド |
操作された核酸調節エレメントならびにその使用方法
|
|
WO2024084075A1
(en)
|
2022-10-20 |
2024-04-25 |
Sparingvision |
Compositions and methods for treating retinal degenerative disorders
|
|
EP4357359A1
(en)
|
2022-10-20 |
2024-04-24 |
Sparingvision |
G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
|
|
CN120112547A
(zh)
|
2022-11-16 |
2025-06-06 |
瑞泽恩制药公司 |
包含膜结合il-12和蛋白酶可裂解接头的嵌合蛋白
|
|
CN120752339A
(zh)
|
2023-01-06 |
2025-10-03 |
国家医疗保健研究所 |
静脉内施用用于治疗疼痛的反义寡核苷酸
|
|
CN118359687A
(zh)
*
|
2023-01-18 |
2024-07-19 |
上海朗昇生物科技有限公司 |
一种新衣壳蛋白变体以及其用途
|
|
IL321968A
(en)
|
2023-02-02 |
2025-09-01 |
Quethera Ltd |
Recombinant adeno-associated virus vector
|
|
KR20250169640A
(ko)
|
2023-03-10 |
2025-12-03 |
디노 테라퓨틱스, 인코포레이티드 |
캡시드 폴리펩타이드 및 이의 사용 방법
|
|
WO2024192281A2
(en)
|
2023-03-15 |
2024-09-19 |
Regenxbio Inc. |
Exon skipping gene therapy constructs, vectors and uses thereof
|
|
WO2024211831A1
(en)
|
2023-04-05 |
2024-10-10 |
Adverum Biotechnologies, Inc. |
Immune landscape signatures for ocular inflammation
|
|
WO2024211780A1
(en)
|
2023-04-07 |
2024-10-10 |
Regenxbio Inc. |
Compositions and methods for recombinant aav production
|
|
WO2024215655A1
(en)
|
2023-04-10 |
2024-10-17 |
Tenaya Therapeutics, Inc. |
Cardioprotective bag3 therapies
|
|
WO2024215653A1
(en)
|
2023-04-10 |
2024-10-17 |
Tenaya Therapeutics, Inc. |
Guide rnas, vectors, and virions for targeting mutations in the pln gene
|
|
WO2024216244A2
(en)
|
2023-04-13 |
2024-10-17 |
Regenxbio Inc. |
Targeting aav capsids, methods of manufacturing and using same
|
|
WO2024229389A1
(en)
*
|
2023-05-03 |
2024-11-07 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of tau-related disorders
|
|
WO2024229425A1
(en)
*
|
2023-05-04 |
2024-11-07 |
Voyager Therapeutics, Inc. |
Aav capsid variants and uses thereof
|
|
WO2024233529A2
(en)
|
2023-05-07 |
2024-11-14 |
Regenxbio Inc. |
Compositions and methods for recombinant aav production
|
|
WO2024238867A1
(en)
|
2023-05-16 |
2024-11-21 |
Regenxbio Inc. |
Vectorized anti-complement antibodies and administration thereof
|
|
WO2024238853A1
(en)
|
2023-05-16 |
2024-11-21 |
Regenxbio Inc. |
Adeno-associated viruses for ocular delivery of gene therapy
|
|
WO2024238859A1
(en)
|
2023-05-16 |
2024-11-21 |
Regenxbio Inc. |
Vectorized c5 inhibitor agents and administration thereof
|
|
WO2024240113A1
(zh)
*
|
2023-05-23 |
2024-11-28 |
北京因诺惟康医药科技有限公司 |
一种腺相关病毒衣壳蛋白、包含其的腺相关病毒、载体及应用
|
|
WO2025008406A1
(en)
|
2023-07-04 |
2025-01-09 |
Institut National de la Santé et de la Recherche Médicale |
Antisense oligonucleotides and their use for the treatment of cancer
|
|
WO2025015317A2
(en)
|
2023-07-13 |
2025-01-16 |
Kriya Therapeutics, Inc. |
Complement pathway inhibitor fusions and methods of using the same
|
|
CN117230117A
(zh)
*
|
2023-08-04 |
2023-12-15 |
中国科学院深圳先进技术研究院 |
重组腺相关病毒包装质粒、突变体及其制备方法和应用
|
|
WO2025049993A1
(en)
|
2023-08-31 |
2025-03-06 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|
|
WO2025075963A1
(en)
|
2023-10-02 |
2025-04-10 |
Regenxbio Inc. |
Methods and formulations for treating mucopolysaccharidosis ii-associated hearing loss with recombinant human iduronate-2-sulfatase
|
|
WO2025090962A1
(en)
|
2023-10-25 |
2025-05-01 |
Regenxbio Inc. |
Compositions and methods for recombinant aav production
|
|
CN117247434B
(zh)
*
|
2023-11-10 |
2024-02-02 |
上海朗昇生物科技有限公司 |
衣壳修饰型病毒载体及其制备和用途
|
|
WO2025106374A1
(en)
|
2023-11-13 |
2025-05-22 |
Juno Therapeutics, Inc. |
Aav production method
|
|
WO2025108407A2
(en)
|
2023-11-23 |
2025-05-30 |
Neuexcell Therapeutics (Suzhou) Co., Ltd. |
Gene therapy compositions and methods for treating glioma
|
|
WO2025113676A1
(en)
|
2023-11-29 |
2025-06-05 |
Neuexcell Therapeutics (Suzhou) Co., Ltd. |
Compositions and methods for treating stroke in primates
|
|
WO2025129085A1
(en)
|
2023-12-15 |
2025-06-19 |
Port Therapeutics, Inc. |
Use of thermal bioswitches in aav-based gene therapy
|
|
CN119080889B
(zh)
*
|
2024-09-18 |
2025-06-24 |
广州译码基因科技有限公司 |
提高aav对眼组织感染能力的衣壳蛋白突变体及应用
|
|
WO2025171227A1
(en)
|
2024-02-08 |
2025-08-14 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|
|
WO2025217214A2
(en)
|
2024-04-08 |
2025-10-16 |
Regenxbio Inc. |
Recombinant adeno-associated viruses and uses thereof
|
|
WO2025217230A1
(en)
|
2024-04-08 |
2025-10-16 |
Regenxbio Inc. |
Vectorized anti-complement antibodies and complement agents and administration thereof
|
|
WO2025214408A1
(en)
|
2024-04-10 |
2025-10-16 |
Skyline Therapeutics (Shanghai) Co., Ltd. |
Optogenetic modulation for vision restoration
|
|
WO2025214404A1
(en)
|
2024-04-10 |
2025-10-16 |
Skyline Therapeutics (Shanghai) Co., Ltd. |
Optogenetic modulation for vision restoration
|
|
WO2025237990A1
(en)
|
2024-05-14 |
2025-11-20 |
Institut National de la Santé et de la Recherche Médicale |
Antisense oligonucleotides and their use for the treatment of pulmonary fibrosis
|
|
CN118955654B
(zh)
*
|
2024-10-15 |
2025-05-16 |
朗信启昇(苏州)生物制药有限公司 |
具有变异衣壳的腺相关病毒病毒体及其用途
|