CY1122902T1 - Ιοσωματιδια αδενο-συσχετιζομενου ιου με καψιδιο παραλλαγματος και μεθοδοι χρησης εξ αυτων - Google Patents

Ιοσωματιδια αδενο-συσχετιζομενου ιου με καψιδιο παραλλαγματος και μεθοδοι χρησης εξ αυτων

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Publication number
CY1122902T1
CY1122902T1 CY20201100437T CY201100437T CY1122902T1 CY 1122902 T1 CY1122902 T1 CY 1122902T1 CY 20201100437 T CY20201100437 T CY 20201100437T CY 201100437 T CY201100437 T CY 201100437T CY 1122902 T1 CY1122902 T1 CY 1122902T1
Authority
CY
Cyprus
Prior art keywords
methods
virus
encapsid
gland
variant
Prior art date
Application number
CY20201100437T
Other languages
English (en)
Inventor
David V. Schaffer
Ryan R. Klimczak
James T. Koerber
John G. Flannery
Deniz DALKARA MOUROT
Meike VISEL
Leah C.T. BYRNE
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of CY1122902T1 publication Critical patent/CY1122902T1/el

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Abstract

Η παρούσα αποκάλυψη παρέχει ιοσωματίδια αδενο-συσχετιζόμενου ιού (ΑΑV) με αλλοιωμένη πρωτεΐνη καψιδίου, όπου τα ιοσωματίδια ΑΑV εκδηλώνουν μεγαλύτερη μολυσματικότητα αμφιβληστροειδικών κυττάρων, όταν χορηγούνται μέσω ενδοϋαλοειδικής ένεσης συγκρινόμενα με ΑΑV φυσικού-τύπου. Η παρούσα αποκάλυψη παρέχει περαιτέρω μεθόδους απελευθέρωσης ενός προϊόντος γονιδίου σε ένα αμφιβληστροειδικό κύτταρο σε ένα άτομο, και μεθόδους αγωγής οφθαλμικής πάθησης.
CY20201100437T 2011-04-22 2020-05-12 Ιοσωματιδια αδενο-συσχετιζομενου ιου με καψιδιο παραλλαγματος και μεθοδοι χρησης εξ αυτων CY1122902T1 (el)

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