|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US8663624B2
(en)
|
2010-10-06 |
2014-03-04 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
RS66184B1
(sr)
*
|
2011-04-22 |
2024-12-31 |
Univ California |
Adeno-povezani virioni virusa sa varijantama kapsida i postupci za njihovu primenu
|
|
TWI775096B
(zh)
|
2012-05-15 |
2022-08-21 |
澳大利亞商艾佛蘭屈澳洲私營有限公司 |
使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
KR20150105956A
(ko)
|
2012-12-12 |
2015-09-18 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
US9567376B2
(en)
|
2013-02-08 |
2017-02-14 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
US10266845B2
(en)
|
2013-02-08 |
2019-04-23 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
EP3747998B1
(en)
|
2013-03-15 |
2024-07-24 |
The Trustees of the University of Pennsylvania |
Compositions for treating mpsi
|
|
EP3517135B1
(en)
|
2013-05-16 |
2025-11-19 |
Beacon Therapeutics (USA), Inc. |
Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases
|
|
ES2897508T3
(es)
|
2013-05-31 |
2022-03-01 |
Univ California |
Variantes de virus adenoasociados y métodos de uso de las mismas
|
|
CN107995927B
(zh)
|
2013-06-17 |
2021-07-30 |
布罗德研究所有限公司 |
用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途
|
|
EP3674411A1
(en)
|
2013-06-17 |
2020-07-01 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
CA2915795C
(en)
|
2013-06-17 |
2021-07-13 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
ES2716615T3
(es)
*
|
2013-06-28 |
2019-06-13 |
Inst Nat Sante Rech Med |
Métodos para expresar un polinucleótido de interés en la retina de un sujeto
|
|
JP6571075B2
(ja)
|
2013-07-08 |
2019-09-04 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
アンチセンスオリゴヌクレオチド介在性エクソンスキッピングを、それを必要とする対象の網膜において行うための方法
|
|
US9585971B2
(en)
|
2013-09-13 |
2017-03-07 |
California Institute Of Technology |
Recombinant AAV capsid protein
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
EP3540051B1
(en)
|
2013-12-12 |
2022-08-17 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hsv and viral diseases and disorders.
|
|
SG10201804973TA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Compositions and Methods of Use of Crispr-Cas Systems in Nucleotide Repeat Disorders
|
|
BR112016013201B1
(pt)
*
|
2013-12-12 |
2023-01-31 |
The Broad Institute, Inc. |
Uso de uma composição compreendendo um sistema crispr-cas no tratamento de uma doença genética ocular
|
|
GB201403684D0
(en)
*
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
WO2015126972A1
(en)
*
|
2014-02-21 |
2015-08-27 |
University Of Florida Research Foundation, Inc. |
Methods and compositions for gene delivery to on bipolar cells
|
|
CA2941640A1
(en)
*
|
2014-03-04 |
2015-09-11 |
University Of Florida Research Foundation, Inc. |
Improved raav vectors and methods for transduction of photoreceptors and rpe cells
|
|
WO2015134812A1
(en)
|
2014-03-05 |
2015-09-11 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
EP3553176A1
(en)
*
|
2014-03-10 |
2019-10-16 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
WO2015138616A1
(en)
*
|
2014-03-11 |
2015-09-17 |
Wayne State University |
A modified mglur6 promoter and methods of use
|
|
KR102288849B1
(ko)
|
2014-03-17 |
2021-08-12 |
애드베룸 바이오테크놀로지스, 인코포레이티드 |
원추세포에서 증강된 유전자 발현을 위한 조성물 및 방법
|
|
EP3122880B1
(en)
|
2014-03-26 |
2021-05-05 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
EP4600255A3
(en)
|
2014-05-02 |
2025-10-22 |
Genzyme Corporation |
Aav vectors for retinal and cns gene therapy
|
|
WO2015191508A1
(en)
|
2014-06-09 |
2015-12-17 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
EP3188762A4
(en)
*
|
2014-07-31 |
2018-01-10 |
The Board of Regents of the University of Oklahoma |
High isomerohydrolase activity mutants of mammalian rpe65
|
|
KR102612871B1
(ko)
|
2014-09-16 |
2023-12-13 |
젠자임 코포레이션 |
마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터
|
|
CN107106689A
(zh)
|
2014-11-05 |
2017-08-29 |
沃雅戈治疗公司 |
用于治疗帕金森病的aadc多核苷酸
|
|
KR102584655B1
(ko)
|
2014-11-14 |
2023-10-06 |
보이저 테라퓨틱스, 인크. |
조절성 폴리뉴클레오티드
|
|
MX2017006216A
(es)
|
2014-11-14 |
2018-08-29 |
Voyager Therapeutics Inc |
Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela).
