|
JP2610889B2
(ja)
|
1987-09-03 |
1997-05-14 |
日本臓器製薬株式会社 |
新規架橋アデニン誘導体
|
|
TW552261B
(en)
|
1996-07-03 |
2003-09-11 |
Japan Energy Corp |
Novel purine derivative
|
|
TR199900389T2
(xx)
|
1996-08-28 |
2000-06-21 |
Pfizer Inc. |
�kame edilmi� 6,5-hetero-bisiklik t�revleri.
|
|
CA2267103C
(en)
|
1996-10-04 |
2006-05-30 |
Kyorin Pharmaceutical Co., Ltd. |
Pyrazolopyridylpyridazinone derivatives and process for the preparation thereof
|
|
AR012634A1
(es)
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
|
US6339089B2
(en)
|
1997-08-13 |
2002-01-15 |
Fujirebio Inc. |
Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
|
|
CA2311742C
(en)
|
1997-11-28 |
2009-06-16 |
Sumitomo Pharmaceuticals Co., Ltd. |
6-amino-9-benzyl-8-hydroxypurine derivatives
|
|
TW572758B
(en)
|
1997-12-22 |
2004-01-21 |
Sumitomo Pharma |
Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
|
|
US6187777B1
(en)
|
1998-02-06 |
2001-02-13 |
Amgen Inc. |
Compounds and methods which modulate feeding behavior and related diseases
|
|
JP2002503662A
(ja)
|
1998-02-17 |
2002-02-05 |
テュラリク インコーポレイテッド |
抗ウイルス性ピリミジン誘導体
|
|
US6110929A
(en)
|
1998-07-28 |
2000-08-29 |
3M Innovative Properties Company |
Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
|
|
JP4342007B2
(ja)
|
1998-08-10 |
2009-10-14 |
大日本住友製薬株式会社 |
キナゾリン誘導体
|
|
JP4315300B2
(ja)
|
1998-08-10 |
2009-08-19 |
大日本住友製薬株式会社 |
新規なキナゾリン誘導体
|
|
WO2000012487A1
(en)
|
1998-08-27 |
2000-03-09 |
Sumitomo Pharmaceuticals Co., Ltd. |
Pyrimidine derivatives
|
|
WO2000048606A1
(en)
*
|
1999-02-18 |
2000-08-24 |
Oxigene, Inc. |
Compositions and methods for use in targeting vascular destruction
|
|
US6583148B1
(en)
|
1999-04-08 |
2003-06-24 |
Krenitsky Pharmaceuticals, Inc. |
Neurotrophic substituted pyrimidines
|
|
US6503908B1
(en)
|
1999-10-11 |
2003-01-07 |
Pfizer Inc |
Pharmaceutically active compounds
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
WO2003055890A1
(en)
|
2001-12-21 |
2003-07-10 |
Bayer Pharmaceuticals Corporation |
Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
|
|
US7091232B2
(en)
|
2002-05-21 |
2006-08-15 |
Allergan, Inc. |
4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
|
|
TW200407143A
(en)
|
2002-05-21 |
2004-05-16 |
Bristol Myers Squibb Co |
Pyrrolotriazinone compounds and their use to treat diseases
|
|
AU2003242252A1
(en)
|
2002-06-07 |
2003-12-22 |
Kyowa Hakko Kogyo Co., Ltd. |
Bicyclic pyrimidine derivatives
|
|
KR101111085B1
(ko)
|
2002-09-27 |
2012-04-12 |
다이닛본 스미토모 세이야꾸 가부시끼가이샤 |
신규 아데닌 화합물 및 그 용도
|
|
US8455458B2
(en)
|
2002-10-16 |
2013-06-04 |
Arthrodynamic Technologies, Animal Health Division, Inc. |
Composition and method for treating connective tissue damage
|
|
JP2007524615A
(ja)
|