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
US11697825B2
(en)
|
2014-12-12 |
2023-07-11 |
Voyager Therapeutics, Inc. |
Compositions and methods for the production of scAAV
|
|
EP3237615B2
(en)
|
2014-12-24 |
2023-07-26 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
|
EP3256170B1
(en)
*
|
2015-02-13 |
2020-09-23 |
University of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
WO2016133917A1
(en)
|
2015-02-16 |
2016-08-25 |
University Of Florida Research Foundation |
Raav vector compositions, methods for targeting vascular endothelial cells and use in treatment of type i diabetes
|
|
CA2977355A1
(en)
*
|
2015-02-20 |
2016-08-25 |
University Of Iowa Research Foundation |
Methods and compositions for treating genetic eye diseases
|
|
KR20170137730A
(ko)
*
|
2015-03-02 |
2017-12-13 |
애드베룸 바이오테크놀로지스, 인코포레이티드 |
망막 추상체에 폴리뉴클레오타이드의 유리체 내 전달을 위한 조성물 및 방법
|
|
EP3277819B1
(en)
*
|
2015-03-24 |
2021-03-03 |
The Regents of The University of California |
Adeno-associated virus variants and methods of use thereof
|
|
US10081659B2
(en)
|
2015-04-06 |
2018-09-25 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Adeno-associated vectors for enhanced transduction and reduced immunogenicity
|
|
JP2018522249A
(ja)
|
2015-04-24 |
2018-08-09 |
エディタス・メディシン、インコーポレイテッド |
Ｃａｓ９分子／ガイドｒｎａ分子複合体の評価
|
|
WO2016183585A1
(en)
*
|
2015-05-14 |
2016-11-17 |
Joslin Diabetes Center, Inc. |
Retinol-binding protein 3 (rbp3) as a protective factor in non-diabetic retinal degeneration
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
CN109536474A
(zh)
|
2015-06-18 |
2019-03-29 |
布罗德研究所有限公司 |
降低脱靶效应的crispr酶突变
|
|
US11390866B2
(en)
*
|
2015-12-04 |
2022-07-19 |
Sorbonne Université |
Promoters and uses thereof
|
|
US11510998B2
(en)
|
2015-12-11 |
2022-11-29 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Gene therapy for combined methylmalonic acidemia/aciduria and hyperhomocysteinemia/homocystinuria, cobalamin C type, and deficiency of MMACHC
|
|
AU2016366549B2
(en)
|
2015-12-11 |
2022-11-10 |
California Institute Of Technology |
Targeting peptides for directing adeno-associated viruses (AAVs)
|
|
GB2545763A
(en)
|
2015-12-23 |
2017-06-28 |
Adverum Biotechnologies Inc |
Mutant viral capsid libraries and related systems and methods
|
|
US10973929B2
(en)
|
2016-02-03 |
2021-04-13 |
The Trustees Of The University Of Pennsylvania |
Gene therapy for treating mucopolysaccharidosis type I
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
MA44873A
(fr)
|
2016-04-15 |
2019-03-13 |
Univ Pennsylvania |
Composition pour le traitement de la dégénérescence maculaire liée a l'âge exsudative
|
|
US11326182B2
(en)
|
2016-04-29 |
2022-05-10 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
|
EP3448411A1
(en)
|
2016-04-29 |
2019-03-06 |
Gensight Biologics SA |
Optogenetic visual restoration using chrimson
|
|
WO2017189964A2
(en)
|
2016-04-29 |
2017-11-02 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
|
WO2017190125A1
(en)
|
2016-04-29 |
2017-11-02 |
Adverum Biotechnologies, Inc. |
Evasion of neutralizing antibodies by a recombinant adeno-associated virus
|
|
WO2017192750A1
(en)
*
|
2016-05-04 |
2017-11-09 |
Oregon Health & Science University |
Recombinant adeno-associated viral vectors
|
|
CN109476707B
(zh)
|
2016-05-13 |
2022-12-02 |
4D分子治疗有限公司 |
腺相关病毒变体衣壳和其使用方法
|
|
RU2758488C2
(ru)
|
2016-05-18 |
2021-10-28 |
Вояджер Терапьютикс, Инк. |
Модулирующие полинуклеотиды
|
|
AU2017268382B2
(en)
|
2016-05-18 |
2023-09-28 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating Huntington's disease
|
|
MA44546B1
(fr)
*
|
2016-06-15 |
2021-03-31 |
Univ California |
Virus adéno-associés variants et procédés d'utilisation
|
|
AU2017286680B2
(en)
*
|
2016-06-16 |
2023-01-19 |
Adverum Biotechnologies, Inc. |
Compositions and methods for reducing ocular neovascularization
|
|
HUE051953T2
(hu)
|
2016-06-16 |
2021-04-28 |
Adverum Biotechnologies Inc |
Idõskori makula degeneráció kezelése AAV2 variáns és aflibercept alkalmazásával
|
|
JP7071332B2
(ja)
*
|
2016-07-29 |
2022-05-18 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
変異カプシドを有するアデノ随伴ウイルスビリオン及びその使用方法
|
|
WO2018026976A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
RU2019109021A
(ru)
|
2016-08-29 |
2020-09-29 |
Уэйн Стейт Юниверсити |
Идентификация мутаций в вариантах каналопсина, имеющих улучшенную чувствительность к свету, и способы их применения
|
|
JP2019531787A
(ja)
|
2016-08-30 |
2019-11-07 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
生物医学的ターゲティング及びデリバリーの方法並びにそれを実行するための装置及びシステム
|
|
US11192925B2
(en)
|
2016-10-19 |
2021-12-07 |
Adverum Biotechnologies, Inc. |
Modified AAV capsids and uses thereof
|
|
WO2018106369A2
(en)
*
|
2016-11-06 |
2018-06-14 |
Nanoscope Technologies Llc |
Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof
|
|
US11236360B2
(en)
|
2016-12-09 |
2022-02-01 |
Regents Of The University Of Minnesota |
Adeno-associated viruses engineered for selectable tropism
|
|
US20210130413A1
(en)
*
|
2017-02-28 |
2021-05-06 |
Adverum Biotechnologies, Inc. |
Modified aav capsids and uses thereof
|
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
EP4653536A2
(en)
|
2017-03-17 |
2025-11-26 |
Adverum Biotechnologies, Inc. |
Compositions and methods for enhanced gene expression
|
|
WO2018189244A1
(en)
*
|
2017-04-11 |
2018-10-18 |
Ruprecht-Karls-Universität Heidelberg |
Adeno-associated virus library
|
|
WO2018191666A1
(en)
|
2017-04-14 |
2018-10-18 |
Regenxbio Inc. |
Treatment of mucopolysaccharidosis ii with recombinant human iduronate-2 sulfatase (ids) produced by human neural or glial cells
|
|
AU2018261790B2
(en)
|
2017-05-05 |
2024-10-03 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
|
|
WO2018204803A1
(en)
|
2017-05-05 |
2018-11-08 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating huntington's disease
|
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
US20200121746A1
(en)
|
2017-06-30 |
2020-04-23 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsids and methods of use thereof
|
|
JP2020526514A
(ja)
|
2017-07-06 |
2020-08-31 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
ムコ多糖症ｉ型を治療するための遺伝子治療
|
|
CN111132626B
(zh)
|
2017-07-17 |
2024-01-30 |
沃雅戈治疗公司 |
轨迹阵列引导系统
|
|
US11680249B2
(en)
|
2017-08-28 |
2023-06-20 |
The Regents Of The University Of California |
Adeno-associated virus capsid variants and methods of use thereof
|
|
FI3684423T3
(fi)
|
2017-09-20 |
2023-06-15 |
4D Molecular Therapeutics Inc |
Adenoassesioidun viruksen kapsidivariantteja ja niiden käyttömenetelmiä
|
|
EP3687582A4
(en)
|
2017-09-29 |
2021-07-14 |
Voyager Therapeutics, Inc. |
RESCUE OF CENTRAL AND PERIPHERAL NEUROLOGICAL PHENOTYPE OF FRIEDREICH ATAXIA BY INTRAVENOUS ADMINISTRATION
|
|
EP4454654A3
(en)
|
2017-10-16 |
2025-02-19 |
Voyager Therapeutics, Inc. |
Treatment of amyotrophic lateral sclerosis (als)
|
|
US11434502B2
(en)
|
2017-10-16 |
2022-09-06 |
Voyager Therapeutics, Inc. |
Treatment of amyotrophic lateral sclerosis (ALS)
|
|
CN111601884A
(zh)
*
|
2017-10-16 |
2020-08-28 |
维格内罗有限责任公司 |
Aav载体
|
|
AU2018350990A1
(en)
|
2017-10-18 |
2020-05-21 |
Regenxbio Inc. |
Treatment of ocular diseases and metastatic colon cancer with human post-translationally modified VEGF-Trap
|
|
AU2018350992A1
(en)
|
2017-10-18 |
2020-05-21 |
Regenxbio Inc. |
Fully-human post-translationally modified antibody therapeutics
|
|
WO2019077159A1
(en)
*
|
2017-10-20 |
2019-04-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
METHODS OF EXPRESSING POLYNUCLEOTIDE OF INTEREST IN CONE PHOTORECCEPTORS OF A SUBJECT COMPRISING SUB-RETINAL ADMINISTRATION OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A RECOMBINANT AAV9 DERIVATIVE VECTOR
|
|
WO2019084015A1
(en)
*
|
2017-10-23 |
2019-05-02 |
Daniel Schmidt |
PROGRAMMABLE SET OF VIRUS COMPOSITES FOR ADMINISTRATION OF GENES TARGETING A RECEPTOR
|
|
AU2018372235B9
(en)
|
2017-11-27 |
2022-03-10 |
4D Molecular Therapeutics Inc. |
Adeno-associated virus variant capsids and use for inhibiting angiogenesis
|
|
BR112020015798A2
(pt)
|
2018-02-01 |
2021-03-09 |
Homology Medicines, Inc. |
Composições de vírus adeno-associado para restaurar função de gene da pah e métodos de uso das mesmas
|
|
US10610606B2
(en)
|
2018-02-01 |
2020-04-07 |
Homology Medicines, Inc. |
Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
|
|
US12291706B2
(en)
|
2018-02-08 |
2025-05-06 |
Applied Stemcell, Inc. |
Methods for screening variant of target gene
|
|
JP7244547B2
(ja)
|
2018-02-19 |
2023-03-22 |
ホモロジー・メディシンズ・インコーポレイテッド |
Ｆ８遺伝子機能を回復させるためのアデノ随伴ウイルス組成物及びその使用の方法
|
|
SG11202008956XA
(en)
|
2018-03-14 |
2020-10-29 |
Editas Medicine Inc |
Systems and methods for the treatment of hemoglobinopathies
|
|
EP3773743A1
(en)
|
2018-04-03 |
2021-02-17 |
Stridebio, Inc. |
Virus vectors for targeting ophthalmic tissues
|
|
CA3098566A1
(en)
|
2018-04-29 |
2019-11-07 |
Zhuchun WU |
Systems and methods of spectrophotometry for the determination of genome content, capsid content and full/empty ratios of adeno-associated virus particles
|
|
EP3787771A1
(en)
|
2018-04-29 |
2021-03-10 |
REGENXBIO Inc. |
Scalable clarification process for recombinant aav production
|
|
CN112368391A
(zh)
*
|
2018-05-11 |
2021-02-12 |
马萨诸塞眼科耳科诊所 |
腺相关病毒的肝脏特异性嗜性
|
|
US11821009B2
(en)
|
2018-05-15 |
2023-11-21 |
Cornell University |
Genetic modification of the AAV capsid resulting in altered tropism and enhanced vector delivery
|
|
MX2020012077A
(es)
|
2018-05-15 |
2021-03-09 |
Voyager Therapeutics Inc |
Composiciones y metodos para el tratamiento de la enfermedad de parkinson.