2003-06-20 |
2007-08-30 |
コーリー ファーマシューティカル ゲーエムベーハー |
低分子トール様レセプター（ｔｌｒ）アンタゴニスト
|
|
ATE465742T1
(de)
|
2003-09-05 |
2010-05-15 |
Anadys Pharmaceuticals Inc |
Tlr7-liganden zur behandlung von hepatitis c
|
|
US8012964B2
(en)
|
2004-03-26 |
2011-09-06 |
Dainippon Sumitomo Pharma Co., Ltd. |
9-substituted 8-oxoadenine compound
|
|
EP1728792A4
(en)
|
2004-03-26 |
2010-12-15 |
Dainippon Sumitomo Pharma Co |
8-OXOADENINVERBINDUNG
|
|
WO2007084413A2
(en)
|
2004-07-14 |
2007-07-26 |
Ptc Therapeutics, Inc. |
Methods for treating hepatitis c
|
|
RU2401833C2
(ru)
|
2004-08-10 |
2010-10-20 |
Янссен Фармацевтика Н.В. |
Производные 1, 2, 4-триазин-6-она, ингибирующие вич
|
|
JP2008509909A
(ja)
*
|
2004-08-11 |
2008-04-03 |
ウィリアムスバーグ・ホールディングス・エルエルシー |
心毒性のない医薬化合物
|
|
JP2008519083A
(ja)
|
2004-11-09 |
2008-06-05 |
エフ．ホフマン−ラ ロシュ アーゲー |
アミノキナゾリン化合物
|
|
US7498409B2
(en)
|
2005-03-24 |
2009-03-03 |
Schering Corporation |
Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists
|
|
MX2007013780A
(es)
|
2005-05-04 |
2008-02-05 |
Pfizer Ltd |
Derivados 2 amido-6-amino-8-oxo purina como moduladores del receptor como tipo peaje (toll) para el tratamiento del cancer y las infecciones virales tal como la hepatitis c.
|
|
AR054122A1
(es)
|
2005-05-12 |
2007-06-06 |
Tibotec Pharm Ltd |
Pirido[2,3-d]pirimidas utiles como inhibidores de hcv, y metodos para la preparacion de las mismas
|
|
US7994360B2
(en)
|
2005-05-16 |
2011-08-09 |
Xtl Biopharmaceuticals Ltd. |
Benzofuran compounds
|
|
TWI404537B
(zh)
*
|
2005-08-19 |
2013-08-11 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
|
|
ES2612890T3
(es)
|
2005-09-01 |
2017-05-19 |
F. Hoffmann-La Roche Ag |
Diaminopirimidinas como moduladores de P2X3 y P2X2/3
|
|
EP1939198A4
(en)
|
2005-09-22 |
2012-02-15 |
Dainippon Sumitomo Pharma Co |
NEW ADENINE COMPOUND
|
|
WO2007056208A2
(en)
|
2005-11-02 |
2007-05-18 |
Cytovia, Inc. |
N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
US20090182140A1
(en)
|
2005-12-02 |
2009-07-16 |
Mitsubishi Tanabe Pharma Corporation |
Alicyclic Heterocyclic Compound
|
|
JP2009528989A
(ja)
|
2006-02-17 |
2009-08-13 |
ファイザー・リミテッド |
Ｔｌｒ７変調剤としての３−デアザプリン誘導体
|
|
US8673929B2
(en)
|
2006-07-20 |
2014-03-18 |
Gilead Sciences, Inc. |
4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
|
|
WO2008009078A2
(en)
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
|
|
JP5500990B2
(ja)
|
2006-12-07 |
2014-05-21 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
ホスホイノシチド３−キナーゼ阻害剤化合物及び使用方法
|
|
CA2672250C
(en)
|
2006-12-20 |
2013-04-30 |
Ian Stansfield |
Antiviral indoles
|
|
ES2456964T3
(es)
|
2007-02-07 |
2014-04-24 |
The Regents Of The University Of California |
Conjugados de agonistas de TLR sintéticos y usos de los mismos