|
|
WO2019240431A1
(ko)
*
|
2018-06-14 |
2019-12-19 |
(주) 에빅스젠 |
세포 투과 펩티드 및 rpe65의 융합 단백질을 포함하는 레버 선천성 흑암시 치료용 약학적 조성물
|
|
WO2019241535A2
(en)
|
2018-06-14 |
2019-12-19 |
Regenxbio Inc. |
Anion exchange chromatography for recombinant aav production
|
|
EP3820885A4
(en)
|
2018-07-11 |
2022-04-20 |
The Brigham & Women's Hospital, Inc. |
METHODS AND COMPOSITIONS FOR ADMINISTRATION OF DRUGS ACROSS THE BLOOD-BRAIN BARRIER
|
|
KR20210043580A
(ko)
|
2018-08-10 |
2021-04-21 |
리젠엑스바이오 인크. |
재조합 aav 생산을 위한 규모 조정 가능한 방법
|
|
KR20210084459A
(ko)
|
2018-09-26 |
2021-07-07 |
캘리포니아 인스티튜트 오브 테크놀로지 |
표적화된 유전자 요법을 위한 아데노-연관 바이러스 조성물
|
|
SG11202103151RA
(en)
|
2018-09-28 |
2021-04-29 |
Voyager Therapeutics Inc |
Frataxin expression constructs having engineered promoters and methods of use thereof
|
|
CN112955557A
(zh)
|
2018-10-01 |
2021-06-11 |
奥特吉尼克斯制药公司 |
用于治疗丙酸血症的基因疗法
|
|
AU2019354995B2
(en)
|
2018-10-02 |
2024-12-12 |
Voyager Therapeutics, Inc. |
Redirection of tropism of AAV capsids
|
|
EP3867412A1
(en)
|
2018-10-15 |
2021-08-25 |
REGENXBIO Inc. |
Method for measuring the infectivity of replication defective viral vectors and viruses
|
|
JP7590968B2
(ja)
*
|
2018-12-05 |
2024-11-27 |
アビオナ・セラピュ―ティクス・インコーポレイテッド |
遺伝子送達のための組み換えアデノ随伴ウイルスベクター
|
|
WO2020123862A1
(en)
*
|
2018-12-12 |
2020-06-18 |
Tesseract Health, Inc, |
Optical apparatus and associated devices for biometric identification and health status determination
|
|
US20220096658A1
(en)
*
|
2018-12-21 |
2022-03-31 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Svcs. |
Adeno-associated viruses and their uses for inner ear therapy
|
|
CN110437317B
(zh)
*
|
2019-01-30 |
2023-05-02 |
上海科技大学 |
具有变异衣壳蛋白的腺相关病毒及其用途
|
|
SG11202108614QA
(en)
|
2019-02-15 |
2021-09-29 |
Sangamo Therapeutics Inc |
Compositions and methods for producing recombinant aav
|
|
WO2020174368A1
(en)
|
2019-02-25 |
2020-09-03 |
Novartis Ag |
Compositions and methods to treat bietti crystalline dystrophy
|
|
US20220154211A1
(en)
|
2019-02-25 |
2022-05-19 |
Novartis Ag |
Compositions and methods to treat bietti crystalline dystrophy
|
|
JP2022522756A
(ja)
|
2019-02-28 |
2022-04-20 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
治療薬の送達のためのアデノ随伴ウイルスベクター
|
|
CN111621502B
(zh)
*
|
2019-02-28 |
2023-05-02 |
武汉纽福斯生物科技有限公司 |
视网膜劈裂蛋白的编码序列、其表达载体构建及其应用
|
|
US20200297869A1
(en)
|
2019-03-04 |
2020-09-24 |
Adverum Biotechnologies, Inc. |
Sequential intravitreal administration of aav gene therapy to contralateral eyes
|
|
EP3715358A1
(en)
*
|
2019-03-28 |
2020-09-30 |
Universität zu Köln |
Mutated adeno-associated virus capsid proteins, aav particle comprising the same and liver directed aav vector gene therapy
|
|
SG11202110607WA
(en)
|
2019-04-01 |
2021-10-28 |
Tenaya Therapeutics Inc |
Adeno-associated virus with engineered capsid
|
|
CN113966236A
(zh)
|
2019-04-03 |
2022-01-21 |
再生生物股份有限公司 |
眼睛病状的基因疗法
|
|
TW202102526A
(zh)
*
|
2019-04-04 |
2021-01-16 |
美商銳進科斯生物股份有限公司 |
重組腺相關病毒及其用途
|
|
EP4310495A3
(en)
|
2019-04-11 |
2024-04-24 |
REGENXBIO Inc. |
Methods of size exclusion chromatography for the characterization of recombinant adeno-associated virus compositions
|
|
JP7630443B2
(ja)
|
2019-04-19 |
2025-02-17 |
レジェンクスバイオ インコーポレーテッド |
アデノ随伴ウイルスベクター製剤及び方法
|
|
BR112021021156A2
(pt)
|
2019-04-24 |
2022-02-08 |
Regenxbio Inc |
Terapêuticos anticorpos totalmente humanos pós-tradução modificados
|
|
US12421526B2
(en)
|
2019-04-24 |
2025-09-23 |
Takara Bio Inc. |
AAV mutant having brain-targeting property
|
|
TW202532428A
(zh)
*
|
2019-04-26 |
2025-08-16 |
美商愛德維仁生物科技公司 |
用於玻璃體內遞送之變異體aav蛋白殼
|
|
JP2022530845A
(ja)
*
|
2019-04-27 |
2022-07-04 |
オクジェン アイエヌシー． |
眼疾患に対するａｄｅｎｏ随伴ウイルス連ウイルスベクター媒介遺伝子治療
|
|
US11737665B2
(en)
|
2019-06-21 |
2023-08-29 |
Tesseract Health, Inc. |
Multi-modal eye imaging with shared optical path
|
|
WO2020264438A2
(en)
|
2019-06-27 |
2020-12-30 |
University Of Florida Research Foundation, Incorporated |
Enhancing aav-mediated transduction of ocular tissues with hyaluronic acid
|
|
WO2021005223A1
(en)
|
2019-07-10 |
2021-01-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of epilepsy
|
|
US20220282276A1
(en)
*
|
2019-07-11 |
2022-09-08 |
Centre National De La Recherche Scientifique |
Chemically-modified adeno-associated virus
|
|
US10653731B1
(en)
|
2019-07-15 |
2020-05-19 |
Vigene Biosciences Inc. |
Recombinantly-modified adeno-associated virus (rAAV) having improved packaging efficiency
|
|
US10557149B1
(en)
|
2019-07-15 |
2020-02-11 |
Vigene Biosciences, Inc. |
Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus
|
|
US10801042B1
(en)
|
2019-07-15 |
2020-10-13 |
Vigene Biosciences, Inc. |
Use of ion concentrations to increase the packaging efficiency of recombinant adeno-associated virus
|
|
US20230042103A1
(en)
|
2019-07-26 |
2023-02-09 |
Regenxbio Inc. |
Engineered nucleic acid regulatory element and methods of uses thereof
|
|
RU2751592C2
(ru)
|
2019-08-22 |
2021-07-15 |
Общество С Ограниченной Ответственностью "Анабион" |
Выделенный модифицированный белок VP1 капсида аденоассоциированного вируса 5 серотипа (AAV5), капсид и вектор на его основе
|
|
WO2021041373A1
(en)
|
2019-08-26 |
2021-03-04 |
Regenxbio Inc. |
Treatment of diabetic retinopathy with fully-human post-translationally modified anti-vegf fab
|
|
WO2021050649A1
(en)
|
2019-09-11 |
2021-03-18 |
Adverum Biotechnologies, Inc. |
Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
|
|
AU2020347276A1
(en)
*
|
2019-09-12 |
2022-03-17 |
Massachusetts Institute Of Technology |
Engineered adeno-associated virus capsids
|
|
GB201913974D0
(en)
|
2019-09-27 |
2019-11-13 |
King S College London |
Vector
|
|
WO2021067598A1
(en)
|
2019-10-04 |
2021-04-08 |
Ultragenyx Pharmaceutical Inc. |
Methods for improved therapeutic use of recombinant aav
|
|
CN114728049A
(zh)
|
2019-10-07 |
2022-07-08 |
再生生物股份有限公司 |
腺相关病毒载体药物组合物和方法
|
|
CA3153902A1
(en)
|
2019-10-16 |
2021-04-22 |
Pardis SABETI |
Engineered muscle targeting compositions
|
|
CN113518824B
(zh)
*
|
2019-10-16 |
2024-02-23 |
上海药明康德新药开发有限公司 |
新的aav变体
|
|
WO2021084133A1
(en)
*
|
2019-10-31 |
2021-05-06 |
Universität Bern |
Aav vector variants for ocular gene delivery
|
|
EP4054651A1
(en)
*
|
2019-11-08 |
2022-09-14 |
Regeneron Pharmaceuticals, Inc. |
Crispr and aav strategies for x-linked juvenile retinoschisis therapy
|
|
WO2021099394A1
(en)
|
2019-11-19 |
2021-05-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Antisense oligonucleotides and their use for the treatment of cancer
|
|
US20230057380A1
(en)
*
|
2019-11-26 |
2023-02-23 |
University Of Massachusetts |
Recombinant adeno-associated virus for delivery of kh902 (conbercept) and uses thereof
|
|
KR20220107222A
(ko)
|
2019-11-28 |
2022-08-02 |
리젠엑스바이오 인크. |
마이크로디스트로핀 유전자 치료 작제물 및 이의 용도
|
|
AU2021206256A1
(en)
*
|
2020-01-10 |
2022-07-28 |
The Brigham And Women's Hospital, Inc. |
Methods and compositions for delivery of immunotherapy agents across the blood-brain barrier to treat brain cancer
|
|
TW202140791A
(zh)
|
2020-01-13 |
2021-11-01 |
美商霍蒙拉奇醫藥公司 |
治療苯酮尿症之方法
|
|
JP2023511382A
(ja)
|
2020-01-22 |
2023-03-17 |
レジェンクスバイオ インコーポレーテッド |
完全ヒトグリコシル化ヒトα－Ｌ－イズロニダーゼ（ＩＤＵＡ）を用いたムコ多糖症Ｉ型の治療
|
|
EP4097238A1
(en)
|
2020-01-29 |
2022-12-07 |
REGENXBIO Inc. |
Treatment of mucopolysaccharidosis iva
|
|
TW202142695A
(zh)
|
2020-01-29 |
2021-11-16 |
美商銳進科斯生物股份有限公司 |
用人類神經或神經膠質細胞產生之重組人類艾杜糖醛酸—２—硫酸酯酶（ｉｄｓ）對ｉｉ型黏多糖病之治療
|
|
IL294781A
(en)
|
2020-02-14 |
2022-09-01 |
Ultragenyx Pharmaceutical Inc |
Gene therapy for treating cdkl5 deficiency disorder
|
|
EP4121544A1
(en)
|
2020-03-19 |
2023-01-25 |
Ultragenyx Pharmaceutical Inc. |
Compositions and methods for reducing reverse packaging of cap and rep sequences in recombinant aav
|
|
EP4127189A1
(en)
|
2020-03-31 |
2023-02-08 |
Ultragenyx Pharmaceutical Inc. |
Gene therapy for treating propionic acidemia
|
|
WO2021204407A1
(en)
|
2020-04-10 |
2021-10-14 |
Sorbonne Université |
G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
|
|
CA3179895A1
(en)
|
2020-04-24 |
2021-10-28 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods for preventing induction of immune responses to the transduced cells expressing a transgene product after ocular gene therapy
|
|
MX2022013411A
(es)
|
2020-04-27 |
2022-11-14 |
4D Molecular Therapeutics Inc |
Genes gla con codones optimizados y usos de los mismos.
|
|
US20230203102A1
(en)
|
2020-05-13 |
2023-06-29 |
Voyager Therapeutics, Inc. |
Redirection of tropism of aav capsids
|
|
TW202208632A
(zh)
|
2020-05-27 |
2022-03-01 |
美商同源醫藥公司 |
用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法
|
|
US12031147B2
(en)
|
2020-05-29 |
2024-07-09 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsids and methods of use thereof
|
|
IL299771A
(en)
|
2020-07-10 |
2023-03-01 |
Inst Nat Sante Rech Med |
Methods and compounds for the treatment of epilepsy
|
|
CN112226461B
(zh)
*
|
2020-08-21 |
2022-04-22 |
华侨大学 |
Cd4阳性细胞特异性基因传递载体及其应用
|
|
JP2023538129A
(ja)
*
|
2020-08-21 |
2023-09-06 |
カプシダ， インコーポレイテッド |
好ましい発現レベルを有するアデノ随伴ウイルス組成物
|
|
US12129287B2
(en)
|
2020-09-14 |
2024-10-29 |
President And Fellows Of Harvard College |
Recombinant adeno associated virus encoding clarin-1 and uses thereof
|
|
WO2022060916A1
(en)
|
2020-09-15 |
2022-03-24 |
Regenxbio Inc. |
Vectorized antibodies for anti-viral therapy
|
|
EP4213890A1
(en)
|
2020-09-15 |
2023-07-26 |
RegenxBio Inc. |
Vectorized lanadelumab and administration thereof
|
|
CN112194706B
(zh)
*
|
2020-09-30 |
2022-03-08 |
广州派真生物技术有限公司 |
腺相关病毒突变体及其应用
|
|
IL301647A
(en)
|
2020-10-07 |
2023-05-01 |
Regenxbio Inc |
Adeno-associated viruses for ocular delivery of gene therapy
|
|
US20230414788A1
(en)
|
2020-10-07 |
2023-12-28 |
Regenxbio Inc. |