|
|
JP2008222557A
(ja)
|
2007-03-08 |
2008-09-25 |
Kotobuki Seiyaku Kk |
ピロロ［３，２−ｄ］ピリミジン誘導体及びこれを有効成分とする医薬組成物
|
|
SI2132209T1
(sl)
|
2007-03-19 |
2014-05-30 |
Astrazeneca Ab |
Spojine 9-substituiranega-8-okso-adenina, kot modulatorji Toll-like receptorja (TLR7)
|
|
AR065784A1
(es)
|
2007-03-20 |
2009-07-01 |
Dainippon Sumitomo Pharma Co |
Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
|
|
EP2138497A4
(en)
|
2007-03-20 |
2012-01-04 |
Dainippon Sumitomo Pharma Co |
NEW ADENINE CONNECTION
|
|
CA2687821C
(en)
|
2007-05-22 |
2015-04-14 |
Boehringer Ingelheim International Gmbh |
Benzimidazolone chymase inhibitors
|
|
SI2170888T1
(sl)
|
2007-06-29 |
2015-10-30 |
Gilead Sciences, Inc. |
Purinski derivati in njihova uporaba kot modulatorjev receptorja tipa toll-7
|
|
US20120121540A1
(en)
|
2007-08-10 |
2012-05-17 |
Franz Ulrich Schmitz |
Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections
|
|
WO2009032668A2
(en)
|
2007-08-28 |
2009-03-12 |
Irm Llc |
2 -biphenylamino-4 -aminopyrimidine derivatives as kinase inhibitors
|
|
WO2009030998A1
(en)
|
2007-09-05 |
2009-03-12 |
Coley Pharmaceutical Group, Inc. |
Pyrimidine compounds as toll-like receptor (tlr) agonists
|
|
PE20091236A1
(es)
|
2007-11-22 |
2009-09-16 |
Astrazeneca Ab |
Derivados de pirimidina como immunomoduladores de tlr7
|
|
US8524716B2
(en)
|
2007-12-24 |
2013-09-03 |
Janssen R&D Ireland |
Macrocyclic indoles as hepatitis C virus inhibitors
|
|
JP2011511073A
(ja)
|
2008-02-07 |
2011-04-07 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Ｔｌｒ７活性化物質による膀胱の疾患の治療
|
|
EP2271345B1
(en)
|
2008-04-28 |
2015-05-20 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
|
US8946239B2
(en)
|
2008-07-10 |
2015-02-03 |
Duquesne University Of The Holy Spirit |
Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
|
|
UY31982A
(es)
|
2008-07-16 |
2010-02-26 |
Boehringer Ingelheim Int |
Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas
|
|
JP5600104B2
(ja)
|
2008-08-01 |
2014-10-01 |
ベンティアールエックス ファーマシューティカルズ， インコーポレイテッド |
Ｔｏｌｌ様受容体アゴニスト処方物およびその使用
|
|
BRPI1010937A2
(pt)
|
2009-05-21 |
2019-09-24 |
Astrazeneca Ab |
composto, uso de um composto, e, método para tratar câncer
|
|
US8637525B2
(en)
|
2009-07-31 |
2014-01-28 |
Bristol-Myers Squibb Company |
Compounds for the reduction of beta-amyloid production
|
|
TWI468402B
(zh)
|
2009-07-31 |
2015-01-11 |
必治妥美雅史谷比公司 |
降低β－類澱粉生成之化合物
|
|
US20120232062A1
(en)
|
2009-10-20 |
2012-09-13 |
Eiger Biopharmaceuticals, Inc. |
Azaindazoles to treat flaviviridae virus infection
|
|
MX2012004706A
(es)
|
2009-10-22 |
2012-06-08 |
Gilead Sciences Inc |
Derivados de purina o deazapurina utiles para el tratamiento de (inter alia) infecciones virales.