Formulations for suprachoroidal administration such as gel formulations
|
|
AU2021358964A1
(en)
|
2020-10-07 |
2023-05-25 |
Regenxbio Inc. |
Formulations for suprachoroidal administration such as formulations with aggregate formation
|
|
WO2022076750A2
(en)
|
2020-10-07 |
2022-04-14 |
Regenxbio Inc. |
Recombinant adeno-associated viruses for cns or muscle delivery
|
|
WO2022076549A1
(en)
|
2020-10-07 |
2022-04-14 |
Regenxbio Inc. |
Formulations for suprachoroidal administration such as high viscosity formulations
|
|
WO2022094157A1
(en)
|
2020-10-28 |
2022-05-05 |
Regenxbio Inc. |
Vectorized anti-cgrp and anti-cgrpr antibodies and administration thereof
|
|
CN116528892A
(zh)
|
2020-10-28 |
2023-08-01 |
再生生物股份有限公司 |
用于眼部适应症的载体化抗TNF-α抗体
|
|
EP4236974A2
(en)
|
2020-10-29 |
2023-09-06 |
RegenxBio Inc. |
Vectorized factor xii antibodies and administration thereof
|
|
CN116457373A
(zh)
|
2020-10-29 |
2023-07-18 |
再生生物股份有限公司 |
用于眼部适应症的载体化TNF-α拮抗剂
|
|
EP4243848A4
(en)
*
|
2020-11-10 |
2025-07-23 |
Avirmax Biopharma Inc |
MODIFIED VIRAL CAPSIDS AND METHODS OF USE
|
|
US20240002839A1
(en)
|
2020-12-02 |
2024-01-04 |
Decibel Therapeutics, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
CA3201743A1
(en)
|
2020-12-16 |
2022-06-23 |
Robert STADELMAN |
Method of producing a recombinant adeno-associated virus particle
|
|
EP4263575A4
(en)
*
|
2020-12-16 |
2025-05-07 |
Children's Medical Research Institute |
Adeno-associated virus capsids and vectors
|
|
WO2022147087A1
(en)
|
2020-12-29 |
2022-07-07 |
Regenxbio Inc. |
Tau-specific antibody gene therapy compositions, methods and uses thereof
|
|
JP2024503895A
(ja)
|
2021-01-21 |
2024-01-29 |
リジェネクスバイオ インコーポレイテッド |
組換えポリペプチド及びウイルスの生成の改善
|
|
CA3209611A1
(en)
|
2021-02-10 |
2022-08-18 |
Regenxbio Inc. |
Treatment of mucopolysaccharidosis ii with recombinant human iduronate-2-sulfatase (ids)
|
|
CN113121652B
(zh)
*
|
2021-04-19 |
2022-10-11 |
上海信致医药科技有限公司 |
视网膜和肌肉高亲和性腺相关病毒衣壳蛋白及相关应用
|
|
CN113121651B
(zh)
*
|
2021-04-19 |
2023-11-17 |
信念医药科技(上海)有限公司 |
低中和抗体腺相关病毒衣壳蛋白
|
|
EP4326339B1
(en)
|
2021-04-20 |
2025-04-02 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Compositions and methods for treating retinal degenerative disorders
|
|
CA3216744A1
(en)
|
2021-04-26 |
2022-11-03 |
Regenxbio Inc. |
Microdystrophin gene therapy administration for treatment of dystrophinopathies
|
|
CA3215855A1
(en)
|
2021-04-27 |
2022-11-03 |
Julie Clark |
Methods of treating ocular diseases using aav2 variants encoding aflibercept
|
|
US20240218397A1
(en)
|
2021-05-04 |
2024-07-04 |
Regenxbio Inc. |
Novel aav vectors and methods and uses thereof
|
|
US20240358857A1
(en)
|
2021-05-11 |
2024-10-31 |
Regenxbio Inc. |
Treatment of duchenne muscular dystrophy and combinations thereof
|
|
AU2022283585A1
(en)
|
2021-05-26 |
2023-12-21 |
Centre National De La Recherche Scientifique - Cnrs - |
G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
|
|
MX2023014041A
(es)
*
|
2021-05-28 |
2023-12-15 |
Shanghai Regenelead Therapies Co Ltd |
Virus adenoasociado recombinante que tiene una capsida variante y su aplicacion.
|
|
EP4346767A4
(en)
*
|
2021-06-03 |
2025-06-25 |
Dyno Therapeutics, Inc. |
CAPSIDE VARIANTS AND METHODS OF USE THEREOF
|
|
EP4366757A1
(en)
|
2021-07-07 |
2024-05-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Synergistic combination of rdcfv2 and rdcvf2l for the treatment of tauopathies
|
|
AU2022307365A1
(en)
|
2021-07-08 |
2024-02-01 |
Tenaya Therapeutics, Inc. |
Optimized expression cassettes for gene therapy
|
|
EP4373947A1
(en)
|
2021-07-19 |
2024-05-29 |
New York University |
Auf1 combination therapies for treatment of muscle degenerative disease
|
|
US20250019721A1
(en)
|
2021-08-11 |
2025-01-16 |
Ultragenyx Pharmaceutical Inc. |
Compositions and methods for treating a muscular dystrophy
|
|
IL310949A
(en)
|
2021-08-20 |
2024-04-01 |
Biocad Joint Stock Co |
Method for producing modified adeno-associated virus capsid
|
|
AR126839A1
(es)
|
2021-08-20 |
2023-11-22 |
Llc «Anabion» |
Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 9 (aav9), cápside y vector basado en esta
|
|
AR126840A1
(es)
|
2021-08-20 |
2023-11-22 |
Llc «Anabion» |
Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 5 (aav5), cápside y vector basado en esta
|
|
CN118202060A
(zh)
|
2021-10-05 |
2024-06-14 |
再生生物股份有限公司 |
用于重组aav生产的组合物和方法
|
|
WO2023060113A1
(en)
|
2021-10-05 |
2023-04-13 |
Regenxbio Inc. |
Compositions and methods for recombinant aav production
|
|
WO2023060269A1
(en)
|
2021-10-07 |
2023-04-13 |
Regenxbio Inc. |
Recombinant adeno-associated viruses for targeted delivery
|
|
WO2023060272A2
(en)
|
2021-10-07 |
2023-04-13 |
Regenxbio Inc. |
Recombinant adeno-associated viruses for cns tropic delivery
|
|
MX2024004217A
(es)
|
2021-10-08 |
2024-06-26 |
Dyno Therapeutics Inc |
Variantes de cápside y métodos de uso de estas.
|
|
US20230338581A1
(en)
|
2021-10-11 |
2023-10-26 |
Sparingvision |
G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
|
|
EP4423285A1
(en)
|
2021-10-28 |
2024-09-04 |
RegenxBio Inc. |
Engineered nucleic acid regulatory elements and methods and uses thereof
|
|
KR20240113624A
(ko)
|
2021-11-02 |
2024-07-22 |
보이저 테라퓨틱스, 인크. |
Aav 캡시드 변이체 및 이의 용도
|
|
US20250297279A1
(en)
*
|
2021-12-15 |
2025-09-25 |
Genans Biotechnology Co., Ltd |
Recombinant aav vectors and use thereof
|
|
CA3243256A1
(en)
|
2022-02-02 |
2023-08-10 |
Adverum Biotechnologies Inc |
Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
|
|
WO2023158990A1
(en)
|
2022-02-16 |
2023-08-24 |
Adverum Biotechnologies, Inc. |
Method of reducing cst fluctuation in neovascular amd by a recombinant adeno-associated virus
|
|
WO2023155828A1
(en)
*
|
2022-02-17 |
2023-08-24 |
Skyline Therapeutics (Shanghai) Co., Ltd. |
Recombinant adeno-associated virus with modified aav capsid polypeptides
|
|
EP4490278A1
(en)
|
2022-03-07 |
2025-01-15 |
Ultragenyx Pharmaceutical Inc. |
Modified batch aav production systems and methods
|
|
EP4493226A1
(en)
|
2022-03-13 |
2025-01-22 |
RegenxBio Inc. |
Modified muscle-specific promoters
|
|
EP4499154A1
(en)
|
2022-03-25 |
2025-02-05 |
REGENXBIO Inc. |
Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy
|
|
TW202345913A
(zh)
|
2022-04-06 |
2023-12-01 |
美商銳進科斯生物股份有限公司 |
用於脈絡膜上投與之調配物諸如凝膠調配物
|
|
TW202404651A
(zh)
|
2022-04-06 |
2024-02-01 |
美商銳進科斯生物股份有限公司 |
用於脈絡膜上投與之調配物諸如形成聚集體之調配物
|
|
AU2023250660A1
(en)
|
2022-04-06 |
2024-10-24 |
Regenxbio Inc. |
Pharmaceutical composition comprising a recombinant adenoassociated virus vector with an expression cassette encoding a transgene for suprachoroidal administration
|
|
WO2023201207A1
(en)
|
2022-04-11 |
2023-10-19 |
Tenaya Therapeutics, Inc. |
Adeno-associated virus with engineered capsid
|
|
CN120590489A
(zh)
*
|
2022-04-12 |
2025-09-05 |
合肥星眸生物科技有限公司 |
一种融合型腺相关病毒及其应用
|
|
US20250249127A1
(en)
|
2022-04-14 |
2025-08-07 |
Regenxbio Inc. |
Gene therapy for treating an ocular disease
|
|
WO2023201277A1
(en)
|
2022-04-14 |
2023-10-19 |
Regenxbio Inc. |
Recombinant adeno-associated viruses for cns tropic delivery
|
|
CN116970648A
(zh)
*
|
2022-04-24 |
2023-10-31 |
上海朗昇生物科技有限公司 |
新型aav衣壳改造株及其用途
|
|
US20250288697A1
(en)
|
2022-05-03 |
2025-09-18 |
Regenxbio Inc. |
Vectorized anti-tnf-alpha inhibitors for ocular indications
|
|
EP4518972A2
(en)
|
2022-05-03 |
2025-03-12 |
RegenxBio Inc. |
Vectorized anti-complement antibodies and complement agents and administration thereof
|
|
KR20250022114A
(ko)
|
2022-06-07 |
2025-02-14 |
애드베룸 바이오테크놀로지스, 인코포레이티드 |
시력 회복을 위한 멜라놉신 변이체
|
|
WO2023239627A2
(en)
|
2022-06-08 |
2023-12-14 |
Regenxbio Inc. |
Methods for recombinant aav production
|
|
EP4558149A1
(en)
|
2022-07-21 |
2025-05-28 |
Institut National de la Santé et de la Recherche Médicale |
Methods and compositions for treating chronic pain disorders
|
|
WO2024033837A1
(en)
|
2022-08-11 |
2024-02-15 |
Institute Of Molecular And Clinical Ophthalmology Basel (Iob) |
Human cone photoreceptor optogenetic constructs
|
|
EP4577663A2
(en)
|
2022-08-24 |
2025-07-02 |
RegenxBio Inc. |
Recombinant adeno-associated viruses and uses thereof
|
|
IL319873A
(en)
|
2022-09-30 |
2025-05-01 |
Regenxbio Inc |
Treatment of eye diseases with recombinant viral vectors containing anti-VEGF FAB
|
|
JP2025534666A
(ja)
|
2022-10-11 |
2025-10-17 |
リジェネックスバイオ インコーポレイテッド |
操作された核酸調節エレメントならびにその使用方法
|
|
AU2023362592A1
(en)
|
2022-10-20 |
2025-05-08 |
Centre National De La Recherche Scientifique |
Compositions and methods for treating retinal degenerative disorders
|
|
US20240207451A1
(en)
|
2022-10-20 |
2024-06-27 |
Sparingvision |
G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
|
|
WO2024107670A1
(en)
|
2022-11-16 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Chimeric proteins comprising membrane bound il-12 with protease cleavable linkers
|
|
CN120752339A
(zh)
|
2023-01-06 |
2025-10-03 |
国家医疗保健研究所 |
静脉内施用用于治疗疼痛的反义寡核苷酸
|
|
CN118359687A
(zh)
*
|
2023-01-18 |
2024-07-19 |
上海朗昇生物科技有限公司 |
一种新衣壳蛋白变体以及其用途
|
|
KR20250142340A
(ko)
|
2023-02-02 |
2025-09-30 |
퀘세라 리미티드 |
재조합 아데노-부속 바이러스 벡터
|
|
TW202502803A
(zh)
|