|
|
KR101094446B1
(ko)
|
2009-11-19 |
2011-12-15 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
|
|
JP2013032290A
(ja)
|
2009-11-20 |
2013-02-14 |
Dainippon Sumitomo Pharma Co Ltd |
新規縮合ピリミジン誘導体
|
|
DE102010040233A1
(de)
|
2010-09-03 |
2012-03-08 |
Bayer Schering Pharma Aktiengesellschaft |
Bicyclische Aza-Heterocyclen und ihre Verwendung
|
|
RU2016118628A
(ru)
|
2010-10-01 |
2018-11-02 |
Вентиркс Фармасьютикалз, Инк. |
Способы лечения аллергических заболеваний
|
|
WO2012066335A1
(en)
|
2010-11-19 |
2012-05-24 |
Astrazeneca Ab |
Phenol compounds als toll -like receptor 7 agonists
|
|
WO2012067269A1
(en)
|
2010-11-19 |
2012-05-24 |
Dainippon Sumitomo Pharma Co., Ltd. |
Aminoalkoxyphenyl compounds and their use in the treatment of disease
|
|
KR101946499B1
(ko)
*
|
2011-04-08 |
2019-02-11 |
얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 |
바이러스 감염 치료를 위한 피리미딘 유도체
|
|
SG194852A1
(en)
|
2011-05-18 |
2013-12-30 |
Janssen R & D Ireland |
Quinazoline derivatives for the treatment of viral infections and further diseases
|
|
UA116083C2
(uk)
|
2011-11-09 |
2018-02-12 |
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі |
Похідні пурину для лікування вірусних інфекцій
|
|
JP6283320B2
(ja)
|
2012-02-08 |
2018-02-21 |
ヤンセン・サイエンシズ・アイルランド・ユーシー |
ウイルス感染の治療のためのピペリジノ−ピリミジン誘導体
|
|
SI3459942T1
(sl)
|
2012-04-24 |
2021-05-31 |
Vertex Pharmaceuticals Incorporated |
Inhibitorji DNA-PK
|
|
PT2872515T
(pt)
|
2012-07-13 |
2016-07-27 |
Janssen Sciences Ireland Uc |
Purinas macrocíclicas para o tratamento de infeções virais
|
|
MX369417B
(es)
|
2012-08-10 |
2019-11-07 |
Janssen Sciences Ireland Uc |
Derivados de alquilpirimidina para el tratamiento de infecciones víricas y otras enfermedades.
|
|
EP2712866A1
(en)
|
2012-10-01 |
2014-04-02 |
Centre National de la Recherche Scientifique (CNRS) |
1,2,4-triazine derivatives for the treatment of viral infections
|
|
SG11201502589YA
(en)
*
|
2012-10-05 |
2015-04-29 |
Janssen Sciences Ireland Uc |
Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases
|
|
EA035327B1
(ru)
|
2012-10-10 |
2020-05-28 |
Янссен Сайенсиз Айрлэнд Юси |
Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний
|
|
ES2655843T3
(es)
|
2012-11-16 |
2018-02-21 |
Janssen Sciences Ireland Uc |
Derivados 2-aminoquinazolínicos sustituidos heterocíclicos para el tratamiento de infecciones víricas
|
|
MY191389A
(en)
*
|
2013-02-21 |
2022-06-22 |
Janssen Sciences Ireland Uc |
2-aminopyrimidine derivatives for the treatment of viral infections
|
|
CN105338983B
(zh)
|
2013-03-29 |
2019-10-25 |
爱尔兰詹森科学公司 |
用于治疗病毒感染的大环脱氮-嘌呤酮
|
|
JP6377139B2
(ja)
|
2013-05-24 |
2018-08-22 |
ヤンセン・サイエンシズ・アイルランド・ユーシー |
ウイルス感染症およびさらなる疾患の処置のためのピリドン誘導体
|
|
JP6763769B2
(ja)
|
2013-06-27 |
2020-09-30 |
ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー |
ウイルス感染症および他の疾病の処置のためのピロロ［３，２−ｄ］ピリミジン誘導体
|
|
MX368625B
(es)
|
2013-07-30 |
2019-10-08 |
Janssen Sciences Ireland Uc |
Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales.
|
|
EP3166938A4
(en)
|
2014-07-11 |
2018-01-17 |
Northwestern University |
2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
|
|
SG11201811448RA
(en)
|
2016-07-01 |
2019-01-30 |
Janssen Sciences Ireland Unlimited Co |
Dihydropyranopyrimidines for the treatment of viral infections
|