2023-03-10 |
2025-01-16 |
美商戴諾治療公司 |
衣殼多肽及其使用方法
|
|
WO2024192281A2
(en)
|
2023-03-15 |
2024-09-19 |
Regenxbio Inc. |
Exon skipping gene therapy constructs, vectors and uses thereof
|
|
WO2024211831A1
(en)
|
2023-04-05 |
2024-10-10 |
Adverum Biotechnologies, Inc. |
Immune landscape signatures for ocular inflammation
|
|
WO2024211780A1
(en)
|
2023-04-07 |
2024-10-10 |
Regenxbio Inc. |
Compositions and methods for recombinant aav production
|
|
WO2024215655A1
(en)
|
2023-04-10 |
2024-10-17 |
Tenaya Therapeutics, Inc. |
Cardioprotective bag3 therapies
|
|
WO2024215653A1
(en)
|
2023-04-10 |
2024-10-17 |
Tenaya Therapeutics, Inc. |
Guide rnas, vectors, and virions for targeting mutations in the pln gene
|
|
WO2024216244A2
(en)
|
2023-04-13 |
2024-10-17 |
Regenxbio Inc. |
Targeting aav capsids, methods of manufacturing and using same
|
|
WO2024229389A1
(en)
*
|
2023-05-03 |
2024-11-07 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of tau-related disorders
|
|
WO2024229425A1
(en)
*
|
2023-05-04 |
2024-11-07 |
Voyager Therapeutics, Inc. |
Aav capsid variants and uses thereof
|
|
WO2024233529A2
(en)
|
2023-05-07 |
2024-11-14 |
Regenxbio Inc. |
Compositions and methods for recombinant aav production
|
|
WO2024238867A1
(en)
|
2023-05-16 |
2024-11-21 |
Regenxbio Inc. |
Vectorized anti-complement antibodies and administration thereof
|
|
WO2024238859A1
(en)
|
2023-05-16 |
2024-11-21 |
Regenxbio Inc. |
Vectorized c5 inhibitor agents and administration thereof
|
|
WO2024238853A1
(en)
|
2023-05-16 |
2024-11-21 |
Regenxbio Inc. |
Adeno-associated viruses for ocular delivery of gene therapy
|
|
WO2024240113A1
(zh)
*
|
2023-05-23 |
2024-11-28 |
北京因诺惟康医药科技有限公司 |
一种腺相关病毒衣壳蛋白、包含其的腺相关病毒、载体及应用
|
|
WO2025008406A1
(en)
|
2023-07-04 |
2025-01-09 |
Institut National de la Santé et de la Recherche Médicale |
Antisense oligonucleotides and their use for the treatment of cancer
|
|
WO2025015317A2
(en)
|
2023-07-13 |
2025-01-16 |
Kriya Therapeutics, Inc. |
Complement pathway inhibitor fusions and methods of using the same
|
|
CN117230117A
(zh)
*
|
2023-08-04 |
2023-12-15 |
中国科学院深圳先进技术研究院 |
重组腺相关病毒包装质粒、突变体及其制备方法和应用
|
|
TW202525832A
(zh)
|
2023-08-31 |
2025-07-01 |
美商戴諾治療公司 |
衣殼多肽及其使用方法(二)
|
|
WO2025075963A1
(en)
|
2023-10-02 |
2025-04-10 |
Regenxbio Inc. |
Methods and formulations for treating mucopolysaccharidosis ii-associated hearing loss with recombinant human iduronate-2-sulfatase
|
|
WO2025090962A1
(en)
|
2023-10-25 |
2025-05-01 |
Regenxbio Inc. |
Compositions and methods for recombinant aav production
|
|
CN117247434B
(zh)
*
|
2023-11-10 |
2024-02-02 |
上海朗昇生物科技有限公司 |
衣壳修饰型病毒载体及其制备和用途
|
|
WO2025106374A1
(en)
|
2023-11-13 |
2025-05-22 |
Juno Therapeutics, Inc. |
Aav production method
|
|
WO2025108407A2
(en)
|
2023-11-23 |
2025-05-30 |
Neuexcell Therapeutics (Suzhou) Co., Ltd. |
Gene therapy compositions and methods for treating glioma
|
|
WO2025113676A1
(en)
|
2023-11-29 |
2025-06-05 |
Neuexcell Therapeutics (Suzhou) Co., Ltd. |
Compositions and methods for treating stroke in primates
|
|
WO2025129085A1
(en)
|
2023-12-15 |
2025-06-19 |
Port Therapeutics, Inc. |
Use of thermal bioswitches in aav-based gene therapy
|
|
CN119080889B
(zh)
*
|
2024-09-18 |
2025-06-24 |
广州译码基因科技有限公司 |
提高aav对眼组织感染能力的衣壳蛋白突变体及应用
|
|
WO2025171227A1
(en)
|
2024-02-08 |
2025-08-14 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|
|
WO2025217230A1
(en)
*
|
2024-04-08 |
2025-10-16 |
Regenxbio Inc. |
Vectorized anti-complement antibodies and complement agents and administration thereof
|
|
WO2025217214A2
(en)
|
2024-04-08 |
2025-10-16 |
Regenxbio Inc. |
Recombinant adeno-associated viruses and uses thereof
|
|
WO2025214408A1
(en)
|
2024-04-10 |
2025-10-16 |
Skyline Therapeutics (Shanghai) Co., Ltd. |
Optogenetic modulation for vision restoration
|
|
WO2025214404A1
(en)
|
2024-04-10 |
2025-10-16 |
Skyline Therapeutics (Shanghai) Co., Ltd. |
Optogenetic modulation for vision restoration
|
|
WO2025237990A1
(en)
|
2024-05-14 |
2025-11-20 |
Institut National de la Santé et de la Recherche Médicale |
Antisense oligonucleotides and their use for the treatment of pulmonary fibrosis
|
|
CN118955654B
(zh)
*
|
2024-10-15 |
2025-05-16 |
朗信启昇(苏州)生物制药有限公司 |
具有变异衣壳的腺相关病毒病毒体及其用途
|